Lipidomics is providing new insight into the metabolic syndrome and its sequelae

Current Opinion in Lipidology

Volumn 22, Issue 3, 2011, Pages 210-215

  Meikle, Peter J ^a,b   Christopher, Michael J ^a  

^a MONASH UNIVERSITY   (Australia)

^b NONE   (Australia)

Author keywords

insulin resistance; lipidomics; metabolic syndrome; steatosis; type 2 diabetes

Indexed keywords

LIPIDOME; LIPOPROTEIN;

ARTICLE; DISORDERS OF MITOCHONDRIAL FUNCTIONS; GENETIC ASSOCIATION; HUMAN; INFLAMMATION; INSULIN RESISTANCE; LIPID METABOLISM; LIPIDOMICS; METABOLIC SYNDROME X; NONALCOHOLIC FATTY LIVER; NONHUMAN; OBESITY; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN FUNCTION;

EID: 85027940419     PISSN: 09579672     EISSN: 14736535     Source Type: Journal    
DOI: 10.1097/MOL.0b013e3283453dbe     Document Type: Article

References (36)

1. Chavez JA, Summers SA. Lipid oversupply, selective insulin resistance, and lipotoxicity: molecular mechanisms. Biochim Biophys Acta2010; 1801:252-265.
2. Han X, Gross RW. Shotgun lipidomics: electrospray ionization mass spectro-metric analysis and quantitation of cellular lipidomes directly from crude extracts of biological samples. Mass Spectrom Rev 2005; 24:367-412. (Pubitemid 40665798)
3. Yang K, Cheng H, Gross RW, Han X. Automated lipid identification and quantification by multidimensional mass spectrometry-based shotgun lipido-mics. Anal Chem 2009; 81:4356-4368.
4. Dennis EA, Deems RA, Harkewicz R, et al. A mouse macrophage lipidome. J Biol Chem 2010; 285:39976-39985.
5. Quehenberger O, Armando AM, Brown AH, et al. Lipidomics reveals a remarkable diversity of lipids in human plasma. J Lipid Res 2010; 51:3299-3305.
6. Pietilainen KH, Sysi-Aho M, Rissanen A, et al. Acquired obesity is associated with changes in the serum lipidomic profile independent of genetic effects: a monozygotic twin study. PLoS One 2007; 2:e218.
7. Fahy E, Subramaniam S, Murphy RC, et al. Update of the LIPID MAPS comprehensive classification system for lipids. J Lipid Res 2009; 50 (Suppl):S9-S14.
8. Schmelzer K, Fahy E, Subramaniam S, Dennis EA. The lipid maps initiative in lipidomics. Methods Enzymol 2007; 432:171-183.
9. Schmitz G, Ruebsaamen K. Metabolism and atherogenic disease association of lysophosphatidylcholine. Atherosclerosis 2010; 208:10-18.
10. Yang LV, Radu CG, Wang L, et al. Gi-independent macrophage chemotaxis to lysophosphatidylcholine via the immunoregulatory GPCR G2A. Blood 2005; 105:1127-1134. (Pubitemid 40170885)
11. Engelmann B. Plasmalogens: targets for oxidants and major lipophilic anti-oxidants. Biochem Soc Trans 2004; 32:147-150. (Pubitemid 38283037)
12. Zoeller RA, Lake AC, Nagan N, et al. Plasmalogens as endogenous antiox-idants: somatic cell mutants reveal the importance of the vinyl ether. Biochem J 1999; 338:769-776. (Pubitemid 29140085)
13. Graessler J, Schwudke D, Schwarz PE, et al. Top-down lipidomics reveals ether lipid deficiency in blood plasma of hypertensive patients. PLoS One 2009; 4:e6261.
14. Kotronen A, Velagapudi VR, Yetukuri L, et al. Serum saturated fatty acids containing triacylglycerols are better markers of insulin resistance than total serum triacylglycerol concentrations. Diabetologia 2009; 52:684-690.
15. Haus JM, Kashyap SR, Kasumov T, et al. Plasma ceramides are elevated in obese subjects with type 2 diabetes and correlate with the severity of insulin resistance. Diabetes 2009; 58:337-343.
16. Wiesner P, Leidl K, Boettcher A, et al. Lipid profiling of FPLC-separated lipoprotein fractions by electrospray ionization tandem mass spectrometry. J Lipid Res 2009; 50:574-585.
17. Scherer M, Leuthauser-Jaschinski K, Ecker J, et al.A rapid and quantitative LC-MS/MS method to profile sphingolipids. J Lipid Res 2010; 51:2001-2011.
18. Scherer M, Bottcher A, Schmitz G, Liebisch G. Sphingolipid profiling of human plasma and FPLC-separated lipoprotein fractions by hydrophilic interaction chromatography tandem mass spectrometry. Biochim Biophys Acta 2011; 1811:68-75.
19. Sysi-Aho M, Vehtari A, Velagapudi VR, et al. Exploring the lipoprotein composition using Bayesian regression on serum lipidomic profiles. Bioinfor-matics 2007; 23:i51 9-i528.
20. Puri P, Wiest MM, Cheung O, et al. The plasma lipidomic signature of nonalcoholic steatohepatitis. Hepatology 2009; 50:1827-1838.
21. Hiukka A, Stahlman M, Pettersson C, et al. ApoCIII-enriched LDL in type 2 diabetes displays altered lipid composition, increased susceptibility for sphingomyelinase, and increased binding to biglycan. Diabetes 2009; 58:2018-2026.
22. Yetukuri L, Soderlund S, Koivuniemi A, et al. Composition and lipid spatial distribution of HDL particles in subjects with low and high HDL-cholesterol. J Lipid Res 2010; 51:2341-2351.
23. Teslovich TM, Musunuru K, Smith AV, et al. Biological, clinical and population relevance of 95 loci for blood lipids. Nature 2010; 466: 707-713.
24. Saxena R, Voight BF, Lyssenko V, et al. Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science 2007; 316:1331-1336. (Pubitemid 46871653)
25. Kathiresan S, Melander O, Guiducci C, et al. Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans. Nat Genet 2008; 40:189-197. (Pubitemid 351171402)
26. Kathiresan S, Willer CJ, Peloso GM, et al. Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet 2009; 41:56-65.
27. Hicks AA, Pramstaller PP, Johansson A, et al. Genetic determinants of circulating sphingolipid concentrations in European populations. PLoS Genet 2009; 5:e1000672.
28. Andreyev AY, Fahy E, Guan Z, et al. Subcellularorganelle lipidomics inTLR-4-activated macrophages. J Lipid Res 2010; 51:2785-2797.
29. Balgoma D, Astudillo AM, Perez-Chacon G, et al. Markers of monocyte activation revealed by lipidomic profiling of arachidonic acid-containing phospholipids. J Immunol 2010; 184:3857-3865.
30. Kotronen A, Seppanen-LaaksoT, Westerbacka J, et al. Comparison of lipid and fatty acid composition of the liver, subcutaneous and intra-abdominal adipose tissue, and serum. Obesity (Silver Spring) 2010; 18:937-944.
31. Pfeiffer K, Gohil V, Stuart RA, et al. Cardiolipin stabilizes respiratory chain supercomplexes. J Biol Chem 2003; 278:52873-52880. (Pubitemid 38035887)
32. Zhang M, Mileykovskaya E, Dowhan W. Gluing the respiratory chain together: cardiolipin is required for supercomplex formation in the inner mitochondrial membrane. J Biol Chem 2002; 277:43553-43556. (Pubitemid 36157767)
33. Han X, Yang J, Yang K, et al. Alterations in myocardial cardiolipin content and composition occur at the very earliest stages of diabetes: a shotgun lipido-mics study. Biochemistry 2007; 46:6417-6428. (Pubitemid 46842885)
34. Kiebish MA, Bell R, Yang K, et al. Dynamic simulation of cardiolipin remodeling: greasing the wheels for an interpretative approach to lipidomics. J Lipid Res 2010; 51:2153-2170.
35. Gonzalez-PerizA, Horrillo R, Ferre N, et al. Obesity-induced insulin resistance and hepatic steatosis are alleviated by omega-3 fatty acids: a role for resolvins and protectins. FASEB J 2009; 23:1946-1957.
36. Hall D, Poussin C, Velagapudi VR, et al. Peroxisomal and microsomal lipid pathways associated with resistance to hepatic steatosis and reduced pro-inflammatory state. J Biol Chem 2010; 285:31011-31023.