Fatty acid oxidation and related gene expression in heart depleted of carnitine by mildronate treatment in the rat

Molecular and Cellular Biochemistry

Volumn 258, Issue 1-2, 2004, Pages 171-182

  Degrace, Pascal ^a   Demizieux, Laurent ^a   Gresti, Joseph ^a   Tsoko, Marcelline ^a   André, Agnès ^b   Demaison, Luc ^b   Clouet, Pierre ^a  

^a UNIVERSITÉ DE BOURGOGNE   (France)

^b CEMAGREF   (France)

Author keywords

Carnitine palmitoyltransferase I; Esterification; Fatty acid transport; Gene regulation; Heart perfusion; Isolated mitochondria; Mildronate

Indexed keywords

CARNITINE; CARNITINE PALMITOYLTRANSFERASE; CARRIER PROTEIN; FATTY ACID; HEART MUSCLE EXTRACT; ISOENZYME; LIPOPROTEIN LIPASE; MESSENGER RNA; MILDRONATE; PALMITIC ACID; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL COMPARTMENTALIZATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENZYME ACTIVITY; ESTERIFICATION; FATTY ACID BLOOD LEVEL; FATTY ACID OXIDATION; FATTY ACID SYNTHESIS; FATTY ACID TRANSPORT; GENE EXPRESSION; HEART; HEART MITOCHONDRION; HEART MUSCLE CELL; HEART PERFUSION; IN VIVO STUDY; ISOLATION PROCEDURE; LIPID BLOOD LEVEL; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN DEPLETION; RAT; REGULATORY MECHANISM; SARCOLEMMA; TISSUE HOMOGENATE; TISSUE LEVEL; TRIACYLGLYCEROL BLOOD LEVEL;

ANIMALS; BIOLOGICAL TRANSPORT; CARDIOVASCULAR AGENTS; CARNITINE; CARNITINE O-PALMITOYLTRANSFERASE; ESTERIFICATION; FATTY ACIDS; GENE EXPRESSION REGULATION; LIPOPROTEIN LIPASE; MALE; METHYLHYDRAZINES; MITOCHONDRIA, HEART; MYOCARDIUM; OXIDATION-REDUCTION; OXYGEN CONSUMPTION; PALMITIC ACID; PERFUSION; RATS; RATS, WISTAR; RNA, MESSENGER; TRIGLYCERIDES;

EID: 1442330857     PISSN: 03008177     EISSN: None     Source Type: Journal    
DOI: 10.1023/B:MCBI.0000012853.20116.06     Document Type: Article

References (65)

1. van der Vusse GJ, Glatz JF, Stam HC, Reneman RS: Fatty acid homeostasis in the normoxic and ischemic heart. Physiol Rev 72: 881-940, 1992
2. Evans RD, Bennett MJ, Hauton D: Perfused heart studies to investigate lipid metabolism. Biochem Soc Trans 28: 113-120, 2000
3. Hoppel CL, Davis AT: Inter-tissue relationships in the synthesis and distribution of carnitine. Biochem Soc Trans 14: 673-674, 1986
4. Paulson DJ: Carnitine deficiency-induced cardiomyopathy. Mol Cell Biochem 180: 33-41, 1998
5. Martin MA, Gomez MA, Guillen F, Bornstein B, Campos Y, Rubio JC, de la Calzada CS, Arenas J: Myocardial carnitine and carnitine palmitoyltransferase deficiencies in patients with severe heart failure. Biochim Biophys Acta 1502: 330-336, 2000
6. Esser V, Britton CH, Weis BC, Foster DW, McGarry JD: Cloning, sequencing, and expression of a cDNA encoding rat liver carnitine palmitoyltransferase I. Direct evidence that a single polypeptide is involved in inhibitor interaction and catalytic function. J Biol Chem 268: 5817-5822, 1993
7. Britton CH, Schultz RA, Zhang B, Esser V, Foster DW, McGarry JD: Human liver mitochondrial carnitine palmitoyltransferase I: Characterization of its cDNA and chromosomal localization and partial analysis of the gene. Proc Natl Acad Sci USA 92: 1984-1988, 1995
8. Esser V, Brown NF, Cowan AT, Foster DW, McGarry JD: Expression of a cDNA isolated from rat brown adipose tissue and heart identifies the product as the muscle isoform of carnitine palmitoyltransferase I (M-CPT I). M-CPT I is the predominant CPT I isoform expressed in both white (epididymal) and brown adipocytes. J Biol Chem 271: 6972-6977, 1996
9. Sul HS, Wang D: Nutritional and hormonal regulation of enzymes in fat synthesis: Studies of fatty acid synthase and mitochondrial glycerol-3-phosphate acyltransferase gene transcription. Annu Rev Nutr 18: 331-351, 1998
10. Andersson M, Wettesten M, Boren J, Magnusson A, Sjoberg A, Rustaeus S, Olofsson SO: Purification of diacylglycerol: acyltransferase from rat liver to near homogeneity. J Lipid Res 35: 535-545, 1994
11. Swanton EM, Saggerson ED: Glycerolipid metabolizing enzymes in rat ventricle and in cardiac myocytes. Biochim Biophys Acta 1346: 93-102, 1997
12. Bjerve KS, Daae LN, Bremer J: Phosphatidic acid biosynthesis in rat liver mitochondria and microsomal fractions. Regulation of fatty acid positional specificity. Biochem J 158: 249-254, 1976
13. Cook GA, Park EA: Expression and regulation of carnitine palmitoyltransferase-Ialpha and -Ibeta genes. Am J Med Sci 318: 43-48, 1999
14. Brandt JM, Djouadi F, Kelly DP: Fatty acids activate transcription of the muscle carnitine palmitoyltransferase I gene in cardiac myocytes via the peroxisome proliferator-activated receptor alpha. J Biol Chem 273: 23786-23792, 1998
15. Abumrad N, Coburn C, Ibrahimi A: Membrane proteins implicated in long-chain fatty acid uptake by mammalian cells: CD36, FATP and FABPpm. Biochim Biophys Acta 1441: 4-13, 1999
16. Simkhovich BZ, Shutenko ZV, Meirena DV, Khagi KB, Mezapuke RJ, Molodchina TN, Kalvins IJ, Lukevics E: 3-(2,2,2-Trimethylhydrazinium)propionate (THP) - a novel gamma-butyrobetaine hydroxylase inhibitor with cardioprotective properties. Biochem Pharmacol 37: 195-202, 1988
17. McGarry JD, Foster DW: An improved and simplified radioisotopic assay for the determination of free and esterified carnitine. J Lipid Res 17: 277-281, 1976
18. Folch J, Lees M, Sloane-Stanley GH: A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 226: 497-509, 1957
19. Niot I, Pacot F, Bouchard P, Gresti J, Bernard A, Bezard J, Clouet P: Involvement of microsomal vesicles in part of the sensitivity of carnitine palmitoyltransferase I to malonyl-CoA inhibition in mitochondrial fractions of rat liver. Biochem J 304: 577-584, 1994
20. Belfrage P, Vaughan M: Simple liquid-liquid partition system for isolation of labeled oleic acid from mixtures with glycerides. J Lipid Res 10: 341-344, 1969
21. Martha L, Palacios E, Deshaies Y: Modulation of triglyceride metabolism by glucocorticoids in diet-induced obesity. Am J Physiol 277: R455-464, 1999
22. Veerkamp JH, Van Moerkerk HT, Glatz JF, Van Hinsbergh VW: Incomplete palmitate oxidation in cell-free systems of rat and human muscles. Biochim Biophys Acta 753: 399-410, 1983
23. Palmer JW, Tandler B, Hoppel CL: Biochemical properties of subsarcolemmal and interfibrillar mitochondria isolated from rat cardiac muscle. J Biol Chem 252: 8731-8739, 1977
24. Pande SV, Parvin R: Characterization of carnitine acylcarnitine translocase system of heart mitochondria. J Biol Chem 251: 6683-6691, 1976
25. Bremer J: The effect of fasting on the activity of liver carnitine palmitoyltransferase and its inhibition by malonyl-CoA. Biochim Biophys Acta 665: 628-631, 1981
26. Clouet P, Henninger C, Pascal M, Bezard J: High sensitivity of carnitine acyltransferase I to malonyl-CoA inhibition in liver of obese Zucker rats. FEBS Lett 182: 331-334, 1985
27. Smith PK, Krohn RI, Hermanson GT, Mallia AK, Gartner FH, Provenzano MD, Fujimoto EK, Goeke NM, Olson BJ, Klenk DC: Measurement of protein using bicinchoninic acid. Anal Biochem 150: 76-85, 1985
28. Chomczynski P, Sacchi N: Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162: 156-159, 1987
29. Broderick TL, Christos SC, Wolf BA, DiDomenico D, Shug AL, Paulson DJ: Fatty acid oxidation and cardiac function in the sodium pivalate model of secondary carnitine deficiency. Metabolism 44: 499-505, 1995
30. Morris GS, Zhou Q, Wolf BA, Christos SC, DiDomenico DF, Shug AL, Paulson DJ: Sodium pivalate reduces cardiac carnitine content and increases glucose oxidation without affecting cardiac functional capacity. Life Sci 57: 2237-2244, 1995
31. Evans JR, Opie LH, Shipp JC: Metabolism of palmitic acid in perfused rat heart. Am J Physiol 205: 766-770, 1963
32. Oram JF, Bennetch SL, Neely JR: Regulation of fatty acid utilization in isolated perfused rat hearts. J Biol Chem 248: 5299-5309, 1973
33. Katz AM, Messineo FC: Lipid-membrane interactions and the pathogenesis of ischemic damage in the myocardium. Circ Res 48: 1-16, 1981
34. Liedtke AJ, DeMaison L, Eggleston AM, Cohen LM, Nellis SH: Changes in substrate metabolism and effects of excess fatty acids in reperfused myocardium. Circ Res 62: 535-542, 1988
35. McGarry JD, Meier JM, Foster DW: The effects of starvation and refeeding on carbohydrate and lipid metabolism in vivo and in the perfused rat liver. The relationship between fatty acid oxidation and esterification in the regulation of ketogenesis. J Biol Chem 248: 270-278, 1973
36. Bontemps L, Demaison L, Dubois F, Pernin C, Mathieu JP, Vidal M, Comet M, Cuchet P: A new experimental model for studies of drug actions on myocardial metabolism. Application to a study of the influence of POCA. Int J Rad Appl Instrum B 14: 459-465, 1987
37. Luiken JJ, van Nieuwenhoven FA, America G, van der Vusse GJ, Glatz JF: Uptake and metabolism of palmitate by isolated cardiac myocytes from adult rats: Involvement of sarcolemmal proteins. J Lipid Res 38: 745-758, 1997
38. Erskine JM, Jensen DR, Eckel RH: Macronutrient regulation of lipoprotein lipase is posttranslational. J Nutr 124: 500-507, 1994
39. Ong JM, Simsolo RB, Saghizadeh M, Goers JW, Kern PA: Effects of exercise training and feeding on lipoprotein lipase gene expression in adipose tissue, heart, and skeletal muscle of the rat. Metabolism 44: 1596-1605, 1995
40. Borensztajn J, Rone MS, Babirak SP, McGarr JA, Oscai LB: Effect of exercise on lipoprotein lipase activity in rat heart and skeletal muscle. Am J Physiol 229: 394-397, 1975
41. Vaziri ND, Liang K, Barton CH: Effect of increased afterload on cardiac lipoprotein lipase and VLDL receptor expression. Biochim Biophys Acta 1436: 577-584, 1999
42. Weis BC, Esser V, Brown N, Foster DW, McGarry JD: Rat heart expresses two forms of mitochondrial carnitine palmitoyltransferase I. J Biol Chem 269: 18712-18715, 1994
43. Yamazaki N, Shinohara Y, Shima A, Terada H: High expression of a novel carnitine palmitoyltransferase I like protein in rat brown adipose tissue and heart: Isolation and characterization of its cDNA clone. FEBS Lett 363: 41-45, 1995
44. Brown NF, Weis BC, Husti JE, Foster DW, McGarry JD: Mitochondrial carnitine palmitoyltransferase I isoform switching in the developing rat heart. J Biol Chem 270: 8952-8957, 1995
45. Robles-Valdes C, McGarry JD, Foster DW: Maternal-fetal carnitine relationship and neonatal ketosis in the rat. J Biol Chem 251: 6007-6012, 1976
46. Chien D, Dean D, Saha AK, Flatt JP, Ruderman NB: Malonyl-CoA content and fatty acid oxidation in rat muscle and liver in vivo. Am J Physiol Endocrinol Metab 279: E259-265, 2000
47. Kent C: CTP:phosphocholine cytidylyltransferase. Biochim Biophys Acta 1348: 79-90, 1997
48. Nielsen LB, Veniant M, Boren J, Raabe M, Wong JS, Tam C, Flynn L, Vanni-Reyes T, Gunn MD, Goldberg IJ, Hamilton RL, Young SG: Genes for apolipoprotein B and microsomal triglyceride transfer protein are expressed in the heart: Evidence that the heart has the capacity to synthesize and secrete lipoproteins. Circulation 98: 13-16, 1998
49. Boren J, Veniant MM, Young SG: Apo B100-containing lipoproteins are secreted by the heart. J Clin Invest 101: 1197-1202, 1998
50. Bonen A, Dyck DJ, Ibrahimi A, Abumrad NA: Muscle contractile activity increases fatty acid metabolism and transport and FAT/CD36. Am J Physiol 276: E642-649, 1999
51. Ibrahimi A, Bonen A, Blinn WD, Hajri T, Li X, Zhong K, Cameron R, Abumrad NA: Muscle-specific overexpression of FAT/CD36 enhances fatty acid oxidation by contracting muscle, reduces plasma triglycerides and fatty acids, and increases plasma glucose and insulin. J Biol Chem 274: 26761-26766, 1999
52. Luiken JJFP, Arumugam Y, Dyck DJ, Bell RC, Pelsers MML, Turcotte LP, Tandon NN, Glatz JFC, Bonen A: Increased rates of fatty acid uptake and plasmalemmal fatty acid transporters in obese Zucker rats. J Biol Chem 276: 40567-40573, 2001
53. Watkins PA, Lu JF, Steinberg SJ, Gould SJ, Smith KD, Braiterman LT: Disruption of the Saccharomyces cerevisiae FAT1 gene decreases very long-chain fatty acyl-CoA synthetase activity and elevates intracellular very long-chain fatty acid concentrations. J Biol Chem 273: 18210-18219, 1998
54. Coe NR, Smith AJ, Frohnert BI, Watkins PA, Bernlohr DA: The fatty acid transport protein (FATP1) is a very long chain acyl-CoA synthetase. J Biol Chem 274: 36300-36304, 1999
55. Storch J, Thumser AE: The fatty acid transport function of fatty acid-binding proteins. Biochim Biophys Acta 1486: 28-44, 2000
56. Glatz JF, van der Vusse GJ: Intracellular transport of lipids. Mol Cell Biochem 88: 37-44, 1989
57. Amri EZ, Bertrand B, Ailhaud G, Grimaldi P: Regulation of adipose cell differentiation. I. Fatty acids are inducers of the aP2 gene expression. J Lipid Res 32: 1449-1456, 1991
58. Hertzel AV, Bernlohr DA: Regulation of adipocyte gene expression by polyunsaturated fatty acids. Mol Cell Biochem 188: 33-39, 1998
59. Keller H, Mahfoudi A, Dreyer C, Hibi AK, Medin J, Ozato K, Wahli W: Peroxisome proliferator-activated receptors and lipid metabolism. Ann NY Acad Sci 684: 157-173, 1993
60. van der Lee KA, Vork MM, De Vries JE, Willemsen PH, Glatz JF, Reneman RS, Van der Vusse GJ, Van Bilsen M: Long-chain fatty acid-induced changes in gene expression in neonatal cardiac myocytes. J Lipid Res 41: 41-47, 2000
61. Muoio DM, Seefeld K, Witters LA, Coleman RA: AMP-activated kinase reciprocally regulates triacylglycerol synthesis and fatty acid oxidation in liver and muscle: Evidence that sn-glycerol-3-phosphate acyltransferase is a novel target. Biochem J 338: 783-791, 1999
62. Schoonjans K, Staels B, Auwerx J: Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression. J Lipid Res 37: 907-925, 1996
63. Motojima K, Passilly P, Peters JM, Gonzalez FJ, Latruffe N: Expression of putative fatty acid transporter genes are regulated by peroxisome proliferator-activated receptor alpha and gamma activators in a tissue- and inducer-specific manner. J Biol Chem 273: 16710-16714, 1998
64. Cook WS, Yeldandi AV, Rao MS, Hashimoto T, Reddy JK: Less extrahepatic induction of fatty acid beta-oxidation enzymes by PPAR alpha. Biochem Biophys Res Commun 278: 250-257, 2000
65. Tsoko M, Beauseigneur F, Gresti J, Niot I, Demarquoy J, Boichot J, Bezard J, Rochette L, Clouet P: Enhancement of activities relative to fatty acid oxidation in the liver of rats depleted of L-carnitine by D-carnitine and a gamma-butyrobetaine hydroxylase inhibitor. Biochem Pharmacol 49: 1403-1410, 1995