Downregulation of ATP-binding cassette subfamily c member 4 increases sensitivity to neoadjuvant radiotherapy for locally advanced rectal carcinoma

Diseases of the Colon and Rectum

Volumn 56, Issue 5, 2013, Pages 600-608

  Yu, Zhi Qi ^a   Zhang, Chang ^a   Wang, Hao ^a   Lao, Xin Yuan ^a   Chai, Rui ^a   Gao, Xian Hua ^a   Cao, Guang Wen ^b   Fu, Chuan Gang ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Locally advanced rectal carcinoma; Neoadjuvant radiotherapy; P binding cassette subfamily C member 4; Radiosensitivity; RNA interference

Indexed keywords

ATP BINDING CASSETTE C4 PROTEIN; CARRIER PROTEINS AND BINDING PROTEINS; FLUOROURACIL; LENTIVIRUS VECTOR; MEMBRANE PROTEIN; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG; ABCC4 PROTEIN, HUMAN; CARCINOEMBRYONIC ANTIGEN; MULTIDRUG RESISTANCE PROTEIN; PROTEIN P53; RNA; SMALL INTERFERING RNA; TP53 PROTEIN, HUMAN; TUMOR MARKER;

ADULT; ADVANCED CANCER; APOPTOSIS; ARTICLE; CANCER PATIENT; CANCER RADIOTHERAPY; CANCER REGRESSION; CARCINOMA CELL; CELL ASSAY; CELL PROLIFERATION; CELL SURVIVAL; CELL VIABILITY; COLONY FORMATION; COLORECTAL CARCINOMA; COMPARATIVE STUDY; CONTROLLED STUDY; DOWN REGULATION; FEMALE; FLOW CYTOMETRY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LINEAR ACCELERATOR; MALE; PROTEIN EXPRESSION; RADIOSENSITIVITY; REAL TIME POLYMERASE CHAIN REACTION; RECTUM CARCINOMA; RNA INTERFERENCE; TREATMENT RESPONSE; WESTERN BLOTTING; ADENOCARCINOMA; ADJUVANT THERAPY; AGED; CELL STRAIN HT29; GENE SILENCING; GENETICS; METABOLISM; METHODOLOGY; MIDDLE AGED; PATHOLOGY; PHYSIOLOGY; PROGNOSIS; RADIATION DOSE; RECTUM TUMOR; RETROSPECTIVE STUDY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADENOCARCINOMA; AGED; BLOTTING, WESTERN; CARCINOEMBRYONIC ANTIGEN; CELL PROLIFERATION; DOWN-REGULATION; FEMALE; GENE KNOCKDOWN TECHNIQUES; HT29 CELLS; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; NEOADJUVANT THERAPY; PROGNOSIS; RADIATION TOLERANCE; RECTAL NEOPLASMS; RETROSPECTIVE STUDIES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; RNA, SMALL INTERFERING; TUMOR MARKERS, BIOLOGICAL; TUMOR SUPPRESSOR PROTEIN P53;

MLCS; MLOWN;

EID: 84878216725     PISSN: 00123706     EISSN: 15300358     Source Type: Journal    
DOI: 10.1097/DCR.0b013e31827c2b80     Document Type: Article

References (22)

1. van Gijn W, Marijnen CA, Nagtegaal ID, et al.; Dutch Colorectal Cancer Group. Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer: 12-year follow-up of the multicentre, randomised controlled TME trial. Lancet Oncol. 2011;12:575-582.
2. Engstrom PF, Arnoletti JP, Benson AB 3rd, et al.; National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology: rectal cancer. J Natl Compr Canc Netw. 2009;7:838-881.
3. Yu ZQ, Zhang C, Lao XY, et al. [Long non-coding RNA influences radiosensitivity of colorectal carcinoma cell lines by regulating cyclin D1 expression]. Zhonghua Wei Chang Wai Ke Za Zhi. 2012;15:288-291.
4. Zhang YH, Wu, Q, Xiao XY, et al. Silencing MRP4 by small interfering RNA reverses acquired DDP resistance of gastric cancer cell. Cancer Lett. 2010;291:76-82.
5. Norris MD, Smith J, Tanabe K, et al. Expression of multidrug transporter MRP4/ABCC4 is a marker of poor prognosis in neuroblastoma and confers resistance to irinotecan in vitro. Mol Cancer Ther. 2005;4:547-553.
6. Bottke D, Koychev D, Busse A, et al. Fractionated irradiation can induce functionally relevant multidrug resistance gene and protein expression in human tumor cell lines. Radiat Res. 2008;170:41-48.
7. Bartkowiak D, Stempfhuber M, Wiegel T, Bottke D. Radiationand chemoinduced multidrug resistance in colon carcinoma cells. Strahlenther Onkol. 2009;185:815-820.
8. van Aubel RA, Smeets PH, Peters JG, Bindels RJ, Russel FG. The MRP4/ABCC4 gene encodes a novel apical organic anion transporter in human kidney proximal tubules: putative efflux pump for urinary cAMP and cGMP. J Am Soc Nephrol. 2002;13:595-603.
9. Bai J, Lai L, Yeo HC, Goh BC, Tan TM. Multidrug resistance protein 4 (MRP4/ABCC4) mediates efflux of bimane-glutathione. Int J Biochem Cell Biol. 2004;36:247-257.
10. Bouzourene H, Bosman FT, Seelentag W, Matter M, Coucke P. Importance of tumor regression assessment in predicting the outcome in patients with locally advanced rectal carcinoma who are treated with preoperative radiotherapy. Cancer. 2002;94:1121-1130.
11. Chang W, Wu L, Cao F, et al. Development of autoantibody signatures as biomarkers for early detection of colorectal carcinoma. Clin Cancer Res. 2011;17:5715-5724.
12. Ji-Fu E, Xing JJ, Hao LQ, Fu CG. Suppression of lung cancer metastasis-related protein 1 (LCMR1) inhibits the growth of colorectal cancer cells. Mol Biol Rep. 2012;39:3675-3681.
13. Dunne AL, Price ME, Mothersill C, McKeown SR, Robson T, Hirst DG. Relationship between clonogenic radiosensitivity, radiation-induced apoptosis and DNA damage/repair in human colon cancer cells. Br J Cancer. 2003;89:2277-2283.
14. Minsky BD. Progress in the treatment of locally advanced clinically resectable rectal cancer. Clin Colorectal Cancer. 2011;10:227-237.
15. Kuremsky JG, Tepper JE, McLeod HL. Biomarkers for response to neoadjuvant chemoradiation for rectal cancer. Int J Radiat Oncol Biol Phys. 2009;74:673-688.
16. Rees DC, Johnson E, Lewinson O. ABC transporters: the power to change. Nat Rev Mol Cell Biol. 2009;10:218-227.
17. Tian Q, Zhang J, Tan TM, et al. Human multidrug resistance associated protein 4 confers resistance to camptothecins. Pharm Res. 2005;22:1837-1853.
18. Chen ZS, Lee K, Walther S, et al. Analysis of methotrexate and folate transport by multidrug resistance protein 4 (ABCC4): MRP4 is a component of the methotrexate efflux system. Cancer Res. 2002;62:3144-3150.
19. Liu YH, Di YM, Zhou ZW, Mo SL, Zhou SF. Multidrug resistance- associated proteins and implications in drug development. Clin Exp Pharmacol Physiol. 2010;37:115-120.
20. Lai L, Tan TM. Role of glutathione in the multidrug resistance protein 4 (MRP4/ABCC4)-mediated efflux of cAMP and resistance to purine analogues. Biochem J. 2002;361(Pt 3):497-503.
21. Fu CG, Tominaga O, Nagawa H, et al. Role of p53 and p21/WAF1 detection in patient selection for preoperative radiotherapy in rectal cancer patients. Dis Colon Rectum. 1998;41:68-74.
22. Ruth AC, Roninson IB. Effects of the multidrug transporter Pglycoprotein on cellular responses to ionizing radiation. Cancer Res. 2000;60:2576-2578.