Indomethacin analogues that enhance doxorubicin cytotoxicity in multidrug resistant cells without cox inhibitory activity

ACS Medicinal Chemistry Letters

Volumn 2, Issue 5, 2011, Pages 353-357

  Arisawa, Mitsuhiro ^a   Kasaya, Yayoi ^a   Obata, Tohru ^b   Sasaki, Takuma ^b   Ito, Mika ^a,c   Abe, Hiroshi ^c   Ito, Yoshihiro ^c   Yamano, Akihito ^d   Shuto, Satoshi ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b AICHI GAKUIN UNIVERSITY   (Japan)

^c RIKEN   (Japan)

^d RIGAKU CORPORATION   (Japan)

Author keywords

Cancer; conformation analysis; cytotoxicity; drug design; nitrogen heterocycles

Indexed keywords

CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; DOXORUBICIN; INDOLE; INDOMETACIN; MULTIDRUG RESISTANCE PROTEIN 1; NONSTEROID ANTIINFLAMMATORY AGENT;

ARTICLE; BIOLOGICAL ACTIVITY; DRUG ACTIVITY; DRUG CONFORMATION; DRUG CYTOTOXICITY; DRUG INHIBITION; ISOMERIZATION; MULTIDRUG RESISTANCE; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; X RAY CRYSTALLOGRAPHY;

EID: 79956090533     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml100292y     Document Type: Article

References (21)

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