Relationship between clonogenic radiosensitivity, radiation-induced apoptosis and DNA damage/repair in human colon cancer cells

British Journal of Cancer

Volumn 89, Issue 12, 2003, Pages 2277-2283

  Dunne, A L ^a   Price, M E ^a   Mothersill, C ^b   McKeown, S R ^a   Robson, T ^a   Hirst, D G ^a  

^a UNIVERSITY OF ULSTER   (United Kingdom)

^b DUBLIN INSTITUTE OF TECHNOLOGY   (Ireland)

Author keywords

Apoptosis; Colon cancer; DNA strand breaks; Predictive assay

Indexed keywords

SINGLE STRANDED DNA;

ACCURACY; ADENOCARCINOMA; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER RADIOTHERAPY; CELL STRUCTURE; CELL SURVIVAL; CLONOGENESIS; CLONOGENIC ASSAY; COLON ADENOCARCINOMA; COLON CANCER; COLORECTAL CARCINOMA; COLORECTAL TUMOR; COMET ASSAY; CONTROLLED STUDY; DISEASE MARKER; DNA DAMAGE; DNA REPAIR; DNA STRAND BREAKAGE; DRUG SCREENING; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; MEASUREMENT; METHODOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; PREDICTION AND FORECASTING; PRIORITY JOURNAL; RADIATION DOSE; RADIATION EXPOSURE; RADIATION RESPONSE; RADIOSENSITIVITY; TUMOR CELL LINE; X RAY;

EID: 0842308784     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6601427     Document Type: Article

References (38)

1. Agaki Y, Ito K, Sawada S (1993) Radiation-induced apoptosis and necrosis in Molt-4 cells; a study of dose-effect relationships and their modification. Int J Radiat Biol 64: 47-56
2. Bock C, Dittmar H, Gemeinhardt H, Bauer E, Greulich KO (1998) Comet assay detects cold repair of UV-A damages in a human B-lymphoblast cell line. Mutat Res 408: 111-120
3. Bush C, McMillan TJ (1993) Micronucleus formation in human tumour cells; lack of correlation with radiosensitivity. Br J Cancer 67: 102-106
4. Davidson SE, West CML (1990) Radiosensitivity testing of primary cervical carcinoma, evaluation of intra and inter tumour heterogeneity. Radiother Oncol 18: 349-356
5. Darzynkiewicz Z, Juan G, Li X, Gorczyca W, Tragagnos F (1997) Cytometry in cell necrobiology; analysis of apoptosis and accidental cell death (necrosis). Cytometry 27: 1-20
6. Dewey WC, Ling CC, Meyn RE (1995) Radiation-induced apoptosis; relevance to radiotherapy. Int J Radiat Oncol Biol Phys 33: 781-796
7. Guo GZ, Sasai K, Oya N, Takaji T, Shibuia K, Hiraoka M (1999) A significant correlation between clonogenic radiosensitivity and a simultaneous assessment of micronucleus and apoptotic cell frequencies. Int J Radiat Oncol Biol Phys 75: 857-864
8. Hu Q, Hill P (1996) Radiosensitivity, apoptosis and repair of DNA double-strand breaks in radiation-sensitive Chinese Hamster ovary cell mutants treated at different dose rates. Radiat Res 146: 636-645
9. Jamali M, Trott KR (1996) Increased micronucleus frequency in the progeny of irradiated Chinese hamster cells. Int J Radiat Biol 69: 301-307
10. Leith J, Faulkner G, Papa P, Michelson S (1991) In vitro radiation survival parameters of human colon tumour cells. Int J Radiat Oncol Biol Phys 20: 203-206
11. MacPhail SH, Banath JP, Yu TY, Chu EH, Lambur H, Olive PL (2003) Expression of phosphorylated histone H2AX in cultured cell lines following exposure to X-rays. Int J Radiat Biol 79: 351-358
12. Mariya J, Streffer C, Fuhrmann C, Wojcik A (1997) Correlation of radiation-induced micronucleus frequency with clonogenic survival in cells of 1 diploid and 2 tetraploid murine tumour cell lines of the same origin. Radiat Res 147: 29-37
13. McGlynn AP, Wasson GR, O'Reilly S, McKelvey-Martin VJ, McNulty H, Strain JJ, McKerr G, Mullan F, Mahmud N, Scott J, Weir DG, Downes CS (2003) Detection of replicative integrity in small colonic biopsies using the BrdUrd comet assay. Br J Cancer 88: 895-901
14. McKelvy-Martin VJ, Ho ET, McKeown SR, Johnston SR, McCarthy PJ, Rahab, NF, Downes CS (1998) Emerging applications of the single cell gel electrophoresis (comet assay). Mutagenesis 13: 1-8
15. 2 delay. Oncogene 12: 237-245
16. McKeown SR, Robson T, Price ME, Ho ETS, Hirst DG, McKelvey-Martin VJ (2003) Potential use of the alkaline comet assay as a predictor of bladder tumour response to radiation. Br J Cancer 89: 2264-2270
17. McMillan TJ, Cassoni AM, Edwards S, Holmes A, Peacock JH (1990) The relationship of DNA double strand break induction to radiosensitivity in human tumour cell lines. Int J Radiat Biol 58: 427-438
18. Moneef MAL, Sherwood BT, Bowman KJ, Kockelbergh RC, Symonds RP, Steward WP, Mellon JK, Jones GDD. (2003) Measures by the alkaline comet assay predict bladder cancer cell radiosensitivity. Br J Cancer 89: 2271-2276
19. Nehls O, Klump B, Holzmann K, Lammering G, Borchard F, Gruenagel HH, Gaco V, Gregor M, Porschen R (1999) Influence of p53 status on prognosis in preoperatively irradiated rectal carcinoma. Cancer. 85: 2541-2518
20. Olive PL, Banath JP, Durand RE (1996) Development of apoptosis and polyploidy in human lymphobast cells as a function of position in the cell cycle at the time of irradiation. Radiat Res 146: 595-602
21. Olive PL, Durand RE (1997) Apoptosis; an indicator of radiosensitivity in vitro? Int J Radiat Biol 71: 695-707
22. 238Pu alpha-particles. Radiat Biol Relat Stud Phys Chem Med 52: 893-902
23. Radford IR (1986) Evidence for a general relationship between the induced level of DNA double-strand breakage and cell-killing after X-irradiation of mammalian cells. Int J Radiat Biol Relat Stud Phys Chem Med 49: 611-620
24. Radford IR, Murphy TK (1994) Radiation response of mouse lymphoid and myeloid cell lines Part III. Different signals can lead to apoptosis and may influence sensitivity to killing by DNA double-strand breakage. Int J Radiat Oncol Biol Phys 65: 229-239
25. Rothkam K, Lobrich M (2003) Evidence for a lack of DNA double-strand break repair in human cells exposed to very low X-ray doses. Proc Natl Acad Sci USA 100: 5057-5062
26. Russell J, Weldon TW, Stanton P (1995) A radioresistant variant derived from a human neuroblastoma cell line is less prone to radiation-induced apoptosis. Cancer Res 55: 4195-4221
27. Singh NP, Stephens RE, Schneider EL (1988) A simple technique for quantitation of low levels of DNA damage in individual cells. Exp Cell Res 175: 184-191
28. Slavotinek A, McMillan TJ, Steel CM (1993) A comparison of micronucleus frequency and radiation survival in lymphoblastoid cell lines. Mutagenesis 8: 569-575
29. Story MD, Stephens LC, Tomasovic SP, Meyn RE (1992) A role for calcium in regulating apoptosis in rat thymocytes irradiated in vitro. Int J Radiat Biol 61: 243-251
30. Villa R, Zaffaroni N, Gornatti D, Costa A, Silvestrini R (1994) Lack of a correlation between micronucleus formation and radiosensitivity in established and primary cultures of human tumours. Br J Cancer 70: 1112-1117
31. Virsik-Peuckert RP, Harder D. (1986) Temperature and the formation of radiation-induced chromosome aberrations. II. The temperature dependence of lesion repair and lesion interaction. Int J Radiat Biol Relat Stud Phys Chem Med 49: 673-681
32. Wandl E, Ono K, Kain R, Herbsthrofer T, Heinert G, Hoeberth K (1989) Linear correlation between surviving fraction and the micronucleus frequency. Int J Radiat Biol 56: 771-775
33. West CML (1992) Intrinsic radiosensitivity as a predictor of patient response to radiotherapy. Br J Radiol 24: 146-152
34. West CML (1993) Intrinsic radiosensitivity and prediction of patient response to radiation therapy for carcinoma of the cervix. Br J Cancer 68: 19-23
35. West CML (1995) Intrinsic radiosensitivity as a predictor of patient response to radiotherapy. Br J Radiol 68: 827-837
36. West CML (1997) The independence of intrinsic radiosensitivity as a prognostic factor for patient response to radiotherapy of carcinoma of the cervix. Br J Cancer 76: 1184-1190
37. Wilks DP, Barry J, Hughs MF, West CML (1996) Assessment of light scatter by nucleosides as a rapid predictive of radiosensitivity. Radiat Res 146: 628-635
38. Yangihara K, Nii M, Numoto M, Kamiya K (1995) Radiation-induced apoptotic cell death in human gastric epithelial cells; correlation between mitotic death and apoptosis. Int J Radiat Biol 67: 677-685