Chemoembolization agents for cancer treatment

European Journal of Pharmaceutical Sciences

Volumn 44, Issue 1-2, 2011, Pages 1-10

  Tam, Kin Y ^a   Leung, Ken Cham Fai ^b   Wang, Yi Xiang J ^c  

^a ASTRAZENECA   (United Kingdom)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^c CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Chemoembolization; Drug eluting particles; Hepatocellular carcinoma; Lipiodol; Microspheres

Indexed keywords

ANTINEOPLASTIC AGENT; DAUNORUBICIN; DC BEAD; DOXORUBICIN; FLUOROURACIL; GELATIN SPONGE; GELFOAM; HEPASPHERE; IODINATED POPPYSEED OIL; IRINOTECAN; LIPIODOL ULTRA FLUID; MEGLUMINE DIATRIZOATE; MICROSPHERE; POLYVINYL ALCOHOL; STARCH; UNCLASSIFIED DRUG;

CANCER SURVIVAL; CANCER THERAPY; CHEMOEMBOLIZATION; CONFERENCE PAPER; CONTROLLED RELEASE FORMULATION; DRUG DELIVERY SYSTEM; HUMAN; LIVER CANCER; NEOPLASM; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTINEOPLASTIC AGENTS; CHEMOEMBOLIZATION, THERAPEUTIC; DRUG CARRIERS; HUMANS; NEOPLASMS; RANDOMIZED CONTROLLED TRIALS AS TOPIC;

EID: 80052031234     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2011.06.013     Document Type: Conference Paper

References (77)

1. R. Adam, E.J. Hagopian, M. Linhares, J. Krissat, E. Savier, D. Azoulay, F. Kunstlinger, D. Castaing, and H. Bismuth A comparison of percutaneous cryosurgery and percutaneous radiofrequency for unresectable hepatic malignancies Arch. Surg. 137 2002 1332 1339 1340
2. R. Adam, V. Lucidi, and H. Bismuth Hepatic colorectal metastases: methods of improving resectability Surg. Clin. North Am. 84 2004 659 671 (Pubitemid 38388289)
3. D.L. Bartlett, J. Berlin, G.Y. Lauwers, W.A. Messersmith, N.J. Petrelli, and A.P. Venook Chemotherapy and regional therapy of hepatic colorectal metastases: expert consensus statement Ann. Surg. Oncol. 13 2006 1284 1292 (Pubitemid 44435795)
4. P. Bastian, R. Bartkowski, H. Kohler, and T. Kissel Chemo-embolization of experimental liver metastases. Part I: distribution of biodegradable microspheres of different sizes in an animal model for the locoregional therapy Eur. J. Pharm. Biopharm. 46 1998 243 254 (Pubitemid 29057670)
5. S. Bhattacharya, J.R. Novell, M.C. Winslet, and K.E. Hobbs Iodized oil in the treatment of hepatocellular carcinoma Br. J. Surg. 81 1994 1563 1571 (Pubitemid 24349924)
6. G. Bonomo, V. Pedicini, L. Monfardini, V.P. Della, D. Poretti, G. Orgera, and F. Orsi Bland embolization in patients with unresectable hepatocellular carcinoma using precise, tightly size-calibrated, anti-inflammatory microparticles: first clinical experience and one-year follow-up Cardiovasc. Intervent. Radiol. 33 2010 552 559
7. F.X. Bosch, J. Ribes, and J. Borras Epidemiology of primary liver cancer Semin. Liver Dis. 19 1999 271 285 (Pubitemid 29488770)
8. C. Breedos, and G. Young The blood supply of neoplasms in the liver Am. J. Pathol. 30 1954 969 977
9. D.B. Brown, T.K. Pilgram, M.D. Darcy, C.E. Fundakowski, M. Lisker-Melman, W.C. Chapman, and J.S. Crippin Hepatic arterial chemoembolization for hepatocellular carcinoma: comparison of survival rates with different embolic agents J. Vasc. Interv. Radiol. 16 2005 1661 1666 (Pubitemid 44431163)
10. I. Burger, K. Hong, R. Schulick, C. Georgiades, P. Thuluvath, M. Choti, I. Kamel, and J.F. Geschwind Transcatheter arterial chemoembolisation in unresectable cholangiocarcinoma: initial experience in a single institution J. Vasc. Interv. Radiol. 16 2005 353 361 (Pubitemid 40354852)
11. C. Camma, F. Schepis, A. Orlando, M. Albanese, L. Shahied, F. Trevisani, P. Andreone, A. Craxi, and M. Cottone Transarterial chemoembolization for unresectable hepatocellular carcinoma: meta-analysis of randomized controlled trials Radiology 224 2002 47 54 (Pubitemid 34680374)
12. B.I. Carr Hepatic arterial 90Yttrium glass microspheres (Therasphere) for unresectable hepatocellular carcinoma: interim safety and survival data on 65 patients Liver Transpl. 10 2004 S107 S110
13. D.H. Choe, M.H. Han, G.H. Kang, K.M. Yeon, and M.C. Han An experimental study of embolic effect according to infusion rate and concentration of suspension in transarterial particulate embolization Invest. Radiol. 32 5 1997 260 267 (Pubitemid 27188326)
14. A.O. Chan, M.F. Yuen, C.K. Hui, W.K. Tso, and C.L. Lai A prospective study regarding the complications of transcatheter intraarterial lipiodol chemoembolization in patients with hepatocellular carcinoma Cancer 94 2002 1747 1752 (Pubitemid 34241113)
15. J.W. Chung Transcatheter arterial chemoembolization of hepatocellular carcinoma Hepatogastroenterology 45 Suppl. 3 1998 1236 1241 (Pubitemid 28372106)
16. D.M. Coldwell, K.R. Stokes, and W.F. Yakes Embolotherapy: agents, clinical applications, and techniques Radiographics 14 623-643 1994 645 646
17. M. Constantin, G. Fundueanu, F. Bortolotti, R. Cortesi, P. Ascenzi, and E. Menegatti Preparation and characterisation of poly(vinyl alcohol)/ cyclodextrin microspheres as matrix for inclusion and separation of drugs Int. J. Pharm. 285 2004 87 96 (Pubitemid 39361539)
18. G.S. Davidson, and K.G. Terbrugge Histologic long-term follow-up after embolization with polyvinyl alcohol particles Am. J. Neuroradiol. 16 1995 843 846
19. J.L. Doppman, N.R. Dunnick, M. Girton, A.S. Fauci, and M.A. Popovsky Bile duct cysts secondary to liver infarcts: report of a case and experimental production by small vessel hepatic artery occlusion Radiology 130 1979 1 5 (Pubitemid 9087316)
20. A.A. Exner, and G.M. Saidel Drug-eluting polymer implants in cancer therapy Expert Opin. Drug Deliv. 5 2008 775 788
21. K. Fujiwara, K. Hayakawa, Y. Nagata, M. Hiraoka, T. Nakamura, Y. Shimizu, and Y. Ikada Experimental embolization of rabbit renal arteries to compare the effects of poly l-lactic acid microspheres with and without epirubicin release against intraarterial injection of epirubicin Cardiovasc. Intervent. Radiol. 23 2000 218 223 (Pubitemid 30421902)
22. J. Gao, F. Qian, A. Szymanski-Exner, N. Stowe, and J. Haaga In vivo drug distribution dynamics in thermoablated and normal rabbit livers from biodegradable polymers J. Biomed. Mater. Res. 62 2002 308 314 (Pubitemid 34988509)
23. C.S. Georgiades, K. Hong, M. D'Angelo, and J.F. Geschwind Safety and efficacy of transarterial chemoembolization in patients with unresectable hepatocellular carcinoma and portal vein thrombosis J. Vasc. Interv. Radiol. 16 2005 1653 1659 (Pubitemid 44431162)
24. M.F. Giroux, R.A. Soulen, and M.C. Soulen Chemoembolization of liver metastasis from breast carcinoma J. Vasc. Interv. Radiol. 15 2004 289 291 (Pubitemid 38316452)
25. M.V. Gonzalez, Y. Tang, G.J. Phillips, A.W. Lloyd, B. Hall, P.W. Stratford, and A.L. Lewis Doxorubicin eluting beads-2: methods for evaluating drug elution and in-vitro:in-vivo correlation J. Mater. Sci. 19 2008 767 775 (Pubitemid 351244006)
26. M. Grosso, C. Vignali, P. Quaretti, A. Nicolini, F. Melchiorre, G. Gallarato, I. Bargellini, P. Petruzzi, S.C. Massa, S. Crespi, and I. Sarti Transarterial chemoembolization for hepatocellular carcinoma with drug-eluting microspheres: preliminary results from an Italian multicentre study Cardiovasc. Intervent. Radiol. 31 2008 1141 1149
27. J.R. Haaga, A.A. Exner, Y. Wang, N.T. Stowe, and P.J. Tarcha Combined tumor therapy by using radiofrequency ablation and 5-FU-laden polymer implants: evaluation in rats and rabbits Radiology 237 2005 911 918 (Pubitemid 41636381)
28. K. Hong, A. Khwaja, E. Liapi, M.S. Torbenson, C.S. Georgiades, and J.F. Geschwind New intra-arterial drug delivery system for the treatment of liver cancer: preclinical assessment in a rabbit model of liver cancer Clin Cancer Res 12 2006 2563 2567
29. G.N. Hortobagyi Anthracyclines in the treatment of cancer. An overview Drugs 54 Suppl. 4 1997 1 7 (Pubitemid 27487789)
30. L. Illum, and S.S. Davis The targeting of drugs parenterally by use of microspheres J. Parenter. Sci. Technol. 36 1982 242 248 (Pubitemid 13202991)
31. T. Kanematsu, K. Inokuchi, K. Sugimachi, T. Furuta, T. Sonoda, S. Tamura, and K. Hasuo Selective effects of lipiodolized antitumor agents J. Surg. Oncol. 25 1984 218 226 (Pubitemid 14132618)
32. J. Kettenbach, A. Stadler, I.V. Katzler, R. Schernthaner, M. Blum, J. Lammer, and T. Rand Drug-loaded microspheres for the treatment of liver cancer: review of current results Cardiovasc. Intervent. Radiol. 31 2008 468 476
33. J.H. Kim, J.W. Chung, J.K. Han, J.H. Park, B.I. Choi, and M.C. Han Transcatheter arterial embolization of the internal mammary artery in hepatocellular carcinoma J. Vasc. Interv. Radiol. 6 71-74 1995 75 77
34. T.D. Kirchhoff, J.S. Bleck, A. Dettmer, A. Chavan, H. Rosenthal, S. Merkesdal, B. Frericks, L. Zender, N.P. Malek, T.F. Greten, S. Kubicka, M.P. Manns, and M. Galanski Transarterial chemoembolization using degradable starch microspheres and iodized oil in the treatment of advanced hepatocellular carcinoma: evaluation of tumor response, toxicity, and survival Hepatobiliary Pancreat. Dis. Int. 6 2007 259 266 (Pubitemid 46925246)
35. J. Lammer, K. Malagari, T. Vogl, F. Pilleul, A. Denys, A. Watkinson, M. Pitton, G. Sergent, T. Pfammatter, S. Terraz, Y. Benhamou, Y. Avajon, T. Gruenberger, M. Pomoni, H. Langenberger, M. Schuchmann, J. Dumortier, C. Mueller, P. Chevallier, R. Lencioni, and P.V. Investigators Prospective randomized study of doxorubicin-eluting-bead embolization in the treatment of hepatocellular carcinoma: results of the PRECISION V study Cardiovasc. Intervent. Radiol. 33 2010 41 52
36. A.L. Lewis, M.V. Gonzalez, S.W. Leppard, J.E. Brown, P.W. Stratford, G.J. Phillips, and A.W. Lloyd Doxorubicin eluting beads-1: effects of drug loading on bead characteristics and drug distribution J. Mater. Sci. Mater. 18 2007 1691 1699 (Pubitemid 47224923)
37. A.L. Lewis, M.V. Gonzalez, A.W. Lloyd, B. Hall, Y.Q. Tang, S.L. Willis, S.W. Leppard, L.C. Wolfenden, R.R. Palmer, and P.W. Stratford DC bead: in vitro characterization of a drug-delivery device for transarterial chemoembolization J. Vasc. Interv. Radiol. 17 2006 335 342 (Pubitemid 44341453)
38. A.L. Lewis, R.R. Taylor, B. Hall, M.V. Gonzalez, S.L. Willis, and P.W. Stratford Pharmacokinetic and safety study of doxorubicin-eluting beads in a porcine model of hepatic arterial embolization J. Vasc. Interv. Radiol. 17 2006 1335 1343 (Pubitemid 44259017)
39. J.M. Llovet, and J. Bruix Systematic review of randomized trials for unresectable hepatocellular carcinoma: chemoembolization improves survival Hepatology 37 2003 429 442 (Pubitemid 36152543)
40. J.M. Llovet, M.I. Real, X. Montana, R. Planas, S. Coll, J. Aponte, C. Ayuso, M. Sala, J. Muchart, R. Sola, J. Rodes, and J. Bruix Arterial embolisation or chemoembolisation versus symptomatic treatment in patients with unresectable hepatocellular carcinoma: a randomised controlled trial Lancet 359 2002 1734 1739 (Pubitemid 34607087)
41. C.M. Lo, H. Ngan, W.K. Tso, C.L. Liu, C.M. Lam, R.T. Poon, S.T. Fan, and J. Wong Randomized controlled trial of transarterial lipiodol chemoembolization for unresectable hepatocellular carcinoma Hepatology 35 2002 1164 1171 (Pubitemid 34454013)
42. R. Lopez-Benitez, G.M. Richter, H.U. Kauczor, S. Stampfl, J. Kladeck, B.A. Radeleff, M. Neukamm, and P.J. Hallscheidt Analysis of nontarget embolization mechanisms during embolization and chemoembolization procedures Cardiovasc. Intervent. Radiol. 32 2009 615 622
43. M. Makuuchi, M. Sukigara, T. Mori, J. Kobayashi, S. Yamazaki, H. Hasegawa, N. Moriyama, K. Takayasu, and S. Hirohashi Bile duct necrosis: complication of transcatheter hepatic arterial embolization Radiology 156 1985 331 334 (Pubitemid 15029758)
44. K. Malagari, K. Chatzimichail, E. Alexopoulou, G. Economou, D. Letsou, V. Vergadis, D. Loggitsi, D. Kelekis, and A. Gouliamos Hepatocellular carcinoma chemoembolization with DC beads Eur. Radiol. 16 2006 24
45. K. Malagari Drug-eluting particles in the treatment of HCC: chemoembolization with doxorubicin-loaded DC Bead (TM) Expert Rev. Anticancer Ther. 8 2008 1643 1650
46. A. Mazziotti, G.L. Grazi, and A. Cavallari Surgical treatment of hepatocellular carcinoma on cirrhosis: a Western experience Hepatogastroenterology 45 Suppl. 3 1998 1281 1287 (Pubitemid 28372114)
47. S. Miyayama, O. Matsui, M. Yamashiro, Y. Ryu, K. Kaito, K. Ozaki, T. Takeda, N. Yoneda, K. Notsumata, D. Toya, N. Tanaka, and T. Mitsui Ultraselective transcatheter arterial chemoembolization with a 2-F tip microcatheter for small hepatocellular carcinomas: relationship between local tumor recurrence and visualization of the portal vein with iodized oil J. Vasc. Interv. Radiol. 18 2007 365 376 (Pubitemid 46616707)
48. H. Nakamura, T. Hashimoto, H. Oi, and S. Sawada Transcatheter oily chemoembolization of hepatocellular carcinoma Radiology 170 1989 783 786 (Pubitemid 19062602)
49. H. Nakamura, T. Tanaka, S. Hori, H. Yoshioka, C. Kuroda, J. Okamura, and M. Sakurai Transcatheter embolization of hepatocellular carcinoma: assessment of efficacy in cases of resection following embolization Radiology 147 1983 401 405 (Pubitemid 13133211)
50. T. Nakashima, and M. Kojiro Pathologic characteristics of hepatocellular carcinoma Semin. Liver Dis. 6 1986 259 266 (Pubitemid 17203554)
51. K. Ohnishi, H. Yoshioka, S. Ito, and K. Fujiwara Prospective randomized controlled trial comparing percutaneous acetic acid injection and percutaneous ethanol injection for small hepatocellular carcinoma Hepatology 27 1998 67 72 (Pubitemid 28041536)
52. K. Osuga, A.A. Khankan, S. Hori, A. Okada, T. Sugiura, M. Maeda, H. Nagano, A. Yamada, T. Murakami, and H. Nakamura Transarterial embolization for large hepatocellular carcinoma with use of superabsorbent polymer microspheres: Initial experience J. Vasc. Interv. Radiol. 13 2002 929 934
53. C.M. Pacella, G. Bizzarri, F. Magnolfi, P. Cecconi, B. Caspani, V. Anelli, A. Bianchini, D. Valle, S. Pacella, G. Manenti, and Z. Rossi Laser thermal ablation in the treatment of small hepatocellular carcinoma: results in 74 patients Radiology 221 2001 712 720 (Pubitemid 33101763)
54. D.M. Parkin, F. Bray, J. Ferlay, and P. Pisani Estimating the world cancer burden: Globocan 2000 Int. J. Cancer 94 2001 153 156 (Pubitemid 32911406)
55. J. Qian, L. Truebenbach, F. Graepler, P. Pereira, P. Huppert, T. Eul, G. Wiemann, and C. Claussen Application of poly-lactide-co-glycolide-microspheres in the transarterial chemoembolization in an animal model of hepatocellular carcinoma World J. Gastroenterol. 9 2003 94 98 (Pubitemid 36131286)
56. D.K. Rajan, M.C. Soulen, T.W. Clark, R.A. Baum, Z.J. Haskal, R.D. Shlansky-Goldberg, and D.B. Freiman Sarcomas metastatic to the liver: response and survival after cisplatin, doxorubicin, mitomycin-C, ethiodol, and polyvinyl alcohol chemoembolization J. Vasc. Interv. Radiol. 12 2001 187 193 (Pubitemid 32167780)
57. T. Rand, C. Loewe, M. Schoder, M.T. Schmook, M. Peck-Radosavljevic, J. Kettenbach, F. Wolf, B. Schneider, and J. Lammer Arterial embolization of unresectable hepatocellular carcinoma with use of microspheres, lipiodol, and cyanoacrylate Cardiovasc. Intervent. Radiol. 28 2005 313 318 (Pubitemid 40880750)
58. J.L. Raoul, D. Heresbach, J.F. Bretagne, D.B. Ferrer, R. Duvauferrier, P. Bourguet, M. Messner, and M. Gosselin Chemoembolization of hepatocellular carcinomas. A study of the biodistribution and pharmacokinetics of doxorubicin Cancer 70 1992 585 590
59. M. Sadick, S. Haas, M. Loehr, M. Elshwi, M.V. Singer, J. Brade, S.O. Schoenberg, and S.J. Diehl Application of DC beads in hepatocellular carcinoma: clinical and radiological results of a drug delivery device for transcatheter superselective arterial embolization Onkologie 33 2010 31 37
60. Y. Sasaki, S. Imaoka, H. Kasugai, M. Fujita, S. Kawamoto, S. Ishiguro, J. Kojima, O. Ishikawa, H. Ohigashi, H. Furukawa, H. Koyama, and T. Iwanaga A new approach to chemoembolization therapy for hepatoma using ethiodized oil, cisplatin, and gelatin sponge Cancer 60 1987 1194 1203 (Pubitemid 17152894)
61. T. Seki, M. Wakabayashi, T. Nakagawa, M. Imamura, T. Tamai, A. Nishimura, N. Yamashiki, A. Okamura, and K. Inoue Percutaneous microwave coagulation therapy for patients with small hepatocellular carcinoma: comparison with percutaneous ethanol injection therapy Cancer 85 1999 1694 1702 (Pubitemid 29169669)
62. T. Shibata, Y. Iimuro, Y. Yamamoto, Y. Maetani, F. Ametani, K. Itoh, and J. Konishi Small hepatocellular carcinoma: comparison of radio-frequency ablation and percutaneous microwave coagulation therapy Radiology 223 2002 331 337 (Pubitemid 34454307)
63. S.W. Shin The current practice of transarterial chemoembolization for the treatment of hepatocellular carcinoma Korean J. Radiol. 10 2009 425 434
64. G.P. Siskin, K. Dowling, R. Virmani, R. Jones, and D. Todd Pathologic evaluation of a spherical polyvinyl alcohol embolic agent in a porcine renal model J. Vasc. Interv. Radiol. 14 2003 89 98 (Pubitemid 36134079)
65. T. Sonomura Optimal size of embolic material in transcatheter arterial embolization of the liver Nippon Igaku Hoshasen Gakkai Zasshi 54 1994 489 499
66. J. Steel, A. Baum, and B. Carr Quality of life in patients diagnosed with primary hepatocellular carcinoma: hepatic arterial infusion of Cisplatin versus 90-Yttrium microspheres (Therasphere) Psychooncology 13 2004 73 79 (Pubitemid 38247763)
67. R.R. Taylor, Y.Q. Tang, M.V. Gonzalez, P.W. Stratford, and A.L. Lewis Irinotecan drug eluting beads for use in chemoembolization: in vitro and in vivo evaluation of drug release properties Eur. J. Pharm. Sci. 30 2007 7 14 (Pubitemid 44908921)
68. C. Tellez, A.B. Benson, M.T. Lyster, M. Talamonti, J. Shaw, M.A. Braun, A.A. Nemcek, and R.L. Vogelzang Phase II trial of chemoembolization for the treatment of metastatic colorectal carcinoma to the liver and review of the literature Cancer 82 1998 1250 1259 (Pubitemid 28155386)
69. Y. Tang, R.R. Taylor, M.V. Gonzalez, A.L. Lewis, and PW. Stratford Evaluation of irinotecan drug-eluting beads: a new drug-device combination product for the chemoembolization of hepatic metastases J. Controlled Release 116 2 2006 e55 e56
70. J.N. Vallee, D. Lo, R. Guillevin, P. Reb, C. Adem, and J. Chiras In vitro study of the compatibility of tris-acryl gelatin microspheres with various chemotherapeutic agents J. Vasc. Interv. Radiol. 14 2003 621 628 (Pubitemid 36618029)
71. M. Varela, M.I. Real, M. Burrel, A. Forner, M. Sala, M. Brunet, C. Ayuso, L. Castells, X. Montana, J.M. Llovet, and J. Bruix Chemoembolization of hepatocellular carcinoma with drug eluting beads: efficacy and doxorubicin pharmacokinetics J. Hepatol. 46 2007 474 481 (Pubitemid 46201723)
72. T.J. Vogl, S. Zangos, K. Eichler, D. Yakoub, and M. Nabil Colorectal liver metastases: regional chemotherapy via transarterial chemoembolization (TACE) and hepatic chemoperfusion: an update Eur. Radiol. 17 2007 1025 1034 (Pubitemid 46766884)
73. T.J. Vogl, T. Gruber, N.N. Naguib, R. Hammerstingl, and N.E. Nour-Eldin Liver metastases of neuroendocrine tumors: treatment with hepatic transarterial chemotherapy using two therapeutic protocols Am. J. Roentgenol. 193 2009 941 947
74. D.D. Von Hoff, M.W. Layard, P. Basa, H.J. Davis, A.L. Von Hoff, M. Rozencweig, and F.M. Muggia Risk factors for doxorubicin-induced congestive heart failure Ann. Intern. Med. 91 1979 710 717 (Pubitemid 10218041)
75. B.D. Weinberg, E. Blanc, and J.M. Ga Polymer implants for intratumoral drug delivery and cancer therapy J. Pharm. Sci. 97 2008 1681 1702
76. R. Yamada, M. Sato, M. Kawabata, H. Nakatsuka, K. Nakamura, and S. Takashima Hepatic artery embolization in 120 patients with unresectable hepatoma Radiology 148 1983 397 401 (Pubitemid 13073577)
77. N. Yamashita, K. Saitou, A. Takagi, and A. Maruyama Preparation and characterization of gelatin sponge millispheres injectable through microcatheters Med. Devices Evid. Res. 2 2009 19 25