Antimitotic herbicides bind to an unidentified site on malarial parasite tubulin and block development of liver-stage Plasmodium parasites

Molecular and Biochemical Parasitology

Volumn 188, Issue 2, 2013, Pages 116-127

  Dempsey, Enda ^a   Prudêncio, Miguel ^b   Fennell, Brian J ^a,d   Gomes Santos, Carina S ^b   Barlow, James W ^c   Bell, Angus ^a  

^a Moyne Institute of Preventive Medicine   (Ireland)

^b INSTITUTO DE MEDICINA MOLECULAR   (Portugal)

^c Stephen's Green ^*  (Ireland)

^d PFIZER INC   (United States)

Author keywords

Antimalarial chemotherapy; Malaria; Microtubules; Plasmodium; Tubulin

Indexed keywords

ALPHA TUBULIN; AMINO ACID; AMIPROPHOSMETHYL; ANTIMITOTIC AGENT; HERBICIDE; ORYZALIN; PROTEIN; TUBULIN; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; DISSOCIATION CONSTANT; DRUG ACTIVITY; DRUG PROTEIN BINDING; ESCHERICHIA COLI; FLUORESCENCE SPECTROSCOPY; HUMAN; HUMAN CELL; LIFE CYCLE STAGE; NONHUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTEIN STRUCTURE; SITE DIRECTED MUTAGENESIS; WILD TYPE;

ANTIPROTOZOAL AGENTS; BINDING SITES; CELL LINE; DNA MUTATIONAL ANALYSIS; HEPATOCYTES; HERBICIDES; HUMANS; MUTAGENESIS, SITE-DIRECTED; PLASMODIUM FALCIPARUM; PROTEIN BINDING; TUBULIN;

ESCHERICHIA COLI; MAMMALIA; PLASMODIUM FALCIPARUM; PLASMODIUM PARASITES;

EID: 84878111842     PISSN: 01666851     EISSN: 18729428     Source Type: Journal    
DOI: 10.1016/j.molbiopara.2013.03.001     Document Type: Article

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