Comparative Study of Chemoembolization Loadable Beads: In vitro Drug Release and Physical Properties of DC Bead and Hepasphere Loaded with Doxorubicin and Irinotecan

Journal of Vascular and Interventional Radiology

Volumn 21, Issue 7, 2010, Pages 1084-1090

  Jordan, Olivier ^a   Denys, Alban ^b   De Baere, Thierry ^c   Boulens, Nathalie ^a   Doelker, Eric ^a  

^a UNIVERSITY OF GENEVA   (Switzerland)

^b LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^c INSTITUT GUSTAVE ROUSSY   (France)

Author keywords

[No Author keywords available]

Indexed keywords

DC BEAD; DOXORUBICIN; HEPASPHERE; IRINOTECAN; MICROSPHERE; SODIUM CHLORIDE; UNCLASSIFIED DRUG;

ARTICLE; CHEMOEMBOLIZATION; COMPARATIVE STUDY; COMPRESSION; DRUG RELEASE; MICROSCOPY; PARTICLE SIZE; PRIORITY JOURNAL; SPECTROPHOTOMETRY;

ABSORPTION; ANTIBIOTICS, ANTINEOPLASTIC; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CAMPTOTHECIN; CAPSULES; DELAYED-ACTION PREPARATIONS; DIFFUSION; DOXORUBICIN; DRUG COMBINATIONS; DRUG COMPOUNDING; EMBOLIZATION, THERAPEUTIC; HARDNESS;

EID: 77953855570     PISSN: 10510443     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jvir.2010.02.042     Document Type: Article

References (15)

1. Kato T., Sato K., Sasaki R., Kakinuma H., and Moriyama M. Targeted cancer chemotherapy with arterial microcapsule chemoembolization: review of 1013 patients. Cancer Chemother Pharmacol 37 (1996) 289-296
2. Lammer J., Malagari K., Vogl T., et al. Prospective randomized study of doxorubicin-eluting-bead embolization in the treatment of hepatocellular carcinoma: results of the Precision V study. Cardiovasc Intervent Radiol 33 (2010) 41-52
3. Saenger J., Leible M., Seelig M.H., and Berger M.R. Chemoembolization of rat liver metastasis with irinotecan and quantification of tumor cell reduction. J Cancer Res Clin Oncol 130 (2004) 203-210
4. Fiorentini G., Aliberti C., Turrisi G., et al. Intraarterial hepatic chemoembolization of liver metastases from colorectal cancer adopting irinotecan-eluting beads: results of a phase II clinical study. In Vivo 21 (2007) 1085-1091
5. Eyol E., Boleij A., Taylor R.R., Lewis A.L., and Berger M.R. Chemoembolisation of rat colorectal liver metastases with drug eluting beads loaded with irinotecan or doxorubicin. Clin Exp Metastasis 25 (2008) 273-282
6. Lewis A.L., Gonzalez M.V., Lloyd A.W., et al. DC Bead: in vitro characterization of a drug-delivery device for transarterial chemoembolization. J Vasc Interv Radiol 17 (2006) 335-342
7. Lewis A.L., Gonzalez M., Leppard S., et al. Doxorubicin eluting beads. I. Effects of drug loading on bead characteristics and drug distribution. J Mat Sci Mat Med 18 (2007) 1691-1699
8. Gonzalez M., Tang Y., Phillips G., et al. Doxorubicin eluting beads. II. Methods for evaluating drug elution and in-vitro:in-vivo correlation. J Mat Sci Mat Med 19 (2007) 767-775
9. Tang Y., Taylor R.R., Gonzalez M.V., Lewis A.L., and Stratford P.W. Evaluation of irinotecan drug-eluting beads: a new drug-device combination product for the chemoembolization of hepatic metastases. J Control Release 116 (2006) e55-e56
10. Taylor R.R., Tang Y., Gonzalez M.V., Stratford P.W., and Lewis A.L. Irinotecan drug eluting beads for use in chemoembolization: in vitro and in vivo evaluation of drug release properties. Eur J Pharm Sci 30 (2007) 7-14
11. Jiaqi Y., Hori S., Minamitani K., et al. A new embolic material: super absorbent polymer (SAP) microsphere and its embolic effects. Nippon Igaku Hoshasen Gakkai Zasshi 56 (1996) 19-24
12. Grosso M., Vignali C., Quaretti P., et al. Transarterial chemoembolization for hepatocellular carcinoma with drug-eluting microspheres: preliminary results from an Italian multicentre study. Cardiovasc Intervent Radiol 31 (2008) 1141-1149
13. U.S. Food and Drug Administration. Guidance for industry CMC5-1995: immediate release solid oral dosage forms (1995). http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/ucm070636.pdf Accessed May 26, 2010
14. Shah V.P., Tsong Y., Sathe P., and Liu J.P. In vitro dissolution profile comparison:- statistics and analysis of the similarity factor, f2. Pharm Res 15 (1998) 889-896
15. Liu Z., Cheung R., Wu X.Y., Ballinger J.R., Bendayan R., and Rauth A.M. A study of doxorubicin loading onto and release from sulfopropyl dextran ion-exchange microspheres. J Control Release 77 (2001) 213-224