Inflammatory markers and depressed mood in older persons: Results from the health, aging and body composition study

Biological Psychiatry

Volumn 54, Issue 5, 2003, Pages 566-572

  Penninx, Brenda W J H ^a   Kritchevsky, Stephen B ^b   Yaffe, Kristine ^c   Newman, Anne B ^d   Simonsick, Eleanor M ^e   Rubin, Susan ^c   Ferrucci, Luigi ^f   Harris, Tamara ^g   Pahor, Marco ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

^e NATIONAL INSTITUTE ON AGING   (United States)

^f Geriatric Department   (Italy)

^g NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

C reactive protein; Depression; Inflammation; Interleukin 6; Old age; Tumor necrosis factor

Indexed keywords

BIOLOGICAL MARKER; C REACTIVE PROTEIN; CYTOKINE; INTERLEUKIN 6; TUMOR NECROSIS FACTOR;

AGED; AGING; ANAMNESIS; ARTICLE; BLOOD LEVEL; BLOOD SAMPLING; BODY COMPOSITION; CONTROLLED STUDY; CORRELATION ANALYSIS; DEPRESSION; FEMALE; HEALTH; HUMAN; INFLAMMATION; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; PATIENT SELECTION; PRIORITY JOURNAL; QUESTIONNAIRE; STATISTICAL ANALYSIS; WORLD HEALTH ORGANIZATION;

EID: 0142042989     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3223(02)01811-5     Document Type: Article

References (39)

1. Arimura A., Takaki A., Komaki G. Interactions between cytokines and the hypothalamic-pituitary-adrenal axis during stress. Ann N Y Acad Sci. 739:1994;270-281.
2. Beekman A.T., Copeland J.R., Prince M.J. Review of community prevalence of depression in later life. Br J Psychiatry. 174:1999;307-311.
3. Beekman A.T., Deeg D.J., Van Limbeek J., Braam A.W., De Vries M.Z., van Tilburg W. Criterion validity of the Center for Epidemiologic Studies Depression scale (CES-D) Results from a community-based sample of older subjects in The Netherlands . Psychol Med. 27:1997;231-235.
4. Berk M., Wadee A.A., Kuschke R.H., O'Neill-Kerr A. Acute phase proteins in major depression. J Psychosom Res. 43:1997;529-534.
5. Capuron L., Ravaud A., Gualde N., Bosmans E., Dantzer R., Maes M., et al. Association between immune activation and early depressive symptoms in cancer patients treated with interleukin-2-based therapy. Psychoneuroendocrinology. 26:2001;797-808.
6. Dentino A.N., Pieper C.F., Rao M.K., Currie M.S., Harris T., Blazer D.G., et al. Association of interleukin-6 and other biologic variables with depression in older people living in the community. J Am Geriatr Soc. 47:1999;6-11.
7. Ershler W.B. Interleukin-6 A cytokine for gerontologists . J Am Geriatr Soc. 41:1993;176-181.
8. Ferrucci L., Harris T.B., Guralnik J.M., Tracy R.P., Corti M.C., Cohen H.J., et al. Serum IL-6 level and the development of disability in older persons. J Am Geriatr Soc. 47:1999;639-646.
9. Harris T.B., Ferrucci L., Tracy R.P., Corti M.C., Wacholder S., Ettinger W.H. Jr, et al. Associations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly. Am J Med. 106:1999;506-512.
10. Hornig M., Goodman D.B., Kamoun M., Amsterdam J.D. Positive and negative acute phase proteins in affective subtypes. J Affect Disord. 49:1998;9-18.
11. Huang B.Y., Cornoni-Huntley J., Hays J.C., Huntley R.R., Galanos A.N., Blazer D.G. Impact of depressive symptoms on hospitalization risk in community-dwelling older persons. J Am Geriatr Soc. 48:2000;1279-1284.
12. Kop W.J., Gottdiener J.S., Tangen C.M., Fried L.P., McBurnie M.A., Walston J., et al. Inflammation and coagulation factors in persons > 65 years of age with symptoms of depression but without evidence of myocardial ischemia. Am J Cardiol. 89:2002;419-424.
13. Lutgendorf S.K., Garand L., Buckwalter K.C., Reimer T.T., Hong S.Y., Lubaroff D.M. Life stress, mood disturbance, and elevated interleukin-6 in healthy older women. J Gerontol A Biol Sci Med Sci. 54:1999;M434-M439.
14. Macy E.M., Hayes T.E., Tracy R.P. Variability in the measurement of C-reactive protein in healthy subjects Implications for reference intervals and epidemiological applications . Clin Chem. 43:1997;52-58.
15. Maes M., Bosmans E., Suy E., Vandervorst C., DeJonckheere C., Raus J. Depression-related disturbances in mitogen-induced lymphocyte responses and interleukin-1 beta and soluble interleukin-2 receptor production. Acta Psychiatr Scand. 84:1991;379-386.
16. Maes M., Lin A.H., Delmeire L., Van Gastel A., Kenis G., De Jongh R., et al. Elevated serum interleukin-6 (IL-6) and IL-6 receptor concentrations in posttraumatic stress disorder following accidental man-made traumatic events. Biol Psychiatry. 45:1999;833-839.
17. Maes M., Meltzer H.Y., Stevens W., Cosyns P., Blockx P. Multiple reciprocal relationships between in vivo cellular immunity and hypothalamic-pituitary-adrenal axis in depression. Psychol Med. 24:1994;167-177.
18. Maes M., Vandoolaeghe E., Ranjan R., Bosmans E., Bergmans R., Desnyder R. Increased serum interleukin-1-receptor-antagonist concentrations in major depression. J Affect Disord. 36:1995;29-36.
19. Musselman D.L., Miller A.H., Porter M.R., Manatunga A., Gao F., Penna S., et al. Higher than normal plasma interleukin-6 concentrations in cancer patients with depression Preliminary findings . Am J Psychiatry. 158:2001;1252-1257.
20. Pahor M., Chrischilles E.A., Guralnik J.M., Brown S.L., Wallace R.B., Carbonin P. Drug data coding and analysis in epidemiologic studies. Eur J Epidemiol. 10:1994;405-411.
21. Penninx B.W., Beekman A.T., Honig A., Deeg D.J., Schoevers R.A., van Eijk J.T., et al. Depression and cardiac mortality Results from a community-based longitudinal study . Arch Gen Psychiatry. 58:2001;221-227.
22. Penninx B.W., Geerlings S.W., Deeg D.J., van Eijk J.T., van Tilburg W., Beekman A.T. Minor and major depression and the risk of death in older persons. Arch Gen Psychiatry. 56:1999;889-895.
23. Penninx B.W., Guralnik J.M., Ferrucci L., Simonsick E.M., Deeg D.J., Wallace R.B. Depressive symptoms and physical decline in community-dwelling older persons. JAMA. 279:1998;1720-1726.
24. Penninx B.W., Guralnik J.M., Mendes de Leon C.F., Pahor M., Visser M., Corti M.C., et al. Cardiovascular events and mortality in newly and chronically depressed persons > 70 years of age. Am J Cardiol. 81:1998;988-994.
25. Radloff L.S. The CES-D scale A self-report depression scale for reseach in the general population . Appl Psychol Meas. 1:1977;385-401.
26. Rao K.M., Pieper C.S., Currie M.S., Cohen H.J. Variability of plasma IL-6 and crosslinked fibrin dimers over time in community dwelling elderly subjects. Am J Clin Pathol. 102:1994;802-805.
27. Reichenberg A., Yirmiya R., Schuld A., Kraus T., Haack M., Morag A., et al. Cytokine-associated emotional and cognitive disturbances in humans. Arch Gen Psychiatry. 58:2001;445-452.
28. Reichlin S. Neuroendocrine-immune interactions. N Engl J Med. 329:1993;1246-1253.
29. Ridker P.M., Cushman M., Stampfer M.J., Tracy R.P., Hennekens C.H. Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men. N Engl J Med. 336:1997;973-979.
30. Ridker P.M., Rifai N., Stampfer M.J., Hennekens C.H. Plasma concentration of interleukin-6 and the risk of future myocardial infarction among apparently healthy men. Circulation. 101:2000;1767-1772.
31. Roubenoff R., Rall L.C. Humoral mediation of changing body composition during aging and chronic inflammation. Nutr Rev. 51:1993;1-11.
32. Schoevers R.A., Geerlings M.I., Beekman A.T., Penninx B.W., Deeg D.J., Jonker C., et al. Association of depression and gender with mortality in old age. Results from the Amsterdam Study of the Elderly (AMSTEL). Br J Psychiatry. 177:2000;336-342.
33. Seidel A., Arolt V., Hunstiger M., Rink L., Behnisch A., Kirchner H. Cytokine production and serum proteins in depression. Scand J Immunol. 41:1995;534-538.
34. Sluzewska A., Rybakowski J., Bosmans E., Sobieska M., Berghmans R., Maes M., et al. Indicators of immune activation in major depression. Psychiatry Res. 64:1996;161-167.
35. Sternberg E.M., Chrousos G.P., Wilder R.L., Gold P.W. The stress response and the regulation of inflammatory disease. Ann Intern Med. 117:1992;854-866.
36. Tracy R.P., Lemaitre R.N., Psaty B.M., Ives D.G., Evans R.W., Cushman M., et al. Relationship of C-reactive protein to risk of cardiovascular disease in the elderly. Results from the Cardiovascular Health Study and the Rural Health Promotion Project. Arterioscler Thromb Vasc Biol. 17:1997;1121-1127.
37. Van Snick J. Interleukin-6 An overview . Annu Rev Immunol. 8:1990;253-278.
38. Yirmiya R. Endotoxin produces a depressive-like episode in rats. Brain Res. 711:1996;163-174.
39. Zhou D., Kusnecov A.W., Shurin M.R., DePaoli M., Rabin B.S. Exposure to physical and psychological stressors elevates plasma interleukin 6 Relationship to the activation of hypothalamic-pituitary-adrenal axis . Endocrinology. 133:1993;2523-2530.