YM155 induces caspase-8 dependent apoptosis through downregulation of survivin and Mcl-1 in human leukemia cells

Biochemical and Biophysical Research Communications

Volumn 435, Issue 1, 2013, Pages 52-57

  Feng, Weiying ^a,b   Yoshida, Akira ^a   Ueda, Takanori ^a  

^a UNIVERSITY OF FUKUI   (Japan)

^b SHAOXING PEOPLE S HOSPITAL   (China)

Author keywords

Apoptosis; Caspase 8; Survivin; YM155

Indexed keywords

BENZYLOXYCARBONYLISOLEUCYLGLUTAMYLTHREONYLASPARTYL FLUOROMETHYL KETONE; CASPASE 3; CASPASE 8; PROTEIN MCL 1; SEPANTRONIUM BROMIDE; SURVIVIN;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IC 50; LEUKEMIA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION;

APOPTOSIS; BLOTTING, WESTERN; CASPASE 3; CASPASE 8; CELL PROLIFERATION; CYSTEINE PROTEINASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; ENZYME ACTIVATION; FLOW CYTOMETRY; GENE EXPRESSION REGULATION, LEUKEMIC; HL-60 CELLS; HUMANS; IMIDAZOLES; INHIBITOR OF APOPTOSIS PROTEINS; INHIBITORY CONCENTRATION 50; LEUKEMIA; MOLECULAR STRUCTURE; NAPHTHOQUINONES; OLIGOPEPTIDES; PROTO-ONCOGENE PROTEINS C-BCL-2; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; U937 CELLS;

EID: 84878200377     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2013.04.036     Document Type: Article

References (35)

1. Orrenius S., Nicotera P., Zhivotovsky B. Cell death mechanisms and their implications in toxicology. Toxicol. Sci. 2011, 119:3-19.
2. Norberg E., Orrenius S., Zhivotovsky B. Mitochondrial regulation of cell death: processing of apoptosis-inducing factor (AIF). Biochem. Biophys. Res. Commun. 2010, 396:95-100.
3. Altieri D.C. Survivin, cancer networks and pathway-directed drug discovery. Nat. Rev. Cancer 2008, 8:61-70.
4. Robertson J.D., Enoksson M., Suomela M., Zhivotovsky B., Orrenius S. Caspase-2 acts upstream of mitochondria to promote cytochrome c release during etoposide-induced apoptosis. J. Biol. Chem. 2002, 277:29803-29809.
5. Alnemri E.S., Livingston D.J., Nicholson D.W., Salvesen G., Thornberry N.A., Wong W.W., Yuan J. Human ICE/CED-3 protease nomenclature. Cell 1996, 87:171.
6. Thornberry N.A., Rano T.A., Peterson E.P., Rasper D.M., Timkey T., Garcia-Calvo M., Houtzager V.M., Nordstrom P.A., Roy S., Vaillancourt J.P., Chapman K.T., Nicholson D.W. A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis. J. Biol. Chem. 1997, 272:17907-17911.
7. Kim P.K., Mahidhara R., Seol D.W. The role of caspase-8 in resistance to cancer chemotherapy. Drug Resist. Updat. 2001, 4:293-296.
8. Fulda S. Caspase-8 in cancer biology and therapy. Cancer Lett. 2009, 281:128-133.
9. Fulda S., Debatin K.M. Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy. Oncogene 2006, 25:4798-4811.
10. Nguyen D.M., Hussain M. The role of the mitochondria in mediating cytotoxicity of anti-cancer therapies. J. Bioenerg. Biomembr. 2007, 39:13-21.
11. Fulda S., Kufer M.U., Meyer E., van Valen F., Dockhorn-Dworniczak B., Debatin K.M. Sensitization for death receptor- or drug-induced apoptosis by re-expression of caspase-8 through demethylation or gene transfer. Oncogene 2001, 20:5865-5877.
12. Kumar S. Caspase function in programmed cell death. Cell Death Differ. 2007, 14:32-43.
13. Ambrosini G., Adida C., Altieri D.C. A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma. Nat. Med. 1997, 3:917-921.
14. Colnaghi R., Connell C.M., Barrett R.M., Wheatley S.P. Separating the anti-apoptotic and mitotic roles of survivin. J. Biol. Chem. 2006, 281:33450-33456.
15. Yoshida A., Zokumasu K., Wano Y., Yamauchi T., Imamura S., Takagi K., Kishi S., Urasaki Y., Tohyama K., Ueda T. Marked upregulation of Survivin and Aurora-B kinase is associated with disease progression in the myelodysplastic syndromes. Haematologica 2012, 97:1372-1379.
16. Monzo M., Rosell R., Felip E., Astudillo J., Sanchez J.J., Maestre J., Martin C., Font A., Barnadas A., Abad A. A novel anti-apoptosis gene: Re-expression of survivin messenger RNA as a prognosis marker in non-small-cell lung cancers. J. Clin. Oncol. 1999, 17:2100-2104.
17. Badran A., Yoshida A., Ishikawa K., Goi T., Yamaguchi A., Ueda T., Inuzuka M. Identification of a novel splice variant of the human anti-apoptopsis gene survivin. Biochem. Biophys. Res. Commun. 2004, 314:902-907.
18. Rodel F., Hoffmann J., Distel L., Herrmann M., Noisternig T., Papadopoulos T., Sauer R., Rodel C. Survivin as a radioresistance factor, and prognostic and therapeutic target for radiotherapy in rectal cancer. Cancer Res. 2005, 65:4881-4887.
19. Altieri D.C. The molecular basis and potential role of survivin in cancer diagnosis and therapy. Trends Mol. Med. 2001, 7:542-547.
20. Chandele A., Prasad V., Jagtap J.C., Shukla R., Shastry P.R. Upregulation of survivin in G2/M cells and inhibition of caspase 9 activity enhances resistance in staurosporine-induced apoptosis. Neoplasia 2004, 6:29-40.
21. Tirro E., Consoli M.L., Massimino M., Manzella L., Frasca F., Sciacca L., Vicari L., Stassi G., Messina L., Messina A., Vigneri P. Altered expression of c-IAP1, survivin, and Smac contributes to chemotherapy resistance in thyroid cancer cells. Cancer Res. 2006, 66:4263-4272.
22. Nakahara T., Kita A., Yamanaka K., Mori M., Amino N., Takeuchi M., Tominaga F., Hatakeyama S., Kinoyama I., Matsuhisa A., Kudoh M., Sasamata M. YM155, a novel small-molecule survivin suppressant, induces regression of established human hormone-refractory prostate tumor xenografts. Cancer Res. 2007, 67:8014-8021.
23. Satoh T., Okamoto I., Miyazaki M., Morinaga R., Tsuya A., Hasegawa Y., Terashima M., Ueda S., Fukuoka M., Ariyoshi Y., Saito T., Masuda N., Watanabe H., Taguchi T., Kakihara T., Aoyama Y., Hashimoto Y., Nakagawa K. Phase I study of YM155, a novel survivin suppressant, in patients with advanced solid tumors. Clin. Cancer Res. 2009, 15:3872-3880.
24. Giaccone G., Zatloukal P., Roubec J., Floor K., Musil J., Kuta M., van Klaveren R.J., Chaudhary S., Gunther A., Shamsili S. Multicenter phase II trial of YM155, a small-molecule suppressor of survivin, in patients with advanced, refractory, non-small-cell lung cancer. J. Clin. Oncol. 2009, 27:4481-4486.
25. Lewis K.D., Samlowski W., Ward J., Catlett J., Cranmer L., Kirkwood J., Lawson D., Whitman E., Gonzalez R. A multi-center phase II evaluation of the small molecule survivin suppressor YM155 in patients with unresectable stage III or IV melanoma. Invest. New Drugs 2011, 29:161-166.
26. Yoshida A., Takemura H., Inoue H., Miyashita T., Ueda T. Inhibition of glutathione synthesis overcomes Bcl-2-mediated topoisomerase inhibitor resistance and induces nonapoptotic cell death via mitochondrial-independent pathway. Cancer Res. 2006, 66:5772-5780.
27. Kaufmann S.H., Karp J.E., Svingen P.A., Krajewski S., Burke P.J., Gore S.D., Reed J.C. Elevated expression of the apoptotic regulator Mcl-1 at the time of leukemic relapse. Blood 1998, 91:991-1000.
28. Na Y.S., Yang S.J., Kim S.M., Jung K.A., Moon J.H., Shin J.S., Yoon D.H., Hong Y.S., Ryu M.H., Lee J.L., Lee J.S., Kim T.W. YM155 induces EGFR suppression in pancreatic cancer cells. PLoS One 2012, 7:e38625.
29. Liu J., Uematsu H., Tsuchida N., Ikeda M.A. Essential role of caspase-8 in p53/p73-dependent apoptosis induced by etoposide in head and neck carcinoma cells. Mol. Cancer 2011, 10:95.
30. Sohn D., Schulze-Osthoff K., Janicke R.U. Caspase-8 can be activated by interchain proteolysis without receptor-triggered dimerization during drug-induced apoptosis. J. Biol. Chem. 2005, 280:5267-5273.
31. Ehrhardt H., Wachter F., Maurer M., Stahnke K., Jeremias I. Important role of caspase-8 for chemosensitivity of ALL cells. Clin. Cancer Res. 2011, 17:7605-7613.
32. Lissat A., Vraetz T., Tsokos M., Klein R., Braun M., Koutelia N., Fisch P., Romero M.E., Long L., Noellke P., Mackall C.L., Niemeyer C.M., Kontny U. Interferon-gamma sensitizes resistant Ewing's sarcoma cells to tumor necrosis factor apoptosis-inducing ligand-induced apoptosis by up-regulation of caspase-8 without altering chemosensitivity. Am. J. Pathol. 2007, 170:1917-1930.
33. de Vries J.F., Wammes L.J., Jedema I., van Dreunen L., Nijmeijer B.A., Heemskerk M.H., Willemze R., Falkenburg J.H., Barge R.M. Involvement of caspase-8 in chemotherapy-induced apoptosis of patient derived leukemia cell lines independent of the death receptor pathway and downstream from mitochondria. Apoptosis 2007, 12:181-193.
34. Hosokawa Y., Sakakura Y., Tanaka L., Okumura K., Yajima T., Kaneko M. Radiation-induced apoptosis is independent of caspase-8 but dependent on cytochrome c and the caspase-9 cascade in human leukemia HL60 cells. J. Radiat. Res. 2005, 46:293-303.
35. Tao Z., Zhou Y., Lu J., Duan W., Qin Y., He X., Lin L., Ding J. Caspase-8 preferentially senses the apoptosis-inducing action of NG-18, a Gambogic acid derivative, in human leukemia HL-60 cells. Cancer Biol. Ther. 2007, 6:691-696.