메뉴 건너뛰기




Volumn 288, Issue 21, 2013, Pages 14936-14948

Pituitary adenylate cyclase-activating polypeptide (PACAP) promotes both survival and neuritogenesis in PC12 cells through activation of nuclear factor κB (NF-κB) pathway: Involvement of extracellular signal-regulated kinase (ERK), calcium, and c-Rel

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; CHEMICAL ACTIVATION; CYTOLOGY; ENZYMES; NEURONS; TRANSCRIPTION;

EID: 84878238398     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.434597     Document Type: Article
Times cited : (17)

References (55)
  • 1
    • 84868669968 scopus 로고    scopus 로고
    • New insights into the control of neurotrophic growth factor receptor signaling: Implications for nervous system development and repair
    • Alsina, F. C., Ledda, F., and Paratcha, G. (2012) New insights into the control of neurotrophic growth factor receptor signaling: implications for nervous system development and repair. J. Neurochem. 123, 652-661
    • (2012) J. Neurochem. , vol.123 , pp. 652-661
    • Alsina, F.C.1    Ledda, F.2    Paratcha, G.3
  • 2
    • 0036523039 scopus 로고    scopus 로고
    • Kip2dependent CDK2 activity
    • Carey, R. G., Li, B., and DiCicco-Bloom, E. (2002) Pituitary adenylate cyclase activating polypeptide anti-mitogenic signaling in cerebral cortical progenitors is regulated by p57Kip2-dependent CDK2 activity. J. Neurosci. 22, 1583-1591 (Pubitemid 35386277)
    • (2002) Journal of Neuroscience , vol.22 , Issue.5 , pp. 1583-1591
    • Carey, R.G.1    Li, B.2    DiCicco-Bloom, E.3
  • 5
    • 0030602003 scopus 로고    scopus 로고
    • Pituitary adenylate cyclase-activating polypeptide protects rat-cultured cortical neurons from glutamate-induced cytotoxicity
    • DOI 10.1016/S0006-8993(96)00920-1, PII S0006899396009201
    • Morio, H., Tatsuno, I., Hirai, A., Tamura, Y., and Saito, Y. (1996) Pituitary adenylate cyclase-activating polypeptide protects rat-cultured cortical neurons from glutamate-induced cytotoxicity. Brain Res. 741, 82-88 (Pubitemid 26426301)
    • (1996) Brain Research , vol.741 , Issue.1-2 , pp. 82-88
    • Morio, H.1    Tatsuno, I.2    Hirai, A.3    Tamura, Y.4    Saito, Y.5
  • 6
    • 0032401022 scopus 로고    scopus 로고
    • Neurotrophic and neuroprotective effects of pituitary adenylate cyclase- activating polypeptide (PACAP) on mesencephalic dopaminergic neurons
    • DOI 10.1002/(SICI)1097-4547(19981201)54:5<698::AID
    • Takei, N., Skoglösa, Y., and Lindholm, D. (1998) Neurotrophic and neuroprotective effects of pituitary adenylate cyclase-activating polypeptide (PACAP) on mesencephalic dopaminergic neurons. J. Neurosci. Res. 54, 698-706 (Pubitemid 28546073)
    • (1998) Journal of Neuroscience Research , vol.54 , Issue.5 , pp. 698-706
    • Takei, N.1    Skoglosa, Y.2    Lindholm, D.3
  • 8
    • 77949721758 scopus 로고    scopus 로고
    • Neurotrophin receptors: Old friends with new partners
    • Schecterson, L. C., and Bothwell, M. (2010) Neurotrophin receptors: old friends with new partners. Dev. Neurobiol. 70, 332-338
    • (2010) Dev. Neurobiol. , vol.70 , pp. 332-338
    • Schecterson, L.C.1    Bothwell, M.2
  • 9
    • 0034511574 scopus 로고    scopus 로고
    • The origin and function of the pituitary adenylate cyclase-activating polypeptide (PACAP)/glucagon superfamily
    • DOI 10.1210/er.21.6.619
    • Sherwood, N. M., Krueckl, S. L., and McRory, J. E. (2000) The origin and function of the pituitary adenylate cyclase-activating polypeptide (PACAP)/glucagon superfamily. Endocr. Rev. 21, 619-670 (Pubitemid 32113287)
    • (2000) Endocrine Reviews , vol.21 , Issue.6 , pp. 619-670
    • Sherwood, N.M.1    Krueckl, S.L.2    Mcrory, J.E.3
  • 12
    • 0026660275 scopus 로고
    • The 38-amino acid form of pituitary adenylate cyclase-activating polypeptide stimulates dual signaling cascades in PC12 cells and promotes neurite outgrowth
    • Deutsch, P. J., and Sun, Y. (1992) The 38-amino acid form of pituitary adenylate cyclase-activating polypeptide stimulates dual signaling cascades in PC12 cells and promotes neurite outgrowth. J. Biol. Chem. 267, 5108-5113
    • (1992) J. Biol. Chem. , vol.267 , pp. 5108-5113
    • Deutsch, P.J.1    Sun, Y.2
  • 13
    • 0038412577 scopus 로고    scopus 로고
    • Microarray and suppression subtractive hybridization analyses of gene expression in pheochromocytoma cells reveal pleiotropic effects of pituitary adenylate cyclase-activating polypeptide on cell proliferation, survival, and adhesion
    • DOI 10.1210/en.2002-0106
    • Grumolato, L., Elkahloun, A. G., Ghzili, H., Alexandre, D., Coulouarn, C., Yon, L., Salier, J. P., Eiden, L. E., Fournier, A., Vaudry, H., and Anouar, Y. (2003) Microarray and suppression subtractive hybridization analyses of gene expression in pheochromocytoma cells reveal pleiotropic effects of pituitary adenylate cyclase-activating polypeptide on cell proliferation, survival, and adhesion. Endocrinology 144, 2368-2379 (Pubitemid 36637089)
    • (2003) Endocrinology , vol.144 , Issue.6 , pp. 2368-2379
    • Grumolato, L.1    Elkahloun, A.G.2    Ghzili, H.3    Alexandre, D.4    Coulouarn, C.5    Yon, L.6    Salier, J.-P.7    Eiden, L.E.8    Fournier, A.9    Vaudry, H.10    Anouar, Y.11
  • 14
    • 0034667635 scopus 로고    scopus 로고
    • NF-κB signaling promotes both cell survival and neurite process formation in nerve growth factor-stimulated PC12 cells
    • Foehr, E. D., Lin, X., O'Mahony, A., Geleziunas, R., Bradshaw, R. A., and Greene, W. C. (2000) NF-κB signaling promotes both cell survival and neurite process formation in nerve growth factor-stimulated PC12 cells. J. Neurosci. 20, 7556-7563
    • (2000) J. Neurosci. , vol.20 , pp. 7556-7563
    • Foehr, E.D.1    Lin, X.2    O'Mahony, A.3    Geleziunas, R.4    Bradshaw, R.A.5    Greene, W.C.6
  • 15
    • 0035911153 scopus 로고    scopus 로고
    • Activation of nuclear factor κB and Bcl-x survival gene expression by nerve growth factor requires tyrosine phosphorylation of IκBα
    • Bui, N. T., Livolsi, A., Peyron, J. F., and Prehn, J. H. (2001) Activation of nuclear factor κB and Bcl-x survival gene expression by nerve growth factor requires tyrosine phosphorylation of IκBα. J. Cell Biol. 152, 753-764
    • (2001) J. Cell Biol. , vol.152 , pp. 753-764
    • Bui, N.T.1    Livolsi, A.2    Peyron, J.F.3    Prehn, J.H.4
  • 16
    • 0031025302 scopus 로고    scopus 로고
    • Inhibition of nuclear factor kappa B (NFκB) activity induces nerve growth factor-resistant apoptosis in PC12 cells
    • DOI 10.1002/(SICI)1097-4547(19970115)47:2<155::AID
    • Taglialatela, G., Robinson, R., and Perez-Polo, J. R. (1997) Inhibition of nuclear factor κB (NFκB) activity induces nerve growth factor-resistant apoptosis in PC12 cells. J. Neurosci. Res. 47, 155-162 (Pubitemid 27053374)
    • (1997) Journal of Neuroscience Research , vol.47 , Issue.2 , pp. 155-162
    • Taglialatela, G.1    Robinson, R.2    Perez-Polo, J.R.3
  • 17
    • 79651473582 scopus 로고    scopus 로고
    • NF-κB in immunobiology
    • Hayden, M. S., and Ghosh, S. (2011) NF-κB in immunobiology. Cell Res. 21, 223-244
    • (2011) Cell Res. , vol.21 , pp. 223-244
    • Hayden, M.S.1    Ghosh, S.2
  • 20
    • 0031172065 scopus 로고    scopus 로고
    • NF-κB: A crucial transcription factor for glial and neuronal cell function
    • DOI 10.1016/S0166-2236(96)01035-1
    • O'Neill, L. A., and Kaltschmidt, C. (1997) NF-κB: a crucial transcription factor for glial and neuronal cell function. Trends Neurosci. 20, 252-258 (Pubitemid 27261456)
    • (1997) Trends in Neurosciences , vol.20 , Issue.6 , pp. 252-258
    • O'Neill, L.A.J.1    Kaltschmidt, C.2
  • 21
    • 0037232409 scopus 로고    scopus 로고
    • PACAP and NGF regulate common and distinct traits of the sympathoadrenal lineage: Effects on electrical properties, gene markers and transcription factors in differentiating PC12 cells
    • DOI 10.1046/j.1460-9568.2003.02426.x
    • Grumolato, L., Louiset, E., Alexandre, D., Aït-Ali, D., Turquier, V., Fournier, A., Fasolo, A., Vaudry, H., and Anouar, Y. (2003) PACAP and NGF regulate common and distinct traits of the sympathoadrenal lineage: effects on electrical properties, gene markers and transcription factors in differentiating PC12 cells. Eur. J. Neurosci. 17, 71-82 (Pubitemid 36098877)
    • (2003) European Journal of Neuroscience , vol.17 , Issue.1 , pp. 71-82
    • Grumolato, L.1    Louiset, E.2    Alexandre, D.3    Ait-Ali, D.4    Turquier, V.5    Fournier, A.6    Fasolo, A.7    Vaudry, H.8    Anouar, Y.9
  • 22
    • 36848999246 scopus 로고    scopus 로고
    • Quantitative imaging assay for NF-κB nuclear translocation in primary human macrophages
    • DOI 10.1016/j.jim.2007.10.015, PII S0022175907003407
    • Noursadeghi, M., Tsang, J., Haustein, T., Miller, R. F., Chain, B. M., Katz, D. R. (2008) Quantitative imaging assay for NF-κB nuclear translocation in primary human macrophages. J. Immunol. Methods 329, 194-200 (Pubitemid 350235475)
    • (2008) Journal of Immunological Methods , vol.329 , Issue.1-2 , pp. 194-200
    • Noursadeghi, M.1    Tsang, J.2    Haustein, T.3    Miller, R.F.4    Chain, B.M.5    Katz, D.R.6
  • 24
    • 0035112978 scopus 로고    scopus 로고
    • NF-κB is involved in the survival of cerebellar granule neurons: Association of Iκβ phosphorylation with cell survival
    • DOI 10.1046/j.1471-4159.2001.00134.x
    • Koulich, E., Nguyen, T., Johnson, K., Giardina, C., and D'mello, S. (2001) NF-κB is involved in the survival of cerebellar granule neurons: association of Iκβ phosphorylation with cell survival. J. Neurochem. 76, 1188-1198 (Pubitemid 32167392)
    • (2001) Journal of Neurochemistry , vol.76 , Issue.4 , pp. 1188-1198
    • Koulich, E.1    Nguyen, T.2    Johnson, K.3    Giardina, C.A.4    D'Mello, S.R.5
  • 26
    • 84864750962 scopus 로고    scopus 로고
    • Signaling through the neuropeptide GPCR PAC1 induces neuritogenesis via a single linear cAMP- and ERK-dependent pathway using a novel cAMP sensor
    • Emery, A. C., and Eiden, L. E. (2012) Signaling through the neuropeptide GPCR PAC1 induces neuritogenesis via a single linear cAMP- and ERK-dependent pathway using a novel cAMP sensor. FASEB J. 26, 3199-3211
    • (2012) FASEB J. , vol.26 , pp. 3199-3211
    • Emery, A.C.1    Eiden, L.E.2
  • 27
    • 77951223899 scopus 로고    scopus 로고
    • Pituitary adenylate cyclase-activating polypeptide (PACAP)/PAC1HOP1 receptor activation coordinates multiple neurotrophic signaling pathways: Akt activation through phosphatidylinositol 3-kinase and vesicle endocytosis for neuronal survival
    • May, V., Lutz, E., MacKenzie, C., Schutz, K. C., Dozark, K., and Braas, K. M. (2010) Pituitary adenylate cyclase-activating polypeptide (PACAP)/PAC1HOP1 receptor activation coordinates multiple neurotrophic signaling pathways: Akt activation through phosphatidylinositol 3-kinase and vesicle endocytosis for neuronal survival. J. Biol. Chem. 285, 9749-9761
    • (2010) J. Biol. Chem. , vol.285 , pp. 9749-9761
    • May, V.1    Lutz, E.2    MacKenzie, C.3    Schutz, K.C.4    Dozark, K.5    Braas, K.M.6
  • 30
    • 84858720808 scopus 로고    scopus 로고
    • Dimer-specific regulatory mechanisms within the NF-κB family of transcription factors
    • Smale, S. T. (2012) Dimer-specific regulatory mechanisms within the NF-κB family of transcription factors. Immunol. Rev. 246, 193-204
    • (2012) Immunol. Rev. , vol.246 , pp. 193-204
    • Smale, S.T.1
  • 32
    • 17744371866 scopus 로고    scopus 로고
    • NF-κB signalling regulates the growth of neural processes in the developing PNS and CNS
    • DOI 10.1242/dev.01702
    • Gutierrez, H., Hale, V. A., Dolcet, X., and Davies, A. (2005) NF-κB signaling regulates the growth of neural processes in the developing PNS and CNS. Development 132, 1713-1726 (Pubitemid 40575870)
    • (2005) Development , vol.132 , Issue.7 , pp. 1713-1726
    • Gutierrez, H.1    Hale, V.A.2    Dolcet, X.3    Davies, A.4
  • 35
    • 79952498248 scopus 로고    scopus 로고
    • TNFR1-induced activation of the classical NF-κB pathway
    • Wajant, H., and Scheurich, P. (2011) TNFR1-induced activation of the classical NF-κB pathway. FEBS J. 278, 862-876
    • (2011) FEBS J. , vol.278 , pp. 862-876
    • Wajant, H.1    Scheurich, P.2
  • 36
    • 0032524150 scopus 로고    scopus 로고
    • The intracellular domain of p55 tumor necrosis factor receptor induces apoptosis which requires different caspases in naive and neuronal PC12 cells
    • DOI 10.1002/(SICI)1097-4547(19980515)52:4<380::AID
    • Haviv, R., and Stein, R. (1998) The intracellular domain of p55 tumor necrosis factor receptor induces apoptosis which requires different caspases in naive and neuronal PC12 cells. J. Neurosci. Res. 52, 380-389 (Pubitemid 28259105)
    • (1998) Journal of Neuroscience Research , vol.52 , Issue.4 , pp. 380-389
    • Haviv, R.1    Stein, R.2
  • 37
    • 0029976817 scopus 로고    scopus 로고
    • An essential role for NF-κB in preventing TNF-α-induced cell death
    • DOI 10.1126/science.274.5288.782
    • Beg, A. A., and Baltimore, D. (1996) An essential role for NF-κB in preventing TNF-αinduced cell death. Science 274, 782-784 (Pubitemid 26398258)
    • (1996) Science , vol.274 , Issue.5288 , pp. 782-784
    • Beg, A.A.1    Baltimore, D.2
  • 38
    • 84858724192 scopus 로고    scopus 로고
    • NF-κB regulation: Lessons from structures
    • Ghosh, G., Wang, V. Y., Huang, D. B., and Fusco, A. (2012) NF-κB regulation: lessons from structures. Immunol. Rev. 246, 36-58
    • (2012) Immunol. Rev. , vol.246 , pp. 36-58
    • Ghosh, G.1    Wang, V.Y.2    Huang, D.B.3    Fusco, A.4
  • 39
    • 0025184764 scopus 로고
    • The mouse c-Rel protein has an N-terminal regulatory domain and a C-terminal transcriptional transactivation domain
    • Bull, P., Morley, K. L., Hoekstra, M. F., Hunter, T., and Verma, I. M. (1990) The mouse c-Rel protein has an N-terminal regulatory domain and a C-terminal transcriptional transactivation domain. Mol. Cell. Biol. 10, 5473-5485
    • (1990) Mol. Cell. Biol. , vol.10 , pp. 5473-5485
    • Bull, P.1    Morley, K.L.2    Hoekstra, M.F.3    Hunter, T.4    Verma, I.M.5
  • 40
    • 20744452337 scopus 로고    scopus 로고
    • Activation of the IκB kinase complex is sufficient for neuronal differentiation of PC12 cells
    • DOI 10.1111/j.1471-4159.2005.03148.x
    • Azoitei, N., Wirth, T., and Baumann, B. (2005) Activation of the IκB kinase complex is sufficient for neuronal differentiation of PC12 cells. J. Neurochem. 93, 1487-1501 (Pubitemid 40853272)
    • (2005) Journal of Neurochemistry , vol.93 , Issue.6 , pp. 1487-1501
    • Azoitei, N.1    Wirth, T.2    Baumann, B.3
  • 42
    • 0033621956 scopus 로고    scopus 로고
    • The Rel/NF-κb family directly activates expression of the apoptosis inhibitor BCl-x(L)
    • DOI 10.1128/MCB.20.8.2687-2695.2000
    • Chen, C., Edelstein, L. C., and Gélinas, C. (2000) The Rel/NF-κB family directly activates expression of the apoptosis inhibitor Bcl-xL. Mol. Cell. Biol. 20, 2687-2695 (Pubitemid 30183487)
    • (2000) Molecular and Cellular Biology , vol.20 , Issue.8 , pp. 2687-2695
    • Chen, C.1    Edelstein, L.C.2    Gelinas, C.3
  • 43
    • 0034423508 scopus 로고    scopus 로고
    • The anti-apoptotic activities of Rel and RelA required during B-cell maturation involve the regulation of Bcl-2 expression
    • Grossmann, M., O'Reilly, L. A., Gugasyan, R., Strasser, A., Adams, J. M., and Gerondakis, S. (2000) The anti-apoptotic activities of Rel and RelA required during B-cell maturation involve the regulation of Bcl-2 expression. EMBO J. 19, 6351-6360
    • (2000) EMBO J. , vol.19 , pp. 6351-6360
    • Grossmann, M.1    O'Reilly, L.A.2    Gugasyan, R.3    Strasser, A.4    Adams, J.M.5    Gerondakis, S.6
  • 44
    • 37349003868 scopus 로고    scopus 로고
    • PKA-Bad-14-3-3 and Akt-Bad-14-3-3 signaling pathways are involved in the protective effects of PACAP against ischemia/reperfusion-induced cardiomyocyte apoptosis
    • DOI 10.1016/j.regpep.2007.09.015, PII S0167011507001930, Satellite Symposium on G-Protein-Couples Receptors (GPCRs)
    • Rácz, B., Gasz, B., Gallyas, F., Jr., Kiss, P., Tamás, A., Szántó, Z., Lubics, A., Lengvári, I., Tóth, G., Hegyi, O., Roth, E., and Reglodi, D. (2008) PKA-Bad-14-3-3 and Akt-Bad-14-3-3 signaling pathways are involved in the protective effects of PACAP against ischemia/reperfusion-induced cardiomyocyte apoptosis. Regul. Pept. 145, 105-115 (Pubitemid 350296368)
    • (2008) Regulatory Peptides , vol.145 , Issue.1-3 , pp. 105-115
    • Racz, B.1    Gasz, B.2    Gallyas Jr., F.3    Kiss, P.4    Tamas, A.5    Szanto, Z.6    Lubics, A.7    Lengvari, I.8    Toth, G.9    Hegyi, O.10    Roth, E.11    Reglodi, D.12
  • 46
    • 0031664979 scopus 로고    scopus 로고
    • The 38-amino-acid form of pituitary adenylate cyclase-activating polypeptide induces neurite outgrowth in PC12 cells that is dependent on protein kinase C and extracellular signal-regulated kinase but not on protein kinase A, nerve growth factor receptor tyrosine kinase, p21(ras) G protein, and pp60(c-src) cytoplasmic tyrosine kinase
    • Lazarovici, P., Jiang, H., and Fink, D., Jr. (1998) The 38-amino-acid form of pituitary adenylate cyclase-activating polypeptide induces neurite outgrowth in PC12 Cells that is dependent on protein kinase C and extracellular signal-regulated kinase but not on protein kinase A, nerve growth factor receptor tyrosine kinase, p21ras G protein, and pp60c-src cytoplasmic tyrosine kinase. Mol. Pharmacol. 54, 547-558 (Pubitemid 28442948)
    • (1998) Molecular Pharmacology , vol.54 , Issue.3 , pp. 547-558
    • Lazarovici, P.1    Jiang, H.2    Fink Jr., D.3
  • 50
    • 0027313506 scopus 로고
    • NF-κB precursor p100 inhibits nuclear translocation and DNA binding of NF-κB/rel-factors
    • Naumann, M., Nieters, A., Hatada, E. N., and Scheidereit, C. (1993) NF-κB precursor p100 inhibits nuclear translocation and DNA binding of NF-κB/rel-factors. Oncogene 8, 2275-2281 (Pubitemid 23226963)
    • (1993) Oncogene , vol.8 , Issue.8 , pp. 2275-2281
    • Naumann, M.1    Nieters, A.2    Hatada, E.N.3    Scheidereit, C.4
  • 51
    • 0034745420 scopus 로고    scopus 로고
    • NF-κB-inducing kinase regulates the processing of NF-κB2 p100
    • DOI 10.1016/S1097-2765(01)00187-3
    • Xiao, G., Harhaj, E. W., and Sun, S. C. (2001) NF-κB-inducing kinase regulates the processing of NF-κB2 p100. Mol. Cell 7, 401-409 (Pubitemid 32206507)
    • (2001) Molecular Cell , vol.7 , Issue.2 , pp. 401-409
    • Xiao, G.1    Harhaj, E.W.2    Sun, S.-C.3
  • 52
    • 3142663912 scopus 로고    scopus 로고
    • Induction of p100 processing by NF-κB-inducing kinase involves docking IκB Kinase (IKK) to p100 and IKK-mediated phosphorylation
    • Xiao, G., Fong, A., and Sun, S. C. (2004) Induction of p100 processing by NF-κB-inducing kinase involves docking IκB Kinase (IKK) to p100 and IKK-mediated phosphorylation. J. Biol. Chem. 279, 30099 -30105
    • (2004) J. Biol. Chem. , vol.279 , pp. 30099-30105
    • Xiao, G.1    Fong, A.2    Sun, S.C.3
  • 53
    • 17944378526 scopus 로고    scopus 로고
    • Activation by IKKα of a second, evolutionary conserved, NF-κB signaling pathway
    • DOI 10.1126/science.1062677
    • Senftleben, U., Cao, Y., Xiao, G., Greten, F. R., Krähn, G., Bonizzi, G., Chen, Y., Hu, Y., Fong, A., Sun, S. C., and Karin, M. (2001) Activation by IKKα of a second, evolutionary conserved, NF-κB signaling pathway. Science 293, 1495-1499 (Pubitemid 32801552)
    • (2001) Science , vol.293 , Issue.5534 , pp. 1495-1499
    • Senftleben, U.1    Cao, Y.2    Xiao, G.3    Greten, F.R.4    Krahn, G.5    Bonizzi, G.6    Chen, Y.7    Hu, Y.8    Fong, A.9    Sun, S.-C.10    Karin, M.11
  • 54
    • 33749265867 scopus 로고    scopus 로고
    • The alternative NF-κB pathway from biochemistry to biology: Pitfalls and promises for future drug development
    • Dejardin, E. (2006) The alternative NF-κB pathway from biochemistry to biology: pitfalls and promises for future drug development. Biochem. Pharmacol. 72, 1161-1179
    • (2006) Biochem. Pharmacol. , vol.72 , pp. 1161-1179
    • Dejardin, E.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.