Ketamine and Peripheral Inflammation

CNS Neuroscience and Therapeutics

Volumn 19, Issue 6, 2013, Pages 403-410

  De Kock, Marc ^a   Loix, Sebastien ^b   Lavand'homme, Patricia ^a  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^b Hospital de Jolimont   (Belgium)

Author keywords

Immune system; Inflammation; Ketamine; Peripheral

Indexed keywords

INTERLEUKIN 1BETA; KETAMINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; OPIATE; TOLL LIKE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA;

ANTIINFLAMMATORY ACTIVITY; CRITICALLY ILL PATIENT; CYTOKINE RELEASE; DIAPEDESIS; DRUG MECHANISM; HUMAN; HYPERALGESIA; IMMUNITY; IMMUNOCOMPETENT CELL; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; NEUTROPHIL; NONHUMAN; OPIOID INDUCED HYPERALGESIA; OUTCOME ASSESSMENT; POSTOPERATIVE COGNITIVE DYSFUNCTION; POSTOPERATIVE PAIN; REVIEW;

ANALGESICS; ANIMALS; COGNITION DISORDERS; HUMANS; INFLAMMATION; KETAMINE; PAIN; POSTOPERATIVE COMPLICATIONS;

EID: 84878160733     PISSN: 17555930     EISSN: 17555949     Source Type: Journal    
DOI: 10.1111/cns.12104     Document Type: Review

References (105)

1. Zhuo M. Plasticity of NMDA receptor NR2B subunit in memory and chronic pain. Mol Brain 2009;2:4.
2. Scheller M, Bufler J, Hertle I, et al. Ketamine blocks currents through mammalian nicotinic acetylcholine receptor channels by interaction with both open and closed state. Anesth Analg 1996;83:830-836.
3. Smith D, Pekoe G, Martin L, Coalgate B. The interaction of ketamine with the opiate receptor. Life Sci 1980;26:789-799.
4. Hayashi Y, Kawaji K, Sun I, et al. Microglia Ca (2+)-activated K (+) channels are possible molecular targets for the analgesic effects of S-ketamine on neuropathic pain. J Neurosci 2011;31:17370-17382.
5. Wallach JV. Endogenous hallucinogens as ligands of the trace amine receptor: a possible role in sensory perception. Med Hypotheses 2009;72:91-94.
6. De Kock M, Lavand'homme P, Waterloos H. Balanced analgesia in the perioperative period: is there a place for ketamine. Pain 2001;92:373-380.
7. Zarate CA, Singh JB, Carlson PJ, et al. A randomized trial of an N-methyl-d-aspartate antagonist in treatment-resistant major depression. Arch Gen Psychiatry 2006;63:856-864.
8. Kimura F, Shimizu H, Yoshidome H, et al. Immunosuppression following surgical and traumatic injury. Surg Today 2010;12:793-808.
9. Marik PE, Flemmer M. The immune response to surgery and trauma: implications for treatment. J Trauma Acute Care Surg 2012;73:801-808.
10. Selye H. Forty years of stress research: principal remaining problems and misconceptions. Can Med Assoc J 1976;115:53-56.
11. Hirsiger S, Simmen H-P, Werner C, Wanner G, Rittirsch D. Danger signals activating the immune response after trauma. Mediators Inflamm 2012;2012:315941.
12. Newton K, Dixit V. Signalling in Innate Immunity and inflammation. Cold Spring Harb Perspect Biol 2012;4:a006049.
13. Kawai T, Akira S. TLR signaling. Semin Immunol 2007;19:24-32.
14. Wagner H, Endogenous TLR. ligands and autoimmunity. Adv Immunol 2006;91:159-173.
15. Kaisho T, Akira S. Toll-like receptor function and signaling. J Allerg Clin Immunol 2006;117:979-987.
16. Arumugam TV, Okun E, Tang S-C, et al. Toll-like receptors in ischemia-reperfusion injury. Shock 2009;32:4-16.
17. Suntharalingam G, Perry MR, Ward S, et al. Cytokine storm in a phase 1 trial of the anti-CD28 monoclonal antibody TGN1412. NEJM 2006;355:1018-1028.
18. Johnston GR, Webster NR. Cytokines and the immunomodulatory function of the vagus nerve. Br J Anaesth 2009;102:453-462.
19. Kohli P, Levy B. Themed section: mediators and receptors in the resolution of inflammation. Review: resolvins and protectins: mediating solutions to inflammation. Br J Pharmacol 2009;158:960-971.
20. Weylandt KH, Chiu CY, Gomolka B, et al. Omega-3 fatty acids and their lipid mediators: towards an understanding of resolving and protectin formation. Omega-3 fatty acids and their resolving/protectin mediators. Prostaglandins Other Lipid Mediat 2012;97:73-82.
21. Levy BD, Clish CB, Schmidt B, Gronert K, Serhan CN. Lipid mediator class switching during acute inflammation: signals resolution. Nat Immun 2001;2:612-619.
22. Milligan E, Watkins LR. Pathological and protective role of glia in chronic pain. Nat Rev Neurosci 2009;10:23-36.
23. Waldburger JM, Firestein GS. Regulation of peripheral inflammation by the central nervous system. Curr Rheumatol Rep 2010;12:370-378.
24. Muenzer JT, Davis CG, Schmidt RE, Dunne WM, Coopersmith CM, Hotckiss RS. Characterization and modulation of the immunosuppressive phase of sepsis. Infect Immun 2010;78:1582-1592.
25. Yli-Hankala A, Kileurvera M, Randell T, et al. Ketamine anesthesia in patients with septic shock. Acta Anaesthesiol Scand 1992;36:483-485.
26. Vanderlinden P, Gilbart E, Engelman E, et al. Comparison of halothane, isoflurane, alfentanil, and ketamine in experimental septic shock. Anesth Analg 1990;70:608-613.
27. Koga K, Ogata M, Takenaka I, Matsumoto T, Shigematzu A. Ketamine suppresses TNF-alpha activity and mortality in carrageenan-sensitized endotoxin shock model. Circ Shock 1994;44:160-168.
28. Shaked G, Czeiger D, Dukhno O, et al. Ketamine improves survival and suppresses IL-6 and TNf alpha production in a model of Gram-negative bacterial sepsis in rats. Resuscitation 2004;62:237-242.
29. Gurfinkel R, Czeiger D, Douvdevani A, et al. Ketamine improves survival in burn injury followed by sepsis in rats. Anesth Analg 2006;103:392-402.
30. Neder Meyer T, Lazaro da Silva A. Ketamine reduces mortality of severely burnt rats, when compared to midazolam plus fentanyl. Burns 2004;30:425-430.
31. Taniguchi T, Takemoto Y, Kanakura H, Kidani Y, Yamamoto K. The dose related effect of ketamine on mortality and cytokine responses to endotoxin-induced shock in rats. Anesth Analg 2003;97:1769-1772.
32. Kawasaki T, Ogata M, Kawasaki C, et al. Ketamine suppresses proinflammatory cytokine production in human whole blood in vitro. Anesth Analg 1999;89:665-669.
33. Takenaka I, Ogata M, Koga K, Matsumoto T, Shigematsu A. Ketamine suppresses endotoxin-induced tumor necrosis factor alpha production in mices. Anesthesiology 1994;80:402-428.
34. Taniguchi T, Kanakura H, Takemoto Y, Kidani Y, Yamamoto K. Effects of ketamine and propofol on the ratio of interleukin-6 to interleukin-10 during endotoxemia in rats. Tohoku J Exp Med 2003;200:85-92.
35. Kawasaki C, Kawasaki T, Ogata M, Nandate K, Shigematsu A. Ketamine isomers suppress superantigen-induced proinflammatory cytokine production in human whole blood. Can J Anaesth 2001;48:819-823.
36. Taniguchi T, Shibata K, Yamamoto K. Ketamine inhibits endotoxin-induced shock in rats. Anesthesiology 2001;95:928-932.
37. Lankveld DPK, Bull S, Van Dijk P, Fink-Gremmels J, Hellebrekers LJ. Ketamine inhibits LPS-induced TNF-alpha and interleukin-6 in an equine macrophage cell line. Vet Res 2005;36:257-262.
38. Chang Y, Chen TL, Sheu JR, Chen RM. Suppressive effects of ketamine on macrophage functions. Toxicol Appl Pharmacol 2005;204:27-35.
39. Pekoe GM, Peden D, Van Dyke K. Impairment of leukocyte myeloperoidase bactericidal mechanisms with ketamine. Agents Actions 1983;13:59-62.
40. Zilberstein G, Levy R, Rachinsky M, et al. Ketamine attenuates neutrophil activation after cardiopulmonary bypass. Anesth Analg 2002;95:531-536.
41. Krumholz W, Endrass J, Hempelmann G. Inhibition of phagocytosis and killing of bacteria by anaesthetic agents in vitro. Br J Anaesth 1995;75:66-70.
42. Larsen B, Hoff G, Wihlhem W, Buchinger H, Wanner G, Bauer M. Effect of intravenous anesthetics on spontaneous and endotoxin-stimulated cytokine response in cultured human whole blood. Anesthesiology 1998;89:1218-1227.
43. Yang J, Li W, Duan M, et al. Large dose ketamine inhibits lipopolysaccharid-induced acute lung injury in rats. Inflamm Res 2005;54:133-137.
44. Li CY, Chou TC, Wong CS, et al. Ketamine inhibits nitric oxide synthase in lipopolysaccharide-treated rat alverolar macrophages. Can J Anaesth 1997;44:989-995.
45. Shimaoka M, Iida T, Ohara A, et al. Ketamine inhibits nitric oxide production in mouse-activated macrophage-like cells. Br J Anaesth 1996;77:238-242.
46. Kelleher ZT, Matsumoto A, Stamler JS, Marshall HE. NOS2 regulation of NF-κB by s-nitrosylation of p65. J Biochem 2007;24:1412-1420.
47. Kim F, Huri DA, Snyder SH. Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxxygenase-2. Science 2005;310:1966-1970.
48. Zahler S, Heindl B, Becker BF. Ketamine does not inhibit inflammatory responses of cultured human endothelial cells but reduces chemotactic activation of neutrophils. Acta Anaesthesiol Scand 1999;43:1011-1016.
49. Hofbauer R, Moser D, Hammerschmidt V, Kapiolis S, Frass M. Ketamine significantly reduces the migration of leukocytes through endothelial cell monolayers. Crit Care Med 1998;26:1545-1549.
50. Schmidt H, Ebeling D, Bauer H, et al. Ketamine attenuates endotoxin-induced leukocyte adherence in rat mesenteric venules. Crit Care Med 1995;23:2008-2014.
51. Weigand M, Schmidt H, Zhao Q, Plaschke K, Martin E, Bardenheuer HJ. Ketamine modulates the stimulated adhesion molecule expression on human neutrophils in vitro. Anesth Analg 2000;90:206-212.
52. Qi XL, Nguyen TL, Andries L, Sys SU, Rouleau JR. Vascular endothelial dysfunction contributes to myocardial depression in ischemia-reperfusion in the rat. Can J Physiol Pharmacol 1998;76:35-45.
53. Dhote F, Carpentier P, Barbier L, et al. Combinations of ketamine and atropine are neuroprotective and reduce neuroinflammation after toxic status epilepticus in mice. Toxicol Appl Pharmacol 2012;259:195-209.
54. Orange JS, Ballas ZK. Natural killer cells in human health and disease. Clin Immunol 2006;118:1-10.
55. Forget P, Collet V, Lavand'homme P, De Kock M. Does analgesia and condition influence immunity after surgery? Effects of fentanyl, ketamine and clonidine on natural killer activity at different ages. Eur J Anaesthesiol 2010;27:233-240.
56. Braun S, Gaza N, Werdehausen R, et al. Ketamine induces apoptosis via mitochondrial pathway in human lymphocytes and neuronal cells. Br J Anaesth 2010;105:347-354.
57. Rossi AG, Sawatzky DA, Walker A, et al. Cyclin kinase inhibitors enhance the resolution of inflammation by promoting inflammatory cells apoptosis. Nat Med 2006;12:1056-1064.
58. Perl M, Chung CS, Ayala A. Apoptosis. Crit Care Med 2005;33:s526-s528.
59. Sakai T, Takashi I, Whitten CW, Giesecke AH, Lipton JM. Ketamine suppresses endotoxin-induced NF-κB expression. Can J Anaesth 2000;47:1019-1024.
60. Sun J, Wang D, Liu H, Xu JG. Ketamine suppresses endotoxin-induced NF-κB activation and cytokines production in the intestine. Acta Anaesth Scand 2004;48:317-321.
61. Bonizzi G, Karin M. The two NF-kappaB activation pathways and their role in innate and adaptative immunity. Trends Immunol 2004;25:280-288.
62. Perkins N. Integrating cell-signalling pathways with NF-kappaB and IKK function. Nat Rev Mol Cell Biol 2007;8:49-62.
63. Hasko G, Cronstein BN. Adenosine: an endogenous regulator of innate immunity. Trends Immunol 2004;25:33-39.
64. Yu M, Shao D, Feng X, Duan M, Xu J. Effects of ketamine on pulmonary Tlr4 expression and NF-kappa-B activation during endotoxemia in rats. Methods Find Exp Clin Pharmacol 2007;29:395-399.
65. Yu M, Shao D, Liu J, Zhu J, Zhang Z, Xu J. Effects of ketamine on levels of cytokines, Nf-kappaB and TLRs in rat intestine during CLP-induced sepsis. Int Immunopharmacol 2007;7:1076-1082.
66. Sikand P, Premkumar L. Potentiation of glutaminergic transmission by protein kinase C-mediated sensitization of TRPV1 at the first sensory synapse. J Physiol 2007;581:631-647.
67. McNeamey TA, Ma Y, Chen Y, et al. A peripheral neuroimmune link: glutamate agonists upregulate NMDA NR1 receptor mRNA and protein, vitmentin, TNF-a, and RANTES in cultured human synoviocytes. Am J Physiol Regul Integr Comp Physiol 2010;298:R584-R598.
68. Zhang LP, Chen Y, Clark BP, et al. The role of type 1 metabromic glutamate receptors in the generation of dorsal root reflexes induced by arthritis or the spinal cord infusion of4-aminopyridine in the anesthetized rat. J Pain 2000;1:151-161.
69. Chang Y, Lee JJ, Hsiao G, et al. Inhibitory effects of ketamine on lipopolysaccharide-induced microglial activation. Mediators Inflamm 2009;2009:705379. Epub.
70. Manjunath S, Sakhare PM. Adenosine and adenosine receptors: newer therapeutic perspective. Indian J Pharmacol 2009;41:97-105.
71. Mc Callion K, Harkin DW, Gardiner KR. Role of adenosine in immunomodulation: review of the literature. Crit Care Med 2004;32:273-277.
72. Mazar J, Rogachev B, Shaked G, et al. Involvement of adenosine in the anti-inflammatory action of ketamine. Anesthesiology 2005;102:1174-1181.
73. Welters ID, Hafer G, Menzebach A, et al. Ketamine inhibits transcription factors activator protein 1 and nuclear factor-kappaB, interleukin-8 production, as well as CD11b and CD16 expression: studies in human leukocytes and leukocytic cell lines. Anesth Analg 2010;110:934-941.
74. Hill GE, Anderson JL, Lyden ER. Ketamine inhibits the proinflammatory cytokin-induced reduction of cardiac intracellular Adenosine accumulation. Anesth Analg 1998;87:1015-1019.
75. Cadieux JS, Leclerc P, St-Onge M, et al. Potentiation of neutrophil cyclooxygenase-2 by adenosine: an early inflammation signal. J Cell Sci 2001;118:1437-1447.
76. Pouliot M, Fiset ME, Massé M, Naccache P, Borgeat P. Adenosine up-regulates cyclooxygenase-2 in human granulocytes: impact on the balance of eicosanoid generation. J Immunol 2002;169:5279-5286.
77. Chiang N, Schwab JM, Fredman G, Kasuga K, Gelman S, Serhan CN. Anesthetics impact the resolution of inflammation. PLoS ONE 2008;3:e1879.
78. LI Y, Li BWan X, et al. NMDA receptor activation stimulates transcription-independent wnt5a protein synthesis via the MAPK signaling pathway. Mol Brain 2012;5:1. http:/www.molecularbrain.com/content/5/1/1.
79. Ghosh S, Hayden M. New regulators of NF-kappaB in inflammation. Nat Rev Immunol 2008;8:837-848.
80. Sulibruk JW, Ward JL, Helmer KS, Adams SD, Zuckerbraun BS, Mercer DW. Ketamine-induced hepatoprotection: the role of heme oxygenase-1. Am J Physiol Gastrointest Liver Physiol 2009;296:G1360-G1369.
81. Gao M, Qian Y, Ji L, Feng G, Sun J. Effect of N-methyl-d-aspartate receptor antagonist on T helper cell differentiation induced by phorbol-myristate-acetate and ionomycine. Cytokines 2011;56:458-465.
82. Gao M, Sun J, Jin W, Qian Y. Morphine, but not ketamine, decreases the ratio of Th1/th2 in CD4-positive cells through T-bet and GATA3. Inflammation 2012;35:1069-1077.
83. Van Berkel BNM, Oranje B, van Ree JM, Verbaten MN, Kahn RS. The effect of low dose ketamine on sensory gating, neuroendocrine secretion and behavior in healthy human subjects. Psychopharmacology 1998;137:271-288.
84. Hergovich N, Singer E, Agneter E, et al. Comparison of the effects of ketamine and memantine on prolactin and cortisol release in men: a randomized, double-blind placebo-controlled trial. Neuropsychopharmacology 2001;24:590-593.
85. Damianopoulos EN, Carey RJ. Evidence for NMDA receptor mediation of cocaine induced corticosterone release and cocaine conditioned stimulant effect. Behav Brain Res 1995;68:219-228.
86. Rofael HZ, Turkall RM, Abdel-Rahman MS. Immunomodulation by cocaine and ketamine in postnatal rats. Toxicology 2003;188:101-104.
87. Roytblat L, Talmor D, Rachinsky M, et al. Ketamine attenuates the interleukin-6 response after cardiopulmonary bypass. Anesth Analg 1998;87:266-271.
88. Bartoc C, Frumento R, Jalbout M, Bennett-Guerrero E, Du E, Nishanian E. A randomised, double-blind, placebo-controlled study assessing the anti-inflammatory effects of ketamine in cardiac surgical patient. J Cardiothorac Vasc Anesth 2006;20:217-222.
89. Zeyneloglu P, Donmez A, Bilezikci B, Mercan S. Effects of ketamine on serum and tracheobronchial aspirate interleukin-6 levels in infants undergoing cardiac surgery. J Cardiothor Vasc Anesth 2005;19:329-333.
90. Yang Z, Chen ZQ, Jiang XQ. Effects of subanesthetic dose of ketamine on perioperative serum cytokines in orthotopic liver transplantation. Nan Fang Yi Ke Da Xue Xue Bao 2006;26:802-804.
91. Dale O, Somogyi A, Li Y, Sullivan T, Shavit Y. Does intraoperative ketamine attenuate inflammatory reactivity following surgery? A systematic review and meta-analysis. Anesth Analg 2012;115:934-943.
92. Inaba H, Kochi A, Yorozu S. Suppression by methylprednisolone of augmented plasma endotoxin-like activity and IL-6 during cardiopulmonary bypass. Br J Anaesth 1994;72:348-350.
93. Cremer J, Martin M, Redl H, et al. Systemic inflammatory response syndrome after cardiac operations. Ann Thorac Surg 1996;61:1714-1720.
94. Hennein H, Ebba H, Rodriguez JL, et al. Relationship of the proinflammatory cytokines to myocardial ischemia and dysfunction after uncomplicated coronary revascularization. J Thorac Cardiovasc Surg 1994;108:626-635.
95. Oka Y, Murata A, Nishijima J, et al. Circulating IL-6 as a useful marker for predicting postoperative complications. Cytokine 1992;4:298-304.
96. Suzuki M, Haraguiti S, Sugimoto K, et al. Low-dose ketamine potentiates epidural analgesia after thoracotomy. Anesthesiology 2006;105:111-119.
97. Stubhaug A, Breivik H, Eide PK, Kreunen M, Foss A. Mapping of punctuate hyperalgesia around a surgical incision demonstrates that ketamine is a powerful suppressor of central sensitization to pain following surgery. Acta Anaesthesiol Scand 1997;41:1124-1132.
98. Remerand F, Le Tendre Ch, Baud A, et al. The early and delayed analgesic effects of ketamine after total hip arthroplasty: a prospective, randomized, controlled, double-blind study. Anesth Analg 2009;109:1963-1967.
99. Celerier E, Rivat C, Jun Y, et al. Long-lasting hyperalgesia induced by fentanyl in rats: preventive effect of ketamine. Anesthesiology 2000;92:465-472.
100. Hutchinson MR, Bland ST, Johnson KW, et al. Opioid-induced glial activation; mechanisms of activation and implications for opioid analgesia, dependence and reward. ScientificWorldJournal 2007;7:98-111.
101. Hutchinson MR, Zhang Y, Shridhar M, et al. Evidence that opioids may have toll like receptor 4 and MD-2 effects. Brain Behav Immun 2010;24:83-95.
102. Hudetz JA, Iqbal S, Gandhi S, et al. Ketamine attenuates post-operative cognitive dysfunction after cardiac surgery. Acta Anaesth Scand 2009;53:864-872.
103. Hu Z, Ou Y, Duan K, Jiang X. Inflammation: a bridge between cognitive dysfunction and Alzheimer's disease. Med Hypotheses 2010;74:722-724.
104. Ramlawi B, Rudolph JL, Mieno S, et al. C-reactive protein and inflammatory response associated to neurocognitive decline following cardiac surgery. Surgery 2006;140:221-226.
105. Wang Y, He H, Zhu W, Duan K, et al. The role of the TLR4 signaling pathway in cognitive deficits following surgery in aged rats. Mol Med Rep 2013;7:1137-1142.