Sex differences in cortical thickness mapped in 176 healthy individuals between 7 and 87 years of age

Cerebral Cortex

Volumn 17, Issue 7, 2007, Pages 1550-1560

  Sowell, Elizabeth R ^a   Peterson, Bradley S ^b   Kan, Eric ^a   Woods, Roger P ^c   Yoshii, June ^a   Bansal, Ravi ^b   Xu, Dongrong ^b   Zhu, Hongtu ^b   Thompson, Paul M ^a   Toga, Arthur W ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Brain size; Gender; Gray matter; MRI; Parietal lobes; Temporal lobes

Indexed keywords

ADOLESCENT; ADULT; AGE DISTRIBUTION; AGED; ANATOMICAL VARIATION; ARTICLE; BODY HEIGHT; BODY SIZE; BRAIN CORTEX; BRAIN REGION; BRAIN SIZE; CHILD; CONTROLLED STUDY; FEMALE; GRAY MATTER; HUMAN; HUMAN EXPERIMENT; IMAGE ANALYSIS; IMAGE PROCESSING; MALE; NORMAL HUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PARIETAL LOBE; PRIORITY JOURNAL; SCHOOL CHILD; SEX DIFFERENCE; STRUCTURE ANALYSIS; TEMPORAL CORTEX; THICKNESS; TISSUE STRUCTURE; COMPUTER ASSISTED DIAGNOSIS; HISTOLOGY; METHODOLOGY; MIDDLE AGED; ORGAN SIZE; PHYSIOLOGY; THREE DIMENSIONAL IMAGING;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CEREBRAL CORTEX; CHILD; FEMALE; HUMANS; IMAGE INTERPRETATION, COMPUTER-ASSISTED; IMAGING, THREE-DIMENSIONAL; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; ORGAN SIZE; SEX FACTORS;

EID: 34547669242     PISSN: 10473211     EISSN: 14602199     Source Type: Journal    
DOI: 10.1093/cercor/bhl066     Document Type: Article

References (67)

1. Allen JS, Damasio H, Grabowski TJ, Bruss J, Zhang W. 2003. Sexual dimorphism and asymmetries in the gray-white composition of the human cerebrum. Neuroimage 18:880-894.
2. Anderson MJ, Legendre P. 1999. An Empirical comparison of permutation methods for tests of partial regression coefficients in a linear model. J Stat Comput Simul 62:271-303.
3. Anderson MJ, Ter Braak CJ. 2003. Permutation tests for multi-factorial analysis of variance. J Stat Comput Simul 73:85-113.
4. Baare WF, Hulshoff Pol HE, Boomsma DI, Posthuma D, de Geus EJ, Schnack HG, van Haren NE, van Oel CJ, Kahn RS. 2001. Quantitative genetic modeling of variation in human brain morphology. Cereb Cortex 11:816-824.
5. Benes FM, Turtle M, Khan Y, Farol P. 1994. Myelination of a key relay zone in the hippocampal formation occurs in the human brain during childhood, adolescence, and adulthood. Arch Gen Psychiatry 51:477-484.
6. Blatter DD, Bigler ED, Gale SD, Johnson SC, Anderson CV, Burnett BM, Parker N, Kurth S, Horn SD. 1995. Quantitative volumetric analysis of brain MR: normative database spanning 5 decades of life. Am J Neuroradiol 16:241-251.
7. Bullmore ET, Suckling J, Overmeyer S, Rabe-Hesketh S, Taylor E, Brammer MJ. 1999. Global, voxel, and cluster tests, by theory and permutation, for a difference between two groups of structural MR images of the brain. IEEE Trans Med Imaging 18:32-42.
8. Caviness VS Jr, Kennedy DN, Richelme C, Rademacher J, Filipek PA. 1996. The human brain age 7-11 years: a volumetric analysis based on magnetic resonance images. Cereb Cortex 6:726-736.
9. Coffey CE, Lucke JF, Saxton JA, Ratcliff G, Unitas LJ, Billig B, Bryan RN. 1998. Sex differences in brain aging: a quantitative magnetic resonance imaging study. Arch Neurol 55:169-179.
10. Courchesne E, Chisum HJ, Townsend J, Cowles A, Covington J, Egaas B, Harwood M, Hinds S, Press GA. 2000. Normal brain development and aging: quantitative analysis at in vivo MR imaging in healthy volunteers. Radiology 216:672-682.
11. De Bellis MD, Keshavan MS, Beers SR, Hall J, Frustaci K, Masalehdan A, Noll J, Boring AM. 2001. Sex differences in brain maturation during childhood and adolescence. Cereb Cortex 11:552-557.
12. DeCarli C, Massaro J, Harvey D, Hald J, Tullberg M, Au R, Beiser A, D'Agostino R, Wolf PA. 2005. Measures of brain morphology and infarction in the framingham heart study: establishing what is normal. Neurobiol Aging 26:491-510.
13. Dekaban AS. 1978. Changes in brain weights during the span of human life: relation of brain weights to body heights and body weights. Ann Neurol 4:345-356.
14. Duvernoy HM, Cabanis EA, Vannson JL. 1991. The human brain: surface, three-dimensional sectional anatomy and MRI. Vienna, Austria: Springer-Verlag.
15. Evans AC, Collins DL, Holmes CJ. 1996. Automatic 3D regional MRI segmentation and statistical probabilistic anatomical maps. New York: Academic Press.
16. Filipek PA, Richelme C, Kennedy DN, Caviness VS Jr. 1994. The young adult human brain: an MRI-based morphometric analysis. Cereb Cortex 4:344-360.
17. Frederikse ME, Lu A, Aylward E, Barta P, Pearlson G. 1999. Sex differences in the inferior parietal lobule. Cereb Cortex 9:896-901.
18. Freedman D, Lane D. 1983. A Nonstochastic interpretation of reported significance levels. J Bus Econ Stat 1:292-298.
19. Ge Y, Grossman RI, Babb JS, Rabin ML, Mannon LJ, Kolson DL. 2002. Age-related total gray matter and white matter changes in normal adult brain. Part II: quantitative magnetization transfer ratio histogram analysis. Am J Neuroradiol 23:1334-1341. (Pubitemid 35033882)
20. Giedd JN, Blumenthal J, Jeffries NO, Castellanos FX, Liu H, Zijdenbos A, Paus T, Evans AC, Rapoport JL. 1999. Brain development during childhood and adolescence: a longitudinal MRI study. Nat Neurosci 2:861-863.
21. Giedd JN, Castellanos FX, Rajapakse JC, Vaituzis AC, Rapoport JL. 1997. Sexual dimorphism of the developing human brain. Prog Neuro-psychopharmacol Biol Psychiatry 21:1185-1201.
22. Goldstein JM, Seidman LJ, Horton NJ, Makris N, Kennedy DN, Caviness VS Jr, Faraone SV, Tsuang MT. 2001. Normal sexual dimorphism of the adult human brain assessed by in vivo magnetic resonance imaging. Cereb Cortex 11:490-497.
23. Good CD, Johnsrude I, Ashburner J, Henson RN, Friston KJ, Frackowiak RS. 2001a. Cerebral asymmetry and the effects of sex and handedness on brain structure: a voxel-based morphometric analysis of 465 normal adult human brains. Neuroimage 14:685-700.
24. Good CD, Johnsrude IS, Ashburner J, Henson RN, Friston KJ, Frackowiak RS. 2001b. A voxel-based morphometric study of ageing in 465 normal adult human brains. Neuroimage 14:21-36.
25. Gur RC, Gunning-Dixon F, Bilker WB, Gur RE. 2002. Sex differences in temporo-limbic and frontal brain volumes of healthy adults. Cereb Cortex 12:998-1003.
26. Gur RC, Turetsky BI, Matsui M, Yan M, Bilker W, Hughett P, Gur RE. 1999. Sex differences in brain gray and white matter in healthy young adults: correlations with cognitive performance. J Neurosci 19:4065-4072.
27. Halpern DF, Tan U. 2001. Stereotypes and steroids: using a psycho-biosocial model to understand cognitive sex differences. Brain Cogn 45:392-414.
28. Harasty J, Double KL, Halliday GM, Kril JJ, McRitchie DA. 1997. Language-associated cortical regions are proportionally larger in the female brain. Arch Neurol 54:171-176.
29. Huttenlocher PR, de Courten C. 1987. The development of synapses in striate cortex of man. Hum Neurobiol 6:1-9.
30. Im K, Lee JM, Lee J, Shin YW, Kim IY, Kwon JS, Kim SI. 2006. Gender difference analysis of cortical thickness in healthy young adults with surface-based methods. Neuroimage.
31. Jernigan TL, Trauner DA, Hesselink JR, Tallal PA. 1991. Maturation of human cerebrum observed in vivo during adolescence. Brain 114:2037-2049.
32. Jones CM, Braithwaite VA, Healy SD. 2003. The evolution of sex differences in spatial ability. Behav Neurosci 117:403-411.
33. Kimura D. 2000. Sex and cognition. Cambridge, MA: MIT Press.
34. Lemaitre H, Crivello F, Grassiot B, Alperovitch A, Tzourio C, Mazoyer B. 2005. Age-and sex-related effects on the neuroanatomy of healthy elderly. Neuroimage 26:900-911.
35. Luders E, Narr KL, Thompson PM, Rex DE, Woods RP, Deluca H, Jancke L, Toga AW. 2006. Gender effects on cortical thickness and the influence of scaling. Hum Brain Mapp 27:314-324.
36. MacDonald D, Avis D, Evans A. 1994. Multiple surface identification and matching in magnetic resonance images. Proc Vis Biomed Comput 2359:160-169.
37. Mazziotta JC, Toga AW, Evans A, Fox P, Lancaster J. 1995. A probabilistic atlas of the human brain: theory and rationale for its development. The International Consortium for Brain Mapping (ICBM). Neuro-image 2:89-101.
38. Murphy DG, DeCarli C, McIntosh AR, Daly E, Mentis MJ, Pietrini P, Szczepanik J, Schapiro MB, Grady CL, Horwitz B, and others. 1996. Sex differences in human brain morphometry and metabolism: an in vivo quantitative magnetic resonance imaging and positron emission tomography study on the effect of aging. Arch Gen Psychiatry 53:585-594.
39. Narr KL, Bilder RM, Toga AW, Woods RP, Rex DE, Szeszko PR, Robinson D, Sevy S, Gunduz-Bruce H, Wang YP, and others. 2005. Mapping cortical thickness and gray matter concentration in first episode schizophrenia. Cereb Cortex 15:708-719.
40. Nopoulos P, Flaum M, O'Leary D, Andreasen NC. 2000. Sexual dimorphism in the human brain: evaluation of tissue volume, tissue composition and surface anatomy using magnetic resonance imaging. Psychiatry Res 98:1-13.
41. Ono M, Kubik S, Abernathey CD. 1990. Atlas of the cerebral sulci. Stuttgart: G. Thieme Verlag.
42. Peters M, Jancke L, Staiger JF, Schlaug G, Huang Y, Steinmetz H. 1998. Unsolved problems in comparing brain sizes in Homo sapiens. Brain Cogn 37:254-285.
43. Pfefferbaum A, Mathalon DH, Sullivan EV, Rawles JM, Zipursky RB, Lim KO. 1994. A quantitative magnetic resonance imaging study of changes in brain morphology from infancy to late adulthood. Arch Neurol 51:874-887.
44. Raz N, Gunning-Dixon F, Head D, Rodrigue KM, Williamson A, Acker JD. 2004. Aging, sexual dimorphism, and hemispheric asymmetry of the cerebral cortex: replicability of regional differences in volume. Neurobiol Aging 25:377-396.
45. Raz N, Gunning FM, Head D, Dupuis JH, McQuain J, Briggs SD, Loken WJ, Thornton AE, Acker JD. 1997. Selective aging of the human cerebral cortex observed in vivo: differential vulnerability of the prefrontal gray matter. Cereb Cortex 7:268-282.
46. Raz N, Lindenberger U, Rodrigue KM, Kennedy KM, Head D, Williamson A, Dahle C, Gerstorf D, Acker JD. 2005. Regional brain changes in aging healthy adults: general trends, individual differences and modifiers. Cereb Cortex 15(11):1676-1689.
47. Resnick SM, Goldszal AF, Davatzikos C, Golski S, Kraut MA, Metter EJ, Bryan RN, Zonderman AB. 2000. One-year age changes in MRI brain volumes in older adults. Cereb Cortex 10:464-472.
48. Roberts JE, Bell MA. 2000. Sex differences on a mental rotation task: variations in electroencephalogram hemispheric activation between children and college students. Dev Neuropsychol 17:199-223.
49. Salat DH, Buckner RL, Snyder AZ, Greve DN, Desikan RS, Busa E, Morris JC, Dale AM, Fischl B. 2004. Thinning of the cerebral cortex in aging. Cereb Cortex 14:721-730.
50. Sapiro G. 2001. Geometric partial differential equations and image analysis. Cambridge, UK: Cambridge University Press.
51. Sommer IE, Aleman A, Bouma A, Kahn RS. 2004. Do women really have more bilateral language representation than men? A meta-analysis of functional imaging studies. Brain 127:1845-1852.
52. Sowell ER, Delis D, Stiles J, Jernigan TL. 2001. Improved memory functioning and frontal lobe maturation between childhood and adolescence: a structural MRI study. J Int Neuropsychol Soc 7:312-322.
53. Sowell ER, Peterson BS, Thompson PM, Welcome SE, Henkenius AL, Toga AW. 2003. Mapping cortical change across the human life span. Nat Neurosci 6:309-315.
54. Sowell ER, Thompson PM, Holmes CJ, Batth R, Jernigan TL, Toga AW. 1999. Localizing age-related changes in brain structure between childhood and adolescence using statistical parametric mapping. Neuroimage 9:587-597.
55. Sowell ER, Thompson PM, Leonard CM, Welcome SE, Kan E, Toga AW. 2004. Longitudinal mapping of cortical thickness and brain growth in normal children. J Neurosci 24(38):8223-8231.
56. Sowell ER, Thompson PM, Mattson SN, Tessner KD, Jernigan TL, Riley EP, Toga AW. 2002. Regional brain shape abnormalities persist into adolescence after heavy prenatal alcohol exposure. Cereb Cortex 12:856-865.
57. Sowell ER, Thompson PM, Rex D, Kornsand D, Tessner KD, Jernigan TL, Toga AW. 2002. Mapping sulcal pattern asymmetry and local cortical surface gray matter distribution in vivo: maturation in perisylvian cortices. Cereb Cortex 12:17-26.
58. Sowell ER, Thompson PM, Tessner KD, Toga AW. 2001. Mapping continued brain growth and gray matter density reduction in dorsal frontal cortex: inverse relationships during postadolescent brain maturation. J Neurosci 21:8819-8829.
59. Sowell ER, Thompson PM, Welcome SE, Henkenius AL, Toga AW, Peterson BS. 2003. Cortical abnormalities in children and adolescents with attention deficit hyperactivity disorder. Lancet 362:1699-1707.
60. Sowell ER, Trauner DA, Gamst A, Jernigan TL. 2002. Development of cortical and subcortical brain structures in childhood and adolescence: a structural MRI study. Dev Med Child Neurol 44:4-16.
61. Sullivan EV, Rosenbloom M, Serventi KL, Pfefferbaum A. 2004. Effects of age and sex on volumes of the thalamus, pons, and cortex. Neurobiol Aging 25:185-192.
62. Thompson PM, Hayashi KM, Sowell ER, Gogtay N, Giedd JN, Rapoport JL, de Zubicaray GI, Janke AL, Rose SE, Semple J, and others. 2004. Mapping cortical change in Alzheimer's disease, brain development, and schizophrenia. Neuroimage 23(Suppl 1):S2-S18.
63. Von Economo CV. 1929. The cytoarchitectonics of the human cerebral cortex. London: Oxford Medical Publications.
64. Witelson SF, Glezer II, Kigar DL. 1995. Women have greater density of neurons in posterior temporal cortex. J Neurosci 15:3418-3428.
65. Woods RP, Grafton ST, Holmes CJ, Cherry SR, Mazziotta JC. 1998. Automated image registration: I. General methods and intrasubject, intramodality validation. J Comput Assist Tomogr 22:139-152.
66. Xu J, Kobayashi S, Yamaguchi S, Iijima K, Okada K, Yamashita K. 2000. Gender effects on age-related changes in brain structure. Am J Neuroradiol 21:112-118.
67. Yakovlev PI, Lecours AR. 1967. The myelogenetic cycles of regional maturation of the brain. In: Minkowski A, editor. Regional development of the brain in early life. Oxford: Blackwell Scientific. p 3-70.