Radiation-induced apoptosis is independent of caspase-8 but dependent on cytochrome c and the caspase-9 cascade in human leukemia HL60 cells

Journal of Radiation Research

Volumn 46, Issue 3, 2005, Pages 293-303

  Hosokawa, Yoichiro ^a   Sakakura, Yasunori ^a   Tanaka, Likinobu ^a   Okumura, Kazuhiko ^a   Yajima, Toshihiko ^a   Kaneko, Masayuki ^a  

^a HEALTH SCIENCES UNIVERSITY OF HOKKAIDO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CELL DEATH; CELL MEMBRANES; CHEMICAL ACTIVATION; ELECTRON SPIN RESONANCE SPECTROSCOPY; IONIZING RADIATION; MITOCHONDRIA; PARAMAGNETIC RESONANCE;

CASPASE 8; CASPASE ACTIVATION; CASPASE-3; CASPASES; CYTOCHROME C; DNA FRAGMENT; ELECTRON PARAMAGNETIC RESONANCE SPECTRUM; HL-60 CELLS; HYDROXYL RADICALS; RADIATION-INDUCED APOPTOSIS;

DISEASES;

CASP8 PROTEIN, HUMAN; CASP9 PROTEIN, HUMAN; CASPASE; CASPASE 8; CASPASE 9; CYTOCHROME C; DNA; HYDROGEN PEROXIDE;

APOPTOSIS; ARTICLE; CELL STRAIN HL 60; COMPARATIVE STUDY; DNA DAMAGE; DOSE RESPONSE; DRUG EFFECT; ENZYME ACTIVATION; HUMAN; METABOLISM; RADIATION DOSE; RADIATION EXPOSURE; RADIATION RESPONSE; SIGNAL TRANSDUCTION;

APOPTOSIS; CASPASE 8; CASPASE 9; CASPASES; CYTOCHROMES C; DNA; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; DOSE-RESPONSE RELATIONSHIP, RADIATION; ENZYME ACTIVATION; HL-60 CELLS; HUMANS; HYDROGEN PEROXIDE; RADIATION DOSAGE; SIGNAL TRANSDUCTION;

EID: 27744482435     PISSN: 04493060     EISSN: 13499157     Source Type: Journal    
DOI: 10.1269/jrr.46.293     Document Type: Article

References (43)

1. Taneja, N., Tjalkens, R., Philbert, M. A. and Rehemtulla, A. (2001) Irradiation of mitochondria initiates apoptosis in a cell free system. Oncogene 20: 167-177.
2. Moritake, T., Tsuboi, K., Anzai, K., Ozawa, T., Ando, K. and Nose, T. (2003) ESR spin trapping of hydroxyl radicals in aqueous solution irradiated with high-LET carbon-ion beams. Radiat. Res. 159: 670-675.
3. Hosokawa, Y., Tanaka, L., Kaneko, M., Sakakura, Y., Tsuruga, E., Irie, K. and Yajima, T. (2002) Apoptosis induced by generated OH radicals inside cells after irradiation. Arch. Histol. Cytol. 65: 301-305.
4. Earnshaw, W. C. (1999) Apoptosis A cellular poison cupboard. Nature 397: 387-389.
5. Ashkenazi, A. and Dixit, V.M. (1998) Death receptors: signaling and modulation. Science 281: 1305-1308.
6. Green, D. R. and Reed, J. C. (1998) Mitochondria and apoptosis. Science 281: 1309-1312.
7. Ding, H. F., Lin, Y. L., McGill, G., Juo, P., Zhu, H., Blenis, J., Yuan, J. and Fisher, D. E. (2000) Essential role for caspase-8 in transcription- independent apoptosis triggered by p53. J. Biol. Chem. 275: 38905-38911.
8. Stennicke, H. R., Jurgensmeier, J. M., Shin, H., Deveraux, Q., Wolf, B. B., Yang, X., Zhou, Q., Ellerby, H. M., Ellerby, L. M., Bredesen, D., Green, D. R., Reed, J. C., Froelich CJ. and Salvesen GS. (1998) Pro-caspase-3 is a major physiologic target of caspase-8. J Biol Chem 273: 27084-27090.
9. Desagher, S., Osen-Sand, A., Nichols, A., Eskes, R., Montessuit, S., lauper, S., Maundrell, K., Antonsson, B. and Martinou, J. C. (1999) Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis. J. Cell Biol. 144: 891-901.
10. Li, H., Zhu, H., Xu, C. and Yuan, J. (1998) Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell 94: 491-501.
11. Wang, K., Yian, X. M., Chao, D. T., Milliman, C. L. and Korsmeyer, S. J. (1996) BID: a novel BH3 domain-only death agonist. Genes Dev. 10: 2859-2869.
12. Thornberry, N. A. and Lazebnik, Y. (1998) Caspases: enemies within. Science 281: 1309-1312.
13. Bodmer, J. L., Holler, N., Reynard, S., Vinciguerra, P., Schneide, r P., Juo, P., Blenis, J. and Tschopp, J. (2000) TRAIL receptor-2 signals apoptosis through FADD and caspase-8. Nat. Cell. Biol. 2: 241-243.
14. Kischkel, F. C., Lawrence. D. A., Chuntharapai. A., Schow, P., Kim, K. J. and Ashkenazi, A. (2000) Apo2L/TRAIL-dependent recruitment of endogenous FADD and caspase-8 to death receptors 4 and 5. Immunity 12: 611-620.
15. Embree-Ku, M., Venturini, D. and Boekelheide, K. (2002) Fas is involved in the p53-dependent apoptotic response to ionizing radiation in mouse testis. Biol. Reprod. 66: 1456-1461.
16. Newton, K. and Strasser, A. (2000) Ionizing radiation and chemotherapeutic drugs induce apoptosis in lymphocytes in the absence of Fas or FADD/MORT1 signaling. Implications for cancer therapy. J Exp Med 191: 195-200.
17. Hakem, R., Hakem, A., Duncan, G. S., Henderson, J. T., Woo, M., Soengas, M. S., Elia, A., de la Pompa, J. L., Kagi, D., Khoo, W., Potter, J., Yoshida, R., Kaufman, S. A., Lowe, S. W., Penninger, J. M. and Mak, T. W. (1998) Differential requirement for caspase 9 in apoptotic pathways in vivo. Cell 94: 339-352.
18. Li, P., Nijhawan, D., Budihardjo, I., Srinivasula, S. M., Ahmad, M., Alnemri, E. S. and Wang, X. (1997) Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 91: 479-489.
19. Soengas, M. S., Alarcon, R. M., Yoshida, H., Giaccia, A. J., Hakem, R., Mak, T. W. and Lowe, S. W. (1999) Apaf-1 and caspase-9 in p53-dependent apoptosis and tumor inhibition. Science 284: 156-159.
20. Sabbatini, P. and McCormick, F. (1999) Phosphoinositide 3-OH kinase (PI3K) and PKB/Akt delay the onset of p53-mediated, transcriptionally dependent apoptosis. J. Biol. Chem. 274: 24263-24269.
21. Sitailo, L. A., Tibudan, S. S. and Denning, M. F. (2002) Activation of caspase-9 is required for UV-induced apoptosis of human keratinocytes. J. Biol. Chem. 277: 19346-19352.
22. Ferguson, H. A., Marietta, P. M. and Van Den Berg, C. L. (2003) UV-induced apoptosis is mediated independent of caspase-9 in MCF-7 cells: a model for cytochrome c resistance. J. Biol . Chem. 278: 45793-45800.
23. Hosokawa, Y., Tanaka, L., Sano, T., Ohnishi, T., Kaneko, M., Shinozki, K. and Minami, S. (2002) ESR detection of OH radicals generated inside cells by X-ray and evaluation of the cytotoxicity of DMPO. Oral Radiology 18: 113-117.
24. Sellins, K. S. and Cohen, J. J. (1987) Gene induction by gamma-irradiation leads to DNA fragmentation in lymphocytes. J Immunol, 139: 3199-3206.
25. Saikumar, P., Dong, Z., Patel, Y., Hall, K., Hopfer, U., Weinberg, J. M. and Venkatachalam, M. A. (1998) Role of hypoxia-induced Bax translocation and cytochrome c release in reoxygenation injury. Oncogene, 17: 3401-3415.
26. Hockenbery, D. M., Oltvai, Z. N., Yin, X. M., Milliman, C. L. and Korsmeyer, S. J. (1993) Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell 75: 241-251.
27. Fujita, H., Morita, I. and Murota, S. (2000) Hydrogen peroxide induced apoptosis of endothelial cells concomitantly with cycloheximide. J. Atheroscler. Thromb. 7: 209-215.
28. Epperly, M. W., Sikora, C. A., DeFilippi, S. J., Gretton, J. A., Zhan, Q., Kufe, D. W. and Greenberger, J. S. (2002) Manganese superoxide dismutase (SOD2) inhibits radiation-induced apoptosis by stabilization of the mitochondrial membrane. Radiat Res. 157: 568-577.
29. Wolf, B. B. and Green, D. R. (1999) Suicidal tendencies: apoptotic cell death by caspase family proteinases. J. Biol. Chem. 274: 20049-20052.
30. Muzio, M., Chinnaiyan, A. M., Kischkel, F. C., O'Rourke, K., Shevchenko, A., Ni, J., Scaffidi, C., Bretz, J. D., Zhang, M., Gentz, R., Mann, M., Krammer, P. H., Peter, M. E. and Dixit, V. M. (1996) FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex. Cell 85: 817-827.
31. Kaufmann, S. H. and Hengartner, M. O. (2001) Programmed cell death: alive and well in the new millennium. Trends Cell Biol. 11: 526-534.
32. Kim, E. C., Yun, B. S., Ryoo, I. J., Min, J. K., Won, M. H., Lee, K. S., Kim, Y. M., Yoo, I. D. and Kwon, Y. G. (2004) Complestatin prevents apoptotic cell death: inhibition of a mitochondrial caspase pathway through AKT/PKB activation. Biochem. Biophys. Res. Commun. 313: 193-204.
33. Slee, E. A., Harte, M. T., Kluck, R. M., Wolf, B. B., Casiano, C. A., Newmeyer, D. D., Wang, H. G., Reed, J. C., Nicholson, D.W., Alnemri, E. S., Green, D. R. and Martin, S. J. (1999) Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner. J. Cell. Biol. 144: 281-292.
34. Shinoura, N., Sakurai, S., Asai, A., Kirino, T. and Hamada, H. (2001) Over-expression of APAF-1 and caspase-9 augments radiation-induced apoptosis in U-373MG glioma cells. Int. J. Cancer 93: 252-261.
35. Belka C, Rudner J, Wesselborg S, Stepczynska A, Marini P, Lepple-Wienhues A, Faltin H, Bamberg M, Budach W, Schulze-Osthoff K. (2000) Differential role of caspase-8 and BID activation during radiation- and CD95-induced apoptosis. Oncogene. 19: 1181-1190.
36. Kataoka T, Schroter M, Hahne M, Schneider P, Irmler M, Thome M, Froelich CJ, Tschopp J. (1998) FLIP prevents apoptosis induced by death receptors but not by perforin/ granzyme B, chemotherapeutic drugs, and gamma irradiation. J Immunol. 161: 3936-3942.
37. Shonai T, Adachi M, Sakata K, Takekawa M, Endo T, Imai K, Hareyama M. (2002) MEK/ERK pathway protects ionizing radiation-induced loss of mitochondrial membrane potential and cell death in lymphocytic leukemia cells. Cell Death Differ. 9: 963-971.
38. Vander Heiden, M. G. and Thompson, C. B. (1999) Bcl-2 proteins: regulators of apoptosis or of mitochondrial homeostasis? Nat. Cell Biol. 1: 209-216.
39. Luo, X., Budihardjo, I., Zou H., Slaughter, C. and Wang, X. (1998) Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors. Cell 94: 481-490.
40. Gariboldi, M. B., Rimoldi, V., Supino, R., Favini, E. and Monti, E. (2000) The nitroxide tempol induces oxidative stress, p21(WAF1/CIP1), and cell death in HL60 cells. Free Radic. Biol. Med. 29: 633-641.
41. Gaumann, A., Tews, D. S., Mayer E., Dahm, M., Petrow, P. K., Otto, M., Kirkpatrick, C. J. and Kriegsmann, J. (2001) Expression of apoptosis-related proteins, p53, and DNA fragmentation in sarcomas of the pulmonary artery. Cancer 92: 1237-1244.
42. Ahmad, K. A., Iskandar, K. B., Hirpara, J. L., Clement, M.-V. and Pervaiz, S. (2004) Hydrogen peroxide-mediated cytololic acidification is a signal for mitochondrial translocation of Bax during drug-induced apoptosis of tumor cells. Cancer Res. 64: 7867-7878.
43. Bellosillo, B., Villamor, N., Lopez-Guillermo, A., (2002) Spontanenous and drug-induced apoptosis is mediated by conformational changes of Bax and Bak in B-cell chronic lymphocytic leukemia. Blood 100: 1810-1816.