Are contact allergens stable in patch test preparations? Investigation of the degradation of d-limonene hydroperoxides in petrolatum

Contact Dermatitis

Volumn 40, Issue 3, 1999, Pages 127-132

  Nilsson, Ulrika ^a   Magnusson, Kerstin ^b   Karlberg, Olof ^b   Karlberg, Ann Therese ^b  

^a STOCKHOLM UNIVERSITY   (Sweden)

^b NATIONAL INSTITUTE FOR WORKING LIFE   (Sweden)

Author keywords

Antioxidant; Chemical degradation; Contact allergens; HPLC; Hydroperoxides of d limonene; Patch test vehicles; Patch testing technique; White petrolatum; tocopheryl acetate

Indexed keywords

ALCOHOL DERIVATIVE; ALPHA TOCOPHEROL; ANTIOXIDANT; CONTACT ALLERGEN; HYDROPEROXIDE; LIMONENE; WHITE PETROLATUM;

ANALYTIC METHOD; ARTICLE; DEGRADATION; OXIDATION; PATCH TEST; REFRIGERATOR; SENSITIZATION; STORAGE; TIME;

EID: 0032989342     PISSN: 01051873     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0536.1999.tb06009.x     Document Type: Article

References (14)

1. Karlberg A-T, Boman A, Melin B. Animal experiments on the allergenicity of d-limonene - the citrus solvent. Ann Occup Hyg 1991: 35: 419-426.
2. Karlberg A-T, Magnusson K, Nilsson U. Air oxidation of d-limonene (the citrus solvent) creates potent allergens. Contact Dermatitis 1992: 26: 332-340.
3. Schenck G O, Neumüller O A, Olhoff G, Schroeter S. Zur Autoxydation des (+)-Limonens. Liebig Ann Chem 1965: 687: 26-39.
4. Karlberg A-T, Shao L P, Nilsson U, Gäfvert E, Nilsson J L G. Hydroperoxides in oxidized d-limonene identified as potent contact allergens. Arch Dermatol Res 1994: 286: 97-103.
5. Ippen H. Chemical report from the company Parafluid, Mineraloelgesellschaft mbH, Hamburg, Germany, 1996.
6. Kneczke M. Apoteket AB, Sweden, personal communication.
7. Nilsson U, Bergh M, Shao L P, Karlberg A-T. Analysis of contact allergenic compounds in oxidised d-limonene. Chromatographia 1996: 420: 199-205.
8. Schieberle P, Maier W, Firl J, Grosch W. HRGC separation of hydroperoxides formed during the photosensitized oxidation of (R)-(+)-limonene. J High Resolut Chromatogr Commun 1987: 10: 588-593.
9. Berg M, Contact allergenic acivity of Tween 8® before and after air exposure. Contact Dermatitis 1997: 37: 9-18.
10. Berg M. Sensitizing potential of acetaldehyde and formaldehyde using a modified cumulative contact enhancement (CCET) test. Contact Dermatitis 1998: 39: 14-20.
11. Karlberg A-T, Magnusson K, Nilsson U. Influence of an anti-oxidant on the Formation of allergenic compounds during auto-oxidation of d-limonene. Ann Occup Hyg 1994: 38:199-207.
12. Karlberg A-T, Dooms-Goossens A. Contact allergy to oxidized d-limonene among dermatitis patients. Contact Dermatitis 1997: 36: 201-206.
13. Karlberg A-T, Bohlinder K, Boman A, Hacksell U, Hermansson J, Jacobsson S, Nilsson J L G. Identification of 15-hydroperoxyabietic acid as a contact allergen in portuguese colophony. J Pharm Pharmacol 1988: 40: 42-47.
14. Karlberg A-T, Gäfvert E. Isolated colophony allergens as screening substances for contact allergy. Contact Dermatitis 1996: 35: 201-207.