Design and synthesis of indomethacin analogues that inhibit P-glycoprotein and/or multidrug resistant protein without Cox inhibitory activity

Journal of Medicinal Chemistry

Volumn 55, Issue 18, 2012, Pages 8152-8163

  Arisawa, Mitsuhiro ^a   Kasaya, Yayoi ^a   Obata, Tohru ^b   Sasaki, Takuma ^b   Nakamura, Tomonori ^c   Araki, Takuya ^c   Yamamoto, Koujirou ^c   Sasaki, Akito ^d   Yamano, Akihito ^d   Ito, Mika ^a,e   Abe, Hiroshi ^e   Ito, Yoshihiro ^e   Shuto, Satoshi ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b AICHI GAKUIN UNIVERSITY   (Japan)

^c GUNMA UNIVERSITY   (Japan)

^d RIGAKU CORPORATION   (Japan)

^e RIKEN   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1 (4 CHLOROBENZOYL) 7 ETHYL 2 METHYLINDOLE 3 YL ACETIC ACID; 1 (4 CHLOROBENZOYL) 7 METHOXY 2 METHYLINDOLE 3 YL ACETIC ACID; 2 [1 (4 CHLOROBENZOYL) 2 ETHYLINDOL 3 YL]ACETIC ACID; 2 [1 (4 CHLOROBENZOYL) 2 METHYLINDOL 3 YL]ACETIC ACID; 2 [1 (4 CHLOROBENZOYL) 2 PHENYLINDOLE 3 YL]ACETIC ACID; 2 [1 (4 CHLOROBENZOYL) 2,7 DIMETHYLINDOLE 3 YL]ACETIC ACID; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; DOXORUBICIN; INDOMETACIN; MULTIDRUG RESISTANCE PROTEIN; NONSTEROID ANTIINFLAMMATORY AGENT; PROSTAGLANDIN SYNTHASE; UNCLASSIFIED DRUG;

ARTICLE; CYTOTOXICITY; DENSITY FUNCTIONAL THEORY; DRUG ACTIVITY; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; HUMAN; HUMAN CELL; ISOMER; PROTON NUCLEAR MAGNETIC RESONANCE; X RAY ANALYSIS;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CELL LINE, TUMOR; CHEMISTRY TECHNIQUES, SYNTHETIC; CYCLOOXYGENASE INHIBITORS; DRUG DESIGN; DRUG RESISTANCE, MULTIPLE; HUMANS; INDOMETHACIN; MODELS, MOLECULAR; MOLECULAR CONFORMATION; P-GLYCOPROTEIN; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES;

EID: 84866852586     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm301084z     Document Type: Article

References (38)

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