Lack of DNA damage induction by okadaic acid, a marine toxin, in the CHO-Hprt and the in vitro UDS assays

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 564, Issue 2, 2004, Pages 139-147

  Le Hégarat, Ludovic ^a   Nesslany, Fabrice ^b   Mourot, Annick ^a   Marzin, Daniel ^b   Fessard, Valérie ^a  

^a Healthy Pigs Production and Experimentation Section   (France)

^b INSTITUT PASTEUR DE LILLE   (France)

Author keywords

CHO Hprt; DNA repair; Genotoxicity; Okadaic acid; UDS

Indexed keywords

HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; MARINE TOXIN; OKADAIC ACID; PHOSPHOPROTEIN PHOSPHATASE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL FRACTIONATION; CHO CELL; CHROMOSOME NUMBER; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; DNA SYNTHESIS; ENZYME INHIBITION; EXCISION REPAIR; GENE LOCUS; GENE MUTATION; GENOTOXICITY; KINETICS; LIVER CELL; MUTAGEN TESTING; MUTANT; NONHUMAN; PRIORITY JOURNAL; RAT; STATISTICAL SIGNIFICANCE; UNSCHEDULED DNA SYNTHESIS;

ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; DNA DAMAGE; DNA REPAIR; DNA REPLICATION; DOSE-RESPONSE RELATIONSHIP, DRUG; HEPATOCYTES; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; MARINE TOXINS; MUTAGENICITY TESTS; OKADAIC ACID; RATS; TIME FACTORS; TRITIUM;

DINOPHYCEAE;

EID: 7044227473     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2004.08.003     Document Type: Article

References (28)

1. T. Yasumoto, Y. Oshima, and M. Yamaguchi Occurrence of a new type of shellfish poisoning in the Tohoku district Bull. Jpn. Soc. Sci. Fish. 46 1978 1249 1275
2. M. Suganuma, H. Fujiki, H. Suguri, S. Yoshizawa, M. Hirota, M. Nakayasu, M. Ojika, K. Wakamatsu, K. Yamada, and T. Sugimura Okadaic acid: an additional non-phorbol-12-tetradecanoate-13-acetate-type tumor promoter Proc. Natl. Acad. Sci. U.S.A. 85 1988 1768 1771
3. M. Suganuma, M. Tatematsu, J. Yatsunami, S. Yoshizawa, S. Okabe, and H. Fujiki An alternative theory of tissue specificity by tumor promotion of okadaic acid in glandular stomach of SD rats Carcinogenesis 13 1992 1841 1845
4. C. Bialojan, and A. Takai Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases. Specificity and kinetics Biochem. J. 256 1988 283 290
5. N. Berndt Roles and regulation of serine/threonine-specific protein phosphatases in the cell cycle Prog. Cell Cycle Res. 5 2003 497 510
6. L. Le Hegarat, L. Puech, V. Fessard, J.M. Poul, and S. Dragacci Aneugenic potential of okadaic acid revealed by the micronucleus assay combined with the FISH technique in CHO-K1 cells Mutagenesis 18 2003 293 298
7. S. Aonuma, T. Ushijima, M. Nakayasu, H. Shima, T. Sugimura, and M. Nagao Mutation induction by okadaic acid, a protein phosphatase inhibitor, in CHL cells, but not in S. typhimurium Mutat. Res. 250 1991 375 381
8. C. Rogers, C. Heroux-Metcalf, and I. Langlois Evaluation of cytotoxicity and genotoxicity of okadaic acid, a non-phorbol ester type tumour promoter, in V79 Chinese hamster lung cells Toxico In Vitro 8 1994 269 276
9. H. Nakagama, S. Kaneko, H. Shima, H. Inamori, H. Fukuda, R. Kominami, T. Sugimura, and M. Nagao Induction of minisatellite mutation in NIH 3T3 cells by treatment with the tumor promoter okadaic acid Proc. Natl. Acad. Sci. U.S.A. 94 1997 10813 10816
10. V. Fessard, Y. Grosse, A. Pfohl Leszkowicz, and S. Puiseux Dao Okadaic acid treatment induces DNA adduct formation in BHK21 C13 fibroblasts and HESV keratinocytes Mutat. Res. 361 1996 133 141
11. A. Traore, I. Baudrimont, S. Ambaliou, S.D. Dano, and E.E. Creppy DNA breaks and cell cycle arrest induced by okadaic acid in Caco-2 cells, a human colonic epithelial cell line Arch. Toxicol. 75 2001 110 117
12. S. Ghosh, N. Paweletz, and D. Schroeter Failure of kinetochore development and mitotic spindle formation in okadaic acid-induced premature mitosis in HeLa cells Exp. Cell Res. 201 1992 535 540
13. J.J. Fernandez, M.L. Candenas, M.L. Souto, M.M. Trujillo, and M. Norte Okadaic acid, useful tool for studying cellular processes Curr. Med. Chem. 9 2002 229 262
14. A. Takai, C. Bialojan, M. Troschka, and J.C. Ruegg Smooth muscle myosin phosphatase inhibition and force enhancement by black sponge toxin FEBS Lett. 217 1987 81 84
15. P. Cohen The structure and regulation of protein phosphatases Annu. Rev. Biochem. 58 1989 453 508
16. R.R. Ariza, S.M. Keyse, J.G. Moggs, and R.D. Wood Reversible protein phosphorylation modulates nucleotide excision repair of damaged DNA by human cell extracts Nucl. Acids Res. 24 1996 433 440
17. P. Douglas, G.B. Moorhead, R. Ye, and S.P. Lees-Miller Protein phosphatases regulate DNA-dependent protein kinase activity J. Biol. Chem. 276 2001 18992 18998
18. M. Herman, Y. Ori, A. Chagnac, T. Weinstein, A. Korzets, D. Zevin, T. Malachi, and U. Gafter DNA repair in mononuclear cells: role of serine/threonine phosphatases J. Lab. Clin. Med. 140 2002 255 262
19. P.O. Seglen Preparation of isolated rat liver cells Meth. Cell Biol. 13 1976 29 83
20. S. Aonuma, T. Ushijima, M. Nakayasu, H. Shima, T. Sugimura, and M. Nagao Mutation induction by okadaic acid, a protein phosphatase inhibitor, in CHL cells, but not in S. typhimurium Mutat. Res. 250 1991 375 381
21. M.J. Aardema, S. Albertini, P. Ami, L.M. Henderson, M. Kirsch-Volders, J.M. Mackay, A.M. Sarrif, D.A. Stringer, and R.D. Taalman Aneuploidy: a report of an ECETOC task force Mutat. Res. 410 1998 3 79
22. H. Shima, H. Tohda, S. Aonuma, M. Nakayasu, A.A. DePaoli-Roach, T. Sugimura, and M. Nagao Characterization of the PP2A alpha gene mutation in okadaic acid-resistant variants of CHO-K1 cells Proc. Natl. Acad. Sci. U.S.A. 91 1994 9267 9271
23. G.M. Williams Detection of chemical carcinogens by unscheduled DNA synthesis in rat liver primary cell cultures Cancer Res. 37 1977 1845 1851
24. R. Benigni, A. Calcagnile, E. Dogliotti, E. Falcone, and A. Giuliani DNA repair induction by cytostatic drugs in proliferating and quiescent MRC-5 cells Teratog. Carcinog. Mutagen. 3 1983 481 490
25. H. Mori, K. Kawai, F. Ohbayashi, T. Kuniyasu, M. Yamazaki, T. Hamasaki, and G.M. Williams Genotoxicity of a variety of mycotoxins in the hepatocyte primary culture/DNA repair test using rat and mouse hepatocytes Cancer Res. 44 1984 2918 2923
26. L. Le Hegarat, V. Fessard, J.M. Poul, S. Dragacci, and P. Sanders Marine toxin okadaic acid induces aneuploidy in CHO-K1 cells in presence of rat liver postmitochondrial fraction, revealed by cytokinesis-block micronucleus assay coupled to FISH Environ. Toxicol. 19 2004 123 128
27. T. Hunter Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling Cell 80 1995 225 236
28. P.T. Cohen, and P. Cohen Discovery of a protein phosphatase activity encoded in the genome of bacteriophage lambda. Probable identity with open reading frame 221 Biochem. J. 260 1989 931 934