메뉴 건너뛰기




Volumn 31, Issue , 2013, Pages 115-127

Central administration of murine interferon-α induces depressive-like behavioral, brain cytokine and neurochemical alterations in mice: A mini-review and original experiments

Author keywords

Cytokine; Depression; Interferon; Serotonin

Indexed keywords

ALPHA INTERFERON; CORTICOSTERONE; DRUG VEHICLE; INTERLEUKIN 1BETA; INTERLEUKIN 6; MESSENGER RNA; SEROTONIN; SEROTONIN RECEPTOR; TUMOR NECROSIS FACTOR ALPHA;

EID: 84878132450     PISSN: 08891591     EISSN: 10902139     Source Type: Journal    
DOI: 10.1016/j.bbi.2012.07.023     Document Type: Article
Times cited : (39)

References (110)
  • 1
    • 79953697662 scopus 로고    scopus 로고
    • 5-HT and the immune system
    • Ahern G.P. 5-HT and the immune system. Curr. Opin. Pharmacol. 2011, 11:29-33.
    • (2011) Curr. Opin. Pharmacol. , vol.11 , pp. 29-33
    • Ahern, G.P.1
  • 2
    • 84893048020 scopus 로고    scopus 로고
    • Modifying 5-HT1A receptor gene expression as a new target for antidepressant therapy
    • Albert P.R., François B.L. Modifying 5-HT1A receptor gene expression as a new target for antidepressant therapy. Front Neurosci. 2010, 4:35.
    • (2010) Front Neurosci. , vol.4 , pp. 35
    • Albert, P.R.1    François, B.L.2
  • 3
    • 34248679889 scopus 로고    scopus 로고
    • Interferon-α effects are exaggerated when administered on a psychosocial stressor backdrop: cytokine, corticosterone and brain monoamine variations
    • Anisman H., Poulter M.O., Gandhi R., Merali Z., Hayley S. Interferon-α effects are exaggerated when administered on a psychosocial stressor backdrop: cytokine, corticosterone and brain monoamine variations. J. Neuroimmunol. 2007, 186:45-53.
    • (2007) J. Neuroimmunol. , vol.186 , pp. 45-53
    • Anisman, H.1    Poulter, M.O.2    Gandhi, R.3    Merali, Z.4    Hayley, S.5
  • 4
    • 41149136175 scopus 로고    scopus 로고
    • Serotonin receptor subtype and p11 mRNA expression in stress-relevant brain regions of suicide and control subjects
    • Anisman H., Du L., Palkovits M., Faludi G., Kovacs G.G., Szontagh-Kishazi P., et al. Serotonin receptor subtype and p11 mRNA expression in stress-relevant brain regions of suicide and control subjects. J. Psychiatry Neurosci. 2008, 33:131-141.
    • (2008) J. Psychiatry Neurosci. , vol.33 , pp. 131-141
    • Anisman, H.1    Du, L.2    Palkovits, M.3    Faludi, G.4    Kovacs, G.G.5    Szontagh-Kishazi, P.6
  • 5
    • 42449095441 scopus 로고    scopus 로고
    • Neurotransmitter, peptide and cytokine processes in relation to depressive disorder: comorbidity between depression and neurodegenerative disorders
    • Anisman H., Merali Z., Hayley S. Neurotransmitter, peptide and cytokine processes in relation to depressive disorder: comorbidity between depression and neurodegenerative disorders. Prog. Neurobiol. 2008, 85:1-74.
    • (2008) Prog. Neurobiol. , vol.85 , pp. 1-74
    • Anisman, H.1    Merali, Z.2    Hayley, S.3
  • 10
    • 14844355112 scopus 로고    scopus 로고
    • Major depression and risk of depressive symptomatology associated with short-term and low-dose interferon-alpha treatment
    • Beratis S., Katrivanou A., Georgiou S., Monastirli A., Pasmatzi E., Gourzis P., Tsambaos D. Major depression and risk of depressive symptomatology associated with short-term and low-dose interferon-alpha treatment. J. Psychosom. Res. 2005, 58:15-18.
    • (2005) J. Psychosom. Res. , vol.58 , pp. 15-18
    • Beratis, S.1    Katrivanou, A.2    Georgiou, S.3    Monastirli, A.4    Pasmatzi, E.5    Gourzis, P.6    Tsambaos, D.7
  • 11
    • 33749044008 scopus 로고    scopus 로고
    • Increased 5-HT(2A) receptor binding in euthymic, medication-free patients recovered from depression: a positron emission study with [(11)C]MDL 100,907
    • Bhagwagar Z., Hinz R., Taylor M., Fancy S., Cowen P., Grasby P. Increased 5-HT(2A) receptor binding in euthymic, medication-free patients recovered from depression: a positron emission study with [(11)C]MDL 100,907. Am. J. Psychiatry 2006, 163:1580-1587.
    • (2006) Am. J. Psychiatry , vol.163 , pp. 1580-1587
    • Bhagwagar, Z.1    Hinz, R.2    Taylor, M.3    Fancy, S.4    Cowen, P.5    Grasby, P.6
  • 12
    • 0033830170 scopus 로고    scopus 로고
    • Role of IL-6 in cytokine-induced sickness behavior: a study with IL-6 deficient mice
    • Bluthé R.M., Michaud B., Poli V., Dantzer R. Role of IL-6 in cytokine-induced sickness behavior: a study with IL-6 deficient mice. Physiol. Behav. 2000, 70:367-373.
    • (2000) Physiol. Behav. , vol.70 , pp. 367-373
    • Bluthé, R.M.1    Michaud, B.2    Poli, V.3    Dantzer, R.4
  • 13
    • 0035894157 scopus 로고    scopus 로고
    • Immunotherapy with interferon-alpha in patients affected by chronic hepatitis C induces an intercorrelated stimulation of the cytokine network and an increase in depressive and anxiety symptoms
    • Bonaccorso S., Puzella A., Marino V., Pasquini M., Biondi M., Artini M., Almerighi C., Levrero M., Egyed B., Bosmans E., Meltzer H.Y., Maes M. Immunotherapy with interferon-alpha in patients affected by chronic hepatitis C induces an intercorrelated stimulation of the cytokine network and an increase in depressive and anxiety symptoms. Psychiatry Res. 2001, 15:45-55.
    • (2001) Psychiatry Res. , vol.15 , pp. 45-55
    • Bonaccorso, S.1    Puzella, A.2    Marino, V.3    Pasquini, M.4    Biondi, M.5    Artini, M.6    Almerighi, C.7    Levrero, M.8    Egyed, B.9    Bosmans, E.10    Meltzer, H.Y.11    Maes, M.12
  • 14
    • 0034008318 scopus 로고    scopus 로고
    • Synergistic effects of interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha: central monoamine, corticosterone, and behavioral variations
    • Brebner K., Hayley S., Zacharko R., Meral i Z., Anisman H. Synergistic effects of interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha: central monoamine, corticosterone, and behavioral variations. Neuropsychopharmacology 2000, 22:566-580.
    • (2000) Neuropsychopharmacology , vol.22 , pp. 566-580
    • Brebner, K.1    Hayley, S.2    Zacharko, R.3    Meral, I.Z.4    Anisman, H.5
  • 15
    • 18844370896 scopus 로고    scopus 로고
    • Interferon-alpha-induced modulation of glucocorticoid and serotonin receptors as a mechanism of depression
    • Cai W., Khaoustov V.I., Xie Q., Pan T., Le W., Yoffe B. Interferon-alpha-induced modulation of glucocorticoid and serotonin receptors as a mechanism of depression. J. Hepatol. 2005, 42:880-887.
    • (2005) J. Hepatol. , vol.42 , pp. 880-887
    • Cai, W.1    Khaoustov, V.I.2    Xie, Q.3    Pan, T.4    Le, W.5    Yoffe, B.6
  • 16
    • 9644276925 scopus 로고    scopus 로고
    • Cytokines and psychopathology: lessons from interferon-alpha
    • Capuron L., Miller A.H. Cytokines and psychopathology: lessons from interferon-alpha. Biol. Psychiatry 2004, 1:819-824.
    • (2004) Biol. Psychiatry , vol.1 , pp. 819-824
    • Capuron, L.1    Miller, A.H.2
  • 17
    • 0036199336 scopus 로고    scopus 로고
    • Neurobehavioural effects of interferon-alpha in cancer patients: phenomenology and paroxetine responsiveness of symptom dimensions
    • Capuron L., Gumnick J.F., Musselman D.L., Lawson D.H., Reemsnyder A., Nemeroff C.B., et al. Neurobehavioural effects of interferon-alpha in cancer patients: phenomenology and paroxetine responsiveness of symptom dimensions. Neuropsychopharmacology 2002, 26:643-652.
    • (2002) Neuropsychopharmacology , vol.26 , pp. 643-652
    • Capuron, L.1    Gumnick, J.F.2    Musselman, D.L.3    Lawson, D.H.4    Reemsnyder, A.5    Nemeroff, C.B.6
  • 18
    • 0035985472 scopus 로고    scopus 로고
    • Association between decreased serum tryptophan concentrations and depressive symptoms in cancer patients undergoing cytokine therapy
    • Capuron L., Ravaud A., Neveu P.J., Miller A.H., Maes M., Dantzer R. Association between decreased serum tryptophan concentrations and depressive symptoms in cancer patients undergoing cytokine therapy. Mol. Psychiatry 2002, 7:468-473.
    • (2002) Mol. Psychiatry , vol.7 , pp. 468-473
    • Capuron, L.1    Ravaud, A.2    Neveu, P.J.3    Miller, A.H.4    Maes, M.5    Dantzer, R.6
  • 20
    • 1842526608 scopus 로고    scopus 로고
    • Baseline mood and psychosocial characteristics of patients developing depressive symptoms during interleukin-2 and/or interferon-alpha cancer therapy.
    • Capuron L., Ravaud A., Miller A.H., Dantzer R. Baseline mood and psychosocial characteristics of patients developing depressive symptoms during interleukin-2 and/or interferon-alpha cancer therapy. Brain Behav. Immun. 2004, 18:205-213.
    • (2004) Brain Behav. Immun. , vol.18 , pp. 205-213
    • Capuron, L.1    Ravaud, A.2    Miller, A.H.3    Dantzer, R.4
  • 21
    • 70349734652 scopus 로고    scopus 로고
    • Does cytokine-induced depression differ from idiopathic major depression in medically healthy individuals?
    • Capuron L., Fornwalt F.B., Knight B.T., Harvey P.D., Ninan P.T., Miller A.H. Does cytokine-induced depression differ from idiopathic major depression in medically healthy individuals?. J. Affect. Disord. 2009, 119:181-185.
    • (2009) J. Affect. Disord. , vol.119 , pp. 181-185
    • Capuron, L.1    Fornwalt, F.B.2    Knight, B.T.3    Harvey, P.D.4    Ninan, P.T.5    Miller, A.H.6
  • 22
    • 33749505083 scopus 로고    scopus 로고
    • Role of IL-1 in poststroke depressive-like behavior in mice
    • Craft T.K., DeVries A.C. Role of IL-1 in poststroke depressive-like behavior in mice. Biol. Psychiatry 2006, 60:812-818.
    • (2006) Biol. Psychiatry , vol.60 , pp. 812-818
    • Craft, T.K.1    DeVries, A.C.2
  • 23
    • 0026665157 scopus 로고
    • Behavioral effects of mouse interferons-alpha and -gamma and human interferon-alpha in mice
    • Crnic L.S., Segall M.A. Behavioral effects of mouse interferons-alpha and -gamma and human interferon-alpha in mice. Brain Res. 1992, 590:277-284.
    • (1992) Brain Res. , vol.590 , pp. 277-284
    • Crnic, L.S.1    Segall, M.A.2
  • 24
    • 0035814432 scopus 로고    scopus 로고
    • The pro-inflammatory cytokine interleukin-18 impairs long-term potentiation and NMDA receptor-mediated transmission in the rat hippocampus in vitro
    • Curran B., O'Connor J.J. The pro-inflammatory cytokine interleukin-18 impairs long-term potentiation and NMDA receptor-mediated transmission in the rat hippocampus in vitro. Neuroscience 2001, 108:83-90.
    • (2001) Neuroscience , vol.108 , pp. 83-90
    • Curran, B.1    O'Connor, J.J.2
  • 25
  • 28
    • 0038698988 scopus 로고    scopus 로고
    • The non-steroidal anti-inflammatory drug diclofenac sodium attenuates IFN-alpha induced alterations to monoamine turnover in prefrontal cortex and hippocampus
    • De La Garza R 2nd., Asnis G.M. The non-steroidal anti-inflammatory drug diclofenac sodium attenuates IFN-alpha induced alterations to monoamine turnover in prefrontal cortex and hippocampus. Brain Res. 2003, 4:70-79.
    • (2003) Brain Res. , vol.4 , pp. 70-79
    • De La Garza, R.2.1    Asnis, G.M.2
  • 31
    • 0027284320 scopus 로고
    • Repeated injections of interferon-alpha A/D in Balb/c mice. Behavioral effects
    • Dunn A.L., Crnic L.S. Repeated injections of interferon-alpha A/D in Balb/c mice. Behavioral effects. Brain Behav. Immun. 1993, 7:104-111.
    • (1993) Brain Behav. Immun. , vol.7 , pp. 104-111
    • Dunn, A.L.1    Crnic, L.S.2
  • 32
    • 67651067679 scopus 로고    scopus 로고
    • An fMRI study of cytokine-induced depressed mood and social pain: the role of sex differences
    • Eisenberger N.I., Inagaki T.K., Rameson L.T., Mashal N.M., Irwin M.R. An fMRI study of cytokine-induced depressed mood and social pain: the role of sex differences. Neuroimage 2009, 47:881-890.
    • (2009) Neuroimage , vol.47 , pp. 881-890
    • Eisenberger, N.I.1    Inagaki, T.K.2    Rameson, L.T.3    Mashal, N.M.4    Irwin, M.R.5
  • 33
    • 84867578266 scopus 로고    scopus 로고
    • Molecular signatures of peripheral blood mononuclear cells during chronic interferon-α treatment: relationship with depression and fatigue
    • Felger J.C., Cole S.W., Pace T.W., Hu F., Woolwine B.J., Doho G.H., Raison C.L., Miller A.H. Molecular signatures of peripheral blood mononuclear cells during chronic interferon-α treatment: relationship with depression and fatigue. Psychol. Med. 2011, 9:1-13.
    • (2011) Psychol. Med. , vol.9 , pp. 1-13
    • Felger, J.C.1    Cole, S.W.2    Pace, T.W.3    Hu, F.4    Woolwine, B.J.5    Doho, G.H.6    Raison, C.L.7    Miller, A.H.8
  • 35
    • 34247128167 scopus 로고    scopus 로고
    • Pretreatment levels of sTNF-R1 and sIL-6R are associated with a higher vulnerability for IFN-alpha-induced depressive symptoms in patients with malignant melanoma
    • Friebe A., Schwarz M.J., Schmid-Wendtner M., Volkenandt M., Schmidt F., Horn M., Janssen G., Schaefer M. Pretreatment levels of sTNF-R1 and sIL-6R are associated with a higher vulnerability for IFN-alpha-induced depressive symptoms in patients with malignant melanoma. J. Immunother. 2007, 30:333-337.
    • (2007) J. Immunother. , vol.30 , pp. 333-337
    • Friebe, A.1    Schwarz, M.J.2    Schmid-Wendtner, M.3    Volkenandt, M.4    Schmidt, F.5    Horn, M.6    Janssen, G.7    Schaefer, M.8
  • 36
    • 77955074803 scopus 로고    scopus 로고
    • Central administration of lipopolysaccharide induces depressive-like behavior in vivo and activates brain indoleamine 2,3 dioxygenase in murine organotypic hippocampal slice cultures
    • Fu X., Zunich S.M., O'Connor J.C., Kavelaars A., Dantzer R., Kelley K.W. Central administration of lipopolysaccharide induces depressive-like behavior in vivo and activates brain indoleamine 2,3 dioxygenase in murine organotypic hippocampal slice cultures. J. Neuroinflammation 2010, 2:7-43.
    • (2010) J. Neuroinflammation , vol.2 , pp. 7-43
    • Fu, X.1    Zunich, S.M.2    O'Connor, J.C.3    Kavelaars, A.4    Dantzer, R.5    Kelley, K.W.6
  • 37
    • 79551684081 scopus 로고    scopus 로고
    • Effects of stressors and immune activating agents on peripheral and central cytokines in mouse strains that differ in stressor responsivity
    • Gibb J., Hayley S., Poulter M.O., Anisman H. Effects of stressors and immune activating agents on peripheral and central cytokines in mouse strains that differ in stressor responsivity. Brain Behav. Immun. 2011, 25:468-482.
    • (2011) Brain Behav. Immun. , vol.25 , pp. 468-482
    • Gibb, J.1    Hayley, S.2    Poulter, M.O.3    Anisman, H.4
  • 39
    • 84856111463 scopus 로고    scopus 로고
    • Psychoneuroimmunology meets neuropsychopharmacology: translational implications of the impact of inflammation on behavior
    • Haroon E., Raison C.L., Miller A.H. Psychoneuroimmunology meets neuropsychopharmacology: translational implications of the impact of inflammation on behavior. Neuropsychopharmacology 2012, 37:137-162.
    • (2012) Neuropsychopharmacology , vol.37 , pp. 137-162
    • Haroon, E.1    Raison, C.L.2    Miller, A.H.3
  • 40
    • 77955661793 scopus 로고    scopus 로고
    • Differential expression of interferon-gamma receptor on human glial cells in vivo and in vitro
    • Hashioka S., Klegeris A., Schwab C., Yu S., McGeer P.L. Differential expression of interferon-gamma receptor on human glial cells in vivo and in vitro. J. Neuroimmunol. 2010, 225(1-2):91-99.
    • (2010) J. Neuroimmunol. , vol.225 , Issue.1-2 , pp. 91-99
    • Hashioka, S.1    Klegeris, A.2    Schwab, C.3    Yu, S.4    McGeer, P.L.5
  • 41
    • 26044443198 scopus 로고    scopus 로고
    • The pathogenesis of clinical depression: stressor- and cytokine-induced alterations of neuroplasticity
    • Hayley S., Poulter M.O., Meral Z., Anisman H. The pathogenesis of clinical depression: stressor- and cytokine-induced alterations of neuroplasticity. Neuroscience 2005, 135:659-678.
    • (2005) Neuroscience , vol.135 , pp. 659-678
    • Hayley, S.1    Poulter, M.O.2    Meral, Z.3    Anisman, H.4
  • 42
    • 65649152524 scopus 로고    scopus 로고
    • Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis
    • Howren M.B., Lamkin D.M., Suls J. Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis. Psychosom. Med. 2009, 71:171-186.
    • (2009) Psychosom. Med. , vol.71 , pp. 171-186
    • Howren, M.B.1    Lamkin, D.M.2    Suls, J.3
  • 44
    • 83055185625 scopus 로고    scopus 로고
    • Neuron-specific effects of interleukin-1β are mediated by a novel isoform of the IL-1 receptor accessory protein
    • Huang Y., Smith D.E., Ibáñez-Sandoval O., Sims J.E., Friedman W.J. Neuron-specific effects of interleukin-1β are mediated by a novel isoform of the IL-1 receptor accessory protein. Neuroscience 2011, 7:18048-18059.
    • (2011) Neuroscience , vol.7 , pp. 18048-18059
    • Huang, Y.1    Smith, D.E.2    Ibáñez-Sandoval, O.3    Sims, J.E.4    Friedman, W.J.5
  • 45
    • 2342568442 scopus 로고    scopus 로고
    • Optimization of multiplexed bead-based cytokine immunoassays for rat serum and brain tissue
    • Hulse R.E., Kunkler P.E., Fedynyshyn J.P., Kraig R.P. Optimization of multiplexed bead-based cytokine immunoassays for rat serum and brain tissue. J. Neurosci. Methods 2004, 136:87-98.
    • (2004) J. Neurosci. Methods , vol.136 , pp. 87-98
    • Hulse, R.E.1    Kunkler, P.E.2    Fedynyshyn, J.P.3    Kraig, R.P.4
  • 46
    • 0033993941 scopus 로고    scopus 로고
    • Effect of single intracerebroventricular injection of alpha-interferon on monoamine concentrations in the rat brain
    • Kamata M., Higuchi H., Yoshimoto M., Yoshida K., Shimizu T. Effect of single intracerebroventricular injection of alpha-interferon on monoamine concentrations in the rat brain. Eur. Neuropsychopharmacol. 2000, 10:129-132.
    • (2000) Eur. Neuropsychopharmacol. , vol.10 , pp. 129-132
    • Kamata, M.1    Higuchi, H.2    Yoshimoto, M.3    Yoshida, K.4    Shimizu, T.5
  • 47
    • 33646083015 scopus 로고    scopus 로고
    • The effect of traumatic brain injury upon the concentration and expression of interleukin-1beta and interleukin-10 in the rat
    • Kamm K., Vanderkolk W., Lawrence C., Jonker M., Davis A.T. The effect of traumatic brain injury upon the concentration and expression of interleukin-1beta and interleukin-10 in the rat. J. Trauma 2006, 60:152-157.
    • (2006) J. Trauma , vol.60 , pp. 152-157
    • Kamm, K.1    Vanderkolk, W.2    Lawrence, C.3    Jonker, M.4    Davis, A.T.5
  • 49
    • 29144494853 scopus 로고    scopus 로고
    • Enhanced expression of brain interferon-alpha and serotonin transporter in immunologically induced fatigue in rats
    • Katafuchi T., Kondo T., Take S., Yoshimura M. Enhanced expression of brain interferon-alpha and serotonin transporter in immunologically induced fatigue in rats. Eur. J. Neurosci. 2005, 22:2817-2826.
    • (2005) Eur. J. Neurosci. , vol.22 , pp. 2817-2826
    • Katafuchi, T.1    Kondo, T.2    Take, S.3    Yoshimura, M.4
  • 51
    • 79952762081 scopus 로고    scopus 로고
    • Depressive symptoms following interferon-α therapy: mediated by immune-induced reductions in brain-derived neurotrophic factor?
    • Kenis G., Prickaerts J., van Os J., Koek G.H., Robaeys G., Steinbusch H.W., Wichers M. Depressive symptoms following interferon-α therapy: mediated by immune-induced reductions in brain-derived neurotrophic factor?. Int. J. Neuropsychopharmacol. 2011, 4:247-253.
    • (2011) Int. J. Neuropsychopharmacol. , vol.4 , pp. 247-253
    • Kenis, G.1    Prickaerts, J.2    van Os, J.3    Koek, G.H.4    Robaeys, G.5    Steinbusch, H.W.6    Wichers, M.7
  • 52
    • 77955499638 scopus 로고    scopus 로고
    • Injury-induced type I IFN signaling regulates inflammatory responses in the central nervous system
    • Khorooshi R., Owens T. Injury-induced type I IFN signaling regulates inflammatory responses in the central nervous system. J Immunol. 2010, 185(2):1258-1264.
    • (2010) J Immunol. , vol.185 , Issue.2 , pp. 1258-1264
    • Khorooshi, R.1    Owens, T.2
  • 53
    • 13244249842 scopus 로고    scopus 로고
    • Prophylactic SSRI during interferon alpha re-therapy in patients with chronic hepatitis C and a history of interferon-induced depression
    • Kraus M.R., Schäfer A., Al-Taie O., Scheurlen M. Prophylactic SSRI during interferon alpha re-therapy in patients with chronic hepatitis C and a history of interferon-induced depression. J. Viral Hepat. 2005, 12:96-100.
    • (2005) J. Viral Hepat. , vol.12 , pp. 96-100
    • Kraus, M.R.1    Schäfer, A.2    Al-Taie, O.3    Scheurlen, M.4
  • 54
    • 34247202021 scopus 로고    scopus 로고
    • Serotonin-1A receptor gene HTR1A variation predicts interferon-induced depression in chronic hepatitis C
    • Kraus M.R., Al-Taie O., Schäfer A., Pfersdorff M., Lesch K.P., Scheurlen M. Serotonin-1A receptor gene HTR1A variation predicts interferon-induced depression in chronic hepatitis C. Gastroenterology 2007, 132:1279-1286.
    • (2007) Gastroenterology , vol.132 , pp. 1279-1286
    • Kraus, M.R.1    Al-Taie, O.2    Schäfer, A.3    Pfersdorff, M.4    Lesch, K.P.5    Scheurlen, M.6
  • 55
    • 0034705443 scopus 로고    scopus 로고
    • Effect of interferon-alpha on tyrosine hydroxylase and catecholamine levels in the brain of rats
    • Kumai T., Tateishi T., Tanaka M., Watanabe M., Shimizu H., Kobayashi S. Effect of interferon-alpha on tyrosine hydroxylase and catecholamine levels in the brain of rats. Life Sci. 2000, 30:663-669.
    • (2000) Life Sci. , vol.30 , pp. 663-669
    • Kumai, T.1    Tateishi, T.2    Tanaka, M.3    Watanabe, M.4    Shimizu, H.5    Kobayashi, S.6
  • 56
    • 84855801183 scopus 로고    scopus 로고
    • Mechanistic explanations how cell-mediated immune activation, inflammation and oxidative and nitrosative stress pathways and their sequels and concomitants play a role in the pathophysiology of unipolar depression
    • Leonard B., Maes M. Mechanistic explanations how cell-mediated immune activation, inflammation and oxidative and nitrosative stress pathways and their sequels and concomitants play a role in the pathophysiology of unipolar depression. Neurosci. Biobehav. Rev. 2012, 36:764-785.
    • (2012) Neurosci. Biobehav. Rev. , vol.36 , pp. 764-785
    • Leonard, B.1    Maes, M.2
  • 57
    • 33744993204 scopus 로고    scopus 로고
    • Interactions between corticotropin-releasing hormone and serotonin: implications for the aetiology and treatment of anxiety disorders
    • Linthorst A.C. Interactions between corticotropin-releasing hormone and serotonin: implications for the aetiology and treatment of anxiety disorders. Handb. Exp. Pharmacol. 2005, 169:181-204.
    • (2005) Handb. Exp. Pharmacol. , vol.169 , pp. 181-204
    • Linthorst, A.C.1
  • 58
    • 70449525454 scopus 로고    scopus 로고
    • Interferon-gamma deficiency modifies the motor and co-morbid behavioral pathology and neurochemical changes provoked by the pesticide paraquat
    • Litteljohn D., Mangano E., Shukla N., Hayley S. Interferon-gamma deficiency modifies the motor and co-morbid behavioral pathology and neurochemical changes provoked by the pesticide paraquat. Neuroscience 2009, 164:1894-1906.
    • (2009) Neuroscience , vol.164 , pp. 1894-1906
    • Litteljohn, D.1    Mangano, E.2    Shukla, N.3    Hayley, S.4
  • 59
    • 77951621696 scopus 로고    scopus 로고
    • Interferon-gamma deficiency modifies the effects of a chronic stressor in mice. Implications for psychological pathology
    • Litteljohn D., Cummings A., Brennan A., Gill A., Chunduri S., Anisman H., Hayley S. Interferon-gamma deficiency modifies the effects of a chronic stressor in mice. Implications for psychological pathology. Brain Behav. Immun. 2010, 24:462-473.
    • (2010) Brain Behav. Immun. , vol.24 , pp. 462-473
    • Litteljohn, D.1    Cummings, A.2    Brennan, A.3    Gill, A.4    Chunduri, S.5    Anisman, H.6    Hayley, S.7
  • 60
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
    • Livak K.J., Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001, 25:402-408.
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 61
    • 5644300777 scopus 로고    scopus 로고
    • The phenomenology and treatment of interferon induced depression
    • Loftis J.M., Hauser P. The phenomenology and treatment of interferon induced depression. J. Affect. Disord. 2004, 82:175-190.
    • (2004) J. Affect. Disord. , vol.82 , pp. 175-190
    • Loftis, J.M.1    Hauser, P.2
  • 62
    • 33751343398 scopus 로고    scopus 로고
    • Administration of pegylated interferon-alpha-2a or -2b does not induce sickness behavior in Lewis rats
    • Loftis J.M., Wall J.M., Pagel R.L., Hauser P. Administration of pegylated interferon-alpha-2a or -2b does not induce sickness behavior in Lewis rats. Psychoneuroendocrinology 2006, 31:1289-1294.
    • (2006) Psychoneuroendocrinology , vol.31 , pp. 1289-1294
    • Loftis, J.M.1    Wall, J.M.2    Pagel, R.L.3    Hauser, P.4
  • 63
    • 0028796205 scopus 로고
    • Evidence for an immune response in major depression: a review and hypothesis
    • Maes M. Evidence for an immune response in major depression: a review and hypothesis. Prog. Neuropsychopharmacol. Biol. Psychiatry 1995, 19:11-38.
    • (1995) Prog. Neuropsychopharmacol. Biol. Psychiatry , vol.19 , pp. 11-38
    • Maes, M.1
  • 64
    • 79954604454 scopus 로고    scopus 로고
    • The new '5-HT' hypothesis of depression: cell-mediated immune activation induces indoleamine 2,3-dioxygenase, which leads to lower plasma tryptophan and an increased synthesis of detrimental tryptophan catabolites (TRYCATs), both of which contribute to the onset of depression
    • Maes M., Leonard B.E., Myint A.M., Kubera M., Verkerk R. The new '5-HT' hypothesis of depression: cell-mediated immune activation induces indoleamine 2,3-dioxygenase, which leads to lower plasma tryptophan and an increased synthesis of detrimental tryptophan catabolites (TRYCATs), both of which contribute to the onset of depression. Prog. Neuropsychopharmacol. Biol. Psychiatry 2011, 35:702-721.
    • (2011) Prog. Neuropsychopharmacol. Biol. Psychiatry , vol.35 , pp. 702-721
    • Maes, M.1    Leonard, B.E.2    Myint, A.M.3    Kubera, M.4    Verkerk, R.5
  • 66
    • 0033912138 scopus 로고    scopus 로고
    • Involvement of central opioid systems in human interferon-alpha induced immobility in the mouse forced swimming test
    • Makino M., Kitano Y., Komiyama C., Hirohashi M., Takasuna K. Involvement of central opioid systems in human interferon-alpha induced immobility in the mouse forced swimming test. Br. J. Pharmacol. 2000, 130:1269-1274.
    • (2000) Br. J. Pharmacol. , vol.130 , pp. 1269-1274
    • Makino, M.1    Kitano, Y.2    Komiyama, C.3    Hirohashi, M.4    Takasuna, K.5
  • 67
    • 0033987762 scopus 로고    scopus 로고
    • Human interferon-alpha induces immobility in the mouse forced swimming test: involvement of the opioid system
    • Makino M., Kitano Y., Komiyama C., Hirohashi M., Kohno M., Moriyama M., Takasuna K. Human interferon-alpha induces immobility in the mouse forced swimming test: involvement of the opioid system. Brain Res. 2000, 852:482-484.
    • (2000) Brain Res. , vol.852 , pp. 482-484
    • Makino, M.1    Kitano, Y.2    Komiyama, C.3    Hirohashi, M.4    Kohno, M.5    Moriyama, M.6    Takasuna, K.7
  • 68
    • 0033977782 scopus 로고    scopus 로고
    • Human interferon-alpha increases immobility in the forced swimming test in rats
    • Makino M., Kitano Y., Komiyama C., Takasuna K. Human interferon-alpha increases immobility in the forced swimming test in rats. Psychopharmacology 2000, 148(1):106-110.
    • (2000) Psychopharmacology , vol.148 , Issue.1 , pp. 106-110
    • Makino, M.1    Kitano, Y.2    Komiyama, C.3    Takasuna, K.4
  • 72
    • 58549087919 scopus 로고    scopus 로고
    • Norman cousins lecture. Mechanisms of cytokine-induced behavioral changes: psychoneuroimmunology at the translational interface
    • Miller A.H. Norman cousins lecture. Mechanisms of cytokine-induced behavioral changes: psychoneuroimmunology at the translational interface. Brain Behav. Immun. 2009, 23:149-158.
    • (2009) Brain Behav. Immun. , vol.23 , pp. 149-158
    • Miller, A.H.1
  • 73
    • 63449122724 scopus 로고    scopus 로고
    • Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression
    • Miller A.H., Maletic V., Raison C.L. Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression. Biol. Psychiatry 2009, 65:732-741.
    • (2009) Biol. Psychiatry , vol.65 , pp. 732-741
    • Miller, A.H.1    Maletic, V.2    Raison, C.L.3
  • 74
    • 0001936333 scopus 로고    scopus 로고
    • Effects of repeated stress on expression of interleukin-6 (IL-6) and IL-6 receptor mRNAs in rat hypothalamus and midbrain
    • Miyahara S., Komori T., Fujiwara R., Shizuya K., Yamamoto M., Ohmori M., Okazaki Y. Effects of repeated stress on expression of interleukin-6 (IL-6) and IL-6 receptor mRNAs in rat hypothalamus and midbrain. Life Sci. 2000, 66:93-98.
    • (2000) Life Sci. , vol.66 , pp. 93-98
    • Miyahara, S.1    Komori, T.2    Fujiwara, R.3    Shizuya, K.4    Yamamoto, M.5    Ohmori, M.6    Okazaki, Y.7
  • 75
    • 77957328857 scopus 로고    scopus 로고
    • Prophylactic antidepressant treatment in patients with hepatitis C on antiviral therapy: a double-blind, placebo-controlled trial
    • Morasco B.J., Loftis J.M., Indest D.W., Ruimy S., Davison J.W., Felker B., Hauser P. Prophylactic antidepressant treatment in patients with hepatitis C on antiviral therapy: a double-blind, placebo-controlled trial. Psychosomatics 2010, 51:401-408.
    • (2010) Psychosomatics , vol.51 , pp. 401-408
    • Morasco, B.J.1    Loftis, J.M.2    Indest, D.W.3    Ruimy, S.4    Davison, J.W.5    Felker, B.6    Hauser, P.7
  • 77
    • 84859563380 scopus 로고    scopus 로고
    • Kynurenines: from the perspective of major psychiatric disorders
    • Myint A.M. Kynurenines: from the perspective of major psychiatric disorders. FEBS J. 2012, 279:1375-1385.
    • (2012) FEBS J. , vol.279 , pp. 1375-1385
    • Myint, A.M.1
  • 78
    • 60449097147 scopus 로고    scopus 로고
    • Neuropsychiatric disorders related to interferon and interleukins treatment
    • Myint A.M., Schwarz M.J., Steinbusch H.W., Leonard B.E. Neuropsychiatric disorders related to interferon and interleukins treatment. Metab. Brain Dis. 2009, 24:55-68.
    • (2009) Metab. Brain Dis. , vol.24 , pp. 55-68
    • Myint, A.M.1    Schwarz, M.J.2    Steinbusch, H.W.3    Leonard, B.E.4
  • 79
    • 73249124584 scopus 로고    scopus 로고
    • Depression in hospitalized patients with malignant melanoma treated with interferon-alpha-2b: primary to induced disorders
    • Navinés R., Gómez-Gil E., Puig S., Baeza I., De Pablo J., Martín-Santos R. Depression in hospitalized patients with malignant melanoma treated with interferon-alpha-2b: primary to induced disorders. Eur. J. Dermatol. 2009, 19:611-615.
    • (2009) Eur. J. Dermatol. , vol.19 , pp. 611-615
    • Navinés, R.1    Gómez-Gil, E.2    Puig, S.3    Baeza, I.4    De Pablo, J.5    Martín-Santos, R.6
  • 81
    • 61449100319 scopus 로고    scopus 로고
    • A genetic rat model of depression, Flinders sensitive line, has a lower density of 5-HT(1A) receptors, but a higher density of 5-HT(1B) receptors, compared to control rats
    • Nishi K., Kanemaru K., Diksic M. A genetic rat model of depression, Flinders sensitive line, has a lower density of 5-HT(1A) receptors, but a higher density of 5-HT(1B) receptors, compared to control rats. Neurochem. Int. 2009, 54:299-307.
    • (2009) Neurochem. Int. , vol.54 , pp. 299-307
    • Nishi, K.1    Kanemaru, K.2    Diksic, M.3
  • 82
    • 65249156122 scopus 로고    scopus 로고
    • Interferon-gamma and tumor necrosis factor-alpha mediate the upregulation of indoleamine 2,3-dioxygenase and the induction of depressive-like behavior in mice in response to bacillus Calmette-Guerin
    • O'Connor J.C., André C., Wang Y., Lawson M.A., Szegedi S.S., Lestage J., Castanon N., Kelley K.W., Dantzer R. Interferon-gamma and tumor necrosis factor-alpha mediate the upregulation of indoleamine 2,3-dioxygenase and the induction of depressive-like behavior in mice in response to bacillus Calmette-Guerin. J. Neurosci. 2009, 29:4200-4209.
    • (2009) J. Neurosci. , vol.29 , pp. 4200-4209
    • O'Connor, J.C.1    André, C.2    Wang, Y.3    Lawson, M.A.4    Szegedi, S.S.5    Lestage, J.6    Castanon, N.7    Kelley, K.W.8    Dantzer, R.9
  • 83
    • 59749102254 scopus 로고    scopus 로고
    • Administration of interferon-alpha in mice provokes peripheral and central modulation of immune cells, accompanied by behavioral effects
    • Orsal A.S., Blois S.M., Bermpohl D., Schaefer M., Coquery N. Administration of interferon-alpha in mice provokes peripheral and central modulation of immune cells, accompanied by behavioral effects. Neuropsychobiology 2008, 58:211-222.
    • (2008) Neuropsychobiology , vol.58 , pp. 211-222
    • Orsal, A.S.1    Blois, S.M.2    Bermpohl, D.3    Schaefer, M.4    Coquery, N.5
  • 84
    • 0030992694 scopus 로고    scopus 로고
    • Permeability of the blood-brain and blood- spinal cord barriers to interferons
    • Pan W., Banks W.A., Kastin A.J. Permeability of the blood-brain and blood- spinal cord barriers to interferons. J Neuroimmunol. 1997, 76(1-2):105-111.
    • (1997) J Neuroimmunol. , vol.76 , Issue.1-2 , pp. 105-111
    • Pan, W.1    Banks, W.A.2    Kastin, A.J.3
  • 85
    • 0036187895 scopus 로고    scopus 로고
    • Higher expression of serotonin 5-HT(2A) receptors in the postmortem brains of teenage suicide victims
    • Pandey G.N., Dwivedi Y., Rizavi H.S., Ren X., Pandey S.C., Pesold C., et al. Higher expression of serotonin 5-HT(2A) receptors in the postmortem brains of teenage suicide victims. Am. J. Psychiatry 2002, 159:419-429.
    • (2002) Am. J. Psychiatry , vol.159 , pp. 419-429
    • Pandey, G.N.1    Dwivedi, Y.2    Rizavi, H.S.3    Ren, X.4    Pandey, S.C.5    Pesold, C.6
  • 86
    • 0036223830 scopus 로고    scopus 로고
    • Expression and regulation of interleukin-1 receptors in the brain. Role in cytokines-induced sickness behavior
    • Parnet P., Kelley K.W., Bluthé R.M., Dantzer R. Expression and regulation of interleukin-1 receptors in the brain. Role in cytokines-induced sickness behavior. J. Neuroimmunol. 2002, 125:5-14.
    • (2002) J. Neuroimmunol. , vol.125 , pp. 5-14
    • Parnet, P.1    Kelley, K.W.2    Bluthé, R.M.3    Dantzer, R.4
  • 87
    • 79952303451 scopus 로고    scopus 로고
    • Inflammation and depression: why poststroke depression may be the norm and not the exception
    • Pascoe M.C., Crewther S.G., Carey L.M., Crewther D.P. Inflammation and depression: why poststroke depression may be the norm and not the exception. Int. J. Stroke 2011, 6:128-135.
    • (2011) Int. J. Stroke , vol.6 , pp. 128-135
    • Pascoe, M.C.1    Crewther, S.G.2    Carey, L.M.3    Crewther, D.P.4
  • 88
    • 50649097768 scopus 로고    scopus 로고
    • Psychiatric side effects of interferon treatment
    • Patten S.B. Psychiatric side effects of interferon treatment. Curr. Drug Saf. 2006, 1:143-150.
    • (2006) Curr. Drug Saf. , vol.1 , pp. 143-150
    • Patten, S.B.1
  • 89
    • 79960225314 scopus 로고    scopus 로고
    • Screening for depression in patients with hepatitis C using the Beck Depression Inventory-II: do somatic symptoms compromise validity?
    • Patterson A.L., Morasco B.J., Fuller B.E., Indest D.W., Loftis J.M., Hauser P. Screening for depression in patients with hepatitis C using the Beck Depression Inventory-II: do somatic symptoms compromise validity?. Gen. Hosp. Psychiatry 2011, 33:354-362.
    • (2011) Gen. Hosp. Psychiatry , vol.33 , pp. 354-362
    • Patterson, A.L.1    Morasco, B.J.2    Fuller, B.E.3    Indest, D.W.4    Loftis, J.M.5    Hauser, P.6
  • 90
    • 14644393659 scopus 로고    scopus 로고
    • Neuropsychiatric adverse effects of interferon-alpha: recognition and management
    • Raison C.L., Demetrashvili M., Capuron L., Miller A.H. Neuropsychiatric adverse effects of interferon-alpha: recognition and management. CNS Drugs 2005, 19:105-123.
    • (2005) CNS Drugs , vol.19 , pp. 105-123
    • Raison, C.L.1    Demetrashvili, M.2    Capuron, L.3    Miller, A.H.4
  • 92
    • 78049442418 scopus 로고    scopus 로고
    • Chronic interferon-alpha administration disrupts sleep continuity and depth in patients with hepatitis C: association with fatigue, motor slowing, and increased evening cortisol
    • Raison C.L., Rye D.B., Woolwine B.J., Vogt G.J., Bautista B.M., Spivey J.R., Miller A.H. Chronic interferon-alpha administration disrupts sleep continuity and depth in patients with hepatitis C: association with fatigue, motor slowing, and increased evening cortisol. Biol. Psychiatry 2010, 68:942-949.
    • (2010) Biol. Psychiatry , vol.68 , pp. 942-949
    • Raison, C.L.1    Rye, D.B.2    Woolwine, B.J.3    Vogt, G.J.4    Bautista, B.M.5    Spivey, J.R.6    Miller, A.H.7
  • 93
    • 66449130960 scopus 로고    scopus 로고
    • Regulation of innate immune responses in the brain
    • Rivest S. Regulation of innate immune responses in the brain. Nat. Rev. Immunol. 2009, 9:429-439.
    • (2009) Nat. Rev. Immunol. , vol.9 , pp. 429-439
    • Rivest, S.1
  • 94
    • 0037088970 scopus 로고    scopus 로고
    • Antidepressant reversal of interferon-alpha-induced anhedonia
    • Sammut S., Bethus I., Goodall G., Muscat R. Antidepressant reversal of interferon-alpha-induced anhedonia. Physiol. Behav. 2002, 75:765-772.
    • (2002) Physiol. Behav. , vol.75 , pp. 765-772
    • Sammut, S.1    Bethus, I.2    Goodall, G.3    Muscat, R.4
  • 95
    • 7444254932 scopus 로고    scopus 로고
    • Serotonin1B receptors: from protein to physiological function and behavior
    • Sari Y. Serotonin1B receptors: from protein to physiological function and behavior. Neurosci. Biobehav. Rev. 2004, 28:565-582.
    • (2004) Neurosci. Biobehav. Rev. , vol.28 , pp. 565-582
    • Sari, Y.1
  • 96
    • 49749101642 scopus 로고    scopus 로고
    • Serum brain-derived neurotrophic factor, depression, and antidepressant medications: meta-analyses and implications
    • Sen S., Duman R., Sanacora G. Serum brain-derived neurotrophic factor, depression, and antidepressant medications: meta-analyses and implications. Biol. Psychiatry 2008, 64:527-532.
    • (2008) Biol. Psychiatry , vol.64 , pp. 527-532
    • Sen, S.1    Duman, R.2    Sanacora, G.3
  • 97
    • 60149086219 scopus 로고    scopus 로고
    • Elevated 5-HT 2A receptors in postmortem prefrontal cortex in major depression is associated with reduced activity of protein kinase A
    • Shelton R.C., Sanders-Bush E., Manier D.H., Lewis D.A. Elevated 5-HT 2A receptors in postmortem prefrontal cortex in major depression is associated with reduced activity of protein kinase A. Neuroscience 2009, 158:1406-1415.
    • (2009) Neuroscience , vol.158 , pp. 1406-1415
    • Shelton, R.C.1    Sanders-Bush, E.2    Manier, D.H.3    Lewis, D.A.4
  • 98
    • 0031040003 scopus 로고    scopus 로고
    • Repeated interferon-alpha administration inhibits dopaminergic neural activity in the mouse brain
    • Shuto H., Kataoka Y., Horikawa T., Fujihara N., Oishi R. Repeated interferon-alpha administration inhibits dopaminergic neural activity in the mouse brain. Brain Res. 1997, 747:348-351.
    • (1997) Brain Res. , vol.747 , pp. 348-351
    • Shuto, H.1    Kataoka, Y.2    Horikawa, T.3    Fujihara, N.4    Oishi, R.5
  • 99
    • 77955926101 scopus 로고    scopus 로고
    • Black sheep get the blues: a psychobiological model of social rejection and depression
    • Slavich G.M., O'Donovan A., Epel E.S., Kemeny M.E. Black sheep get the blues: a psychobiological model of social rejection and depression. Neurosci. Biobehav. Rev. 2010, 35:39-45.
    • (2010) Neurosci. Biobehav. Rev. , vol.35 , pp. 39-45
    • Slavich, G.M.1    O'Donovan, A.2    Epel, E.S.3    Kemeny, M.E.4
  • 100
    • 33750321709 scopus 로고    scopus 로고
    • The etiology of poststroke depression: a review of the literature and a new hypothesis involving inflammatory cytokines
    • Spalletta G., Bossù P., Ciaramella A., Bria P., Caltagirone C., Robinson R.G. The etiology of poststroke depression: a review of the literature and a new hypothesis involving inflammatory cytokines. Mol. Psychiatry 2006, 11:984-991.
    • (2006) Mol. Psychiatry , vol.11 , pp. 984-991
    • Spalletta, G.1    Bossù, P.2    Ciaramella, A.3    Bria, P.4    Caltagirone, C.5    Robinson, R.G.6
  • 101
    • 0031718663 scopus 로고    scopus 로고
    • Inflammation and glial responses in ischemic brain lesions
    • Stoll G., Jander S., Schroeter M. Inflammation and glial responses in ischemic brain lesions. Prog. Neurobiol. 1998, 56:149-171.
    • (1998) Prog. Neurobiol. , vol.56 , pp. 149-171
    • Stoll, G.1    Jander, S.2    Schroeter, M.3
  • 102
    • 4344645758 scopus 로고    scopus 로고
    • Longitudinal course of depression, fatigue, and quality of life in patients with high risk melanoma receiving adjuvant interferon
    • Trask P.C., Paterson A.G., Esper P., Pau J., Redman B. Longitudinal course of depression, fatigue, and quality of life in patients with high risk melanoma receiving adjuvant interferon. Psychooncology 2004, 13:526-536.
    • (2004) Psychooncology , vol.13 , pp. 526-536
    • Trask, P.C.1    Paterson, A.G.2    Esper, P.3    Pau, J.4    Redman, B.5
  • 104
    • 47749113634 scopus 로고    scopus 로고
    • Morphine suppresses intracellular interferon-alpha expression in neuronal cells
    • Wan Q., Wang X., Wang Y.J., Song L., Wang S.H., Ho W.Z. Morphine suppresses intracellular interferon-alpha expression in neuronal cells. J. Neuroimmunol. 2008, 199:1-9.
    • (2008) J. Neuroimmunol. , vol.199 , pp. 1-9
    • Wan, Q.1    Wang, X.2    Wang, Y.J.3    Song, L.4    Wang, S.H.5    Ho, W.Z.6
  • 105
    • 33744937396 scopus 로고    scopus 로고
    • Baseline immune activation as a risk factor for the onset of depression during interferon-alpha treatment
    • Wichers M.C., Kenis G., Leue C., Koek G., Robaeys G., Maes M. Baseline immune activation as a risk factor for the onset of depression during interferon-alpha treatment. Biol. Psychiatry 2006, 60:77-79.
    • (2006) Biol. Psychiatry , vol.60 , pp. 77-79
    • Wichers, M.C.1    Kenis, G.2    Leue, C.3    Koek, G.4    Robaeys, G.5    Maes, M.6
  • 106
    • 33846491758 scopus 로고    scopus 로고
    • Interferon-alpha-induced depressive symptoms are related to changes in the cytokine network but not to cortisol
    • Wichers M.C., Kenis G., Koek G.H., Robaeys G., Nicolson N.A., Maes M. Interferon-alpha-induced depressive symptoms are related to changes in the cytokine network but not to cortisol. J. Psychosom. Res. 2007, 62:207-214.
    • (2007) J. Psychosom. Res. , vol.62 , pp. 207-214
    • Wichers, M.C.1    Kenis, G.2    Koek, G.H.3    Robaeys, G.4    Nicolson, N.A.5    Maes, M.6
  • 107
    • 77957189292 scopus 로고    scopus 로고
    • Activation of brain macrophages/microglia cells in hepatitis C infection
    • Wilkinson J., Radkowski M., Eschbacher J.M., Laskus T. Activation of brain macrophages/microglia cells in hepatitis C infection. Gut 2010, 59:1394-1400.
    • (2010) Gut , vol.59 , pp. 1394-1400
    • Wilkinson, J.1    Radkowski, M.2    Eschbacher, J.M.3    Laskus, T.4
  • 108
    • 0028988111 scopus 로고
    • Microglial localization of alpha-interferon receptor in human brain tissues
    • Yamada T., Yamanaka I. Microglial localization of alpha-interferon receptor in human brain tissues. Neurosci. Lett. 1995, 189:73-76.
    • (1995) Neurosci. Lett. , vol.189 , pp. 73-76
    • Yamada, T.1    Yamanaka, I.2
  • 110
    • 29244478608 scopus 로고    scopus 로고
    • Early increase in mRNA levels of pro-inflammatory cytokines and their interactions in the mouse hippocampus after transient global ischemia
    • Zhu Y., Saito K., Murakami Y., Asano M., Iwakura Y., Seishima M. Early increase in mRNA levels of pro-inflammatory cytokines and their interactions in the mouse hippocampus after transient global ischemia. Neurosci. Lett. 2006, 393:122-126.
    • (2006) Neurosci. Lett. , vol.393 , pp. 122-126
    • Zhu, Y.1    Saito, K.2    Murakami, Y.3    Asano, M.4    Iwakura, Y.5    Seishima, M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.