Considerations for measuring iron in post-mortem tissue of Parkinson's disease patients

Journal of Neural Transmission

Volumn 119, Issue 12, 2012, Pages 1515-1521

  Hare, Dominic J ^a,b   Gerlach, Manfred ^c   Riederer, Peter ^c  

^a UNIVERSITY OF TECHNOLOGY SYDNEY   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c UNIVERSITY HOSPITAL WÜRZBURG   (Germany)

Author keywords

Aetiopathogenesis; Iron analysis; M ssbauer spectroscopy; Parkinson's disease; Post mortem analysis; Sample preparation

Indexed keywords

FERRIC ION; FERROUS ION; HYDROGEN PEROXIDE; IRON; NITRIC ACID; PERCHLORIC ACID; POLYMER;

ATOMIC ABSORPTION SPECTROMETRY; AUTOPSY; BRAIN ASYMMETRY; BRAIN LEVEL; BRAIN TISSUE; CONTAMINATION; HUMAN; IRON METABOLISM; MASS SPECTROMETRY; MOSSBAUER SPECTROSCOPY; NEUTRON ACTIVATION ANALYSIS; PARKINSON DISEASE; POSTMORTEM CHANGE; PRIORITY JOURNAL; REVIEW; SPECTROSCOPY; TISSUE FIXATION; TISSUE PRESERVATION;

AUTOPSY; BRAIN; HUMANS; IRON; PARKINSON DISEASE; SELECTION BIAS; SPECIMEN HANDLING; TISSUE FIXATION;

EID: 84878348349     PISSN: 03009564     EISSN: 14351463     Source Type: Journal    
DOI: 10.1007/s00702-012-0898-4     Document Type: Review

References (62)

1. Andrási E, Igaz S, Szoboszlai N, Farkas É, Ajtony Z (1999) Several methods to determine heavy metals in the human brain. Spectrochim Acta B 54:819-825
2. Ashoka S, Peake BM, Bremner G, Hageman KJ, Reid MR (2009) Comparison of digestion methods for ICP-MS determination of trace elements in fish tissues. Anal Chim Acta 653:191-199
3. Becker JS, Niehren S, Matusch A, Wu B, Hsieh HF, Kumtabtim U, Hamester M, Plaschke-Schlütter S, Salber D (2010) Scaling down the bioimaging of metals by laser microdissection inductively coupled plasma mass spectrometry (LMD-ICP-MS). Int J Mass Spectrom 294:1-6
4. Bohic S, Murphy K, Paulus W, Cloetens P, Salomé M, Susini J, Double K (2008) Intracellular chemical imaging of the developmental phases of human neuromelanin using synchrotron X-ray microspectroscopy. Anal Chem 80:9557-9566
5. Bornhorst JA, Hunt JW, Urry FM, McMillin GA (2005) Comparison of sample preservation methods for clinical trace element analysis by inductively coupled plasma mass spectrometry. Am J Clin Pathol 123:578-583
6. Braak H, Tredici KD, Rüb U, de Vos RAI, Jansen Steur ENH, Braak E (2003) Staging of brain pathology related to sporadic Parkinson's disease. Neurobiol Aging 24:197-211
7. Bush VJ, Moyer TP, Batts KP, Parisi JE (1995) Essential and toxic element concentrations in fresh and formalin-fixed human autopsy tissues. Clin Chem 41:284-294
8. Castellani RJ, Siedlak SL, Perry G, Smith MA (2000) Sequestration of iron by Lewy bodies in Parkinson's disease. Acta Neuropathol 100:111-114
9. Chuaanusorn W, Webb J, Macey DJ, Pootrakul P, StPierre TG (1997) The effect of histological processing on the form of iron in iron-loaded human tissues. BBA Mol Basis Dis 1360:255-261
10. Clegg M, Keen C, Lönnerdal B, Hurley L (1981) Influence of ashing techniques on the analysis of trace elements in animal tissue. Biol Trace Elem Res 3:107-115
11. Cornelis R, Hoste J, Versieck J (1982) Potential interferences inherent in neutron-activation analysis of trace elements in biological materials. Talanta 29:1029-1034
12. Dexter DT, Wells FR, Lees AJ, Agid F, Agid Y, Jenner P, Marsden CD (1989) Increased nigral iron content and alterations in other metal ions occurring in brain in Parkinson's disease. J Neurochem 52:1830-1836
13. Dexter DT, Carayon A, Javoy-Agid F, Agid Y, Wells FR, Daniel SE, Lees AJ, Jenner P, Marsden CD (1991) Alterations in the levels of iron, ferritin and other trace metals in Parkinson's disease and other neurodegenerative diseases affecting the basal ganglia. Brain 114:1953-1975
14. Double KL, Gerlach M, Schünemann V, Trautwein AX, Zecca L, Gallorini M, Youdim MBH, Riederer P, Ben-Shachar D (2003) Iron-binding characteristics of neuromelanin of the human substantia nigra. Biochem Pharmacol 66:489-494
15. Engstrom E, Stenberg A, Senioukh S, Edelbro R, Baxter DC, Rodushkin I (2004) Multi-elemental characterization of soft biological tissues by inductively coupled plasma-sector field mass spectrometry. Anal Chim Acta 521:123-135
16. Faucheux BA, Martin ME, Beaumont C, Hunot S, Hauw JJ, Agid Y, Hirsch EC (2002) Lack of up-regulation of ferritin is associated with sustained iron regulatory protein-1 binding activity in the substantia nigra of patients with Parkinson's disease. J Neurochem 83:320-330
17. Faucheux BA, Martin ME, Beaumont C, Hauw JJ, Agid Y, Hirsch EC (2003) Neuromelanin associated redox-active iron is increased in the substantia nigra of patients with Parkinson's disease. J Neurochem 86:1142-1148
18. Fenton HJH (1894) Oxidation of tartaric acid in presence of iron. Chem Soc J 65:899-909
19. Gałazka-Friedman J, Bauminger ER, Friedman A, Barcikowska M, Hechel D, Nowik I (1996) Iron in parkinsonian and control substantia nigra - a mössbauer spectroscopy study. Mov Disord 11:8-16
20. Gellein K, Flaten TP, Erikson KM, Aschner M, Syversen T (2008) Leaching of trace elements from biological tissue by formalin fixation. Biol Trace Elem Res 121:221-225
21. Gerlach M, Ben-Shachar D, Riederer P, Youdim MBH (1994) Altered brain metabolism of iron as a cause of neurodegenerative diseases? J Neurochem 63:793-807
22. Gerlach M, Double K, Riederer P, Hirsch E, Jellinger K, Jenner P, Trautwein A, Youdim MBH (1997) Letter to the editor: iron in the parkinsonian substantia nigra. Mov Disord 12:256-263
23. Gerlach M, Double K, Götz M, Youdim M, Riederer P (2006a) The role of iron in the pathogenesis of Parkinson's disease. In: Sigel A, Sigel H, Sigel R (eds) Neurodegenerative diseases and metal ions: metal ions in life science, vol 1. Wiley, Chichester, pp 125-149
24. Gerlach M, Double KL, Youdim MBH, Riederer P (2006b) Potential sources of increased iron in the substantia nigra of parkinsonian patients. J Neural Transm Suppl 70:133-142
25. Gorell JM, Ordidge RJ, Brown GG, Deniau J-C, Buderer NM, Helpern JA (1995) Increased iron-related MRI contrast in the substantia nigra in Parkinson's disease. Neurology 45:1138-1143
26. Gutteridge JMC, Rowley DA, Halliwell B (1981) Superoxide-dependent formation of hydroxyl radicals in the presence of iron salts - detection of free iron in biological-systems by using bleomycin-dependent degradation of dna. Biochem J 199:263-265
27. Gutteridge JMC, Cao W, Chevion M (1991) Bleomycin-detectable iron in brain-tissue. Free Rad Res Commun 11:317-320
28. Gwozdz R, Grass F (2004) Contamination by human fingers: the Midas touch. J Radioanal Nucl Chem 259:173-176
29. Hallgren B, Sourander P (1958) The effect of age on the non-haemin iron in the human brain. J Neurochem 3:41-51
30. Hare D, Reedy B, Grimm R, Wilkins S, Volitakis I, George J, Cherny RA, Bush AI, Finkelstein DI, Doble P (2009) Quantitative elemental bio-imaging of Mn, Fe, Cu and Zn in 6-hydroxydopamine Parkinsonism mouse models. Metallomics 1:53-58
31. Hare DJ, George JL, Grimm R, Wilkins S, Adlard PA, Cherny RA, Bush AI, Finkelstein DI, Doble P (2010) Three-dimensional elemental bio-imaging of Fe, Zn, Cu, Mn and P in a 6-hydroxydopamine lesioned mouse brain. Metallomics 2:745-753
32. Hare D, Austin C, Doble P (2012a) Quantification strategies for elemental imaging of biological samples using laser ablation-inductively coupled plasma-mass spectrometry. Analyst 137:1527-1537
33. Hare DJ, Lee JK, Beavis AD, van Gramberg A, George J, Adlard PA, Finkelstein DI, Doble PA (2012b) Three-dimensional atlas of iron, copper, and zinc in the mouse cerebrum and brainstem. Anal Chem 84:3990-3997
34. Harrison WW, Netsky MG, Brown MD (1968) Trace elements in human brain: copper, zinc, iron, and magnesium. Clin Chim Acta 21:55
35. Hoenig M (2001) Preparation steps in environmental trace element analysis - facts and traps. Talanta 54:1021-1038
36. Kakhlon O, Cabantchik ZI (2002) The labile iron pool: characterization, measurement, and participation in cellular processes. Free Rad Biol Med 33:1037-1046
37. Koeppen AH (2003) A brief history of brain iron research. J Neurol Sci 207:95-97
38. Laxen DPH, Harrison RM (1981) Cleaning methods for polythene containers prior to the determination of trace-metals in fresh-water samples. Anal Chem 53:345-350
39. Lhermitte J, Kraus WM, McAlpine D (1924) On the occurrence of abnormal deposits of iron in the brain in Parkinsonism with special reference to its localisation. J Neurol Psychopathol 5:195-208
40. Lux F, Bereznai T, Haeberlin ST (1987) Minimization of the blank values in the neutron-activation analysis of biological samples considering the whole procedure. J Radioanal Nucl Chem 112:161-168
41. McRae R, Bagchi P, Sumalekshmy S, Fahrni CJ (2009) In situ imaging of metals in cells and tissues. Chem Rev 109:4780-4827
42. Moody JR, Lindstrom RM (1977) Selection and cleaning of plastic containers for storage of trace element samples. Anal Chem 49:2264-2267
43. Owen AD, Schapira AHV, Jenner P, Marsden CD (1997) Indices of oxidative stress in Parkinson's disease, Alzheimer's disease and dementia with Lewy bodies. J Neural Trans Suppl 51:167-173
44. Panayi AE, Spyrou NM, Ubertalli LC, White MA, Part P (1999) Determination of trace elements in porcine brain by inductively coupled plasma-mass spectrometry, electrothermal atomic absorption spectrometry, and instrumental neutron activation analysis. Biol Trace Elem Res 71-72:529-540
45. Quintana C, Bellefqih S, Laval JY, Guerquin-Kern JL, Wu TD, Avila J, Ferrer I, Arranz R, Patino C (2006) Study of the localization of iron, ferritin, and hemosiderin in Alzheimer's disease hippocampus by analytical microscopy at the subcellular level. J Struct Biol 153:42-54
46. Rahil-Khazen R, Bolann BJ, Myking A, Ulvik RJ (2002a) Multi-element analysis of trace element levels in human autopsy tissues by using inductively coupled atomic emission spectrometry technique (ICP-AES). J Trace Elem Med Biol 16:15-25
47. Rahil-Khazen R, Bolann BJ, Ulvik RJ (2002b) Correlations of trace element levels within and between different normal autopsy tissues analyzed by inductively coupled plasma atomic emission spectrometry (ICP-AES). Biometals 15:87-98
48. Riederer P, Sofic E, Rausch WD, Schmidt B, Reynolds GP, Jellinger K, Youdim MBH (1989) Transition-metals, ferritin, glutathione, and ascorbic-acid in parkinsonian brains. J Neurochem 52:515-520
49. Schapira AH, Jenner P (2011) Etiology and pathogenesis of Parkinson's disease. Mov Disord 26:1049-1055
50. Schrag M, Dickson A, Jiffry A, Kirsch D, Vinters HV, Kirsch W (2010) The effect of formalin fixation on the levels of brain transition metals in archived samples. Biometals 23:1123-1127
51. Sian-Hülsmann J, Mandel S, Youdim MBH, Riederer P (2011) The relevance of iron in the pathogenesis of Parkinson's disease. J Neurochem 118:939-957
52. Sofic E, Riederer P, Heinsen H, Beckmann H, Reynolds GP, Hebenstreit G, Youdim MBH (1988) Increased iron (III) and total iron content in post mortem substantia nigra of parkinsonian brain. J Neural Transm 74:199-205
53. Versieck J (1983) Biological sample collection and preparation for trace element analysis. TrAC Trends Anal Chem 2:110-113
54. Versieck J, Barbier F, Cornelis R, Hoste J (1982) Sample contamination as a source of error in trace-element analysis of biological samples. Talanta 29:973-984
55. Versieck J, Vanballenberghe L, De Kesel A, Van Renterghem D (1987) Accuracy of biological trace-element determinations. Biol Trace Elem Res 12:45-54
56. Wypijewska A, Galazka-Friedman J, Bauminger ER, Wszolek ZK, Schweitzer KJ, Dickson DW, Jaklewicz A, Elbaum D, Friedman A (2010) Iron and reactive oxygen species activity in parkinsonian substantia nigra. Parkinsonism Relat Disord 16:329-333
57. Xu X, Wang Q, Zhang M (2008) Age, gender, and hemispheric differences in iron deposition in the human brain: an in vivo MRI study. Neuroimage 40:35-42
58. Zecca L, Pietra R, Goj C, Mecacci C, Radice D, Sabbioni E (1994) Iron and other metals in neuromelanin, substantia nigra, and putamen of human brain. J Neurochem 62:1097-1101
59. Zecca L, Gallorini M, Schünemann V, Trautwein AX, Gerlach M, Riederer P, Vezzoni P, Tampellini D (2001) Iron, neuromelanin and ferritin content in the substantia nigra of normal subjects at different ages: consequences for iron storage and neurodegenerative processes. J Neurochem 76:1766-1773
60. Zecca L, Stroppolo A, Gatti A, Tampellini D, Toscani M, Gallorini M, Giaveri G, Arosio P, Santambrogio P, Fariello RG (2004a) The role of iron and copper molecules in the neuronal vulnerability of locus coeruleus and substantia nigra during aging. Proc Natl Acad Sci USA 101:9843
61. Zecca L, Youdim MBH, Riederer P, Connor JR, Crichton RR (2004b) Iron, brain ageing and neurodegenerative disorders. Nat Rev Neurosci 5:863-873
62. Zecca L, Zucca FA, Toscani M, Adorni F, Giaveri G, Rizzio E, Gallorini M (2005) Iron, copper and their proteins in substantia nigra of human brain during aging. J Radioanal Nucl Chem 263:733-737