A dual-functionally modified chitosan derivative for efficient liver-targeted gene delivery

Journal of Biomedical Materials Research - Part A

Volumn 101 A, Issue 7, 2013, Pages 1888-1897

  Xiao, Bo ^a,b   Wang, Xiaoyu ^a   Qiu, Zhiye ^a   Ma, Jun ^a   Zhou, Lei ^a   Wan, Ying ^a   Zhang, Shengmin ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b GEORGIA STATE UNIVERSITY   (United States)

Author keywords

chitosan; galactosylation; gene delivery; liver specificity; quaternization

Indexed keywords

CONFOCAL LASER SCANNING MICROSCOPY; GALACTOSYLATED CHITOSAN; GALACTOSYLATION; GENE DELIVERY; NARROW SIZE DISTRIBUTIONS; PHYSICOCHEMICAL PROPERTY; QUATERNIZATION; TRANSFECTION EFFICIENCY;

CELL CULTURE; DNA; GENE TRANSFER; GENES; TURBIDITY; X RAY DIFFRACTION;

CHITOSAN;

CHITOSAN DERIVATIVE; GALACTOSYLATED CHITOSAN HYDROXYPROPYLTRIMETHYLAMMONIUM; PLASMID DNA; POLYETHYLENEIMINE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL STRUCTURE; COMPLEX FORMATION; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; CYTOTOXICITY; GENE DELIVERY SYSTEM; GENE VECTOR; HUMAN; HUMAN CELL; INFRARED SPECTROSCOPY; PHYSICAL CHEMISTRY; PROTON NUCLEAR MAGNETIC RESONANCE; SYNTHESIS; TURBIDITY; X RAY DIFFRACTION;

CELL LINE, TUMOR; CELL SURVIVAL; CHITOSAN; CRYSTALLIZATION; DNA; ELECTROPHORESIS, AGAR GEL; GENE TARGETING; GENE TRANSFER TECHNIQUES; HELA CELLS; HUMANS; INDICATORS AND REAGENTS; LIVER; MAGNETIC RESONANCE SPECTROSCOPY; PARTICLE SIZE; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; TRANSFECTION; X-RAY DIFFRACTION;

EID: 84878286392     PISSN: 15493296     EISSN: 15524965     Source Type: Journal    
DOI: 10.1002/jbm.a.34493     Document Type: Article

References (37)

1. Pack DW, Hoffman AS, Pun S, Stayton PS,. Design and development of polymers for gene delivery. Nat Rev Drug Discov 2005; 4: 581-593.
2. Dai H, Jiang X, Tan GC, Chen Y, Torbenson M, Leong KW, Mao HQ,. Chitosan-DNA nanoparticle delivered by intrabiliary infusion enhance liver-targeted gene delivery. Int J Nanomed 2006; 1: 507-522.
3. Kim TH, Park IK, Nah JW, Choi YJ, Cho CS,. Galactosylated chitosan/DNA nanoparticles prepared using water-soluble chitosan as a gene carrier. Biomaterials 2004; 25: 3783-3792.
4. Liu J, Jiang ZZ, Zhou JB, Zhang SM, Saltzman WM,. Enzyme-synthesized poly(amine-co-esters) as nonviral vectors for gene delivery. J Biomed Mater Res A 2011; 96: 456-465.
5. Rekha MR, Sharma CP,. Hemocompatible pullulan-polyethyleneimine conjugates for liver cell gene delivery: In vitro evaluation of cellular uptake, intracellular trafficking and transfection efficiency. Acta Biomater 2011; 7: 370-379.
6. Peer D, Karp JM, Hong S, Farokhzad OC, Margalit R, Langer R,. Nanocarriers as an emerging platform for cancer therapy. Nat Nanotechnol 2007; 2: 751-760.
7. Gao SY, Chen JN, Xu XR, Ding Z, Yang YH, Hua ZC, Zhang J,. Galactosylated low molecular weight chitosan as DNA carrier for hepatocyte-targeting. Int J Pharm 2003; 255: 57-68.
8. Moreira C, Oliveira H, Pires LR, Simóes S, Barbosa MA, Pêgo AP,. Improving chitosan-mediated gene transfer by the introduction of intracellular buffering moieties into the chitosan backbone. Acta Biomater 2009; 5: 2995-3006.
9. Hashimoto M, Morimoto M, Saimoto H, Shigemasa Y, Sato T,. Lactosylated chitosan for DNA delivery into hepatocytes: The effect of lactosylation on the physicochemical properties and intracellular trafficking of pDNA/chitosan complexes. Bioconjug Chem 2006; 17: 309-316.
10. Peng ZX, Wang L, Du L, Guo SR, Wang XQ, Tang TT,. Adjustment of the antibacterial activity and biocompatibility of hydroxypropyltrimethyl ammonium chloride chitosan by varying the degree of substitution of quaternary ammonium. Carbohydr Polym 2010; 81: 275-283.
11. Wu H, Zhang J, Xiao B, Zan X, Gao J, Wan Y,. N-(2-hydroxypropyl)-3- trimethylammonium chitosan-poly(ε-caprolactone) copolymers and their antibacterial activity. Carbohydr Polym 2011; 83: 824-830.
12. Thanou M, Florea BI, Geldof M, Junginger HE, Borchard G,. Quaternized chitosan oligomers as novel gene delivery vectors in epithelial cell lines. Biomaterials 2000; 23: 153-159.
13. Kean T, Roth S, Thanou M,. Trimethylated chitosans as non-viral gene delivery vectors: Cytotoxicity and transfection efficiency. J Control Release 2005; 103: 643-653.
14. Wan Y, Peppley B, Creber KAM, Bui VT, Halliop E,. Quaternized-chitosan membranes for possible applications in alkaline fuel cells. J Power Sources 2008; 185: 183-187.
15. Wu J, Su ZG, Ma GH,. A thermo- and pH-sensitive hydrogel composed of quaternized chitosan/glycerophosphate. Int J Pharm 2006; 315: 1-11.
16. Xiao B, Wan Y, Wang XY, Zha QC, Liu HM, Qiu ZY, Zhang SM,. Synthesis and characterization of N-(2-hydroxy)propyl-3-trimethyl ammonium chitosan chloride for potential application in gene delivery. Colloids Surf B Biointerfaces 2012; 91: 168-174.
17. Wan Y, Creber KAM, Peppley B, Bui VT,. Ionic conductivity and tensile properties of hydroxyethyl and hydroxypropyl chitosan membranes. J Polym Sci Part B: Polym Phys 2004; 42: 1379-1397.
18. Lavertu M, Méthot S, Tran-Khanh N, Buschmann MD,. High efficiency gene transfer using chitosan/DNA nanoparticles with specific combination of molecular weight and degree of deacetylation. Biomaterials 2006; 27: 4815-4824.
19. Wan Y, Creber KAM, Peppley B, Bui VT,. Structure and ionic conductivity of a series of di-o-butyrylchitosan membranes. J Appl Polym Sci 2004; 94: 2309-2323.
20. Chung TW, Yang J, Akaike T, Cho KY, Nah JW, Kim SI, Cho CS,. Preparation of alginate/galactosylated chitosan scaffold for hepatocyte attachment. Biomaterials 2002; 23: 2827-2834.
21. Mansouri S, Cuie Y, Winnik F, Shi Q, Lavigne P, Benderdour M, Beaumont E, Fernandes JC,. Characterization of folate-chitosan-DNA nanoparticles for gene therapy. Biomaterials 2006; 27: 2060-2065.
22. Cho J, Grant J, Piquette-Miller M, Allen C,. Synthesis and physicochemical and dynamic mechanical properties of a water-soluble chitosan derivative as a biomaterial. Biomacromolecules 2006; 7: 2845-2855.
23. Lim SH, Hudson SM,. Synthesis and antimicrobial activity of a water-soluble chitosan derivative with a fiber-reactive group. Carbohydr Res 2004; 339: 313-319.
24. Sun Y, Wan AJ,. Preparation of nanoparticles composed of chitosan and its derivatives as delivery systems for macromolecules. J Appl Polym Sci 2007; 105: 552-561.
25. Feng ZQ, Chu XH, Huang NP, Wang T, Wang YC, Shi XL, Ding Y, Gu ZZ,. The effect of nanofibrous galactosylated chitosan scaffolds on the formation of rat primary hepatocyte aggregates and the maintenance of liver function. Biomaterials 2009; 30: 2753-2763.
26. Yao Z, Zhang C, Ping QN, Yu LL,. A series of novel chitosan derivatives: Synthesis, characterization and micellar solubilization of paclitaxel. Carbohydr Polym 2007; 68: 781-792.
27. Xiao B, Wan Y, Zhao MQ, Liu YQ, Zhang SM,. Preparation and characterization of antimicrobial chitosan-N-arginine with different degrees of substitution. Carbohydr Polym 2011; 83: 144-150.
28. Zhu JH, Wang XW, Ng S, Quek CH, Ho HT, Lao XJ, Yu H,. Encapsulating live cells with water-soluble chitosan in physiological conditions. J Biotechnol 2005; 117: 355-365.
29. Velegol D, Feick JD, Collins LR,. Electrophoresis of spherical particles with a random distribution of zeta potential or surface charge. J Colloid Interface Sci 2000; 230: 114-121.
30. Liu YM, Reineke TM,. Hydroxyl stereochemistry and amine number within poly(glycoamidoamine)s affect intracellular DNA delivery. J Am Chem Soc 2005; 127: 3004-3015.
31. Song YB, Sun YX, Zhang XZ, Zhou JP, Zhang LN,. Homogeneous quaternization of cellulose in NaOH/urea aqueous solutions as gene carriers. Biomacromolecules 2008; 9: 2259-2264.
32. Berger J, Reist M, Mayer JM, Felt O, Gurny R,. Structure and interactions in chitosan hydrogels formed by complexation or aggregation for biomedical applications. Eur J Pharm Biopharm 2004; 57: 35-52.
33. Vinogradov SV, Bronich TK, Kabanov AV,. Nanosized cationic hydrogels for drug delivery: Preparation, properties and interactions with cells. Adv Drug Deliv Rev 2002; 54: 135-147.
34. Wong K, Sun GB, Zhang XQ, Dai H, Liu Y, He CB, Leong KW,. PEI-g-chitosan, a novel gene delivery system with transfection efficiency comparable to polyethylenimine in vitro and after liver administration in vivo. Bioconjug Chem 2006; l17: 152-158.
35. Kievit FM, Veiseh O, Bhattarai N, Fang C, Gunn JW, Lee D, Ellenbogen RG, Olson JM, Zhang MQ,. PEI-PEG-chitosan-copolymer-coated iron oxide nanoparticles for safe gene delivery: Synthesis, complexation, and transfection. Adv Funct Mater 2009; 19: 2244-2251.
36. Ryser HJP,. A membrane effect of basic polymers dependent on molecular size. Nature 1967; 215: 934.
37. Bottega R, Epand RM,. Inhibition of protein-kinase-c by cationic amphiphiles. Biochemistry 1992; 31: 9025-9030.