Cardio-metabolic risk factors and cortical thickness in a neurologically healthy male population: Results from the psychological, social and biological determinants of ill health (pSoBid) study

NeuroImage: Clinical

Volumn 2, Issue 1, 2013, Pages 646-657

  Krishnadas, Rajeev ^a   McLean, John ^a   Batty, David G ^b,c   Burns, Harry ^d   Deans, Kevin A ^f,g   Ford, Ian ^a   McConnachie, Alex ^a   McGinty, Agnes ^h   McLean, Jennifer S ⁱ   Millar, Keith ^a   Sattar, Naveed ^a   Shiels, Paul G ^e   Velupillai, Yoga N ^j   Packard, Chris J ^h   Cavanagh, Jonathan ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b MEDICAL RESEARCH COUNCIL   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d SCOTTISH GOVERNMENT   (United Kingdom)

^e UNIVERSITY OF GLASGOW   (United Kingdom)

^f GLASGOW ROYAL INFIRMARY   (United Kingdom)

^g ABERDEEN ROYAL INFIRMARY   (United Kingdom)

^h Glasgow Clinical Research Facility   (United Kingdom)

ⁱ Glasgow Centre for Population Health   (United Kingdom)

^j UNIVERSITY OF LIMERICK   (Ireland)

more..

Author keywords

Cardiovascular risk; Cholesterol; Cortical thickness; Inflammation; Metabolic risk

Indexed keywords

C REACTIVE PROTEIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; INTERCELLULAR ADHESION MOLECULE 1; LIPID; LOW DENSITY LIPOPROTEIN; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; VERY LOW DENSITY LIPOPROTEIN CHOLESTEROL;

ADULT; ARTICLE; BLOOD CHEMISTRY; BRAIN ATHEROSCLEROSIS; BRAIN CORTEX; BRAIN REGION; CARDIOMETABOLIC RISK; CLINICAL ARTICLE; CONTROLLED STUDY; CORTICAL THICKNESS (BRAIN); DIAGNOSTIC TEST ACCURACY STUDY; DIFFUSION WEIGHTED IMAGING; DISEASE MARKER; EDUCATIONAL STATUS; HUMAN; LEFT HEMISPHERE; LIPID ANALYSIS; MALE; METABOLIC DISORDER; NEUROIMAGING; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PSYCHOLOGICAL ASPECT; RISK FACTOR; SMOKING; SOCIAL ASPECT; SUPRASYLVIAN GYRUS; TRIACYLGLYCEROL BLOOD LEVEL; CARDIOVASCULAR DISEASE; CHOLESTEROL BLOOD LEVEL; ENZYME LINKED IMMUNOSORBENT ASSAY; HYPERCHOLESTEROLEMIA; HYPERTRIGLYCERIDEMIA; NUCLEAR MAGNETIC RESONANCE SCANNER; POPULATION BASED CASE CONTROL STUDY; SENSITIVITY AND SPECIFICITY;

EID: 84878311142     PISSN: None     EISSN: 22131582     Source Type: Journal    
DOI: 10.1016/j.nicl.2013.04.012     Document Type: Article

References (88)

1. R. Bender, and S. Lange Adjusting for multiple testing - when and how? Journal of Clinical Epidemiology 54 4 2001 343 349 (Pubitemid 32303457)
2. S.R. Bornstein, A. Schuppenies, M.L. Wong, and J. Licinio Approaching the shared biology of obesity and depression: the stress axis as the locus of gene-environment interactions Molecular Psychiatry 11 2006 892 902 (Pubitemid 44470212)
3. V.A. Cardenas, B. Reed, L.L. Chao, H. Chui, N. Sanossian, C.C. Decarli, W. Mack, J. Kramer, H.N. Hodis, M. Yan, M.H. Buonocore, O. Carmichael, W.J. Jagust, and M.W. Weiner Associations among vascular risk factors, carotid atherosclerosis, and cortical volume and thickness in older adults Stroke 43 11 2012 2865 2870
4. J. Cavanagh, C. Paterson, J. McLean, S. Pimlott, M. McDonald, J. Patterson, D. Wyper, and I. McInnes Tumour necrosis factor blockade mediates altered serotonin transporter availability in rheumatoid arthritis: a clinical, proof-of-concept study Annals of the Rheumatic Diseases 69 2010 1251 1252
5. A.M. Dale, B. Fischl, and M.I. Sereno Cortical surface-based analysis. I. Segmentation and surface reconstruction NeuroImage 9 1999 179 194 (Pubitemid 29369874)
6. J. Danesh, S. Kaptoge, A.G. Mann, N. Sarwar, A. Wood, S.B. Angleman, F. Wensley, J.P. Higgins, L. Lennon, G. Eiriksdottir, A. Rumley, P.H. Whincup, G.D. Lowe, and V. Gudnason Long-term interleukin-6 levels and subsequent risk of coronary heart disease: two new prospective studies and a systematic review PLoS Medicine 5 2008 e78
7. P. de Jonge, and A.M. Roest Depression and cardiovascular disease: the end of simple models The British Journal of Psychiatry 201 2012 337 338
8. K.A. Deans, V. Bezlyak, I. Ford, G.D. Batty, H. Burns, J. Cavanagh, E. de Groot, A. McGinty, K. Millar, P.G. Shiels, C. Tannahill, Y.N. Velupillai, N. Sattar, and C.J. Packard Differences in atherosclerosis according to area level socioeconomic deprivation: cross sectional, population based study BMJ 339 2009 b4170
9. M.A. Denke, C.T. Sempos, and S.M. Grundy Excess body weight. An under-recognized contributor to dyslipidemia in white American women Archives of Internal Medicine 154 1994 401 410 (Pubitemid 24072213)
10. J. Dietrich The adhesion molecule ICAM-1 and its regulation in relation with the blood-brain barrier Journal of Neuroimmunology 128 2002 58 68 (Pubitemid 34722364)
11. Y. Dowlati, N. Herrmann, W. Swardfager, H. Liu, L. Sham, E.K. Reim, and K.L. Lanctot A meta-analysis of cytokines in major depression Biological Psychiatry 67 2010 446 457
12. C. Drake, H. Boutin, M.S. Jones, A. Denes, B.W. McColl, J.R. Selvarajah, S. Hulme, R.F. Georgiou, R. Hinz, A. Gerhard, A. Vail, C. Prenant, P. Julyan, R. Maroy, G. Brown, A. Smigova, K. Herholz, M. Kassiou, D. Crossman, S. Francis, S.D. Proctor, J.C. Russell, S.J. Hopkins, P.J. Tyrrell, N.J. Rothwell, and S.M. Allan Brain inflammation is induced by co-morbidities and risk factors for stroke Brain, Behavior, and Immunity 25 2011 1113 1122
13. S. Ehrlich, S. Brauns, A. Yendiki, B.C. Ho, V. Calhoun, S.C. Schulz, R.L. Gollub, and S.R. Sponheim Associations of cortical thickness and cognition in patients with schizophrenia and healthy controls Schizophrenia Bulletin 38 2012 1050 1062
14. M.F. Elias, P.K. Elias, L.M. Sullivan, P.A. Wolf, and R.B. D'Agostino Obesity, diabetes and cognitive deficit: the Framingham Heart Study Neurobiology of Aging 26 Suppl. 1 2005 11 16
15. P.K. Elias, M.F. Elias, R.B. D'Agostino, L.M. Sullivan, and P.A. Wolf Serum cholesterol and cognitive performance in the Framingham Heart Study Psychosomatic Medicine 67 2005 24 30
16. B. Fischl, and A.M. Dale Measuring the thickness of the human cerebral cortex from magnetic resonance images Proceedings of the National Academy of Sciences of the United States of America 97 2000 11050 11055
17. B. Fischl, M.I. Sereno, and A.M. Dale Cortical surface-based analysis. II: inflation, flattening, and a surface-based coordinate system NeuroImage 9 1999 195 207 (Pubitemid 29369875)
18. B. Fischl, N. Rajendran, E. Busa, J. Augustinack, O. Hinds, B.T.T. Yeo, H. Mohlberg, K. Amunts, and K. Zilles Cortical folding patterns and predicting cytoarchitecture Cerebral cortex (New York, N Y: 1991) 18 2008 1973 1980 (Pubitemid 352019918)
19. P.G. Frank, and M.P. Lisanti ICAM-1: role in inflammation and in the regulation of vascular permeability American Journal of Physiology. Heart and Circulatory Physiology 295 2008 H926 H927
20. K. Friston Ten ironic rules for non-statistical reviewers NeuroImage 61 2012 1300 1310
21. J. Gallacher, A. Bayer, G. Lowe, M. Fish, J. Pickering, S. Pedro, F. Dunstan, J. White, J. Yarnell, and Y. Ben-Shlomo Is sticky blood bad for the brain? Hemostatic and inflammatory systems and dementia in the Caerphilly Prospective Study Arteriosclerosis, Thrombosis, and Vascular Biology 30 2010 599 604
22. T.L. Gruenewald, A.S. Karlamangla, P. Hu, S. Stein-Merkin, C. Crandall, B. Koretz, and T.E. Seeman History of socioeconomic disadvantage and allostatic load in later life Social Science & Medicine 74 2012 75 83
23. J. Gunstad, R.H. Paul, R.A. Cohen, D.F. Tate, M.B. Spitznagel, S. Grieve, and E. Gordon Relationship between body mass index and brain volume in healthy adults The International Journal of Neuroscience 118 2008 1582 1593
24. P. Habets, M. Marcelis, E. Gronenschild, M. Drukker, and J. van Os Reduced cortical thickness as an outcome of differential sensitivity to environmental risks in schizophrenia Biological Psychiatry 69 2011 487 494
25. D.J. Hagler Jr., A.P. Saygin, and M.I. Sereno Smoothing and cluster thresholding for cortical surface-based group analysis of fMRI data NeuroImage 33 2006 1093 1103 (Pubitemid 44708789)
26. J. Hannestad, K. Subramanyam, N. Dellagioia, B. Planeta-Wilson, D. Weinzimmer, B. Pittman, and R.E. Carson Glucose metabolism in the insula and cingulate is affected by systemic inflammation in humans Journal of Nuclear Medicine 53 2012 601 607
27. N.A. Harrison, L. Brydon, C. Walker, M.A. Gray, A. Steptoe, and H.D. Critchley Inflammation causes mood changes through alterations in subgenual cingulate activity and mesolimbic connectivity Biological Psychiatry 66 2009 407 414
28. M. Helfand, D.I. Buckley, M. Freeman, R. Fu, K. Rogers, C. Fleming, and L.L. Humphrey Emerging risk factors for coronary heart disease: a summary of systematic reviews conducted for the U.S. Preventive Services Task Force Annals of Internal Medicine 151 2009 496 507
29. Y.Y. Hoogendam, J.N. van der Geest, F. van der Lijn, A. van der Lugt, W.J. Niessen, G.P. Krestin, A. Hofman, M.W. Vernooij, M.M. Breteler, and M.A. Ikram Determinants of cerebellar and cerebral volume in the general elderly population Neurobiology of Aging 33 2012 2774 2781
30. J. Huber, C. Campos, K. Mark, and T. Davis Alterations in blood-brain barrier ICAM-1 expression and brain microglial activation after lambda-carrageenan-induced inflammatory pain American Journal of Heart and Circulation Physiology 290 2006
31. V. Isaac, S. Sim, H. Zheng, V. Zagorodnov, E.S. Tai, and M. Chee Adverse associations between visceral adiposity, brain structure, and cognitive performance in healthy elderly Frontiers in Aging Neuroscience 3 2011 12
32. A.L. Jefferson, J.M. Massaro, P.A. Wolf, S. Seshadri, R. Au, R.S. Vasan, M.G. Larson, J.B. Meigs, J.F. Keaney, I. Lipinska, S. Kathiresan, E.J. Benjamin, and C. DeCarli Inflammatory biomarkers are associated with total brain volume: the Framingham Heart Study Neurology 68 2007 1032 1038 (Pubitemid 46569138)
33. R.P. Juster, B.S. McEwen, and S.J. Lupien Allostatic load biomarkers of chronic stress and impact on health and cognition Neuroscience and Biobehavioral Reviews 35 2010 2 16
34. T. Kin, S. Yamano, R. Sakurai, M. Kajitani, Y. Okahashi, N. Nishiura, Y. Saito, and S. Ueno Carotid atherosclerosis is associated with brain atrophy in Japanese elders Gerontology 53 2007 1 6 (Pubitemid 44973689)
35. S. Knox, P. Welsh, V. Bezlyak, A. McConnachie, E. Boulton, K.A. Deans, I. Ford, G. David Batty, H. Burns, J. Cavanagh, K. Millar, I.B. McInnes, J. McLean, Y. Velupillai, P. Shiels, C. Tannahill, C.J. Packard, A. Michael Wallace, and N. Sattar 25-Hydroxyvitamin D is lower in deprived groups, but is not associated with carotid intima media thickness or plaques: results from pSoBid Atherosclerosis 223 2012 437 441
36. R.M. Krauss, M. Winston, R.N. Fletcher, and S.M. Grundy Obesity: impact of cardiovascular disease Circulation 98 1998 1472 1476
37. R. Krishnadas, and J. Cavanagh Depression: an inflammatory illness? Journal of Neurology, Neurosurgery, and Psychiatry 83 2012 495 502
38. S. Kuhn, F. Schubert, and J. Gallinat Reduced thickness of medial orbitofrontal cortex in smokers Biological Psychiatry 68 2010 1061 1065
39. J. Lekakis, I. Ikonomidis, Z. Papoutsi, P. Moutsatsou, M. Nikolaou, J. Parissis, and D.T. Kremastinos Selective serotonin re-uptake inhibitors decrease the cytokine-induced endothelial adhesion molecule expression, the endothelial adhesiveness to monocytes and the circulating levels of vascular adhesion molecules International Journal of Cardiology 139 2010 150 158
40. E.C. Leritz, D.H. Salat, V.J. Williams, D.M. Schnyer, J.L. Rudolph, L. Lipsitz, B. Fischl, R.E. McGlinchey, and W.P. Milberg Thickness of the human cerebral cortex is associated with metrics of cerebrovascular health in a normative sample of community dwelling older adults NeuroImage 54 2011 2659 2671
41. D.E. Linden The challenges and promise of neuroimaging in psychiatry Neuron 73 2012 8 22
42. J.-P. Liu, Y. Tang, S. Zhou, B.H. Toh, C. McLean, and H. Li Cholesterol involvement in the pathogenesis of neurodegenerative diseases Molecular and Cellular Neurosciences 43 2010 33 42
43. Y. Liu, V. Julkunen, T. Paajanen, E. Westman, L.O. Wahlund, A. Aitken, T. Sobow, P. Mecocci, M. Tsolaki, B. Vellas, S. Muehlboeck, C. Spenger, S. Lovestone, A. Simmons, and H. Soininen Education increases reserve against Alzheimer's disease - evidence from structural MRI analysis Neuroradiology 54 2012 929 938
44. M.W. Lorenz, H.S. Markus, M.L. Bots, M. Rosvall, and M. Sitzer Prediction of clinical cardiovascular events with carotid intima-media thickness: a systematic review and meta-analysis Circulation 115 2007 459 467 (Pubitemid 46184197)
45. G. Luc, D. Arveiler, A. Evans, P. Amouyel, J. Ferrieres, J.M. Bard, L. Elkhalil, J.C. Fruchart, and P. Ducimetiere Circulating soluble adhesion molecules ICAM-1 and VCAM-1 and incident coronary heart disease: the PRIME study Atherosclerosis 170 2003 169 176 (Pubitemid 37083576)
46. A.L. Marsland, P.J. Gianaros, S.M. Abramowitch, S.B. Manuck, and A.R. Hariri Interleukin-6 covaries inversely with hippocampal grey matter volume in middle-aged adults Biological Psychiatry 64 2008 484 490
47. J. McAfoose, and B.T. Baune Evidence for a cytokine model of cognitive function Neuroscience and Biobehavioral Reviews 33 2009 355 366
48. B.S. McEwen, and T. Seeman Protective and damaging effects of mediators of stress. Elaborating and testing the concepts of allostasis and allostatic load Annals of the New York Academy of Sciences 896 1999 30 47 (Pubitemid 30040236)
49. D. McGuinness, L.M. McGlynn, P.C. Johnson, A. MacIntyre, G.D. Batty, H. Burns, J. Cavanagh, K.A. Deans, I. Ford, A. McConnachie, A. McGinty, J.S. McLean, K. Millar, C.J. Packard, N.A. Sattar, C. Tannahill, Y.N. Velupillai, and P.G. Shiels Socio-economic status is associated with epigenetic differences in the pSoBid cohort International Journal of Epidemiology 41 2012 151 160
50. J. McLean, R. Krishnadas, G.D. Batty, H. Burns, K.A. Deans, I. Ford, A. McConnachie, A. McGinty, J.S. McLean, K. Millar, N. Sattar, P.G. Shiels, C. Tannahill, Y.N. Velupillai, C.J. Packard, B.R. Condon, D.M. Hadley, and J. Cavanagh Early life socioeconomic status, chronic physiological stress and hippocampal N-acetyl aspartate concentrations Behavioural Brain Research 235 2012 225 230
51. B.J. Miller, P. Buckley, W. Seabolt, A. Mellor, and B. Kirkpatrick Meta-analysis of cytokine alterations in schizophrenia: clinical status and antipsychotic effects Biological Psychiatry 70 2011 663 671
52. S.J. Nicholls, E.M. Tuzcu, I. Sipahi, P. Schoenhagen, S.L. Hazen, F. Ntanios, C.-C. Wun, and S.E. Nissen Effects of obesity on lipid-lowering, anti-inflammatory, and antiatherosclerotic benefits of atorvastatin or pravastatin in patients with coronary artery disease (from the REVERSAL study) The American Journal of Cardiology 97 2006 1553 1557 (Pubitemid 43737023)
53. T. Noguchi Soluble intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 concentrations, and leukocyte count in smokers Environmental Health and Preventive Medicine 4 1999 71 74 (Pubitemid 29406439)
54. C.J. Packard, V. Bezlyak, J.S. McLean, G.D. Batty, I. Ford, H. Burns, J. Cavanagh, K.A. Deans, M. Henderson, A. McGinty, K. Millar, N. Sattar, P.G. Shiels, Y.N. Velupillai, and C. Tannahill Early life socioeconomic adversity is associated in adult life with chronic inflammation, carotid atherosclerosis, poorer lung function and decreased cognitive performance: a cross-sectional, population-based study BMC Public Health 11 2011 42
55. L. Palaniyappan, and P.F. Liddle Differential effects of surface area, gyrification and cortical thickness on voxel based morphometric deficits in schizophrenia NeuroImage 60 2012 693 699
56. M.S. Panizzon, C. Fennema-Notestine, L.T. Eyler, T.L. Jernigan, E. Prom-Wormley, M. Neale, K. Jacobson, M.J. Lyons, M.D. Grant, C.E. Franz, H. Xian, M. Tsuang, B. Fischl, L. Seidman, A. Dale, and W.S. Kremen Distinct genetic influences on cortical surface area and cortical thickness Cerebral Cortex 19 2009 2728 2735
57. A.C. Phillips, G.D. Batty, J.J.C.S.V. van Zanten, L.H. Mortensen, I.J. Deary, C.M. Calvin, and D. Carroll Cognitive ability in early adulthood is associated with systemic inflammation in middle age: the Vietnam experience study Brain, Behavior, and Immunity 25 2011 298 301
58. F. Piras, F. Salani, P. Bossu, C. Caltagirone, and G. Spalletta High serum levels of transforming growth factor beta1 are associated with increased cortical thickness in cingulate and right frontal areas in healthy subjects Journal of Neuroinflammation 9 2012 42
59. R.A. Poldrack, J.A. Mumford, and T.E. Nichols Handbook of Functional MRI Data Analysis 2011 Cambridge University Press Cambridge
60. T.J. Quinn, J. Gallacher, I.J. Deary, G.D. Lowe, C. Fenton, and D.J. Stott Association between circulating hemostatic measures and dementia or cognitive impairment: systematic review and meta-analyzes Journal of Thrombosis and Haemostasis 9 2011 1475 1482
61. C.A. Raji, A.J. Ho, N.N. Parikshak, J.T. Becker, O.L. Lopez, L.H. Kuller, X. Hua, A.D. Leow, A.W. Toga, and P.M. Thompson Brain structure and obesity Human Brain Mapping 31 2010 353 364
62. P. Rakic Evolution of the neocortex: a perspective from developmental biology Nature Reviews Neuroscience 10 2009 724 735
63. J.E. Roeters van Lennep, H.T. Westerveld, D.W. Erkelens, and E.E. van der Wall Risk factors for coronary heart disease: implications of gender Cardiovascular Research 53 2002 538 549 (Pubitemid 34175246)
64. H.D. Rosas, A.K. Liu, S. Hersch, M. Glessner, R.J. Ferrante, D.H. Salat, A. van der Kouwe, B.G. Jenkins, A.M. Dale, and B. Fischl Regional and progressive thinning of the cortical ribbon in Huntington's disease Neurology 58 2002 695 701 (Pubitemid 34211546)
65. T. Schaberg, M. Rau, R. Oerter, U. Liebers, W. Rahn, D. Kaiser, C. Witt, and H. Lode Expression of adhesion molecules in peripheral pulmonary vessels from smokers and nonsmokers Lung 174 1996 71 81 (Pubitemid 26067680)
66. H.D. Schmidt, R.C. Shelton, and R.S. Duman Functional biomarkers of depression: diagnosis, treatment, and pathophysiology Neuropsychopharmacology 36 2011 2375 2394
67. S.W. Seo, J.M. Lee, K. Im, J.S. Park, S.H. Kim, S.T. Kim, H.J. Ahn, J. Chin, H.K. Cheong, M.W. Weiner, and D.L. Na Cortical thinning related to periventricular and deep white matter hyperintensities Neurobiology of Aging 33 2012 1156 1167
68. S.W. Seo, J.M. Lee, K. Im, J.S. Park, S.H. Kim, S.T. Kim, J.H. Ahn, M.J. Kim, G.H. Kim, J.H. Kim, J.H. Roh, H.K. Cheong, and D.L. Na Cardiovascular risk factors cause cortical thinning in cognitively impaired patients: relationships among cardiovascular risk factors, white matter hyperintensities, and cortical atrophy Alzheimer Disease and Associated Disorders 26 2012 106 112
69. L. Shamai, E. Lurix, M. Shen, G.M. Novaro, S. Szomstein, R. Rosenthal, A.V. Hernandez, and C.R. Asher Association of body mass index and lipid profiles: evaluation of a broad spectrum of body mass index patients including the morbidly obese Obesity Surgery 21 2011 42 47
70. P.G. Shiels, L.M. McGlynn, A. MacIntyre, P.C. Johnson, G.D. Batty, H. Burns, J. Cavanagh, K.A. Deans, I. Ford, A. McConnachie, A. McGinty, J.S. McLean, K. Millar, N. Sattar, C. Tannahill, Y.N. Velupillai, and C.J. Packard Accelerated telomere attrition is associated with relative household income, diet and inflammation in the pSoBid cohort PLoS One 6 2011 e22521
71. A. Smith, C. Patterson, J. Yarnell, A. Rumley, Y. Ben-Shlomo, and G. Lowe Which hemostatic markers add to the predictive value of conventional risk factors for coronary heart disease and ischemic stroke? The Caerphilly Study Circulation 112 2005 3080 3087 (Pubitemid 43113439)
72. A. Solomon, V. Leoni, M. Kivipelto, A. Besga, A.R. Öksengård, P. Julin, L. Svensson, L.-O. Wahlund, N. Andreasen, B. Winblad, H. Soininen, and I. Björkhem Plasma levels of 24S-hydroxycholesterol reflect brain volumes in patients without objective cognitive impairment but not in those with Alzheimer's disease Neuroscience Letters 462 2009 89 93
73. E.R. Sowell, B.S. Peterson, E. Kan, R.P. Woods, J. Yoshii, R. Bansal, D. Xu, H. Zhu, P.M. Thompson, and A.W. Toga Sex differences in cortical thickness mapped in 176 healthy individuals between 7 and 87 years of age Cerebral Cortex 17 2007 1550 1560
74. J.H. Stein, C.E. Korcarz, R.T. Hurst, E. Lonn, C.B. Kendall, E.R. Mohler, S.S. Najjar, C.M. Rembold, W.S. Post American Society of Echocardiography Carotid Intima-Media Thickness Task Force Use of carotid ultrasound to identify subclinical vascular disease and evaluate cardiovascular disease risk: a consensus statement from the American Society of Echocardiography Carotid Intima-Media Thickness Task Force. Endorsed by the Society for Vascular Medicine Journal of the American Society of Echocardiography 21 2008 93 111 (quiz 189-190) (Pubitemid 351193107)
75. Y. Taki, B. Thyreau, S. Kinomura, K. Sato, R. Goto, K. Wu, M. Kakizaki, I. Tsuji, R. Kawashima, and H. Fukuda Correlation between high-sensitivity C-reactive protein and brain gray matter volume in healthy elderly subjects Human Brain Mapping 2012 10.1002/hbm.22073
76. C.E. Teunissen, M.P. van Boxtel, H. Bosma, E. Bosmans, J. Delanghe, C. De Bruijn, A. Wauters, M. Maes, J. Jolles, H.W. Steinbusch, and J. de Vente Inflammation markers in relation to cognition in a healthy aging population Journal of Neuroimmunology 134 2003 142 150 (Pubitemid 36054172)
77. P.P. Toth High-density lipoprotein and cardiovascular risk Circulation 109 2004 1809 1812 (Pubitemid 38509111)
78. T. Umemura, T. Kawamura, H. Umegaki, S. Mashita, A. Kanai, T. Sakakibara, N. Hotta, and G. Sobue Endothelial and inflammatory markers in relation to progression of ischaemic cerebral small-vessel disease and cognitive impairment: a 6-year longitudinal study in patients with type 2 diabetes mellitus Journal of Neurology, Neurosurgery, and Psychiatry 82 2011 1186 1194
79. I.M. van der Meer, M.L. Bots, A. Hofman, A.I. del Sol, D.A. van der Kuip, and J.C. Witteman Predictive value of noninvasive measures of atherosclerosis for incident myocardial infarction: the Rotterdam Study Circulation 109 2004 1089 1094 (Pubitemid 38332611)
80. Y.N. Velupillai, C.J. Packard, G.D. Batty, V. Bezlyak, H. Burns, J. Cavanagh, K. Deans, I. Ford, A. McGinty, K. Millar, N. Sattar, P. Shiels, and C. Tannahill Psychological, social and biological determinants of ill health (pSoBid): study protocol of a population-based study BMC Public Health 8 2008 126
81. K. Walther, A.C. Birdsill, E.L. Glisky, and L. Ryan Structural brain differences and cognitive functioning related to body mass index in older females Human Brain Mapping 31 2010 1052 1064
82. S.G. Wannamethee, P.H. Whincup, L. Lennon, A. Rumley, and G.D. Lowe Fibrin D-dimer, tissue-type plasminogen activator, von Willebrand factor, and risk of incident stroke in older men Stroke 43 2012 1206 1211
83. M.A. Ward, B.B. Bendlin, D.G. McLaren, T.M. Hess, C.L. Gallagher, E.K. Kastman, H.A. Rowley, S. Asthana, C.M. Carlsson, M.A. Sager, and S.C. Johnson Low HDL cholesterol is associated with lower gray matter volume in cognitively healthy adults Frontiers in Aging Neuroscience 2 2010
84. H. Wersching, T. Duning, H. Lohmann, S. Mohammadi, C. Stehling, M. Fobker, M. Conty, J. Minnerup, E.B. Ringelstein, K. Berger, M. Deppe, and S. Knecht Serum C-reactive protein is linked to cerebral microstructural integrity and cognitive function Neurology 74 2010 1022 1029
85. V.J. Williams, E.C. Leritz, J. Shepel, R.E. McGlinchey, W.P. Milberg, J.L. Rudolph, L.A. Lipsitz, and D.H. Salat Interindividual variation in serum cholesterol is associated with regional white matter tissue integrity in older adults Human Brain Mapping 2012 10.1002/hbm.22030
86. C.B. Wright, R.L. Sacco, T.R. Rundek, J.B. Delman, L.E. Rabbani, and M.S.V. Elkind Interleukin-6 is associated with cognitive function: the Northern Manhattan Study Journal of Stroke and Cerebrovascular Diseases 15 2006 34 38 (Pubitemid 43087716)
87. K. Yaffe, K. Lindquist, B.W. Penninx, E.M. Simonsick, M. Pahor, S. Kritchevsky, L. Launer, L. Kuller, S. Rubin, and T. Harris Inflammatory markers and cognition in well-functioning African-American and white elders Neurology 61 2003 76 80 (Pubitemid 36818750)
88. S. Yokum, J. Ng, and E. Stice Relation of regional gray and white matter volumes to current BMI and future increases in BMI: a prospective MRI study International journal of obesity 36 2012 656 664 (2005)