CRHR1 genotypes, neural circuits and the diathesis for anxiety and depression

Molecular Psychiatry

Volumn 18, Issue 6, 2013, Pages 700-707

  Rogers, J ^a,b   Raveendran, M ^a   Fawcett, G L ^a   Fox, A S ^c,d   Shelton, S E ^c,e   Oler, J A ^c,e   Cheverud, J ^f   Muzny, D M ^a   Gibbs, R A ^a   Davidson, R J ^c,d,e   Kalin, N H ^c,d,e  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b SOUTHWEST NATIONAL PRIMATE RESEARCH CENTER   (United States)

^c UNIVERSITY OF WISCONSIN MADISON   (United States)

^d UNIVERSITY OF WISCONSIN MADISON   (United States)

^e UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^f WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

amygdala; corticotrophin releasing hormone; genetic association; hippocampus; non human primate; rhesus macaque

Indexed keywords

CORTICOTROPIN RELEASING FACTOR RECEPTOR 1; FLUORODEOXYGLUCOSE F 18;

AMINO ACID SEQUENCE; AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANXIETY; ANXIETY DISORDER; ARTICLE; BRAIN METABOLISM; CHILDHOOD DISEASE; CONNECTOME; CONTROLLED STUDY; CRHR1 GENE; DEPRESSION; EXON; FEMALE; GENE; GENE EXPRESSION; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HIPPOCAMPUS; HUMAN; INTRAPARIETAL SULCUS; MALE; NONHUMAN; PHENOTYPE; POSITRON EMISSION TOMOGRAPHY; PRECUNEUS; PRIORITY JOURNAL; PROTEIN STRUCTURE; RHESUS MONKEY; SINGLE NUCLEOTIDE POLYMORPHISM; TEMPERAMENT;

ANIMALS; ANXIETY; BRAIN; DEPRESSION; DISEASE MODELS, ANIMAL; FEMALE; FLUORODEOXYGLUCOSE F18; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; MACACA MULATTA; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; POSITRON-EMISSION TOMOGRAPHY; RECEPTORS, CORTICOTROPIN-RELEASING HORMONE;

EID: 84878263698     PISSN: 13594184     EISSN: 14765578     Source Type: Journal    
DOI: 10.1038/mp.2012.152     Document Type: Article

References (45)

1. Arborelius L, Owens MJ, Plotsky PM, Nemeroff CB. The role of corticotropin-releasing factor in depression and anxiety disorders. J Endocrinol 1999; 160: 1-12.
2. Binder EB, Nemeroff CB. The CRF system, stress, depression and anxiety-insights from human genetic studies. Mol Psychiatry 2010; 15: 574-588.
3. Liu Z, Zhu F, Wang G, Xiao Z, Wang H, Tang J et al. Association of corticotropin-releasing hormone receptor1 gene SNP and haplotype with major depression. Neurosci Lett 2006; 404: 358-362.
4. Keck ME, Kern N, Erhardt A, Unschuld PG, Ising M, Salyakina D et al. Combined effects of exonic polymorphisms in CRHR1 and AVPR1B genes in a case/control study for panic disorder. Am J Med Genet B Neuropsychiatr Genet 2008; 147B: 1196-1204.
5. Bradley RG, Binder EB, Epstein MP, Tang Y, Nair HP, Liu W et al. Influence of child abuse on adult depression: moderation by the corticotropin-releasing hormone receptor gene. Arch Gen Psychiatry 2008; 65: 190-200.
6. Heim C, Bradley B, Mletzko TC, Deveau TC, Musselman DL, Nemeroff CB et al. Effect of childhood trauma on adult depression and neuroendocrine function: sex-specific moderation by CRH receptor 1 gene. Front Behav Neurosci 2009; 3: 41.
7. Polanczyk G, Caspi A, Williams B, Price TS, Danese A, Sugden K et al. Protective effect of CRHR1 gene variants on the development of adult depression following childhood maltreatment: replication and extension. Arch Gen Psychiatry 2009; 66: 978-985.
8. Tyrka AR, Price LH, Gelernter J, Schepker C, Anderson GM, Carpenter LL. Interaction of childhood maltreatment with the corticotropin-releasing hormone receptor gene: effects on hypothalamic-pituitary-adrenal axis reactivity. Biol Psychiatry 2009; 66: 681-685.
9. Licinio J, O'Kirwan F, Irizarry K, Merriman B, Thakur S, Jepson R et al. Association of a corticotropin-releasing hormone receptor 1 haplotype and antidepressant treatment response in Mexican-Americans. Mol Psychiatry 2004; 9: 1075-1082.
10. Liu Z, Zhu F, Wang G, Xiao Z, Tang J, Liu W et al. Association study of cortico-tropin-releasing hormone receptor1 gene polymorphisms and antidepressant response in major depressive disorders. Neurosci Lett 2007; 414: 155-158.
11. Kalin NH, Shelton SE. Nonhuman primate models to study anxiety, emotion regulation, and psychopathology. Ann NY Acad Sci 2003; 1008: 189-200.
12. Rapee RM, Schniering CA, Hudson JL. Anxiety disorders during childhood and adolescence: origins and treatment. Annu Rev Clin Psychol 2009; 5: 311-341.
13. Fox NA, Henderson HA, Marshall PJ, Nichols KE, Ghera MM. Behavioral inhibition: linking biology and behavior within a developmental framework. Annu Rev Psy-chol 2005; 56: 235-262.
14. Rogers J, Shelton SE, Shelledy W, Garcia R, Kalin NH. Genetic influences on behavioral inhibition and anxiety in juvenile rhesus macaques. Genes Brain Behav 2008; 7: 463-469.
15. Fox AS, Shelton SE, Oakes TR, Davidson RJ, Kalin NH. Trait-like brain activity during adolescence predicts anxious temperament in primates. PLoS ONE 2008; 3: e2570.
16. Kalin NH, Shelton SE. Ontogeny and stability of separation and threat-induced defensive behaviors in rhesus monkeys during the first year of life. Am J Primatol 1998; 44: 125-135.
17. Oler JA, Fox AS, Shelton SE, Rogers J, Dyer TD, Davidson RJ et al. Amygdalar and hippocampal substrates of anxious temperament differ in their heritability. Nature 2010; 466: 864-868.
18. Kalin NH, Shelton SE, Rickman M, Davidson RJ. Individual differences in freezing and cortisol in infant and mother rhesus monkeys. Behav Neurosci 1998; 112: 251-254.
19. Kalin NH, Shelton SE. Defensive behaviors in infant rhesus monkeys: environmental cues and neurochemical regulation. Science 1989; 243: 1718-1721.
20. Kalin NH, Shelton SE, Fox AS, Oakes TR, Davidson RJ. Brain regions associated with the expression and contextual regulation of anxiety in primates. Biol Psychiatry 2005; 58: 796-804.
21. Fox AS, Oakes TR, Shelton SE, Converse AK, Davidson RJ, Kalin NH. Calling for help is independently modulated by brain systems underlying goal-directed behavior and threat perception. Proc Nat Acad Sci USA 2005; 102: 4176-4179.
22. Jenkinson M, Bannister P, Brady M, Smith S. Improved optimization for the robust and accurate linear registration and motion correction of brain images. NeuroImage 2002; 17: 825-841.
23. Zhang Y, Brady M, Smith S. Segmentation of brain MR images through a hidden Markov random field model and the expectation-maximization algorithm. IEEE Trans Med Imaging 2001; 20: 45-57.
24. Barrett JC, Fry B, Maller J, Daly MJ. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005; 21: 263-265.
25. Almasy L, Blangero J. Multipoint quantitative-trait linkage analysis in general pedigrees. Am J Hum Genet 1998; 62: 1198-1211.
26. Cheverud JM. A simple correction for multiple comparisons in interval mapping genome scans. Heredity 2001; 87(Pt 1): 52-58.
27. Roy A, Kucukural A, Zhang Y. I-TASSER: a unified platform for automated protein structure and function prediction. Nat Protoc 2010; 5: 725-738.
28. Parham KL, Zervou S, Karteris E, Catalano RD, Old RW, Hillhouse EW. Promoter analysis of human corticotropin-releasing factor (CRF) type 1 receptor and regulation by CRF and urocortin. Endocrinology 2004; 145: 3971-3983.
29. Refojo D, Schweizer M, Kuehne C, Ehrenberg S, Thoeringer C, Vogl AM et al. Glutamatergic and dopaminergic neurons mediate anxiogenic and anxiolytic effects of CRHR1. Science 2011; 333: 1903-1907.
30. Grefkes C, Fink GR. The functional organization of the intraparietal sulcus in humans and monkeys. J Anat 2005; 207: 3-17.
31. Cavanna AE, Trimble MR. The precuneus: a review of its functional anatomy and behavioural correlates. Brain 2006; 129(Pt 3): 564-583.
32. Murat B, Devost D, Andres M, Mion J, Boulay V, Corbani M et al. V1b and CRHR1 receptor heterodimerization mediates synergistic biological actions of vaso-pressin and CRH. Mol Endocrinol 2012; 26: 502-520.
33. Smoller JW, Rosenbaum JF, Biederman J, Kennedy J, Dai D, Racette SR et al. Association of a genetic marker at the corticotropin-releasing hormone locus with behavioral inhibition. Biol Psychiatry 2003; 54: 1376-1381.
34. Barr CS, Dvoskin RL, Gupte M, Sommer W, Sun H, Schwandt ML et al. Functional CRH variation increases stress-induced alcohol consumption in primates. Proc Natl Acad Sci USA 2009; 106: 14593-14598.
35. Muller MB, Zimmermann S, Sillaber I, Hagemeyer TP, Deussing JM, Timpl P et al. Limbic corticotropin-releasing hormone receptor 1 mediates anxiety-related behavior and hormonal adaptation to stress. Nat Neurosci 2003; 6: 1100-1107.
36. Ressler KJ, Bradley B, Mercer KB, Deveau TC, Smith AK, Gillespie CF et al. Polymorphisms in CRHR1 and the serotonin transporter loci: gene x gene x environment interactions on depressive symptoms. Am J Med Genet B Neuropsychiatr Genet 153B: 812-824.
37. Barr CS, Newman TK, Becker ML, Parker CC, Champoux M, Lesch KP et al. The utility of the non-human primate; model for studying gene by environment interactions in behavioral research. Genes Brain Behav 2003; 2: 336-340.
38. Barr CS, Schwandt M, Lindell SG, Chen SA, Goldman D, Suomi SJ et al. Association of a functional polymorphism in the mu-opioid receptor gene with alcohol response and consumption in male rhesus macaques. Arch Gen Psychiatry 2007; 64: 369-376.
39. Vallender EJ, Ruedi-Bettschen D, Miller GM, Platt DM. A pharmacogenetic model of naltrexone-induced attenuation of alcohol consumption in rhesus monkeys. Drug Alcohol Depend 2010; 109: 252-256.
40. Markovic D, Papadopoulou N, Teli T, Randeva H, Levine MA, Hillhouse EW et al. Differential responses of corticotropin-releasing hormone receptor type 1 variants to protein kinase C phosphorylation. J Pharmacol Exp Ther 2006; 319: 1032-1042.
41. Teli T, Markovic D, Hewitt ME, Levine MA, Hillhouse EW, Grammatopoulos DK. Structural domains determining signalling characteristics of the CRH-receptor type 1 variant R1beta and response to PKC phosphorylation. Cell Signal 2008; 20: 40-49.
42. Vincent JL, Patel GH, Fox MD, Snyder AZ, Baker JT, Van Essen DC et al. Intrinsic functional architecture in the anaesthetized monkey brain. Nature 2007; 447: 83-86.
43. Johnson N, Fletcher O, Palles C, Rudd M, Webb E, Sellick G et al. Counting potentially functional variants in BRCA1, BRCA2 and ATM predicts breast cancer susceptibility. Hum Mol Genet 2007; 16: 1051-1057.
44. Singleton A, Hardy J. A generalizable hypothesis for the genetic architecture of disease: pleomorphic risk loci. Hum Mol Genet 2011; 20: R158-R162.
45. Achkar JP, Duerr R. The expanding universe of inflammatory bowel disease genetics. Curr Opin Gastroenterol 2008; 24: 429-434.