메뉴 건너뛰기




Volumn 386, Issue 6, 2013, Pages 541-550

Activated peroxisomal fatty acid metabolism improves cardiac recovery in ischemia-reperfusion

Author keywords

3 (2,2,2 Trimethylhydrazinium) propionate; Carnitine palmitoyltransferase I; Mitochondria; Peroxisomes; PPAR PGC1 pathway

Indexed keywords

3 (2,2,2 TRIMETHYLHYDRAZINIUM) PROPIONATE; CARNITINE; CARNITINE PALMITOYLTRANSFERASE I; FATTY ACID; MESSENGER RNA; PALMITOYLCARNITINE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PROPIONIC ACID; UNCLASSIFIED DRUG;

EID: 84878015345     PISSN: 00281298     EISSN: 14321912     Source Type: Journal    
DOI: 10.1007/s00210-013-0849-0     Document Type: Article
Times cited : (39)

References (36)
  • 1
    • 0031978533 scopus 로고    scopus 로고
    • Cardioprotective profile of MET-88, an inhibitor of carnitine synthesis, and insulin during hypoxia in isolated perfused rat hearts
    • 9565769 10.1111/j.1472-8206.1998.tb00936.x 1:CAS:528:DyaK1cXislenurg%3D
    • Asaka N, Muranaka Y, Kirimoto T, Miyake H (1998) Cardioprotective profile of MET-88, an inhibitor of carnitine synthesis, and insulin during hypoxia in isolated perfused rat hearts. Fundam Clin Pharmacol 12:158-163
    • (1998) Fundam Clin Pharmacol , vol.12 , pp. 158-163
    • Asaka, N.1    Muranaka, Y.2    Kirimoto, T.3    Miyake, H.4
  • 2
    • 79955442316 scopus 로고    scopus 로고
    • AMPK activation, a preventive therapeutic target in the transition from cardiac injury to heart failure
    • 21285292 10.1093/cvr/cvr034 1:CAS:528:DC%2BC3MXlt1GlsLk%3D
    • Beauloye C, Bertrand L, Horman S, Hue L (2011) AMPK activation, a preventive therapeutic target in the transition from cardiac injury to heart failure. Cardiovasc Res 90:224-233
    • (2011) Cardiovasc Res , vol.90 , pp. 224-233
    • Beauloye, C.1    Bertrand, L.2    Horman, S.3    Hue, L.4
  • 3
    • 0036701588 scopus 로고    scopus 로고
    • Mildronate: Cardioprotective action through carnitine-lowering effect
    • 12242052 10.1016/S1050-1738(02)00175-5 1:CAS:528:DC%2BD38XntVaqsbY%3D
    • Dambrova M, Liepinsh E, Kalvinsh I (2002) Mildronate: cardioprotective action through carnitine-lowering effect. Trends Cardiovasc Med 12:275-279
    • (2002) Trends Cardiovasc Med , vol.12 , pp. 275-279
    • Dambrova, M.1    Liepinsh, E.2    Kalvinsh, I.3
  • 5
    • 1442330857 scopus 로고    scopus 로고
    • Fatty acid oxidation and related gene expression in heart depleted of carnitine by mildronate treatment in the rat
    • 15030182 10.1023/B:MCBI.0000012853.20116.06 1:CAS:528: DC%2BD2cXlt1aqtg%3D%3D
    • Degrace P, Demizieux L, Gresti J, Tsoko M, Andre A, Demaison L, Clouet P (2004) Fatty acid oxidation and related gene expression in heart depleted of carnitine by mildronate treatment in the rat. Mol Cell Biochem 258:171-182
    • (2004) Mol Cell Biochem , vol.258 , pp. 171-182
    • Degrace, P.1    Demizieux, L.2    Gresti, J.3    Tsoko, M.4    Andre, A.5    Demaison, L.6    Clouet, P.7
  • 6
    • 0033001756 scopus 로고    scopus 로고
    • Insulin improves functional and metabolic recovery of reperfused working rat heart
    • 10391275 10.1016/S0003-4975(99)00326-4 1:STN:280:DyaK1MzhvVWmuw%3D%3D
    • Doenst T, Richwine RT, Bray MS, Goodwin GW, Frazier OH, Taegtmeyer H (1999) Insulin improves functional and metabolic recovery of reperfused working rat heart. Ann Thorac Surg 67:1682-1688
    • (1999) Ann Thorac Surg , vol.67 , pp. 1682-1688
    • Doenst, T.1    Richwine, R.T.2    Bray, M.S.3    Goodwin, G.W.4    Frazier, O.H.5    Taegtmeyer, H.6
  • 7
    • 79953765816 scopus 로고    scopus 로고
    • Peroxisome proliferator activated receptor-alpha (PPARalpha) and PPAR gamma coactivator-1alpha (PGC-1alpha) regulation of cardiac metabolism in diabetes
    • 21286700 10.1007/s00246-011-9889-8
    • Duncan JG (2011) Peroxisome proliferator activated receptor-alpha (PPARalpha) and PPAR gamma coactivator-1alpha (PGC-1alpha) regulation of cardiac metabolism in diabetes. Pediatr Cardiol 32:323-328
    • (2011) Pediatr Cardiol , vol.32 , pp. 323-328
    • Duncan, J.G.1
  • 8
    • 34248589911 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) regulatory cascade in cardiac physiology and disease
    • 17502589 10.1161/CIRCULATIONAHA.107.670588
    • Finck BN, Kelly DP (2007) Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) regulatory cascade in cardiac physiology and disease. Circulation 115:2540-2548
    • (2007) Circulation , vol.115 , pp. 2540-2548
    • Finck, B.N.1    Kelly, D.P.2
  • 10
    • 0023807336 scopus 로고
    • Properties and subcellular localization of myocardial fatty acyl-coenzyme A oxidase
    • 3414812 1:CAS:528:DyaL1cXmt1Ggu70%3D
    • Harrison EH, Walusimbi-Kisitu M (1988) Properties and subcellular localization of myocardial fatty acyl-coenzyme A oxidase. Am J Physiol 255:H441-H445
    • (1988) Am J Physiol , vol.255
    • Harrison, E.H.1    Walusimbi-Kisitu, M.2
  • 11
    • 0033652408 scopus 로고    scopus 로고
    • Cardioprotective effects of MET-88, a gamma-butyrobetaine hydroxylase inhibitor, on cardiac dysfunction induced by ischemia/reperfusion in isolated rat hearts
    • 11093075 10.1159/000028407 1:CAS:528:DC%2BD3cXosFKqtLg%3D
    • Hayashi Y, Tajima K, Kirimoto T, Miyake H, Matsuura N (2000) Cardioprotective effects of MET-88, a gamma-butyrobetaine hydroxylase inhibitor, on cardiac dysfunction induced by ischemia/reperfusion in isolated rat hearts. Pharmacology 61:238-243
    • (2000) Pharmacology , vol.61 , pp. 238-243
    • Hayashi, Y.1    Tajima, K.2    Kirimoto, T.3    Miyake, H.4    Matsuura, N.5
  • 12
    • 79961039309 scopus 로고    scopus 로고
    • Targeting AMPK for cardiac protection: Opportunities and challenges
    • 21147121 10.1016/j.yjmcc.2010.12.004 1:CAS:528:DC%2BC3MXhtFymt7jN
    • Kim M, Tian R (2011) Targeting AMPK for cardiac protection: opportunities and challenges. J Mol Cell Cardiol 51:548-553
    • (2011) J Mol Cell Cardiol , vol.51 , pp. 548-553
    • Kim, M.1    Tian, R.2
  • 14
    • 0038000658 scopus 로고    scopus 로고
    • Effects of fatty acids in isolated mitochondria: Implications for ischemic injury and cardioprotection
    • 12793979 1:CAS:528:DC%2BD3sXlsFGitLs%3D
    • Korge P, Honda HM, Weiss JN (2003) Effects of fatty acids in isolated mitochondria: implications for ischemic injury and cardioprotection. Am J Physiol Heart Circ Physiol 285:H259-H269
    • (2003) Am J Physiol Heart Circ Physiol , vol.285
    • Korge, P.1    Honda, H.M.2    Weiss, J.N.3
  • 16
    • 33846117009 scopus 로고    scopus 로고
    • Mildronate, an inhibitor of carnitine biosynthesis, induces an increase in gamma-butyrobetaine contents and cardioprotection in isolated rat heart infarction
    • 17204911 10.1097/01.fjc.0000250077.07702.23 1:CAS:528: DC%2BD2sXhsFymuw%3D%3D
    • Liepinsh E, Vilskersts R, Loca D, Kirjanova O, Pugovichs O, Kalvinsh I, Dambrova M (2006) Mildronate, an inhibitor of carnitine biosynthesis, induces an increase in gamma-butyrobetaine contents and cardioprotection in isolated rat heart infarction. J Cardiovasc Pharmacol 48:314-319
    • (2006) J Cardiovasc Pharmacol , vol.48 , pp. 314-319
    • Liepinsh, E.1    Vilskersts, R.2    Loca, D.3    Kirjanova, O.4    Pugovichs, O.5    Kalvinsh, I.6    Dambrova, M.7
  • 18
    • 84878019596 scopus 로고    scopus 로고
    • The regulation of energy metabolism pathways through L-carnitine homeostasis
    • C. Croniger (eds) InTech Rijeka
    • Liepinsh E, Kalvinsh I, Dambrova M (2011a) The regulation of energy metabolism pathways through L-carnitine homeostasis. In: Croniger C (ed) Role of the adipocyte in development of type 2 diabetes. InTech, Rijeka, pp 107-128
    • (2011) Role of the Adipocyte in Development of Type 2 Diabetes , pp. 107-128
    • Liepinsh, E.1    Kalvinsh, I.2    Dambrova, M.3
  • 19
    • 79953775086 scopus 로고    scopus 로고
    • Anti-diabetic effects of mildronate alone or in combination with metformin in obese Zucker rats
    • 21371472 10.1016/j.ejphar.2011.02.019 1:CAS:528:DC%2BC3MXktF2itrk%3D
    • Liepinsh E, Skapare E, Svalbe B, Makrecka M, Cirule H, Dambrova M (2011b) Anti-diabetic effects of mildronate alone or in combination with metformin in obese Zucker rats. Eur J Pharmacol 658:277-283
    • (2011) Eur J Pharmacol , vol.658 , pp. 277-283
    • Liepinsh, E.1    Skapare, E.2    Svalbe, B.3    Makrecka, M.4    Cirule, H.5    Dambrova, M.6
  • 20
    • 79953775086 scopus 로고    scopus 로고
    • Anti-diabetic effects of mildronate alone or in combination with metformin in obese Zucker rats
    • 21371472 10.1016/j.ejphar.2011.02.019 1:CAS:528:DC%2BC3MXktF2itrk%3D
    • Liepinsh E, Skapare E, Svalbe B, Makrecka M, Cirule H, Dambrova M (2011c) Anti-diabetic effects of mildronate alone or in combination with metformin in obese Zucker rats. Eur J Pharmacol 658:277-283
    • (2011) Eur J Pharmacol , vol.658 , pp. 277-283
    • Liepinsh, E.1    Skapare, E.2    Svalbe, B.3    Makrecka, M.4    Cirule, H.5    Dambrova, M.6
  • 21
    • 0030858058 scopus 로고    scopus 로고
    • Measurements of fatty acid and carbohydrate metabolism in the isolated working rat heart
    • 9278241 10.1023/A:1006875823561 1:CAS:528:DyaK2sXlvVGitLw%3D
    • Lopaschuk GD, Barr RL (1997) Measurements of fatty acid and carbohydrate metabolism in the isolated working rat heart. Mol Cell Biochem 172:137-147
    • (1997) Mol Cell Biochem , vol.172 , pp. 137-147
    • Lopaschuk, G.D.1    Barr, R.L.2
  • 22
    • 64249101080 scopus 로고    scopus 로고
    • Etomoxir-induced partial carnitine palmitoyltransferase-I (CPT-I) inhibition in vivo does not alter cardiac long-chain fatty acid uptake and oxidation rates
    • 19138173 10.1042/BJ20082159 1:CAS:528:DC%2BD1MXjs1yntb8%3D
    • Luiken JJ, Niessen HE, Coort SL, Hoebers N, Coumans WA, Schwenk RW, Bonen A, Glatz JF (2009) Etomoxir-induced partial carnitine palmitoyltransferase-I (CPT-I) inhibition in vivo does not alter cardiac long-chain fatty acid uptake and oxidation rates. Biochem J 419:447-455
    • (2009) Biochem J , vol.419 , pp. 447-455
    • Luiken, J.J.1    Niessen, H.E.2    Coort, S.L.3    Hoebers, N.4    Coumans, W.A.5    Schwenk, R.W.6    Bonen, A.7    Glatz, J.F.8
  • 23
    • 33845326985 scopus 로고    scopus 로고
    • Peroxisomal beta-oxidation - A metabolic pathway with multiple functions
    • 17028011 10.1016/j.bbamcr.2006.08.034 1:CAS:528:DC%2BD28Xhtlakur%2FK
    • Poirier Y, Antonenkov VD, Glumoff T, Hiltunen JK (2006) Peroxisomal beta-oxidation - a metabolic pathway with multiple functions. Biochim Biophys Acta 1763:1413-1426
    • (2006) Biochim Biophys Acta , vol.1763 , pp. 1413-1426
    • Poirier, Y.1    Antonenkov, V.D.2    Glumoff, T.3    Hiltunen, J.K.4
  • 25
    • 77952321987 scopus 로고    scopus 로고
    • The plasma carnitine concentration regulates renal OCTN2 expression and carnitine transport in rats
    • 20303936 10.1016/j.ejphar.2010.02.045 1:CAS:528:DC%2BC3cXlsFGnt74%3D
    • Schurch R, Todesco L, Novakova K, Mevissen M, Stieger B, Krahenbuhl S (2010) The plasma carnitine concentration regulates renal OCTN2 expression and carnitine transport in rats. Eur J Pharmacol 635:171-176
    • (2010) Eur J Pharmacol , vol.635 , pp. 171-176
    • Schurch, R.1    Todesco, L.2    Novakova, K.3    Mevissen, M.4    Stieger, B.5    Krahenbuhl, S.6
  • 27
    • 84860168205 scopus 로고    scopus 로고
    • Inhibition of fatty acid metabolism ameliorates disease activity in an animal model of multiple sclerosis
    • 22355598 10.1038/srep00079
    • Shriver LP, Manchester M (2011) Inhibition of fatty acid metabolism ameliorates disease activity in an animal model of multiple sclerosis. Sci Rep 1:79
    • (2011) Sci Rep , vol.1 , pp. 79
    • Shriver, L.P.1    Manchester, M.2
  • 29
    • 50549197155 scopus 로고
    • Citryl-CoA an substrate for the citrate-cleavage enzyme
    • 14068533 10.1016/0926-6569(63)90146-9 1:CAS:528:DyaF3sXktlKktLs%3D
    • Srere PA (1963) Citryl-CoA an substrate for the citrate-cleavage enzyme. Biochim Biophys Acta 73:523-525
    • (1963) Biochim Biophys Acta , vol.73 , pp. 523-525
    • Srere, P.A.1
  • 30
    • 67651085380 scopus 로고    scopus 로고
    • PPARs and the orchestration of metabolic fuel selection
    • 19646653 10.1016/j.phrs.2009.03.014 1:CAS:528:DC%2BD1MXptl2htbc%3D
    • Sugden MC, Zariwala MG, Holness MJ (2009) PPARs and the orchestration of metabolic fuel selection. Pharmacol Res 60:141-150
    • (2009) Pharmacol Res , vol.60 , pp. 141-150
    • Sugden, M.C.1    Zariwala, M.G.2    Holness, M.J.3
  • 33
    • 62949240070 scopus 로고    scopus 로고
    • Mildronate, a regulator of energy metabolism, reduces atherosclerosis in apoE/LDLR-/- mice
    • 19325254 10.1159/000210015 1:CAS:528:DC%2BD1MXlvFWlsbk%3D
    • Vilskersts R, Liepinsh E, Mateuszuk L, Grinberga S, Kalvinsh I, Chlopicki S, Dambrova M (2009) Mildronate, a regulator of energy metabolism, reduces atherosclerosis in apoE/LDLR-/- mice. Pharmacology 83:287-293
    • (2009) Pharmacology , vol.83 , pp. 287-293
    • Vilskersts, R.1    Liepinsh, E.2    Mateuszuk, L.3    Grinberga, S.4    Kalvinsh, I.5    Chlopicki, S.6    Dambrova, M.7
  • 34
    • 37349129856 scopus 로고    scopus 로고
    • Metabolic therapy for the treatment of ischemic heart disease: Reality and expectations
    • 18035928 10.1586/14779072.5.6.1123 1:CAS:528:DC%2BD2sXhtlKltbzJ
    • Wang W, Lopaschuk GD (2007) Metabolic therapy for the treatment of ischemic heart disease: reality and expectations. Expert Rev Cardiovasc Ther 5:1123-1134
    • (2007) Expert Rev Cardiovasc Ther , vol.5 , pp. 1123-1134
    • Wang, W.1    Lopaschuk, G.D.2
  • 35
    • 0025093631 scopus 로고
    • Automated assays for superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase activity
    • 2327564 10.1016/0003-2697(90)90668-Y 1:CAS:528:DyaK3cXhtlCru70%3D
    • Wheeler CR, Salzman JA, Elsayed NM, Omaye ST, Korte DW Jr (1990) Automated assays for superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase activity. Anal Biochem 184:193-199
    • (1990) Anal Biochem , vol.184 , pp. 193-199
    • Wheeler, C.R.1    Salzman, J.A.2    Elsayed, N.M.3    Omaye, S.T.4    Korte, Jr.D.W.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.