Role of mechanical-stress inducible protein Hcs24/CTGF/CCN2 in cartilage growth and regeneration: Mechanical stress induces expression of Hcs24/CTGF/CCN2 in a human chondrocytic cell line HCS-2/8, rabbit costal chondrocytes and meniscus tissue cells

Biorheology

Volumn 45, Issue 3-4, 2008, Pages 289-299

  Nishida, Takashi ^a   Maeda, Azusa ^a   Kubota, Satoshi ^a   Takigawa, Masaharu ^a  

^a OKAYAMA UNIVERSITY   (Japan)

Author keywords

Aggrecan; Chondrocytes; Hypertrophic chondrocyte specific gene product 24 connective tissue growth factor CCN family 2 (Hcs24 CTGF CCN2); Mechanical stress; Mechanobiology; Meniscus cells

Indexed keywords

AGGRECAN; CONNECTIVE TISSUE GROWTH FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE;

ARTICULAR CARTILAGE; CARTILAGE CELL; CONFERENCE PAPER; CONTROLLED STUDY; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; HYALINE CARTILAGE; KNEE MENISCUS; MECHANICAL STRESS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; TENSION; TISSUE METABOLISM; TISSUE REGENERATION;

AGGRECANS; ANIMALS; CARTILAGE; CELL LINE; CHONDROCYTES; CONNECTIVE TISSUE GROWTH FACTOR; EXTRACELLULAR MATRIX; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASES; RABBITS; REGENERATION; STRESS, MECHANICAL; STRESS, PHYSIOLOGICAL;

EID: 52449124581     PISSN: 0006355X     EISSN: None     Source Type: Journal    
DOI: 10.3233/BIR-2008-0478     Document Type: Conference Paper

References (26)

1. M.A. Adams, The mechanical environment of chondrocytes in articular cartilage, Biorheology 43 (2006), 537-545.
2. A.M. Ahmed, The load-bearing role of the knee meniscus, in: Knee Meniscus: Basic and Clinical Foundations, V.C. Mow, S.P. Arnoczky and D.W. Jackson, eds, Raven Press, New York, 1992, pp. 59-73.
3. D.R. Brigstock, R. Goldschmeding, K. Katsube, S.C.-T. Lam, L.F. Lau, K.M. Lyons, C. Naus, B. Perbal, B. Riser, M. Takigawa and H. Yeger, Proposal for a unified CCN nomenclature, Mol. Pathol. 56 (2003), 127-128.
4. B. Fermor, D. Jeffcoat, A. Hennerbichler, D.S. Pisetsky, J.B. Weinberg and F. Guilak, The effects of cyclic mechanical strain and tumor necrosis factor alpha on the response of cells of the meniscus, Osteoarthr. Cartilage 12 (2004), 956-962.
5. T. Fujisawa, T. Hattori, K. Takahashi, T. Kuboki, A. Yamashita and M. Takigawa, Cyclic mechanical stress induces extracellular matrix degradation in cultured chondrocytes via gene expression of matrix metalloproteinases and interleukin-1, J. Biochem. 125 (1999), 966-975.
6. T. Fukubayashi and H. Kurosawa, The contact area and pressure distribution pattern of the knee. A study of normal and osteosrthrotic joints, Acta Orthop. Scand. 51 (1980), 871-879.
7. F. Guilak and V.C. Mow, The mechanical environment of the chondrocytes: a biphasic finite element model of cell-matrix interactions in articular cartilage, J. Biomech. 33 (2000), 1663-1673.
8. S. Ivkovic, B. Yoon, S. Popoff, F. Safadi, D. Libuda, R. Stephenson, A. Daluiski and K.M. Lyons, Connective tissue growth factor coordinates chondrogenesis and angiogenesis during skeletal development, Development 130 (2003), 2779-2791.
9. T. Nakanishi, Y. Kimura, T. Tamura, H. Ichikawa, Y. Yamaai, T. Sugimoto and M. Takigawa, Cloning of a mRNA preferentially expressed in chondrocytes by differential display-PCR from a human chondrocytic cell line that is identical with connective tissue growth factor (CTGF) mRNA, Biochem. Biophys. Res. Commun. 234 (1997), 206-210.
10. T. Nakanishi, T. Nishida, T. Shimo, K. Kobayashi, T. Kubo, T. Tamatani, K. Tezuka and M. Takigawa, Effects of CTGF/Hcs24, a product of a hypertrophic chondrocyte-specific gene, on the proliferation and differentiation of chondrocytes in culture, Endocrinology 141 (2000), 264-273.
11. E. Nakata, T. Nakanishi, A. Kawai, K. Asaumi, M. Asano, T. Nishida, S. Mitani, H. Inoue and M. Takigawa, Expression of connective tissue growth factor/hypertrophic chondrocyte-specific gene product 24 (CTGF/Hcs24) during fracture healing, Bone 31 (2002), 441-447.
12. T. Nishida, H. Kawaki, R.M. Baxter, R.A. DeYoung, M. Takigawa and K.M. Lyons, CCN2 (connective tissue growth factor) is essential for extracellular matrix production and integrin signaling in chondrocytes, J. Cell Commun. Signal. 1 (2007), 45-58.
13. T. Nishida, S. Kubota, T. Fukunaga, S. Kondo, G. Yosimichi, T. Nakanishi, T. Takano-Yamamoto and M. Takigawa, CTGF/Hcs24, hypertrophic chondrocyte-specific gene product, interacts with perlecan in regulating the proliferation and differentiation of chondrocytes, J. Cell. Physiol. 196 (2003), 265-275.
14. T. Nishida, S. Kubota, S. Kojima, T. Kuboki, K. Nakao, T. Kushibiki, Y. Tabata and M. Takigawa, Regeneration of defects in articular cartilage in rat knee joints by CCN2 (connective tissue growth factor), J. Bone Miner. Res. 19 (2004), 1308-1319.
15. T. Nishida, S. Kubota, T. Nakanishi, T. Kuboki, G. Yosimichi, S. Kondo and M. Takigawa, CTGF/Hcs24, a hypertrophic chondrocyte-specific gene product, stimulates proliferation and differentiation, but not hypertrophy of cultured articular chondrocytes, J. Cell. Physiol. 192 (2002), 55-63.
16. B. Perbal and M. Takigawa, The CCN family of proteins: An overview, in: CCN Proteins, B. Perbal and M. Takigawa, eds, Imperial College Press, London, 2005, pp. 1-18.
17. Y.H. Shen, J. Godlewski, J. Zhu, P. Sathyanarayana, V. Leaner, M. J. Birrer, A. Rana and G. Tzivion, Cross-talk between JNK/SAPK and ERK/MAPK pathways - sustained activation of JNK blocks ERK activation by mitogenic factors, J. Biol. Chem. 278 (2003), 26715-26721.
18. M.A. Sweigart and K.A. Athanasiou, Tensile and compressive properties of the medial rabbit meniscus, Proc. Inst. Mech. Eng. 219 (2005), 337-347.
19. M. Takigawa, CTGF/Hcs24 as a multifunctional growth factor for fibroblasts, chondrocytes and vascular endothelial cells, Drug News Perspect. 16 (2003), 11-21.
20. I. Tamura, J. Rosenbloom, E. Macarak and B. Chaqour, Regulation of Cry61 gene expression by mechanical stretch through multiple signaling pathways, Am. J. Physiol. Cell. Physiol. 281 (2001), C1524-C1532.
21. M.L. Upton, J. Chen and L.A. Setton, Region-specific constitutive gene expression in the adult porcine meniscus, J. Orthop. Res. 24 (2006), 1562-1570.
22. P.C.M. Verdonk, R.G. Forsyth, J. Wang, K.F. Almqvist, R. Verdonk, E.M. Veys and G. Verbruggen, Characterization of human knee menisucus cell phenotype, Osteoarthr. Cartilage 13 (2005), 548-560.
23. T.L. Vincent, M.A. Hermansson, M. Bolton, R. Wait and J. Saklatvala, Basic FGF mediates an immediate response of articular cartilage to mechanical injury, Proc. Natl. Acad. Sci. USA 99 (2002), 8259-8264.
24. T.L. Vincent, M.A. Hermansson, U.N. Hansen, A.A. Amis and J. Saklatvala, Basic fibroblast growth factor mediates transduction of mechanical signals when articular cartilage is loaded, Arthrit. Rheum. 50 (2004), 526-533.
25. J.G. Wang, M. Miyazu, P. Xiang, S.N. Li, M. Sokabe and K. Naruse, Stretch-induced cell proliferation is mediated by FAK-MAPK pathway, Life Sci. 76 (2005), 2817-2825.
26. T. Yamashiro, T. Fukunaga, N. Kobashi, H. Kamioka, T. Nakanishi, M. Takigawa and T. Takano-Yamamoto, Mechanical stimulation induces CTGF expression in rat osteocytes, J. Dent. Res. 80 (2001), 461-465.