Additive toxicity of limonene and 50% oxygen and the role of glutathione in detoxification in human lung cells

Toxicology

Volumn 170, Issue 1-2, 2002, Pages 75-88

  Rolseth, Veslemoy ^a   Djurhuus, Rune ^a   Svardal, Asbjorn M ^b  

^a NUI AS   (Norway)

^b INSTITUTE OF MARINE RESEARCH   (Norway)

Author keywords

Glutathione; Human fibroblasts; Hyperoxia; Limonene; Toxicity

Indexed keywords

GLUTATHIONE; LIMONENE; OXYGEN;

ACUTE TOXICITY; ARTICLE; CELL CULTURE; CONTROLLED STUDY; CYTOTOXICITY; DETOXIFICATION; EXPOSURE; HUMAN; HUMAN CELL; LUNG ALVEOLUS CELL; OXIDATION; PRIORITY JOURNAL;

CELL DIVISION; CELLS, CULTURED; CYCLOHEXENES; FIBROBLASTS; GLUTATHIONE; HUMANS; LUNG; METABOLIC DETOXICATION, DRUG; MITOCHONDRIA; MONOTERPENES; OXIDATION-REDUCTION; OXYGEN; SOLVENTS; TERPENES;

EID: 0037079931     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(01)00537-6     Document Type: Article

References (46)

1. Hyperoxia inhibits proliferation of cultured rat tracheal smooth muscle cells
2. Effects of hyperoxia on human endothelial cell proliferation and morphology in vitro
3. Glutathione protection in alveolar type II cells from fetal and neonatal rabbits
4. Senescence-like growth arrest induced by hydrogen peroxide in human diploid fibroblast F65 cells
5. Effects of hyperoxia on DNA synthesis in cultured porcine aortic endothelial cells
6. Prevention and therapy of cancer by dietary monoterpenes
7. Human metabolism of the experimental cancer therapeutic agent D-limonene
8. Increase in endothelial cell glutathione and precursor amino acid uptake by diethyl maleate and hyperoxia
9. Cysteamine increases homocysteine export and glutathione content by independent mechanisms in C3H/10T1/2 cells
10. Growth state dependent increase in glutathione by homocysteine and other thiols, and homocysteine formation in glutathione depleted mouse cell lines
11. Modulation of glutathione content and the effect on methionine auxotrophy and cellular distribution of homocysteine and cysteine in mouse cell lines
12. Toxicity of hyperoxia and high pressure on C3H/10T1/2 cells and effects on cellular glutathione
13. Glutathione in the cellular defense of human lung cells exposed to hyperoxia and high pressure
14. D-limonene exposure to humans by inhalation: Uptake, distribution, elimination, and effects on the pulmonary function
15. Reactions of alkenes with ozone in the gas phase: A matrix-isolation study of secondary ozonides and carbonyl-containing reaction products
16. Prevention and therapy of mammary cancer by monoterpenes
17. Isoprenoids suppress the growth of murine B16 melanomas in vitro and in vivo
18. Limonene
19. Air oxidation of D-limonene (the citrus solvent) creates potent allergens
20. Hydroperoxides in oxidized D-limonene identified as potent contact allergens
21. Regulatory classification of substances oxidized to skin sensitizers on exposure to air
22. 3-carene and turpentine, and acceptable levels of monoterpenes in occupational and indoor environment
23. Investigation of D-limonene use during aircraft maintenance degreasing operations
24. Antioxidant defense mechanisms in cultured pleural mesothelial cells
25. Studies on the metabolism of D-limonene (p-mentha-1,8-diene). IV. Isolation and characterization of new metabolites and species differences in metabolism
26. Effects of R-(+)- and S-(-)-limonene on the respiratory tract in mice
27. Determination of in vivo redox status of cysteine, cysteinylglycine, homocysteine, and glutathione in plasma
28. Glutathione metabolism
29. Glutathione
30. Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines
31. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
32. Biotransformation of xenobiotics
33. Free radicals and lung disease
34. Evaluation of a soluble tetrazolium/formazan assay for cell growth and drug sensitivity in culture using human and other tumor cell lines
35. Determination of reduced, oxidized, and protein-bound glutathione in human plasma with precolumn derivatization with monobromobimane and liquid chromatography
36. Contribution of hyperoxia to reduced pulmonary function after deep saturation dives
37. Effects of dietary anticarcinogens on rat gastrointestinal glutathione peroxidase activity
38. Effects of the sulforaphane analog compound 30, indole-3-carbinol, D-limonene or relafen on glutathione S-transferases and glutathione peroxidase of the rat digestive tract
39. Differential cytotoxicity of buthionine sulfoximine to "normal" and transformed human lung fibroblast cells
40. D-limonene mechanistic data and risk assessment: Absolute species-specific cytotoxicity, enhanced cell proliferation, and tumor promotion
41. Are we measuring the relevant indoor pollutants?
42. Formation of strong airway irritants in terpene/ozone mixtures
43. Species difference in the resistibility of embryonic fibroblasts against oxygen-induced growth inhibition
44. Anethofuran, carvone, and limonene: Potential cancer chemopreventive agents from dill weed oil and caraway oil