ING4 inhibits the translation of proto-oncogene MYC by interacting with AUF1

FEBS Letters

Volumn 587, Issue 11, 2013, Pages 1597-1604

  Lu, Meiling ^a,b   Pan, Chunyang ^a   Zhang, Lantian ^a   Ding, Chenhong ^a,c   Chen, Fei ^c   Wang, Qinwan ^b   Wang, Kesheng ^b   Zhang, Xin ^a,c  

^a CHINESE NATIONAL HUMAN GENOME CENTER AT SHANGHAI   (China)

^b TONGJI UNIVERSITY SCHOOL OF MEDICINE   (China)

^c SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

AUF1; Cell proliferation; ING4; MYC; Translation

Indexed keywords

HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN D; INHIBITOR OF GROWTH 4; MESSENGER RNA; MYC PROTEIN; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; ARTICLE; AU RICH ELEMENT; CANCER INHIBITION; CELL PROLIFERATION; CELL STRAIN K 562; CHROMATIN IMMUNOPRECIPITATION; COMPLEX FORMATION; CONTROLLED STUDY; EMBRYO; FEMALE; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; IN VITRO STUDY; MASS SPECTROMETRY; ONCOGENE C MYC; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; TRANSLATION REGULATION;

CELL CYCLE PROTEINS; CELL PROLIFERATION; GENE EXPRESSION REGULATION; HEK293 CELLS; HELA CELLS; HETEROGENEOUS-NUCLEAR RIBONUCLEOPROTEIN D; HOMEODOMAIN PROTEINS; HUMANS; IMMUNOPRECIPITATION; K562 CELLS; NUCLEAR LOCALIZATION SIGNALS; PROTEIN BINDING; PROTEIN BIOSYNTHESIS; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN ISOFORMS; PROTO-ONCOGENE PROTEINS C-MYC; RIBONUCLEOPROTEINS; RNA, MESSENGER; TUMOR SUPPRESSOR PROTEINS;

EID: 84878221449     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2013.04.004     Document Type: Article

References (29)

1. A.H. Coles, and S.N. Jones The ING gene family in the regulation of cell growth and tumorigenesis J. Cell. Physiol. 218 2009 45 57
2. L.P. Zhan, Q.Y. Li, Y. Zhang, T.J. Zhang, Z.C. Yuan, and P.S. Lu Mechanism of ING4 mediated inhibition of the proliferation and migration of human glioma cell line U251 Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 27 2011 1188 1190
3. J.C. Shen, M. Unoki, D. Ythier, A. Duperray, L. Varticovski, K. Kumamoto, R. Pedeux, and C.C. Harris Inhibitor of growth 4 suppresses cell spreading and cell migration by interacting with a novel binding partner, liprin alpha1 Cancer Res. 67 2007 2552 2558
4. I. Garkavtsev, S.V. Kozin, O. Chernova, L. Xu, F. Winkler, E. Brown, G.H. Barnett, and R.K. Jain The candidate tumour suppressor protein ING4 regulates brain tumour growth and angiogenesis Nature 428 2004 328 332
5. X. Zhang ING4 induces G2/M cell cycle arrest and enhances the chemosensitivity to DNA-damage agents in HepG2 cells FEBS Lett. 570 2004 7 12
6. S. Kim, A.L. Welm, and J.M. Bishop A dominant mutant allele of the ING4 tumor suppressor found in human cancer cells exacerbates MYC-initiated mouse mammary tumorigenesis Cancer Res. 70 2010 5155 5162
7. V.B. Mathema, and Y.S. Koh Inhibitor of growth-4 mediates chromatin modification and has a suppressive effect on tumorigenesis and innate immunity Tumour Biol. 33 2012 1 7
8. M. Shiseki P29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity Cancer Res. 63 2003 2373 2378
9. S. Colla The new tumor-suppressor gene inhibitor of growth family member 4 (ING4) regulates the production of proangiogenic molecules by myeloma cells and suppresses hypoxia-inducible factor-1 alpha (HIF-1alpha) activity: involvement in myeloma-induced angiogenesis Blood 110 2007 4464 4475
10. A. Ozer, L.C. Wu, and R.K. Bruick The candidate tumor suppressor ING4 represses activation of the hypoxia inducible factor (HIF) Proc. Natl. Acad. Sci. USA 102 2005 7481 7486
11. S. Nozell The ING4 tumor suppressor attenuates NF-kappaB activity at the promoters of target genes Mol. Cell. Biol. 28 2008 6632 6645
12. T. Hung ING4 mediates crosstalk between histone H3 K4 trimethylation and H3 acetylation to attenuate cellular transformation Mol. Cell 33 2009 248 256
13. N. Saksouk HBO1 HAT complexes target chromatin throughout gene coding regions via multiple PHD finger interactions with histone H3 tail Mol. Cell 33 2009 257 265
14. C.Y. Chen, and A.B. Shyu AU-rich elements: characterization and importance in mRNA degradation Trends Biochem. Sci. 20 1995 465 470
15. F.M. Gratacos, and G. Brewer The role of AUF1 in regulated mRNA decay Wiley Interdiscip Rev RNA 1 2010 457 473
16. G. Laroia, R. Cuesta, G. Brewer, and R.J. Schneider Control of mRNA decay by heat shock-ubiquitin-proteasome pathway Science 284 1999 499 502
17. J.Y. Lu, N. Bergman, N. Sadri, and R.J. Schneider Assembly of AUF1 with eIF4G-poly(A) binding protein complex suggests a translation function in AU-rich mRNA decay RNA 12 2006 883 893
18. F. Sagliocco, B. Laloo, B. Cosson, L. Laborde, M. Castroviejo, J. Rosenbaum, J. Ripoche, and C. Grosset The ARE-associated factor AUF1 binds poly(A) in vitro in competition with PABP Biochem. J. 400 2006 337 347
19. W. Wang, J.L. Martindale, X. Yang, F.J. Chrest, and M. Gorospe Increased stability of the p16 mRNA with replicative senescence EMBO Rep. 6 2005 158 164
20. J.Y. Lu, N. Sadri, and R.J. Schneider Endotoxic shock in AUF1 knockout mice mediated by failure to degrade proinflammatory cytokine mRNAs Genes Dev. 20 2006 3174 3184
21. K. Mazan-Mamczarz, Y. Kuwano, M. Zhan, E.J. White, J.L. Martindale, A. Lal, and M. Gorospe Identification of a signature motif in target mRNAs of RNA-binding protein AUF1 Nucleic Acids Res. 37 2009 204 214
22. S. Lin, W. Wang, G.M. Wilson, X. Yang, G. Brewer, N.J. Holbrook, and M. Gorospe Down-regulation of cyclin D1 expression by prostaglandin A(2) is mediated by enhanced cyclin D1 mRNA turnover Mol. Cell. Biol. 20 2000 7903 7913
23. B. Liao, Y. Hu, and G. Brewer Competitive binding of AUF1 and TIAR to MYC mRNA controls its translation Nat. Struct. Mol. Biol. 14 2007 511 518
24. X. Zhang, K.S. Wang, Z.Q. Wang, L.S. Xu, Q.W. Wang, F. Chen, D.Z. Wei, and Z.G. Han Nuclear localization signal of ING4 plays a key role in its binding to p53 Biochem. Biophys. Res. Commun. 331 2005 1032 1038
25. G. Brewer An A + U-rich element RNA-binding factor regulates c-myc mRNA stability in vitro Mol. Cell. Biol. 11 1991 2460 2466
26. Y. Doyon ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation Mol. Cell 21 2006 51 64
27. Q. Guo, and W. Fast Citrullination of inhibitor of growth 4 (ING4) by peptidylarginine deminase 4 (PAD4) disrupts the interaction between ING4 and p53 J. Biol. Chem. 286 2011 17069 17078
28. S. Culurgioni, I.G. Munoz, A. Moreno, A. Palacios, M. Villate, I. Palmero, G. Montoya, and F.J. Blanco Crystal structure of inhibitor of growth 4 (ING4) dimerization domain reveals functional organization of ING family of chromatin-binding proteins J. Biol. Chem. 287 2012 10876 10884
29. A. Palacios The dimeric structure and the bivalent recognition of H3K4me3 by the tumor suppressor ING4 suggests a mechanism for enhanced targeting of the HBO1 complex to chromatin J. Mol. Biol. 396 2010 1117 1127