-
1
-
-
0031978533
-
Cardioprotective profile of MET-88, an inhibitor of carnitine synthesis, and insulin during hypoxia in isolated perfused rat hearts
-
9565769 10.1111/j.1472-8206.1998.tb00936.x 1:CAS:528:DyaK1cXislenurg%3D
-
Asaka N, Muranaka Y, Kirimoto T, Miyake H (1998) Cardioprotective profile of MET-88, an inhibitor of carnitine synthesis, and insulin during hypoxia in isolated perfused rat hearts. Fundam Clin Pharmacol 12:158-163
-
(1998)
Fundam Clin Pharmacol
, vol.12
, pp. 158-163
-
-
Asaka, N.1
Muranaka, Y.2
Kirimoto, T.3
Miyake, H.4
-
2
-
-
79955442316
-
AMPK activation, a preventive therapeutic target in the transition from cardiac injury to heart failure
-
21285292 10.1093/cvr/cvr034 1:CAS:528:DC%2BC3MXlt1GlsLk%3D
-
Beauloye C, Bertrand L, Horman S, Hue L (2011) AMPK activation, a preventive therapeutic target in the transition from cardiac injury to heart failure. Cardiovasc Res 90:224-233
-
(2011)
Cardiovasc Res
, vol.90
, pp. 224-233
-
-
Beauloye, C.1
Bertrand, L.2
Horman, S.3
Hue, L.4
-
3
-
-
0036701588
-
Mildronate: Cardioprotective action through carnitine-lowering effect
-
12242052 10.1016/S1050-1738(02)00175-5 1:CAS:528:DC%2BD38XntVaqsbY%3D
-
Dambrova M, Liepinsh E, Kalvinsh I (2002) Mildronate: cardioprotective action through carnitine-lowering effect. Trends Cardiovasc Med 12:275-279
-
(2002)
Trends Cardiovasc Med
, vol.12
, pp. 275-279
-
-
Dambrova, M.1
Liepinsh, E.2
Kalvinsh, I.3
-
4
-
-
52949141438
-
Effect of inhibiting carnitine biosynthesis on male rat sexual performance
-
18640137 10.1016/j.physbeh.2008.06.012 1:CAS:528:DC%2BD1cXhtFOlsLzJ
-
Dambrova M, Cirule H, Svalbe B, Zvejniece L, Pugovichs O, Zorenko T, Kalvinsh I, Liepinsh E, Belozertseva I (2008) Effect of inhibiting carnitine biosynthesis on male rat sexual performance. Physiol Behav 95:341-347
-
(2008)
Physiol Behav
, vol.95
, pp. 341-347
-
-
Dambrova, M.1
Cirule, H.2
Svalbe, B.3
Zvejniece, L.4
Pugovichs, O.5
Zorenko, T.6
Kalvinsh, I.7
Liepinsh, E.8
Belozertseva, I.9
-
5
-
-
1442330857
-
Fatty acid oxidation and related gene expression in heart depleted of carnitine by mildronate treatment in the rat
-
15030182 10.1023/B:MCBI.0000012853.20116.06 1:CAS:528: DC%2BD2cXlt1aqtg%3D%3D
-
Degrace P, Demizieux L, Gresti J, Tsoko M, Andre A, Demaison L, Clouet P (2004) Fatty acid oxidation and related gene expression in heart depleted of carnitine by mildronate treatment in the rat. Mol Cell Biochem 258:171-182
-
(2004)
Mol Cell Biochem
, vol.258
, pp. 171-182
-
-
Degrace, P.1
Demizieux, L.2
Gresti, J.3
Tsoko, M.4
Andre, A.5
Demaison, L.6
Clouet, P.7
-
6
-
-
0033001756
-
Insulin improves functional and metabolic recovery of reperfused working rat heart
-
10391275 10.1016/S0003-4975(99)00326-4 1:STN:280:DyaK1MzhvVWmuw%3D%3D
-
Doenst T, Richwine RT, Bray MS, Goodwin GW, Frazier OH, Taegtmeyer H (1999) Insulin improves functional and metabolic recovery of reperfused working rat heart. Ann Thorac Surg 67:1682-1688
-
(1999)
Ann Thorac Surg
, vol.67
, pp. 1682-1688
-
-
Doenst, T.1
Richwine, R.T.2
Bray, M.S.3
Goodwin, G.W.4
Frazier, O.H.5
Taegtmeyer, H.6
-
7
-
-
79953765816
-
Peroxisome proliferator activated receptor-alpha (PPARalpha) and PPAR gamma coactivator-1alpha (PGC-1alpha) regulation of cardiac metabolism in diabetes
-
21286700 10.1007/s00246-011-9889-8
-
Duncan JG (2011) Peroxisome proliferator activated receptor-alpha (PPARalpha) and PPAR gamma coactivator-1alpha (PGC-1alpha) regulation of cardiac metabolism in diabetes. Pediatr Cardiol 32:323-328
-
(2011)
Pediatr Cardiol
, vol.32
, pp. 323-328
-
-
Duncan, J.G.1
-
8
-
-
34248589911
-
Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) regulatory cascade in cardiac physiology and disease
-
17502589 10.1161/CIRCULATIONAHA.107.670588
-
Finck BN, Kelly DP (2007) Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) regulatory cascade in cardiac physiology and disease. Circulation 115:2540-2548
-
(2007)
Circulation
, vol.115
, pp. 2540-2548
-
-
Finck, B.N.1
Kelly, D.P.2
-
9
-
-
37449031461
-
Prevention of cardiac hypertrophy and heart failure by silencing of NF-kappaB
-
18037434 10.1016/j.jmb.2007.10.006 1:CAS:528:DC%2BD2sXhsVOlt73F
-
Gupta S, Young D, Maitra RK, Gupta A, Popovic ZB, Yong SL, Mahajan A, Wang Q, Sen S (2008) Prevention of cardiac hypertrophy and heart failure by silencing of NF-kappaB. J Mol Biol 375:637-649
-
(2008)
J Mol Biol
, vol.375
, pp. 637-649
-
-
Gupta, S.1
Young, D.2
Maitra, R.K.3
Gupta, A.4
Popovic, Z.B.5
Yong, S.L.6
Mahajan, A.7
Wang, Q.8
Sen, S.9
-
10
-
-
0023807336
-
Properties and subcellular localization of myocardial fatty acyl-coenzyme A oxidase
-
3414812 1:CAS:528:DyaL1cXmt1Ggu70%3D
-
Harrison EH, Walusimbi-Kisitu M (1988) Properties and subcellular localization of myocardial fatty acyl-coenzyme A oxidase. Am J Physiol 255:H441-H445
-
(1988)
Am J Physiol
, vol.255
-
-
Harrison, E.H.1
Walusimbi-Kisitu, M.2
-
11
-
-
0033652408
-
Cardioprotective effects of MET-88, a gamma-butyrobetaine hydroxylase inhibitor, on cardiac dysfunction induced by ischemia/reperfusion in isolated rat hearts
-
11093075 10.1159/000028407 1:CAS:528:DC%2BD3cXosFKqtLg%3D
-
Hayashi Y, Tajima K, Kirimoto T, Miyake H, Matsuura N (2000) Cardioprotective effects of MET-88, a gamma-butyrobetaine hydroxylase inhibitor, on cardiac dysfunction induced by ischemia/reperfusion in isolated rat hearts. Pharmacology 61:238-243
-
(2000)
Pharmacology
, vol.61
, pp. 238-243
-
-
Hayashi, Y.1
Tajima, K.2
Kirimoto, T.3
Miyake, H.4
Matsuura, N.5
-
12
-
-
79961039309
-
Targeting AMPK for cardiac protection: Opportunities and challenges
-
21147121 10.1016/j.yjmcc.2010.12.004 1:CAS:528:DC%2BC3MXhtFymt7jN
-
Kim M, Tian R (2011) Targeting AMPK for cardiac protection: opportunities and challenges. J Mol Cell Cardiol 51:548-553
-
(2011)
J Mol Cell Cardiol
, vol.51
, pp. 548-553
-
-
Kim, M.1
Tian, R.2
-
13
-
-
60549100329
-
PPAR{alpha} attenuates the proinflammatory response in activated mesangial cells
-
19036849 10.1152/ajprenal.00484.2007 1:CAS:528:DC%2BD1MXitVejurw%3D
-
Kono K, Kamijo Y, Hora K, Takahashi K, Higuchi M, Kiyosawa K, Shigematsu H, Gonzalez FJ, Aoyama T (2009) PPAR{alpha} attenuates the proinflammatory response in activated mesangial cells. Am J Physiol Renal Physiol 296:F328-F336
-
(2009)
Am J Physiol Renal Physiol
, vol.296
-
-
Kono, K.1
Kamijo, Y.2
Hora, K.3
Takahashi, K.4
Higuchi, M.5
Kiyosawa, K.6
Shigematsu, H.7
Gonzalez, F.J.8
Aoyama, T.9
-
14
-
-
0038000658
-
Effects of fatty acids in isolated mitochondria: Implications for ischemic injury and cardioprotection
-
12793979 1:CAS:528:DC%2BD3sXlsFGitLs%3D
-
Korge P, Honda HM, Weiss JN (2003) Effects of fatty acids in isolated mitochondria: implications for ischemic injury and cardioprotection. Am J Physiol Heart Circ Physiol 285:H259-H269
-
(2003)
Am J Physiol Heart Circ Physiol
, vol.285
-
-
Korge, P.1
Honda, H.M.2
Weiss, J.N.3
-
15
-
-
84867190368
-
The cardioprotective effect of mildronate is diminished after co-treatment with L-carnitine
-
21903968 10.1177/1074248411419502 1:CAS:528:DC%2BC38Xpt1yisLs%3D
-
Kuka J, Vilskersts R, Cirule H, Makrecka M, Pugovics O, Kalvinsh I, Dambrova M, Liepinsh E (2012) The cardioprotective effect of mildronate is diminished after co-treatment with L-carnitine. J Cardiovasc Pharmacol Ther 17:215-222
-
(2012)
J Cardiovasc Pharmacol Ther
, vol.17
, pp. 215-222
-
-
Kuka, J.1
Vilskersts, R.2
Cirule, H.3
Makrecka, M.4
Pugovics, O.5
Kalvinsh, I.6
Dambrova, M.7
Liepinsh, E.8
-
16
-
-
33846117009
-
Mildronate, an inhibitor of carnitine biosynthesis, induces an increase in gamma-butyrobetaine contents and cardioprotection in isolated rat heart infarction
-
17204911 10.1097/01.fjc.0000250077.07702.23 1:CAS:528: DC%2BD2sXhsFymuw%3D%3D
-
Liepinsh E, Vilskersts R, Loca D, Kirjanova O, Pugovichs O, Kalvinsh I, Dambrova M (2006) Mildronate, an inhibitor of carnitine biosynthesis, induces an increase in gamma-butyrobetaine contents and cardioprotection in isolated rat heart infarction. J Cardiovasc Pharmacol 48:314-319
-
(2006)
J Cardiovasc Pharmacol
, vol.48
, pp. 314-319
-
-
Liepinsh, E.1
Vilskersts, R.2
Loca, D.3
Kirjanova, O.4
Pugovichs, O.5
Kalvinsh, I.6
Dambrova, M.7
-
17
-
-
70350324903
-
Protective effects of mildronate in an experimental model of type 2 diabetes in Goto-Kakizaki rats
-
19594753 10.1111/j.1476-5381.2009.00319.x 1:CAS:528:DC%2BD1MXhsVKmu7jE
-
Liepinsh E, Vilskersts R, Zvejniece L, Svalbe B, Skapare E, Kuka J, Cirule H, Grinberga S, Kalvinsh I, Dambrova M (2009) Protective effects of mildronate in an experimental model of type 2 diabetes in Goto-Kakizaki rats. Br J Pharmacol 157:1549-1556
-
(2009)
Br J Pharmacol
, vol.157
, pp. 1549-1556
-
-
Liepinsh, E.1
Vilskersts, R.2
Zvejniece, L.3
Svalbe, B.4
Skapare, E.5
Kuka, J.6
Cirule, H.7
Grinberga, S.8
Kalvinsh, I.9
Dambrova, M.10
-
19
-
-
79953775086
-
Anti-diabetic effects of mildronate alone or in combination with metformin in obese Zucker rats
-
21371472 10.1016/j.ejphar.2011.02.019 1:CAS:528:DC%2BC3MXktF2itrk%3D
-
Liepinsh E, Skapare E, Svalbe B, Makrecka M, Cirule H, Dambrova M (2011b) Anti-diabetic effects of mildronate alone or in combination with metformin in obese Zucker rats. Eur J Pharmacol 658:277-283
-
(2011)
Eur J Pharmacol
, vol.658
, pp. 277-283
-
-
Liepinsh, E.1
Skapare, E.2
Svalbe, B.3
Makrecka, M.4
Cirule, H.5
Dambrova, M.6
-
20
-
-
79953775086
-
Anti-diabetic effects of mildronate alone or in combination with metformin in obese Zucker rats
-
21371472 10.1016/j.ejphar.2011.02.019 1:CAS:528:DC%2BC3MXktF2itrk%3D
-
Liepinsh E, Skapare E, Svalbe B, Makrecka M, Cirule H, Dambrova M (2011c) Anti-diabetic effects of mildronate alone or in combination with metformin in obese Zucker rats. Eur J Pharmacol 658:277-283
-
(2011)
Eur J Pharmacol
, vol.658
, pp. 277-283
-
-
Liepinsh, E.1
Skapare, E.2
Svalbe, B.3
Makrecka, M.4
Cirule, H.5
Dambrova, M.6
-
21
-
-
0030858058
-
Measurements of fatty acid and carbohydrate metabolism in the isolated working rat heart
-
9278241 10.1023/A:1006875823561 1:CAS:528:DyaK2sXlvVGitLw%3D
-
Lopaschuk GD, Barr RL (1997) Measurements of fatty acid and carbohydrate metabolism in the isolated working rat heart. Mol Cell Biochem 172:137-147
-
(1997)
Mol Cell Biochem
, vol.172
, pp. 137-147
-
-
Lopaschuk, G.D.1
Barr, R.L.2
-
22
-
-
64249101080
-
Etomoxir-induced partial carnitine palmitoyltransferase-I (CPT-I) inhibition in vivo does not alter cardiac long-chain fatty acid uptake and oxidation rates
-
19138173 10.1042/BJ20082159 1:CAS:528:DC%2BD1MXjs1yntb8%3D
-
Luiken JJ, Niessen HE, Coort SL, Hoebers N, Coumans WA, Schwenk RW, Bonen A, Glatz JF (2009) Etomoxir-induced partial carnitine palmitoyltransferase-I (CPT-I) inhibition in vivo does not alter cardiac long-chain fatty acid uptake and oxidation rates. Biochem J 419:447-455
-
(2009)
Biochem J
, vol.419
, pp. 447-455
-
-
Luiken, J.J.1
Niessen, H.E.2
Coort, S.L.3
Hoebers, N.4
Coumans, W.A.5
Schwenk, R.W.6
Bonen, A.7
Glatz, J.F.8
-
23
-
-
33845326985
-
Peroxisomal beta-oxidation - A metabolic pathway with multiple functions
-
17028011 10.1016/j.bbamcr.2006.08.034 1:CAS:528:DC%2BD28Xhtlakur%2FK
-
Poirier Y, Antonenkov VD, Glumoff T, Hiltunen JK (2006) Peroxisomal beta-oxidation - a metabolic pathway with multiple functions. Biochim Biophys Acta 1763:1413-1426
-
(2006)
Biochim Biophys Acta
, vol.1763
, pp. 1413-1426
-
-
Poirier, Y.1
Antonenkov, V.D.2
Glumoff, T.3
Hiltunen, J.K.4
-
24
-
-
83155173464
-
The role of PPAR in myocardial response to ischemia in normal and diseased heart
-
22131314 10.4149/gpb-2011-04-329 1:CAS:528:DC%2BC38XisVSnu7w%3D
-
Ravingerova T, Adameova A, Carnicka S, Nemcekova M, Kelly T, Matejikova J, Galatou E, Barlaka E, Lazou A (2011) The role of PPAR in myocardial response to ischemia in normal and diseased heart. Gen Physiol Biophys 30:329-341
-
(2011)
Gen Physiol Biophys
, vol.30
, pp. 329-341
-
-
Ravingerova, T.1
Adameova, A.2
Carnicka, S.3
Nemcekova, M.4
Kelly, T.5
Matejikova, J.6
Galatou, E.7
Barlaka, E.8
Lazou, A.9
-
25
-
-
77952321987
-
The plasma carnitine concentration regulates renal OCTN2 expression and carnitine transport in rats
-
20303936 10.1016/j.ejphar.2010.02.045 1:CAS:528:DC%2BC3cXlsFGnt74%3D
-
Schurch R, Todesco L, Novakova K, Mevissen M, Stieger B, Krahenbuhl S (2010) The plasma carnitine concentration regulates renal OCTN2 expression and carnitine transport in rats. Eur J Pharmacol 635:171-176
-
(2010)
Eur J Pharmacol
, vol.635
, pp. 171-176
-
-
Schurch, R.1
Todesco, L.2
Novakova, K.3
Mevissen, M.4
Stieger, B.5
Krahenbuhl, S.6
-
26
-
-
70350349886
-
Novel role of FATP1 in mitochondrial fatty acid oxidation in skeletal muscle cells
-
19429947 10.1194/jlr.M800535-JLR200 1:CAS:528:DC%2BD1MXhtVCgsrbJ
-
Sebastian D, Guitart M, Garcia-Martinez C, Mauvezin C, Orellana-Gavalda JM, Serra D, Gomez-Foix AM, Hegardt FG, Asins G (2009) Novel role of FATP1 in mitochondrial fatty acid oxidation in skeletal muscle cells. J Lipid Res 50:1789-1799
-
(2009)
J Lipid Res
, vol.50
, pp. 1789-1799
-
-
Sebastian, D.1
Guitart, M.2
Garcia-Martinez, C.3
Mauvezin, C.4
Orellana-Gavalda, J.M.5
Serra, D.6
Gomez-Foix, A.M.7
Hegardt, F.G.8
Asins, G.9
-
27
-
-
84860168205
-
Inhibition of fatty acid metabolism ameliorates disease activity in an animal model of multiple sclerosis
-
22355598 10.1038/srep00079
-
Shriver LP, Manchester M (2011) Inhibition of fatty acid metabolism ameliorates disease activity in an animal model of multiple sclerosis. Sci Rep 1:79
-
(2011)
Sci Rep
, vol.1
, pp. 79
-
-
Shriver, L.P.1
Manchester, M.2
-
29
-
-
50549197155
-
Citryl-CoA an substrate for the citrate-cleavage enzyme
-
14068533 10.1016/0926-6569(63)90146-9 1:CAS:528:DyaF3sXktlKktLs%3D
-
Srere PA (1963) Citryl-CoA an substrate for the citrate-cleavage enzyme. Biochim Biophys Acta 73:523-525
-
(1963)
Biochim Biophys Acta
, vol.73
, pp. 523-525
-
-
Srere, P.A.1
-
30
-
-
67651085380
-
PPARs and the orchestration of metabolic fuel selection
-
19646653 10.1016/j.phrs.2009.03.014 1:CAS:528:DC%2BD1MXptl2htbc%3D
-
Sugden MC, Zariwala MG, Holness MJ (2009) PPARs and the orchestration of metabolic fuel selection. Pharmacol Res 60:141-150
-
(2009)
Pharmacol Res
, vol.60
, pp. 141-150
-
-
Sugden, M.C.1
Zariwala, M.G.2
Holness, M.J.3
-
31
-
-
49849093271
-
Different effects of palmitoyl-L-carnitine and palmitoyl-CoA on mitochondrial function in rat ventricular myocytes
-
18469143 10.1152/ajpheart.01307.2007 1:CAS:528:DC%2BD1cXoslygtbk%3D
-
Tominaga H, Katoh H, Odagiri K, Takeuchi Y, Kawashima H, Saotome M, Urushida T, Satoh H, Hayashi H (2008) Different effects of palmitoyl-L-carnitine and palmitoyl-CoA on mitochondrial function in rat ventricular myocytes. Am J Physiol Heart Circ Physiol 295:H105-H112
-
(2008)
Am J Physiol Heart Circ Physiol
, vol.295
-
-
Tominaga, H.1
Katoh, H.2
Odagiri, K.3
Takeuchi, Y.4
Kawashima, H.5
Saotome, M.6
Urushida, T.7
Satoh, H.8
Hayashi, H.9
-
32
-
-
84860134902
-
Stimulation of glucose oxidation protects against acute myocardial infarction and reperfusion injury
-
Ussher JR, Wang W, Gandhi M, Keung W, Samokhvalov V, Oka T, Wagg CS, Jaswal JS, Harris RA, Clanachan AS, Dyck JR, Lopaschuk GD (2012) Stimulation of glucose oxidation protects against acute myocardial infarction and reperfusion injury. Cardiovasc Res 94:359-369
-
(2012)
Cardiovasc Res
, vol.94
, pp. 359-369
-
-
Ussher, J.R.1
Wang, W.2
Gandhi, M.3
Keung, W.4
Samokhvalov, V.5
Oka, T.6
Wagg, C.S.7
Jaswal, J.S.8
Harris, R.A.9
Clanachan, A.S.10
Dyck, J.R.11
Lopaschuk, G.D.12
-
33
-
-
62949240070
-
Mildronate, a regulator of energy metabolism, reduces atherosclerosis in apoE/LDLR-/- mice
-
19325254 10.1159/000210015 1:CAS:528:DC%2BD1MXlvFWlsbk%3D
-
Vilskersts R, Liepinsh E, Mateuszuk L, Grinberga S, Kalvinsh I, Chlopicki S, Dambrova M (2009) Mildronate, a regulator of energy metabolism, reduces atherosclerosis in apoE/LDLR-/- mice. Pharmacology 83:287-293
-
(2009)
Pharmacology
, vol.83
, pp. 287-293
-
-
Vilskersts, R.1
Liepinsh, E.2
Mateuszuk, L.3
Grinberga, S.4
Kalvinsh, I.5
Chlopicki, S.6
Dambrova, M.7
-
34
-
-
37349129856
-
Metabolic therapy for the treatment of ischemic heart disease: Reality and expectations
-
18035928 10.1586/14779072.5.6.1123 1:CAS:528:DC%2BD2sXhtlKltbzJ
-
Wang W, Lopaschuk GD (2007) Metabolic therapy for the treatment of ischemic heart disease: reality and expectations. Expert Rev Cardiovasc Ther 5:1123-1134
-
(2007)
Expert Rev Cardiovasc Ther
, vol.5
, pp. 1123-1134
-
-
Wang, W.1
Lopaschuk, G.D.2
-
35
-
-
0025093631
-
Automated assays for superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase activity
-
2327564 10.1016/0003-2697(90)90668-Y 1:CAS:528:DyaK3cXhtlCru70%3D
-
Wheeler CR, Salzman JA, Elsayed NM, Omaye ST, Korte DW Jr (1990) Automated assays for superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase activity. Anal Biochem 184:193-199
-
(1990)
Anal Biochem
, vol.184
, pp. 193-199
-
-
Wheeler, C.R.1
Salzman, J.A.2
Elsayed, N.M.3
Omaye, S.T.4
Korte, Jr.D.W.5
-
36
-
-
0242525729
-
Activation of peroxisome proliferator-activated receptor-alpha protects the heart from ischemia/reperfusion injury
-
14557369 10.1161/01.CIR.0000093187.42015.6C 1:CAS:528: DC%2BD3sXos1Snu7s%3D
-
Yue TL, Bao W, Jucker BM, Gu JL, Romanic AM, Brown PJ, Cui J, Thudium DT, Boyce R, Burns-Kurtis CL, Mirabile RC, Aravindhan K, Ohlstein EH (2003) Activation of peroxisome proliferator-activated receptor-alpha protects the heart from ischemia/reperfusion injury. Circulation 108:2393-2399
-
(2003)
Circulation
, vol.108
, pp. 2393-2399
-
-
Yue, T.L.1
Bao, W.2
Jucker, B.M.3
Gu, J.L.4
Romanic, A.M.5
Brown, P.J.6
Cui, J.7
Thudium, D.T.8
Boyce, R.9
Burns-Kurtis, C.L.10
Mirabile, R.C.11
Aravindhan, K.12
Ohlstein, E.H.13
|