Association of a genetic marker at the corticotropin-releasing hormone locus with behavioral inhibition

Biological Psychiatry

Volumn 54, Issue 12, 2003, Pages 1376-1381

  Smoller, Jordan W ^a   Rosenbaum, Jerrold F ^a   Biederman, Joseph ^a   Kennedy, John ^a,b   Dai, Daisy ^a,b   Racette, Stephanie R ^a   Laird, Nan M ^c   Kagan, Jerome ^d   Snidman, Nancy ^d   Hirshfeld Becker, Dina ^a   Tsuang, Ming T ^a,c   Sklar, Pamela B ^a   Slaugenhaupt, Susan A ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^d HARVARD UNIVERSITY   (United States)

Author keywords

Anxiety; Anxiety disorders; Behavioral inhibition; CRH; Genetic; Temperament

Indexed keywords

CORTICOTROPIN RELEASING FACTOR;

ALLELE; ARTICLE; CONTROLLED STUDY; FAMILY; FEMALE; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENETIC ASSOCIATION; GENOTYPE; HUMAN; INHIBITION (PSYCHOLOGY); MALE; PANIC; PRESCHOOL CHILD; PRIORITY JOURNAL; PROGENY; PSYCHOLOGIC ASSESSMENT; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 10744225112     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3223(03)00598-5     Document Type: Article

References (36)

1. Arborelius L., Owens M.J., Plotsky P.M., Nemeroff C.B. The role of corticotropin-releasing factor in depression and anxiety disorders. J Endocrinol. 160:1999;1-12.
2. Bakshi V.P., Kalin N.H. Corticotropin-releasing hormone and animal models of anxiety Gene-environment interactions . Biol Psychiatry. 48:2000;1175-1198.
3. Biederman J., Hirshfeld-Becker D.R., Rosenbaum J.F., Herot C., Friedman D., Snidman N., et al. Further evidence of association between behavioral inhibition and social anxiety in children. Am J Psychiatry. 158:2001;1673-1679.
4. Buetow K.H., Edmonson M., MacDonald R., Clifford R., Yip P., Kelley J., et al. High-throughput development and characterization of a genomewide collection of gene-based single nucleotide polymorphism markers by chip-based matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Proc Natl Acad Sci U S A. 98:2001;581-584.
5. Centner T., Yano J., Kimura E., McElhinny A.S., Pelin K., Witt C.C., et al. Identification of muscle specific ring finger proteins as potential regulators of the titin kinase domain. J Mol Biol. 306:2001;717-726.
6. Daly M.J., Rioux J.D., Schaffner S.F., Hudson T.J., Lander E.S. High-resolution haplotype structure in the human genome. Nat Genet. 29:2001;229-232.
7. Davis M. Functional neuroanatomy of anxiety and fear A focus on the amygdala . Charney D., Nestler E., Bunney B. Neurobiology of Mental Illness. 1999;463-474 Oxford University Press, New York.
8. DiLalla L., Kagan J., Reznick J. Genetic etiology of behavioral inhibition among 2-year-old children. Infant Behav Dev. 17:1994;405-412.
9. Flint J. Genetic influences on emotionality. Pfaff D., Joh T., Maxson S. Genetic Influences on Neural and Behavioral Functions. 2000;431-457 CRC Press, Boca Raton, FL.
10. Gu J., Sadler L., Daiger S., Wells D., Wagner M. Dinucleotide repeat polymorphism at the CRH gene. Hum Mol Genet. 2:1993;85.
11. Hayward C., Killen J., Kraemer H., Taylor C. Linking self-reported childhood behavioral inhibition to adolescent social phobia. J Am Acad Child Adolesc Psychiatry. 37:1998;1308-1316.
12. Hedrick P. Gametic disequilibrium measures Proceed with caution . Genetics. 117:1987;331-341.
13. Horvath S., Xu X., Laird N.M. The family based association test method Strategies for studying general genotype-phenotype associations . Eur J Hum Genet. 9:2001;301-306.
14. Kagan J. Galen's Prophecy. 1994;Basic Books, New York.
15. Kagan J., Reznick S., Snidman N. Biological bases of childhood shyness. Science. 240:1988;167-171.
16. Kagan J., Snidman N. Early childhood predictors of adult anxiety disorders. Biol Psychiatry. 46:1999;1536-1541.
17. Kalin N.H., Larson C., Shelton S.E., Davidson R.J. Asymmetric frontal brain activity, cortisol, and behavior associated with fearful temperament in rhesus monkeys. Behav Neurosci. 112:1998;286-292.
18. Kalin N.H., Shelton S.E., Davidson R.J. Cerebrospinal fluid corticotropin-releasing hormone levels are elevated in monkeys with patterns of brain activity associated with fearful temperament. Biol Psychiatry. 47:2000;579-585.
19. Knapp M. The transmission/disequilibrium test and parental-genotype reconstruction The reconstruction-combined transmission/disequilibrium test . Am J Hum Genet. 64:1999;861-870.
20. Laird N.M., Horvath S., Xu X. Implementing a unified approach to family-based tests of association. Genet Epidemiol. 19:(suppl 1):2000;S36-42.
21. Lange C., Laird N.M. Power calculations for a general class of family-based association tests Dichotomous traits . Am J Hum Genet. 71:2002;575-584.
22. Leboyer M. Searching for alternative phenotypes in psychiatric genetics. Leboyer M., Bellivier F. Psychiatric Genetics Methods and Reviews . 2003;145-161 Humana Press, Totowa, NJ.
23. Marks I. Fears, Phobias and Rituals. 1987;Oxford University Press, New York.
24. Plomin R., Emde R.N., Braungart J.M., Campos J., Corley R., Fulker D.W., et al. Genetic change and continuity from fourteen to twenty months The MacArthur Longitudinal Twin Study . Child Dev. 64:1993;1354-1376.
25. Rabinowitz D., Laird N. A unified approach to adjusting association tests for population admixture with arbitrary pedigree structure and arbitrary missing marker information. Hum Hered. 50:2000;211-223.
26. Reich D.E., Cargill M., Bolk S., Ireland J., Sabeti P.C., Richter D.J., et al. Linkage disequilibrium in the human genome. Nature. 411:2001;199-204.
27. Robinson J., Kagan J., Reznick J., Corley R. The heritability of inhibited and uninhibited behavior A twin study . Dev Psychol. 28:1992;1030-1037.
28. Rosenbaum J.F., Biederman J., Hirshfeld-Becker D.R., Kagan J., Snidman N., Friedman D., et al. A controlled study of behavioral inhibition in children of parents with panic disorder and depression. Am J Psychiatry. 157:2000;2002-2010.
29. Schmidt L.A., Fox N.A., Schulkin J., Gold P.W. Behavioral and psychophysiological correlates of self-presentation in temperamentally shy children. Dev Psychobiol. 35:1999;119-135.
30. Schwartz C., Snidman N., Kagan J. Adolescent social anxiety as an outcome of inhibited temperament in childhood. J Am Acad Child Adolesc Psychiatry. 38:1999;1008-1015.
31. Smoller J., Tsuang M. Panic and phobic anxiety Defining phenotypes for genetic studies . Am J Psychiatry. 155:1998;1152-1162.
32. Smoller J.W., Rosenbaum J.F., Biederman J., Susswein L.S., Kennedy J., Kagan J., et al. Genetic association analysis of behavioral inhibition using candidate loci from mouse models. Am J Med Genet. 105:2001;226-235.
33. Spielman R., Ewens W. A sibship test for linkage in the presence of association The sib transmission/disequilibrium test . Am J Hum Genet. 62:1998;450-458.
34. Stenzel-Poore M., Heinrichs S., Rivest S., Koob G., Vale W. Overproduction of corticotropin-releasing factor in transgenic mice A genetic model of anxiogenic behavior . J Neurosci. 14:1994;2579-2584.
35. van Gaalen M., Stenzel-Poore M., Holsboer F., Steckler T. Effects of transgenic overproduction of CRH on anxiety-like behavior. Eur J Neurosci. 15:2002;2007-2015.
36. Whittaker J., Lewis C. The effect of family structure on linkage tests using allelic association. Am J Hum Genet. 63:1998;889-897.