메뉴 건너뛰기




Volumn 29, Issue 3, 2013, Pages 189-197

Effect of okadaic acid on carpet shell clam (Ruditapes decussatus) haemocytes by in vitro exposure and harmful algal bloom simulation assays

Author keywords

Apoptosis; Flow cytometry; Haemocyte; Harmful algal bloom; Okadaic acid

Indexed keywords

ESTERASE; OKADAIC ACID;

EID: 84878015563     PISSN: 07422091     EISSN: 15736822     Source Type: Journal    
DOI: 10.1007/s10565-013-9246-1     Document Type: Article
Times cited : (51)

References (64)
  • 1
    • 56949092585 scopus 로고    scopus 로고
    • Okadaic acid protects human neuroblatoma SH-SY5Y cells from 1-methyl-4-phenylpyridinium ion-induced apoptosis
    • 19000740 10.1016/j.neulet.2008.10.103 1:CAS:528:DC%2BD1cXhsVKru7%2FM
    • Ahn KH, Kim YS, Kim SY, Hub Y, Park C, Jeong JW. Okadaic acid protects human neuroblatoma SH-SY5Y cells from 1-methyl-4-phenylpyridinium ion-induced apoptosis. Neurosci Lett. 2009;449:93-7.
    • (2009) Neurosci Lett , vol.449 , pp. 93-97
    • Ahn, K.H.1    Kim, Y.S.2    Kim, S.Y.3    Hub, Y.4    Park, C.5    Jeong, J.W.6
  • 2
    • 25844449208 scopus 로고    scopus 로고
    • Effects of the pathogenic Vibrio tapetis on defence factors of susceptible and non-susceptible bivalve species: I. Haemocyte changes following in vitro challenge
    • 16023865 10.1016/j.fsi.2005.05.012 1:CAS:528:DC%2BD2MXhtVKis7jJ
    • Allam B, Ford SE. Effects of the pathogenic Vibrio tapetis on defence factors of susceptible and non-susceptible bivalve species: I. Haemocyte changes following in vitro challenge. Fish Shellfish Immunol. 2006;20:374-83.
    • (2006) Fish Shellfish Immunol , vol.20 , pp. 374-383
    • Allam, B.1    Ford, S.E.2
  • 3
    • 0036671515 scopus 로고    scopus 로고
    • Flow cytometric comparison of haemocytes from three species of bivalve mollusks
    • 12400864 10.1006/fsim.2001.0389 1:STN:280:DC%2BD38nktFGhug%3D%3D
    • Allam B, Ashton-Alcox KA, Ford SE. Flow cytometric comparison of haemocytes from three species of bivalve mollusks. Fish Shellfish Immunol. 2002;13:141-58.
    • (2002) Fish Shellfish Immunol , vol.13 , pp. 141-158
    • Allam, B.1    Ashton-Alcox, K.A.2    Ford, S.E.3
  • 4
    • 33645555776 scopus 로고    scopus 로고
    • Effects of tumour necrosis factor α (TNFα) on Mytilus haemocytes: Role of stress-activated mitogen-activated protein kinases (MAPKs)
    • 16060858 10.1042/BC20050049 1:CAS:528:DC%2BD28Xis1eqt7k%3D
    • Betti M, Ciacci C, Lorusso LC, Canonico B, Falcioni T, Gallo G, et al. Effects of tumour necrosis factor α (TNFα) on Mytilus haemocytes: role of stress-activated mitogen-activated protein kinases (MAPKs). Biol Cell. 2006;98:233-44.
    • (2006) Biol Cell , vol.98 , pp. 233-244
    • Betti, M.1    Ciacci, C.2    Lorusso, L.C.3    Canonico, B.4    Falcioni, T.5    Gallo, G.6    Canesi, L.7
  • 5
    • 58649089584 scopus 로고    scopus 로고
    • In vivo experiments for the evaluation of genotoxic and cytotoxic effects of Triclosan in Zebra mussel hemocytes
    • 19117617 10.1016/j.aquatox.2008.11.008 1:CAS:528:DC%2BD1MXhtlSgt7w%3D
    • Binelli A, Cogni D, Parolini M, Riva C, Provini A. In vivo experiments for the evaluation of genotoxic and cytotoxic effects of Triclosan in Zebra mussel hemocytes. Aquat Toxicol. 2009;91:238-44.
    • (2009) Aquat Toxicol , vol.91 , pp. 238-244
    • Binelli, A.1    Cogni, D.2    Parolini, M.3    Riva, C.4    Provini, A.5
  • 6
    • 0023691731 scopus 로고
    • Inhibitory effect of a marine-sponge toxin okadaic acid on protein phosphatases. Specificity and kinetics
    • Biolojan C, Takai A. Inhibitory effect of a marine-sponge toxin okadaic acid on protein phosphatases. Specificity and kinetics. Biochem J. 1988;256:283-90.
    • (1988) Biochem J , vol.256 , pp. 283-290
    • Biolojan, C.1    Takai, A.2
  • 8
    • 33845367029 scopus 로고    scopus 로고
    • Apoptosis induced by protein phosphatase 2A (PP2A) inhibition in T leukemia cells is negatively regulated by PP2A-associated p38 mitogen-activated protein kinase
    • 16844342 10.1016/j.cellsig.2006.05.030 1:CAS:528:DC%2BD28Xhtlalt7jN
    • Boudreau RT, Conrad DM, Hoskin DW. Apoptosis induced by protein phosphatase 2A (PP2A) inhibition in T leukemia cells is negatively regulated by PP2A-associated p38 mitogen-activated protein kinase. Cell Signal. 2007;19:139-51.
    • (2007) Cell Signal , vol.19 , pp. 139-151
    • Boudreau, R.T.1    Conrad, D.M.2    Hoskin, D.W.3
  • 9
    • 0034906262 scopus 로고    scopus 로고
    • Toxin composition of the toxic dinoflagellate Prorocentrum lima isolated from different locations along the Galician coast (NW Spain)
    • 11478961 10.1016/S0041-0101(01)00126-X 1:CAS:528:DC%2BD3MXlsFKht7Y%3D
    • Bravo I, Fernández ML, Ramilo I, Martínez A. Toxin composition of the toxic dinoflagellate Prorocentrum lima isolated from different locations along the Galician coast (NW Spain). Toxicon. 2001;39:1537-45.
    • (2001) Toxicon , vol.39 , pp. 1537-1545
    • Bravo, I.1    Fernández, M.L.2    Ramilo, I.3    Martínez, A.4
  • 10
    • 1542283580 scopus 로고    scopus 로고
    • Cytoskeletal disruption is the key factor that triggers apoptosis in okadaic acid-treated neruroblastoma cells
    • 14652712 10.1007/s00204-003-0505-4 1:CAS:528:DC%2BD2cXhtFGjsb0%3D
    • Cabado AG, Leira F, Vieytes MR, Vieites JM, Botana LM. Cytoskeletal disruption is the key factor that triggers apoptosis in okadaic acid-treated neruroblastoma cells. Arch Toxicol. 2004;78:74-85.
    • (2004) Arch Toxicol , vol.78 , pp. 74-85
    • Cabado, A.G.1    Leira, F.2    Vieytes, M.R.3    Vieites, J.M.4    Botana, L.M.5
  • 11
    • 0035158611 scopus 로고    scopus 로고
    • Surface interactions between Escherichia coli and hemocytes of the Mediterranean mussel Mytilus galloprovincialis Lam leading to efficient bacterial clearance
    • 11133482 10.1128/AEM.67.1.464-468.2001 1:CAS:528:DC%2BD3MXjtVWktg%3D%3D
    • Canesi L, Pruzzo C, Tarsi R, Gallo G. Surface interactions between Escherichia coli and hemocytes of the Mediterranean mussel Mytilus galloprovincialis Lam leading to efficient bacterial clearance. Appl Environ Microbiol. 2001;67:464-8.
    • (2001) Appl Environ Microbiol , vol.67 , pp. 464-468
    • Canesi, L.1    Pruzzo, C.2    Tarsi, R.3    Gallo, G.4
  • 13
    • 22844447621 scopus 로고    scopus 로고
    • Micronucleus test in mussels Perna perna fed with the toxic dinoflagellate Prorocentrum lima
    • 10.1007/s00204-004-0645-1
    • Carvalho Pinto-Silva CR, Creppy EE, Matias WC. Micronucleus test in mussels Perna perna fed with the toxic dinoflagellate Prorocentrum lima. Arch Toxicol. 2005;79:422-6.
    • (2005) Arch Toxicol , vol.79 , pp. 422-426
    • Carvalho Pinto-Silva, C.R.1    Creppy, E.E.2    Matias, W.C.3
  • 15
    • 62949249358 scopus 로고    scopus 로고
    • Functional and molecular immune response of Mediterranean mussel (Mytilus galloprovincialis) haemocytes against pathogen-associated molecular patterns and bacteria
    • 19340955 10.1016/j.fsi.2009.02.001 1:CAS:528:DC%2BD1MXjvVait7o%3D
    • Costa MM, Prado-Alvarez M, Gestal C, Li H, Roch P, Novoa B, et al. Functional and molecular immune response of Mediterranean mussel (Mytilus galloprovincialis) haemocytes against pathogen-associated molecular patterns and bacteria. Fish Shellfish Immunol. 2009;26:515-23.
    • (2009) Fish Shellfish Immunol , vol.26 , pp. 515-523
    • Costa, M.M.1    Prado-Alvarez, M.2    Gestal, C.3    Li, H.4    Roch, P.5    Novoa, B.6    Figueras, A.7
  • 16
    • 40449106805 scopus 로고    scopus 로고
    • Immunological responses of the Manila clam (Ruditapes philippinarum) with varying parasite (Perkinsus olseni) burden, during a long-term exposure to the harmful alga, Karenia selliformis, and possible interactions
    • 18171580 10.1016/j.toxicon.2007.11.006
    • da Silva PM, Hégaret H, Lambert C, Wikfors GH, Goïc NL, Shumway SE, et al. Immunological responses of the Manila clam (Ruditapes philippinarum) with varying parasite (Perkinsus olseni) burden, during a long-term exposure to the harmful alga, Karenia selliformis, and possible interactions. Toxicon. 2008;51:563-73.
    • (2008) Toxicon , vol.51 , pp. 563-573
    • Da Silva, P.M.1    Hégaret, H.2    Lambert, C.3    Wikfors, G.H.4    Goïc, N.L.5    Shumway, S.E.6    Soudant, P.7
  • 17
    • 0025247905 scopus 로고
    • Identification of okadaic acid from a Caribbean dinoflagellate, Prorocentrum concavum
    • 2349579 10.1016/0041-0101(90)90074-H 1:CAS:528:DyaK3cXitFahtrg%3D
    • Dickey RW, Bobzin SC, Faulkner DJ, Bencsath FA, Andrzejewski D. Identification of okadaic acid from a Caribbean dinoflagellate, Prorocentrum concavum. Toxicon. 1990;28:371-7.
    • (1990) Toxicon , vol.28 , pp. 371-377
    • Dickey, R.W.1    Bobzin, S.C.2    Faulkner, D.J.3    Bencsath, F.A.4    Andrzejewski, D.5
  • 18
    • 0035851409 scopus 로고    scopus 로고
    • Toxicity of domoic acid in the marine mussel Mytilus edulis
    • 11595305 10.1016/S0166-445X(01)00178-3 1:CAS:528:DC%2BD3MXntlOqs70%3D
    • Dizer H, Fischer B, Harabawy AS, Hennion MC, Hansen PD. Toxicity of domoic acid in the marine mussel Mytilus edulis. Aquat Toxicol. 2001;55:149-56.
    • (2001) Aquat Toxicol , vol.55 , pp. 149-156
    • Dizer, H.1    Fischer, B.2    Harabawy, A.S.3    Hennion, M.C.4    Hansen, P.D.5
  • 19
    • 0001438085 scopus 로고
    • Cellular defense mechanisms of oysters and mussels
    • Feng SY. Cellular defense mechanisms of oysters and mussels. Am Fish Soc Spec Publ. 1988;18:153-68.
    • (1988) Am Fish Soc Spec Publ , vol.18 , pp. 153-168
    • Feng, S.Y.1
  • 20
    • 0026079797 scopus 로고
    • The marine toxin okadaic acid is a potent neurotoxin for cultured cerebellar neurons
    • 10.1016/0024-3205(91)90398-U
    • Fernández MT, Zitko V, Gascón S, Novelli A. The marine toxin okadaic acid is a potent neurotoxin for cultured cerebellar neurons. Life Sci. 1991;49:157-62.
    • (1991) Life Sci , vol.49 , pp. 157-162
    • Fernández, M.T.1    Zitko, V.2    Gascón, S.3    Novelli, A.4
  • 21
    • 0030602178 scopus 로고    scopus 로고
    • Inhibition of protein phosphatases induces IGF-1-blocked neurotrophin-insensitive neuronal apoptosis
    • 8946962 10.1016/S0014-5793(96)01192-1
    • Fernández-Sánchez MT, García-Rodríguez A, Díaz-Trelles R, Novelli A. Inhibition of protein phosphatases induces IGF-1-blocked neurotrophin-insensitive neuronal apoptosis. FEBS Lett. 1996;398:106-12.
    • (1996) FEBS Lett , vol.398 , pp. 106-112
    • Fernández-Sánchez, M.T.1    García-Rodríguez, A.2    Díaz-Trelles, R.3    Novelli, A.4
  • 22
    • 79952045455 scopus 로고    scopus 로고
    • Comparative study of various immune parameters in three bivalve species during a natural bloom of Dinophysis acuminata in Santa Catarina Island, Brazil
    • 10.3390/toxins2051166
    • Ferraz-Mello D, de Oliveira Proença LA, Barracco MA. Comparative study of various immune parameters in three bivalve species during a natural bloom of Dinophysis acuminata in Santa Catarina Island, Brazil. Toxins. 2010;2:1166-78.
    • (2010) Toxins , vol.2 , pp. 1166-1178
    • Ferraz-Mello, D.1    De Oliveira Proença, L.A.2    Barracco, M.A.3
  • 23
    • 79961078127 scopus 로고    scopus 로고
    • Evaluation of genotoxicity in gills and hemolymph of clam Ruditapes decussatus fed with the toxic dinoflagellate Prorocentrum lima
    • 21707422 10.1080/15287394.2011.582025
    • Flórez-Barrós F, Prado-Alvarez M, Méndez J, Fernández-Tajes J. Evaluation of genotoxicity in gills and hemolymph of clam Ruditapes decussatus fed with the toxic dinoflagellate Prorocentrum lima. J Toxicol Environ Health Part A. 2011;74:971-9.
    • (2011) J Toxicol Environ Health Part A , vol.74 , pp. 971-979
    • Flórez-Barrós, F.1    Prado-Alvarez, M.2    Méndez, J.3    Fernández-Tajes, J.4
  • 24
    • 77952475321 scopus 로고    scopus 로고
    • Targets and effects of yessotoxin okadaic acid and palytoxin: A differential review
    • 20411120 10.3390/md8030658 1:CAS:528:DC%2BC3cXjvVKisLo%3D
    • Franchini A, Malagoli D, Ottaviani E. Targets and effects of yessotoxin okadaic acid and palytoxin: a differential review. Mar Drugs. 2010;8:658-77.
    • (2010) Mar Drugs , vol.8 , pp. 658-677
    • Franchini, A.1    Malagoli, D.2    Ottaviani, E.3
  • 25
    • 1842844346 scopus 로고    scopus 로고
    • In vitro effects of cadmium and mercury on Pacific oyster, Crassostrea gigas (Thunberg), haemocytes
    • 15123292 10.1016/j.fsi.2003.08.007 1:CAS:528:DC%2BD2cXisFyltLs%3D
    • Gagnaire B, Thomas-Guyon H, Renault T. In vitro effects of cadmium and mercury on Pacific oyster, Crassostrea gigas (Thunberg), haemocytes. Fish Shellfish Immunol. 2004;16:501-12.
    • (2004) Fish Shellfish Immunol , vol.16 , pp. 501-512
    • Gagnaire, B.1    Thomas-Guyon, H.2    Renault, T.3
  • 26
    • 32144451037 scopus 로고    scopus 로고
    • Pollutant effects on Pacific oyster, Crassostra gigas (Thunberg), hemocytes: Screening of 23 molecules using flow cytometry
    • 16463015 10.1007/s10565-006-0011-6 1:CAS:528:DC%2BD28XhtFWmurw%3D
    • Gagnaire B, Thomas-Guyon H, Burgeot T, Renault T. Pollutant effects on Pacific oyster, Crassostra gigas (Thunberg), hemocytes: screening of 23 molecules using flow cytometry. Cell Biol Toxicol. 2006;22:1-14.
    • (2006) Cell Biol Toxicol , vol.22 , pp. 1-14
    • Gagnaire, B.1    Thomas-Guyon, H.2    Burgeot, T.3    Renault, T.4
  • 27
    • 36049026588 scopus 로고    scopus 로고
    • The effects of feeding Karlodinium veneficum (PLY # 103; Gymnodinium veneficum Ballantine) to the blue mussel Mytilus edulis
    • 10.1016/j.hal.2007.05.004 1:CAS:528:DC%2BD1cXnvFagsA%3D%3D
    • Galimany E, Place AR, Ramón M, Jutson M, Pipe RK. The effects of feeding Karlodinium veneficum (PLY # 103; Gymnodinium veneficum Ballantine) to the blue mussel Mytilus edulis. Harmful Algae. 2008a;7:91-8.
    • (2008) Harmful Algae , vol.7 , pp. 91-98
    • Galimany, E.1    Place, A.R.2    Ramón, M.3    Jutson, M.4    Pipe, R.K.5
  • 28
    • 45849115465 scopus 로고    scopus 로고
    • Pathology and immune response of the blue mussel (Mytilus edulis L.) after an exposure to the harmful dinoflagellate Prorocentrum minimum
    • 10.1016/j.hal.2008.01.001
    • Galimany E, Sunila I, Hégaret H, Ramón M, Wikfors GH. Pathology and immune response of the blue mussel (Mytilus edulis L.) after an exposure to the harmful dinoflagellate Prorocentrum minimum. Harmful Algae. 2008b;7:630-8.
    • (2008) Harmful Algae , vol.7 , pp. 630-638
    • Galimany, E.1    Sunila, I.2    Hégaret, H.3    Ramón, M.4    Wikfors, G.H.5
  • 29
    • 45849141924 scopus 로고    scopus 로고
    • Experimental exposure of the blue mussel (Mytilus edulis, L.) to the toxic dinoflagellate Alexandrium fundyense: Histopathology, immune responses, and recovery
    • 10.1016/j.hal.2008.02.006 1:CAS:528:DC%2BD1cXovFemtL0%3D
    • Galimany E, Sunila I, Hégaret H, Ramón M, Wikfors GH. Experimental exposure of the blue mussel (Mytilus edulis, L.) to the toxic dinoflagellate Alexandrium fundyense: histopathology, immune responses, and recovery. Harmful Algae. 2008c;7:702-11.
    • (2008) Harmful Algae , vol.7 , pp. 702-711
    • Galimany, E.1    Sunila, I.2    Hégaret, H.3    Ramón, M.4    Wikfors, G.H.5
  • 30
    • 77953304066 scopus 로고    scopus 로고
    • First evidence of Okadaic acid acyl-derivative and Dinophysistoxin-3 in mussel samples collected in Chiloe Island, Southern Chile
    • 20519842 10.2131/jts.35.335
    • García C, Pruzzo M, Rodríguez-Unda N, Contreras C, Lagos N. First evidence of Okadaic acid acyl-derivative and Dinophysistoxin-3 in mussel samples collected in Chiloe Island, Southern Chile. J Toxicol Sci. 2010;35:335-44.
    • (2010) J Toxicol Sci , vol.35 , pp. 335-344
    • García, C.1    Pruzzo, M.2    Rodríguez-Unda, N.3    Contreras, C.4    Lagos, N.5
  • 31
    • 38949170128 scopus 로고    scopus 로고
    • Immune responses of mussel haemocyte subpopulations are differentially regulated by enzymes of the PI 3K, PKC and ERK kinase families
    • 18045688 10.1016/j.dci.2007.10.004
    • García-García E, Prado-Alvarez M, Novoa B, Figueras A, Rosales C. Immune responses of mussel haemocyte subpopulations are differentially regulated by enzymes of the PI 3K, PKC and ERK kinase families. Dev Comp Immunol. 2008;32:637-53.
    • (2008) Dev Comp Immunol , vol.32 , pp. 637-653
    • García-García, E.1    Prado-Alvarez, M.2    Novoa, B.3    Figueras, A.4    Rosales, C.5
  • 32
    • 36749021586 scopus 로고    scopus 로고
    • Analysis of differentially expressed genes in response to bacterial stimulation in haemocytes of the carpet-shell clam Ruditapes decussatus: Identification of new antimicrobial peptides
    • 17881157 10.1016/j.gene.2007.07.030 1:CAS:528:DC%2BD2sXhsVSjsbfE
    • Gestal C, Costa M, Figueras A, Novoa B. Analysis of differentially expressed genes in response to bacterial stimulation in haemocytes of the carpet-shell clam Ruditapes decussatus: identification of new antimicrobial peptides. Gene. 2007;406:134-43.
    • (2007) Gene , vol.406 , pp. 134-143
    • Gestal, C.1    Costa, M.2    Figueras, A.3    Novoa, B.4
  • 33
    • 0027013046 scopus 로고
    • Isolation of analogues of okadaic acid from cultures of Prorocentrum lima
    • 1340349 1:STN:280:DyaK2c%2FjsVemtw%3D%3D
    • Granade HR, Bencsath FA, Dickey RW. Isolation of analogues of okadaic acid from cultures of Prorocentrum lima. Bull Soc Pathol Exot. 1992;85:478-80.
    • (1992) Bull Soc Pathol Exot , vol.85 , pp. 478-480
    • Granade, H.R.1    Bencsath, F.A.2    Dickey, R.W.3
  • 34
    • 10944225264 scopus 로고    scopus 로고
    • Time-dependent changes in haemocytes of eastern oysters, Crassostrea virginica, and northern bay scallops, Argopecten irradians irradians, exposed to a cultured strain of Prorocentrum minimum
    • 10.1016/j.hal.2003.12.004
    • Hégaret H, Wikfors GH. Time-dependent changes in haemocytes of eastern oysters, Crassostrea virginica, and northern bay scallops, Argopecten irradians irradians, exposed to a cultured strain of Prorocentrum minimum. Harmful Algae. 2005a;4:187-99.
    • (2005) Harmful Algae , vol.4 , pp. 187-199
    • Hégaret, H.1    Wikfors, G.H.2
  • 35
    • 10944248582 scopus 로고    scopus 로고
    • Effects of natural and field-simulated blooms of the dinoflagellate Prorocentrum minimum upon haemocytes of eastern oysters, Crassostrea virginica, from two different populations
    • 10.1016/j.hal.2003.12.005
    • Hégaret H, Wikfors GH. Effects of natural and field-simulated blooms of the dinoflagellate Prorocentrum minimum upon haemocytes of eastern oysters, Crassostrea virginica, from two different populations. Harmful Algae. 2005b;4:201-9.
    • (2005) Harmful Algae , vol.4 , pp. 201-209
    • Hégaret, H.1    Wikfors, G.H.2
  • 36
    • 34548319443 scopus 로고    scopus 로고
    • Hemocyte responses of Manila clam, Ruditapes philippinarum, with varying parasite, Perkinsus olseni, severity to toxic-algal exposures
    • 17727971 10.1016/j.aquatox.2007.07.007
    • Hégaret H, da Silva PM, Wikfors GH, Lambert C, De Bettignies T, Shumway SE, et al. Hemocyte responses of Manila clam, Ruditapes philippinarum, with varying parasite, Perkinsus olseni, severity to toxic-algal exposures. Aquat Toxicol. 2007;84:469-79.
    • (2007) Aquat Toxicol , vol.84 , pp. 469-479
    • Hégaret, H.1    Da Silva, P.M.2    Wikfors, G.H.3    Lambert, C.4    De Bettignies, T.5    Shumway, S.E.6    Soudant, P.7
  • 37
    • 77952668177 scopus 로고    scopus 로고
    • Combined effects of a parasite, QPX, and the harmful-alga, Prorocentrum minimum on northern quahogs, Mercenaria mercenaria
    • 20110123 10.1016/j.marenvres.2009.12.008
    • Hégaret H, Smolowitz RM, Sunila I, Shumway SE, Alix J, Dixon M, et al. Combined effects of a parasite, QPX, and the harmful-alga, Prorocentrum minimum on northern quahogs, Mercenaria mercenaria. Mar Environ Res. 2010;69:337-44.
    • (2010) Mar Environ Res , vol.69 , pp. 337-344
    • Hégaret, H.1    Smolowitz, R.M.2    Sunila, I.3    Shumway, S.E.4    Alix, J.5    Dixon, M.6    Wikfors, G.H.7
  • 38
    • 79959545658 scopus 로고    scopus 로고
    • In vitro interactions between several species of harmful algae and haemocytes of bivalve molluscs
    • 21340660 10.1007/s10565-011-9186-6
    • Hégaret H, da Silva PM, Wikfors GH, Haberkorn H, Shumway SE, Soudant P. In vitro interactions between several species of harmful algae and haemocytes of bivalve molluscs. Cell Biol Toxicol. 2011;27:249-66.
    • (2011) Cell Biol Toxicol , vol.27 , pp. 249-266
    • Hégaret, H.1    Da Silva, P.M.2    Wikfors, G.H.3    Haberkorn, H.4    Shumway, S.E.5    Soudant, P.6
  • 39
    • 58149230974 scopus 로고    scopus 로고
    • Multiple signal transduction pathways in okadaic acid induced apoptosis in HeLa cells
    • 19084044 10.1016/j.tox.2008.11.013 1:CAS:528:DC%2BD1MXktF2jtw%3D%3D
    • Jayaraj R, Gupta N, Lakshamana Rao PV. Multiple signal transduction pathways in okadaic acid induced apoptosis in HeLa cells. Toxicology. 2009;256:118-27.
    • (2009) Toxicology , vol.256 , pp. 118-127
    • Jayaraj, R.1    Gupta, N.2    Lakshamana Rao, P.V.3
  • 40
    • 79960641722 scopus 로고    scopus 로고
    • In vitro effects of noradrenaline on Akoya pearl oyster (Pinctada imbricata) haemocytes
    • 21664977 10.1016/j.fsi.2011.05.025 1:CAS:528:DC%2BC3MXpslWqtrw%3D
    • Kuchel RP, Raftos DA. In vitro effects of noradrenaline on Akoya pearl oyster (Pinctada imbricata) haemocytes. Fish Shellfish Immunol. 2011;31:365-72.
    • (2011) Fish Shellfish Immunol , vol.31 , pp. 365-372
    • Kuchel, R.P.1    Raftos, D.A.2
  • 41
    • 24344433292 scopus 로고    scopus 로고
    • Collapse of mitochondrial membrane potential and caspases activation are early events in okadaic acid-treated Caco-2 cells
    • 16135376 10.1016/j.toxicon.2005.07.007 1:CAS:528:DC%2BD2MXpvVSlsL4%3D
    • Lago J, Santaclara F, Vieites JM, Cabado AG. Collapse of mitochondrial membrane potential and caspases activation are early events in okadaic acid-treated Caco-2 cells. Toxicon. 2005;46:579-86.
    • (2005) Toxicon , vol.46 , pp. 579-586
    • Lago, J.1    Santaclara, F.2    Vieites, J.M.3    Cabado, A.G.4
  • 42
    • 0038054697 scopus 로고    scopus 로고
    • Aneugenic potential of okadaic acid revealed by the micronucleus assay combined with the FISH technique in CHO-K1 cells
    • 12714697 10.1093/mutage/18.3.293
    • Le Hégarat L, Puech L, Fessard V, Poul JM, Dragacci S. Aneugenic potential of okadaic acid revealed by the micronucleus assay combined with the FISH technique in CHO-K1 cells. Mutagenesis. 2003;18:293-8.
    • (2003) Mutagenesis , vol.18 , pp. 293-298
    • Le Hégarat, L.1    Puech, L.2    Fessard, V.3    Poul, J.M.4    Dragacci, S.5
  • 43
    • 7044227473 scopus 로고    scopus 로고
    • Lack of DNA damage induction by okadaic acid, a marine toxin, in the CHO-Hprt and the in vitro UDS assays
    • 15507378 10.1016/j.mrgentox.2004.08.003
    • Le Hégarat L, Nesslany F, Mourot A, Marzin D, Fessard V. Lack of DNA damage induction by okadaic acid, a marine toxin, in the CHO-Hprt and the in vitro UDS assays. Mutat Res. 2004;564:139-47.
    • (2004) Mutat Res , vol.564 , pp. 139-147
    • Le Hégarat, L.1    Nesslany, F.2    Mourot, A.3    Marzin, D.4    Fessard, V.5
  • 44
    • 25844453511 scopus 로고    scopus 로고
    • Okadaic acid: Chromosomal non-disjunction analysis in human lymphocytes and study of aneugenic pathway in CHO-K1 cells
    • 15885711 10.1016/j.mrfmmm.2005.02.011
    • Le Hégarat L, Orsière T, Botta A, Fessard V. Okadaic acid: chromosomal non-disjunction analysis in human lymphocytes and study of aneugenic pathway in CHO-K1 cells. Mutat Res. 2005;578:53-63.
    • (2005) Mutat Res , vol.578 , pp. 53-63
    • Le Hégarat, L.1    Orsière, T.2    Botta, A.3    Fessard, V.4
  • 45
    • 0036151289 scopus 로고    scopus 로고
    • Characterization of distinct apoptotic changes induced by okadaic acid and yessotoxin in the BE(2)-M17 neuroblastoma cell line
    • 11812636 10.1016/S0887-2333(01)00095-9 1:CAS:528:DC%2BD38Xms1akuw%3D%3D
    • Leira F, Alvarez C, Vieites JM, Vieytes MR, Botana LM. Characterization of distinct apoptotic changes induced by okadaic acid and yessotoxin in the BE(2)-M17 neuroblastoma cell line. Toxicol In vitro. 2002;16:23-31.
    • (2002) Toxicol in Vitro , vol.16 , pp. 23-31
    • Leira, F.1    Alvarez, C.2    Vieites, J.M.3    Vieytes, M.R.4    Botana, L.M.5
  • 46
    • 0038634845 scopus 로고    scopus 로고
    • Development of a F actin-based live-cell fluorimetric microplate assay for diarrhetic shellfish toxins
    • 12758250 10.1016/S0003-2697(02)00230-0 1:CAS:528:DC%2BD3sXjvFWntbw%3D
    • Leira F, Alvarez C, Cabado AG, Vieites JM, Vieytes MR, Botana LM. Development of a F actin-based live-cell fluorimetric microplate assay for diarrhetic shellfish toxins. Anal Biochem. 2003;317:129-35.
    • (2003) Anal Biochem , vol.317 , pp. 129-135
    • Leira, F.1    Alvarez, C.2    Cabado, A.G.3    Vieites, J.M.4    Vieytes, M.R.5    Botana, L.M.6
  • 47
    • 38349053133 scopus 로고    scopus 로고
    • Effect of the marine toxins okadaic acid and palytoxin on mussel phagocytosis
    • 18083046 10.1016/j.fsi.2007.10.012 1:CAS:528:DC%2BD1cXptlCmsg%3D%3D
    • Malagoli D, Casarini L, Ottaviani E. Effect of the marine toxins okadaic acid and palytoxin on mussel phagocytosis. Fish Shellfish Immunol. 2008;24:180-6.
    • (2008) Fish Shellfish Immunol , vol.24 , pp. 180-186
    • Malagoli, D.1    Casarini, L.2    Ottaviani, E.3
  • 48
    • 0042781264 scopus 로고
    • The amoebocytes of lamellibranch molluscs, with special reference to the circulating amoebocytes
    • Narain AS. The amoebocytes of lamellibranch molluscs, with special reference to the circulating amoebocytes. Malacol Rev. 1973;6:1-12.
    • (1973) Malacol Rev , vol.6 , pp. 1-12
    • Narain, A.S.1
  • 50
    • 59349110435 scopus 로고    scopus 로고
    • Differentially expressed genes of the carpet shell clam Ruditapes decussatus against Perkinsus olseni
    • 19028428 10.1016/j.fsi.2008.03.002 1:CAS:528:DC%2BD1MXhs1eqsL4%3D
    • Prado-Alvarez M, Gestal C, Novoa B, Figueras A. Differentially expressed genes of the carpet shell clam Ruditapes decussatus against Perkinsus olseni. Fish Shellfish Immunol. 2009;26:72-83.
    • (2009) Fish Shellfish Immunol , vol.26 , pp. 72-83
    • Prado-Alvarez, M.1    Gestal, C.2    Novoa, B.3    Figueras, A.4
  • 51
    • 84867213394 scopus 로고    scopus 로고
    • Effects of okadaic acid on haemocytes from Mytilus galloprovincialis: A comparison between field and laboratory studies
    • 23000349 10.1016/j.marenvres.2012.08.011 1:CAS:528:DC%2BC38XhsVOhs7zF
    • Prado-Alvarez M, Flórez-Barrós F, Sexto-Iglesias A, Méndez J, Fernandez-Tajes J. Effects of okadaic acid on haemocytes from Mytilus galloprovincialis: a comparison between field and laboratory studies. Mar Environ Res. 2012a;81:90-3.
    • (2012) Mar Environ Res , vol.81 , pp. 90-93
    • Prado-Alvarez, M.1    Flórez-Barrós, F.2    Sexto-Iglesias, A.3    Méndez, J.4    Fernandez-Tajes, J.5
  • 52
    • 84859241901 scopus 로고    scopus 로고
    • Morphological characterization and functional immune response of the carpet shell clam (Ruditapes decussatus) haemocytes after bacterial stimulation
    • 22051180 10.1016/j.fsi.2011.10.019 1:CAS:528:DC%2BC3MXhs1Ciu77L
    • Prado-Alvarez M, Romero A, Balseiro P, Dios S, Novoa B, Figueras A. Morphological characterization and functional immune response of the carpet shell clam (Ruditapes decussatus) haemocytes after bacterial stimulation. Fish Shellfish Immunol. 2012b;32:69-78.
    • (2012) Fish Shellfish Immunol , vol.32 , pp. 69-78
    • Prado-Alvarez, M.1    Romero, A.2    Balseiro, P.3    Dios, S.4    Novoa, B.5    Figueras, A.6
  • 53
    • 0032544721 scopus 로고    scopus 로고
    • Okadaic acid-induced apoptosis of HL60 leukemia cells is preceded by destabilization of bcl-2 mRNA and downregulation of bcl-2 protein
    • 9762907 10.1016/S0014-5793(98)01070-9 1:CAS:528:DyaK1cXmt1emtLs%3D
    • Riordan FA, Foroni L, Hoffbrand AV, Mehta AB, Wickremasinghe GR. Okadaic acid-induced apoptosis of HL60 leukemia cells is preceded by destabilization of bcl-2 mRNA and downregulation of bcl-2 protein. FEBS Lett. 1998;435:195-8.
    • (1998) FEBS Lett , vol.435 , pp. 195-198
    • Riordan, F.A.1    Foroni, L.2    Hoffbrand, A.V.3    Mehta, A.B.4    Wickremasinghe, G.R.5
  • 54
    • 0035178875 scopus 로고    scopus 로고
    • The toxic responses induced by okadaic acid involve processing of multiple caspase isoforms
    • 11137534 10.1016/S0041-0101(00)00202-6 1:CAS:528:DC%2BD3MXmsVyltg%3D%3D
    • Rossini GP, Sgarbi N, Malaguti C. The toxic responses induced by okadaic acid involve processing of multiple caspase isoforms. Toxicon. 2001;39:763-70.
    • (2001) Toxicon , vol.39 , pp. 763-770
    • Rossini, G.P.1    Sgarbi, N.2    Malaguti, C.3
  • 55
    • 26944433741 scopus 로고    scopus 로고
    • Effect of okadaic acid on integrins and structural proteins in BE(2)-M17 cells
    • 15937665 10.1007/s00204-005-0679-z 1:CAS:528:DC%2BD2MXhtFahtrvL
    • Santaclara F, Lago J, Vieites JM, Cabado AG. Effect of okadaic acid on integrins and structural proteins in BE(2)-M17 cells. Arch Toxicol. 2005;79:582-6.
    • (2005) Arch Toxicol , vol.79 , pp. 582-586
    • Santaclara, F.1    Lago, J.2    Vieites, J.M.3    Cabado, A.G.4
  • 56
    • 0032123422 scopus 로고    scopus 로고
    • Intracellular effects of okadaic acid in the blue mussel Mytilus edulis and rainbow trout Oncorhynchus mykiss
    • 10.1016/S0141-1136(97)00099-8 1:CAS:528:DyaK1cXmtVOitbk%3D
    • Svensson S, Förlin L. Intracellular effects of okadaic acid in the blue mussel Mytilus edulis and rainbow trout Oncorhynchus mykiss. Mar Environ Res. 1998;46:449-52.
    • (1998) Mar Environ Res , vol.46 , pp. 449-452
    • Svensson, S.1    Förlin, L.2
  • 57
    • 0042929508 scopus 로고    scopus 로고
    • Mussel blood cells, resistant to the cytotoxic effects of okadaic acid, do not express cell membrane p-glycoprotein activity (multixenobiotic resistance)
    • 12932699 10.1016/S0166-445X(03)00097-3 1:CAS:528:DC%2BD3sXmsVKit74%3D
    • Svensson S, Särngren A, Förlin L. Mussel blood cells, resistant to the cytotoxic effects of okadaic acid, do not express cell membrane p-glycoprotein activity (multixenobiotic resistance). Aquat Toxicol. 2003;65:27-37.
    • (2003) Aquat Toxicol , vol.65 , pp. 27-37
    • Svensson, S.1    Särngren, A.2    Förlin, L.3
  • 58
    • 0035048323 scopus 로고    scopus 로고
    • DNA breaks and cell cycle arrest induced by okadaic acid in Caco-2 cells, a human colonic epithelial cell line
    • 11354906 10.1007/s002040000188
    • Traoré A, Baudrimont I, Ambaliou S, Dano SD, Creppy EE. DNA breaks and cell cycle arrest induced by okadaic acid in Caco-2 cells, a human colonic epithelial cell line. Arch Toxicol. 2001;75:110-7.
    • (2001) Arch Toxicol , vol.75 , pp. 110-117
    • Traoré, A.1    Baudrimont, I.2    Ambaliou, S.3    Dano, S.D.4    Creppy, E.E.5
  • 59
    • 77953915529 scopus 로고    scopus 로고
    • Assessment of okadaic acid effects on cytotoxicity, DNA damage and DNA repair in human cells
    • 20621797 10.1016/j.mrfmmm.2010.05.004 1:CAS:528:DC%2BC3cXotVSrtL8%3D
    • Valdiglesias V, Méndez J, Pásaro E, Cemeli E, Anderson D, Laffon B. Assessment of okadaic acid effects on cytotoxicity, DNA damage and DNA repair in human cells. Mutat Res. 2010;689:74-9.
    • (2010) Mutat Res , vol.689 , pp. 74-79
    • Valdiglesias, V.1    Méndez, J.2    Pásaro, E.3    Cemeli, E.4    Anderson, D.5    Laffon, B.6
  • 60
    • 56849104094 scopus 로고    scopus 로고
    • Marine toxins and cytoskeleton: Okadaic acid and dinophysistoxins
    • 19016863 10.1111/j.1742-4658.2008.06711.x 1:CAS:528:DC%2BD1cXhsFahtr3O
    • Vale C, Botana LM. Marine toxins and cytoskeleton: okadaic acid and dinophysistoxins. FEBS J. 2008;275:6060-6.
    • (2008) FEBS J , vol.275 , pp. 6060-6066
    • Vale, C.1    Botana, L.M.2
  • 61
    • 0029043888 scopus 로고
    • A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labeled Annexin v
    • 7622868 10.1016/0022-1759(95)00072-I 1:CAS:528:DyaK2MXnt1Ojsbo%3D
    • Vermes I, Haanen C, Steffens-Nakken H, Reutelingsperger C. A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labeled Annexin V. J Immunol Methods. 1995;184:39-51.
    • (1995) J Immunol Methods , vol.184 , pp. 39-51
    • Vermes, I.1    Haanen, C.2    Steffens-Nakken, H.3    Reutelingsperger, C.4
  • 62
    • 0030798116 scopus 로고    scopus 로고
    • Apoptosis induction by inhibitors of Ser/Thr phosphatases 1 and 2A is associated with transglutaminase activation in two different human epithelial tumour lines
    • 10.1016/S0014-5793(97)00896-X
    • Von Zezschwitz C, Vorwerk H, Tergau F, Steinfelder HJ. Apoptosis induction by inhibitors of Ser/Thr phosphatases 1 and 2A is associated with transglutaminase activation in two different human epithelial tumour lines. FEBS Lett. 1997;413:147-51.
    • (1997) FEBS Lett , vol.413 , pp. 147-151
    • Von Zezschwitz, C.1    Vorwerk, H.2    Tergau, F.3    Steinfelder, H.J.4
  • 63
    • 0035542677 scopus 로고    scopus 로고
    • Flow cytometric assessment of haemocyte sub-populations in the European flat oyster, Ostrea edulis, haemolymph
    • 11592584 10.1006/fsim.2001.0335 1:STN:280:DC%2BD3MrksFGgsQ%3D%3D
    • Xue QG, Renault T, Chilmonczyk S. Flow cytometric assessment of haemocyte sub-populations in the European flat oyster, Ostrea edulis, haemolymph. Fish Shellfish Immunol. 2001;11:557-67.
    • (2001) Fish Shellfish Immunol , vol.11 , pp. 557-567
    • Xue, Q.G.1    Renault, T.2    Chilmonczyk, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.