메뉴 건너뛰기




Volumn 28, Issue 4, 2012, Pages 905-915

The role of indoleamine 2,3-dioxygenase in a mouse model of neuroinflammation-induced depression

Author keywords

Depression; indoleamine 2,3 dioxygenase; lipopolysaccharide; neuroinflammation; positron emission tomography

Indexed keywords

1 METHYL TRYPTOPHAN; INDOLEAMINE 2,3 DIOXYGENASE; KYNURENINE; LIPOPOLYSACCHARIDE; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE C 11; TRYPTOPHAN; UNCLASSIFIED DRUG;

EID: 84858055157     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-2011-111097     Document Type: Article
Times cited : (102)

References (50)
  • 1
    • 33747877627 scopus 로고    scopus 로고
    • Microglial senescence: Does the brain's immune system have an expiration date?
    • Streit WJ (2006) Microglial senescence: Does the brain's immune system have an expiration date? Trends Neurosci 29, 506-510.
    • (2006) Trends Neurosci , vol.29 , pp. 506-510
    • Streit, W.J.1
  • 2
    • 76849113421 scopus 로고    scopus 로고
    • Neuroinflammation in Alzheimer's disease and major depression
    • Dobos N, Korf J, Luiten PG, Eisel UL (2010) Neuroinflammation in Alzheimer's disease and major depression. Biol Psychiatry 67, 503-504.
    • (2010) Biol Psychiatry , vol.67 , pp. 503-504
    • Dobos, N.1    Korf, J.2    Luiten, P.G.3    Eisel, U.L.4
  • 4
    • 77249128045 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha mediates the blood-brain barrier dysfunction induced by activated microglia in mouse brain microvascular endothelial cells
    • Nishioku T, Matsumoto J, Dohgu S, Sumi N, Miyao K, Takata F, Shuto H, Yamauchi A, Kataoka Y (2010) Tumor necrosis factor-alpha mediates the blood-brain barrier dysfunction induced by activated microglia in mouse brain microvascular endothelial cells. J Pharmacol Sci 112, 251-254.
    • (2010) J Pharmacol Sci , vol.112 , pp. 251-254
    • Nishioku, T.1    Matsumoto, J.2    Dohgu, S.3    Sumi, N.4    Miyao, K.5    Takata, F.6    Shuto, H.7    Yamauchi, A.8    Kataoka, Y.9
  • 6
    • 59649098348 scopus 로고    scopus 로고
    • PET imaging of the peripheral benzodiazepine receptor: Monitoring disease progression and therapy response in neurodegenerative disorders
    • Doorduin J, de Vries EF, Dierckx RA, Klein HC (2008) PET imaging of the peripheral benzodiazepine receptor: Monitoring disease progression and therapy response in neurodegenerative disorders. Curr Pharm Des 14, 3297-3315.
    • (2008) Curr Pharm des , vol.14 , pp. 3297-3315
    • Doorduin, J.1    De Vries, E.F.2    Dierckx, R.A.3    Klein, H.C.4
  • 7
    • 34250696978 scopus 로고    scopus 로고
    • Positron Emission Tomography Imaging of Neuroinflammation
    • DOI 10.1016/j.nurt.2007.04.006, PII S1933721307000797
    • Cagnin A, Kassiou M, Meikle SR, Banati RB (2007) Positron emission tomography imaging of neuroinflammation. Neurotherapeutics 4, 443-452. (Pubitemid 46962405)
    • (2007) Neurotherapeutics , vol.4 , Issue.3 , pp. 443-452
    • Cagnin, A.1    Kassiou, M.2    Meikle, S.R.3    Banati, R.B.4
  • 9
    • 0029815299 scopus 로고    scopus 로고
    • The evolution of psychiatric symptoms in Alzheimer's disease: A natural history study
    • Jost BC, Grossberg GT (1996) The evolution of psychiatric symptoms in Alzheimer's disease: A natural history study. J Am Geriatr Soc 44, 1078-1081. (Pubitemid 26304552)
    • (1996) Journal of the American Geriatrics Society , vol.44 , Issue.9 , pp. 1078-1081
    • Jost, B.C.1    Grossberg, G.T.2
  • 10
    • 0033917741 scopus 로고    scopus 로고
    • Is depression a risk factor for dementia or cognitive decline? A review
    • Jorm AF (2000) Is depression a risk factor for dementia or cognitive decline? A review. Gerontology 46, 219-227.
    • (2000) Gerontology , vol.46 , pp. 219-227
    • Jorm, A.F.1
  • 11
    • 0035670095 scopus 로고    scopus 로고
    • History of depression as a risk factor for dementia: An updated review
    • Jorm AF (2001) History of depression as a risk factor for dementia: An updated review. Aust N Z J Psychiatry 35, 776-781.
    • (2001) Aust N Z J Psychiatry , vol.35 , pp. 776-781
    • Jorm, A.F.1
  • 12
    • 78049351929 scopus 로고    scopus 로고
    • Long-term cognitive impairment and functional disability among survivors of severe sepsis
    • Iwashyna TJ, Ely EW, Smith DM, Langa KM (2010) Long-term cognitive impairment and functional disability among survivors of severe sepsis. JAMA 304, 1787-1794.
    • (2010) JAMA , vol.304 , pp. 1787-1794
    • Iwashyna, T.J.1    Ely, E.W.2    Smith, D.M.3    Langa, K.M.4
  • 13
    • 37249094173 scopus 로고    scopus 로고
    • From inflammation to sickness and depression: When the immune system subjugates the brain
    • DOI 10.1038/nrn2297, PII NRN2297
    • Dantzer R, O'Connor JC, Freund GG, Johnson RW, Kelley KW (2008) From inflammation to sickness and depression: When the immune system subjugates the brain. Nat Rev Neurosci 9, 46-56. (Pubitemid 350295688)
    • (2008) Nature Reviews Neuroscience , vol.9 , Issue.1 , pp. 46-56
    • Dantzer, R.1    O'Connor, J.C.2    Freund, G.G.3    Johnson, R.W.4    Kelley, K.W.5
  • 14
    • 0025910497 scopus 로고
    • The macrophage theory of depression
    • Smith RS (1991) The macrophage theory of depression. Med Hypotheses 35, 298-306.
    • (1991) Med Hypotheses , vol.35 , pp. 298-306
    • Smith, R.S.1
  • 15
    • 63449122724 scopus 로고    scopus 로고
    • Inflammation and its discontents: The role of cytokines in the pathophysiology of major depression
    • Miller AH, Maletic V, Raison CL (2009) Inflammation and its discontents: The role of cytokines in the pathophysiology of major depression. Biol Psychiatry 65, 732-741.
    • (2009) Biol Psychiatry , vol.65 , pp. 732-741
    • Miller, A.H.1    Maletic, V.2    Raison, C.L.3
  • 16
    • 34548809845 scopus 로고    scopus 로고
    • Inflammation, depression and dementia: Are they connected?
    • Leonard BE (2007) Inflammation, depression and dementia: Are they connected? Neurochem Res 32, 1749-1756.
    • (2007) Neurochem Res , vol.32 , pp. 1749-1756
    • Leonard, B.E.1
  • 17
    • 34547794475 scopus 로고    scopus 로고
    • The immune-mediated alteration of serotonin and glutamate: Towards an integrated view of depression
    • DOI 10.1038/sj.mp.4002006, PII 4002006
    • Muller N, Schwarz MJ (2007) The immune-mediated alteration of serotonin and glutamate: Towards an integrated view of depression. Mol Psychiatry 12, 988-1000. (Pubitemid 350006207)
    • (2007) Molecular Psychiatry , vol.12 , Issue.11 , pp. 988-1000
    • Muller, N.1    Schwarz, M.J.2
  • 18
    • 70449890181 scopus 로고    scopus 로고
    • Tryptophan as an evolutionarily conserved signal to brain serotonin: Molecular evidence and psychiatric implications
    • Russo S, Kema IP, Bosker F, Haavik J, Korf J (2009) Tryptophan as an evolutionarily conserved signal to brain serotonin: Molecular evidence and psychiatric implications. World J Biol Psychiatry 10, 258-268.
    • (2009) World J Biol Psychiatry , vol.10 , pp. 258-268
    • Russo, S.1    Kema, I.P.2    Bosker, F.3    Haavik, J.4    Korf, J.5
  • 19
    • 37849027118 scopus 로고    scopus 로고
    • The immune effects of TRYCATs (tryptophan catabolites along the IDO pathway): Relevance for depression - And other conditions characterized by tryptophan depletion induced by inflammation
    • Maes M, Mihaylova I, Ruyter MD, Kubera M, Bosmans E (2007) The immune effects of TRYCATs (tryptophan catabolites along the IDO pathway): Relevance for depression - and other conditions characterized by tryptophan depletion induced by inflammation. Neuro Endocrinol Lett 28, 826-831.
    • (2007) Neuro Endocrinol Lett , vol.28 , pp. 826-831
    • Maes, M.1    Mihaylova, I.2    Ruyter, M.D.3    Kubera, M.4    Bosmans, E.5
  • 20
    • 23044462498 scopus 로고    scopus 로고
    • Indoleamine 2,3 dioxygenase and quinolinic acid Immunoreactivity in Alzheimer's disease hippocampus
    • DOI 10.1111/j.1365-2990.2005.00655.x
    • Guillemin GJ, Brew BJ, Noonan CE, Takikawa O, Cullen KM (2005) Indoleamine 2,3dioxygenase and quinolinic acid immunoreactivity in Alzheimer's disease hippocampus. Neuropathol Appl Neurobiol 31, 395-404. (Pubitemid 41059860)
    • (2005) Neuropathology and Applied Neurobiology , vol.31 , Issue.4 , pp. 395-404
    • Guillemin, G.J.1    Brew, B.J.2    Noonan, C.E.3    Takikawa, O.4    Cullen, K.M.5
  • 23
    • 33847759064 scopus 로고    scopus 로고
    • Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration
    • DOI 10.1002/glia.20467
    • Qin L, Wu X, Block ML, Liu Y, Breese GR, Hong JS, Knapp DJ, Crews FT (2007) Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration. Glia 55, 453-462. (Pubitemid 46383175)
    • (2007) GLIA , vol.55 , Issue.5 , pp. 453-462
    • Qin, L.1    Wu, X.2    Block, M.L.3    Liu, Y.4    Breese, G.R.5    Hong, J.-S.6    Knapp, D.J.7    Crews, F.T.8
  • 24
    • 50049113248 scopus 로고    scopus 로고
    • Spatio-temporal differences in the profile of murine brain expression of proinflammatory cytokines and indoleamine 2,3-dioxygenase in response to peripheral lipopolysaccharide administration
    • Andre C, O'Connor JC, Kelley KW, Lestage J, Dantzer R, Castanon N (2008) Spatio-temporal differences in the profile of murine brain expression of proinflammatory cytokines and indoleamine 2,3-dioxygenase in response to peripheral lipopolysaccharide administration. J Neuroimmunol 200, 90-99.
    • (2008) J Neuroimmunol , vol.200 , pp. 90-99
    • Andre, C.1    O'Connor, J.C.2    Kelley, K.W.3    Lestage, J.4    Dantzer, R.5    Castanon, N.6
  • 25
    • 0036429151 scopus 로고    scopus 로고
    • The enzyme indoleamine 2,3-dioxygenase is induced in the mouse brain in response to peripheral administration of lipopolysaccharide and superantigen
    • DOI 10.1016/S0889-1591(02)00014-4, PII S0889159102000144
    • Lestage J, Verrier D, Palin K, Dantzer R (2002) The enzyme indoleamine 2,3-dioxygenase is induced in the mouse brain in response to peripheral administration of lipopolysaccharide and superantigen. Brain Behav Immun 16, 596-601. (Pubitemid 35333740)
    • (2002) Brain, Behavior, and Immunity , vol.16 , Issue.5 , pp. 596-601
    • Lestage, J.1    Verrier, D.2    Palin, K.3    Dantzer, R.4
  • 27
    • 44949138266 scopus 로고    scopus 로고
    • Neuroinflammatory response to lipopolysaccharide is exacerbated in mice genetically deficient in cyclooxygenase-2
    • Aid S, Langenbach R, Bosetti F (2008) Neuroinflammatory response to lipopolysaccharide is exacerbated in mice genetically deficient in cyclooxygenase-2. J Neuroinflammation 5, 17.
    • (2008) J Neuroinflammation , vol.5 , pp. 17
    • Aid, S.1    Langenbach, R.2    Bosetti, F.3
  • 28
    • 77953620042 scopus 로고    scopus 로고
    • Neuronal overexpression of cyclooxygenase-2 does not alter the neuroinflammatory response during brain innate immune activation
    • Aid S, Parikh N, Palumbo S, Bosetti F (2010) Neuronal overexpression of cyclooxygenase-2 does not alter the neuroinflammatory response during brain innate immune activation. Neurosci Lett 478, 113-118.
    • (2010) Neurosci Lett , vol.478 , pp. 113-118
    • Aid, S.1    Parikh, N.2    Palumbo, S.3    Bosetti, F.4
  • 29
    • 43249109884 scopus 로고    scopus 로고
    • Genetic deletion or pharmacological inhibition of cyclooxygenase-1 attenuate lipopolysaccharide-induced inflammatory response and brain injury
    • DOI 10.1096/fj.07-9411com
    • Choi SH, Langenbach R, Bosetti F (2008) Genetic deletion or pharmacological inhibition of cyclooxygenase-1 attenuate lipopolysaccharide- induced inflammatory response and brain injury. FASEB J 22, 1491-1501. (Pubitemid 351656789)
    • (2008) FASEB Journal , vol.22 , Issue.5 , pp. 1491-1501
    • Choi, S.-H.1    Langenbach, R.2    Bosetti, F.3
  • 30
    • 16444372307 scopus 로고    scopus 로고
    • Neuronal oxidative damage and denritic degeneration following activation of CD14-dependent innate immune response in vivo
    • Milatovic D, Zaja-Milatovic S, Montine KS, Shie FS, Montine TJ (2004) Neuronal oxidative damage and denritic degeneration following activation of CD14-dependent innate immune response in vivo. J Neuroinflammation 1, 20.
    • (2004) J Neuroinflammation , vol.1 , pp. 20
    • Milatovic, D.1    Zaja-Milatovic, S.2    Montine, K.S.3    Shie, F.S.4    Montine, T.J.5
  • 32
    • 77956831579 scopus 로고    scopus 로고
    • Exchange protein activated by cyclic AMP 2 (Epac2) plays a specific and time-limited role in memory retrieval
    • Ostroveanu A, van der Zee EA, Eisel UL, Schmidt M, Nijholt IM (2009) Exchange protein activated by cyclic AMP 2 (Epac2) plays a specific and time-limited role in memory retrieval. Hippocampus 20, 1018-1026.
    • (2009) Hippocampus , vol.20 , pp. 1018-1026
    • Ostroveanu, A.1    Van Der Zee, E.A.2    Eisel, U.L.3    Schmidt, M.4    Nijholt, I.M.5
  • 33
    • 65049087189 scopus 로고    scopus 로고
    • Pretreatment with lovastatin prevents N-methyl-D-aspartate-induced neurodegeneration in the magnocellular nucleus basalis and behavioral dysfunction
    • Dolga AM, Granic I, Nijholt IM, Nyakas C, van der Zee EA, Luiten PG, Eisel UL (2009) Pretreatment with lovastatin prevents N-methyl-D-aspartate- induced neurodegeneration in the magnocellular nucleus basalis and behavioral dysfunction. J Alzheimers Dis 17, 327-336.
    • (2009) J Alzheimers Dis , vol.17 , pp. 327-336
    • Dolga, A.M.1    Granic, I.2    Nijholt, I.M.3    Nyakas, C.4    Van Der Zee, E.A.5    Luiten, P.G.6    Eisel, U.L.7
  • 34
    • 2042546746 scopus 로고    scopus 로고
    • In search of a depressed mouse: Utility of models for studying depression-related behavior in genetically modified mice
    • DOI 10.1038/sj.mp.4001457
    • Cryan JF, Mombereau C (2004) In search of a depressed mouse: Utility of models for studying depression-related behavior in genetically modified mice. Mol Psychiatry 9, 326-357. (Pubitemid 38534696)
    • (2004) Molecular Psychiatry , vol.9 , Issue.4 , pp. 326-357
    • Cryan, J.F.1    Mombereau, C.2
  • 35
    • 33947643561 scopus 로고    scopus 로고
    • A-kinase anchoring protein 150 in the mouse brain is concentrated in areas involved in learning and memory
    • DOI 10.1016/j.brainres.2007.01.117, PII S0006899307002764
    • Ostroveanu A, Van der Zee EA, Dolga AM, Luiten PG, Eisel UL, Nijholt IM (2007) A-kinase anchoring protein 150 in the mouse brain is concentrated in areas involved in learning and memory. Brain Res 1145, 97-107. (Pubitemid 46497987)
    • (2007) Brain Research , vol.1145 , Issue.1 , pp. 97-107
    • Ostroveanu, A.1    Van Der, Z.E.A.2    Dolga, A.M.3    Luiten, P.G.M.4    Eisel, U.L.M.5    Nijholt, I.M.6
  • 36
    • 5044220930 scopus 로고    scopus 로고
    • IDO expression by dendritic cells: Tolerance and tryptophan catabolism
    • DOI 10.1038/nri1457
    • Mellor AL, Munn DH (2004) IDO expression by dendritic cells: Tolerance and tryptophan catabolism. Nat Rev Immunol 4, 762-774. (Pubitemid 39336293)
    • (2004) Nature Reviews Immunology , vol.4 , Issue.10 , pp. 762-774
    • Mellor, A.L.1    Munn, D.H.2
  • 37
    • 60449106709 scopus 로고    scopus 로고
    • Plasma tryptophan, kynurenine and 3-hydroxykynurenine measurement using automated on-line solid-phase extraction HPLC-tandem mass spectrometry
    • de Jong WH, Smit R, Bakker SJ, de Vries EG, Kema IP (2009) Plasma tryptophan, kynurenine and 3-hydroxykynurenine measurement using automated on-line solid-phase extraction HPLC-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 877, 603-609.
    • (2009) J Chromatogr B Analyt Technol Biomed Life Sci , vol.877 , pp. 603-609
    • De Jong, W.H.1    Smit, R.2    Bakker, S.J.3    De Vries, E.G.4    Kema, I.P.5
  • 38
    • 0032509740 scopus 로고    scopus 로고
    • Chronic neuroinflammation in rats reproduces components of the neurobiology of Alzheimer's disease
    • DOI 10.1016/S0006-8993(97)01215-8, PII S0006899397012158
    • Hauss-Wegrzyniak B, Dobrzanski P, Stoehr JD, Wenk GL (1998) Chronic neuroinflammation in rats reproduces components of the neurobiology of Alzheimer's disease. Brain Res 780, 294-303. (Pubitemid 28082916)
    • (1998) Brain Research , vol.780 , Issue.2 , pp. 294-303
    • Hauss-Wegrzyniak, B.1    Dobrzanski, P.2    Stoehr, J.D.3    Wenk, G.L.4
  • 39
    • 59249085094 scopus 로고    scopus 로고
    • Evidence for a cytokine model of cognitive function
    • McAfoose J, Baune BT (2009) Evidence for a cytokine model of cognitive function. Neurosci Biobehav Rev 33, 355-366.
    • (2009) Neurosci Biobehav Rev , vol.33 , pp. 355-366
    • McAfoose, J.1    Baune, B.T.2
  • 40
    • 77955074803 scopus 로고    scopus 로고
    • Central administration of lipopolysaccharide induces depressive-like behavior in vivo and activates brain indoleamine 2,3 dioxygenase in murine organotypic hippocampal slice cultures
    • Fu X, Zunich SM, O'Connor JC, Kavelaars A, Dantzer R, Kelley KW (2010) Central administration of lipopolysaccharide induces depressive-like behavior in vivo and activates brain indoleamine 2,3 dioxygenase in murine organotypic hippocampal slice cultures. J Neuroinflammation 7, 43.
    • (2010) J Neuroinflammation , vol.7 , pp. 43
    • Fu, X.1    Zunich, S.M.2    O'Connor, J.C.3    Kavelaars, A.4    Dantzer, R.5    Kelley, K.W.6
  • 41
    • 34248581135 scopus 로고    scopus 로고
    • Lipopolysaccharide induces delayed FosB/DeltaFosB immunostaining within the mouse extended amygdala, hippocampus and hypothalamus, that parallel the expression of depressive-like behavior
    • DOI 10.1016/j.psyneuen.2007.03.005, PII S0306453007000637
    • Frenois F, Moreau M, O'Connor J, Lawson M, Micon C, Lestage J, Kelley KW, Dantzer R, Castanon N (2007) Lipopolysaccharide induces delayed FosB/DeltaFosB immunostaining within the mouse extended amygdala, hippocampus and hypothalamus, that parallel the expression of depressive-like behavior. Psychoneuroendocrinology 32, 516-531. (Pubitemid 46756007)
    • (2007) Psychoneuroendocrinology , vol.32 , Issue.5 , pp. 516-531
    • Frenois, F.1    Moreau, M.2    O'Connor, J.3    Lawson, M.4    Micon, C.5    Lestage, J.6    Kelley, K.W.7    Dantzer, R.8    Castanon, N.9
  • 42
    • 72049083989 scopus 로고    scopus 로고
    • Minimal penetration of lipopolysaccharide across the murine blood-brain barrier
    • Banks WA, Robinson SM (2010) Minimal penetration of lipopolysaccharide across the murine blood-brain barrier. Brain Behav Immun 24, 102-109.
    • (2010) Brain Behav Immun , vol.24 , pp. 102-109
    • Banks, W.A.1    Robinson, S.M.2
  • 43
    • 0028930324 scopus 로고
    • Independent down-regulation of central and peripheral tumor necrosis factor production as a result of lipopolysaccharide tolerance in mice
    • Faggioni R, Fantuzzi G, Villa P, Buurman W, Van Tits LJH, Ghezzi P (1995) Independent down-regulation of central and peripheral tumor necrosis factor production as a result of lipopolysaccharide tolerance in mice. Infect Immun 63, 1473-1477.
    • (1995) Infect Immun , vol.63 , pp. 1473-1477
    • Faggioni, R.1    Fantuzzi, G.2    Villa, P.3    Buurman, W.4    Van Tits, L.J.H.5    Ghezzi, P.6
  • 44
    • 33845628839 scopus 로고    scopus 로고
    • What is immune privilege (not)?
    • DOI 10.1016/j.it.2006.11.004, PII S1471490606003267
    • Galea I, Bechmann I, Perry VH (2007) What is immune privilege (not)? Trends Immunol 28, 12-18. (Pubitemid 44960159)
    • (2007) Trends in Immunology , vol.28 , Issue.1 , pp. 12-18
    • Galea, I.1    Bechmann, I.2    Perry, V.H.3
  • 46
    • 0033928598 scopus 로고    scopus 로고
    • Characterisation of kynurenine pathway metabolism in human astrocytes and implications in neuropathogenesis
    • Guillemin GJ, Smith DG, Kerr SJ, Smythe GA, Kapoor V, Armati PJ, Brew BJ (2000) Characterisation of kynurenine pathway metabolism in human astrocytes and implications in neuropathogenesis. Redox Report 5, 108-111. (Pubitemid 30488525)
    • (2000) Redox Report , vol.5 , Issue.2-3 , pp. 108-111
    • Guillemin, G.J.1    Smith, D.G.2    Kerr, S.J.3    Smythe, G.A.4    Kapoor, V.5    Armati, P.J.6    Brew, B.J.7
  • 47
    • 67349121577 scopus 로고    scopus 로고
    • Neural regulation of endocrine and autonomic stress responses
    • Ulrich-Lai YM, Herman JP (2009) Neural regulation of endocrine and autonomic stress responses. Nat Rev Neurosci 10, 397-409.
    • (2009) Nat Rev Neurosci , vol.10 , pp. 397-409
    • Ulrich-Lai, Y.M.1    Herman, J.P.2
  • 48
    • 33749606430 scopus 로고    scopus 로고
    • Lipopolysaccharide has indomethacin-sensitive actions on Fos expression in topographically organized subpopulations of serotonergic neurons
    • DOI 10.1016/j.bbi.2006.01.006, PII S0889159106000316
    • Hollis JH, Evans AK, Bruce KP, Lightman SL, Lowry CA (2006) Lipopolysaccharide has indomethacin-sensitive actions on Fos expression in topographically organized subpopulations of serotonergic neurons. Brain Behav Immun 20, 569-577. (Pubitemid 44540334)
    • (2006) Brain, Behavior, and Immunity , vol.20 , Issue.6 , pp. 569-577
    • Hollis, J.H.1    Evans, A.K.2    Bruce, K.P.E.3    Lightman, S.L.4    Lowry, C.A.5
  • 50
    • 0028968980 scopus 로고
    • Effect of bacterial endotoxin and interleukin-1 beta on hippocampal serotonergic neurotransmission, behavioral activity, and free corticosterone levels: An in vivo microdialysis study
    • Linthorst AC, Flachskamm C, Muller-Preuss P, Holsboer F, Reul JM (1995) Effect of bacterial endotoxin and interleukin-1 beta on hippocampal serotonergic neurotransmission, behavioral activity, and free corticosterone levels: An in vivo microdialysis study. J Neurosci 15, 2920-2934.
    • (1995) J Neurosci , vol.15 , pp. 2920-2934
    • Linthorst, A.C.1    Flachskamm, C.2    Muller-Preuss, P.3    Holsboer, F.4    Reul, J.M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.