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Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 12, 2013, Pages 3620-3626

The use of virtual screening and differential scanning fluorimetry for the rapid identification of fragments active against MEK1

(15) Amaning, Kwame a Lowinski, Maryse a Vallee, Francois a Steier, Valerie a Marcireau, Christophe b Ugolini, Antonio b Delorme, Cecile b Foucalt, Frédéric b McCort, Gary b Derimay, Nathalie c Andouche, Cyrielle c Vougier, Stephanie d Llopart, Sylvie e Halland, Nis f Rak, Alexey a

a SANOFI (France)

b Oncology Group (France)

c Lead Identification Technologies (France)

d Lead Identification Technologies (France)

e Protein Production and Characterisation (France)

f Parallel Synthesis and Natural Product Chemistry (Germany)

Author keywords

Differential scanning fluorimetry; Fragment screening; MEK1; Virtual screening

Indexed keywords

ENZYME INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1 INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; COMPUTER MODEL; COST EFFECTIVENESS ANALYSIS; DIFFERENTIAL SCANNING FLUORIMETRY; FLUOROMETRY; IC 50; SCREENING; VALIDATION STUDY; VIRTUAL REALITY; WORKFLOW; X RAY CRYSTALLOGRAPHY;

CRYSTALLOGRAPHY, X-RAY; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; FLUOROMETRY; HUMANS; MAP KINASE KINASE 1; MODELS, MOLECULAR; PHOSPHORYLATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84878105999 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2013.04.003 Document Type: Article

Times cited : (21)

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