Conformation and atropisomeric properties of indometacin derivatives

Chemistry - A European Journal

Volumn 19, Issue 22, 2013, Pages 7056-7063

  Wakamatsu, Shintaro ^a   Takahashi, Yuka ^a   Tabata, Hidetsugu ^a   Oshitari, Tetsuta ^a   Tani, Norihiko ^a   Azumaya, Isao ^b   Katsumoto, Yukiteru ^c   Tanaka, Takeyuki ^d   Hosoi, Shinzo ^e   Natsugari, Hideaki ^a   Takahashi, Hideyo ^a  

^a TEIKYO UNIVERSITY   (Japan)

^b TOKUSHIMA BUNRI UNIVERSITY   (Japan)

^c HIROSHIMA UNIVERSITY   (Japan)

^d EHIME UNIVERSITY   (Japan)

^e KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

chirality; conformational analysis; drug design; nitrogen heterocycles; stereochemistry

Indexed keywords

ATROPISOMERS; BIOACTIVE CONFORMATION; CONFORMATIONAL ANALYSIS; CYCLOOXYGENASE 2; DRUG DESIGN; INDOLE MOIETY; NITROGEN HETEROCYCLES; NMR STUDIES;

CHIRALITY; STEREOCHEMISTRY; STEREOSELECTIVITY; X RAY CRYSTALLOGRAPHY;

CONFORMATIONS;

DRUG DERIVATIVE; INDOMETACIN; PROSTAGLANDIN SYNTHASE INHIBITOR;

ARTICLE; CHEMISTRY; CONFORMATION; DRUG DESIGN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

CRYSTALLOGRAPHY, X-RAY; CYCLOOXYGENASE INHIBITORS; DRUG DESIGN; INDOMETHACIN; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR CONFORMATION; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84878088708     PISSN: 09476539     EISSN: 15213765     Source Type: Journal    
DOI: 10.1002/chem.201300064     Document Type: Article

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