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Volumn 12, Issue 6, 2002, Pages 275-279

Mildronate: Cardioprotective action through carnitine-lowering effect

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CARBOHYDRATE; CARNITINE; FATTY ACID; GLUCOSE; MILDRONATE; RANOLAZINE; TRIMETAZIDINE;

EID: 0036701588     PISSN: 10501738     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1050-1738(02)00175-5     Document Type: Review
Times cited : (123)

References (36)
  • 1
    • 0031978533 scopus 로고    scopus 로고
    • Cardioprotective profile of MET-88, an inhibitor of carnitine synthesis, and insulin during hypoxia in isolated perfused rat hearts
    • Asaka N., Muranaka Y., Kirimoto T., Miyake H. Cardioprotective profile of MET-88, an inhibitor of carnitine synthesis, and insulin during hypoxia in isolated perfused rat hearts. Fundam Clin Pharmacol. 12:1998;158-163.
    • (1998) Fundam Clin Pharmacol , vol.12 , pp. 158-163
    • Asaka, N.1    Muranaka, Y.2    Kirimoto, T.3    Miyake, H.4
  • 3
    • 85031379096 scopus 로고    scopus 로고
    • Use of mildronate in the treatment of heart failure-I in 40-50 year old men
    • in Russian
    • Boicov SA, Ovchinikov JB, Zaharova AI, Buliko TM: 1998. Use of mildronate in the treatment of heart failure-I in 40-50 year old men [in Russian]. Klin Med Patofiz 1-2:25-29.
    • (1998) Klin Med Patofiz , vol.1-2 , pp. 25-29
    • Boicov, S.A.1    Ovchinikov, J.B.2    Zaharova, A.I.3    Buliko, T.M.4
  • 4
    • 0021024932 scopus 로고
    • Carnitine-metabolism and functions
    • Bremer J. Carnitine-metabolism and functions. Physiol Rev. 63:1983;1420-1480.
    • (1983) Physiol Rev , vol.63 , pp. 1420-1480
    • Bremer, J.1
  • 5
    • 0033979080 scopus 로고    scopus 로고
    • Metabolic aspects of programmed cell survival and cell death in the heart
    • Depre C., Taegtmeyer H. Metabolic aspects of programmed cell survival and cell death in the heart. Cardiovasc Res. 45:2000;538-548.
    • (2000) Cardiovasc Res , vol.45 , pp. 538-548
    • Depre, C.1    Taegtmeyer, H.2
  • 6
    • 0000707075 scopus 로고    scopus 로고
    • Reduction of carnitine content by inhibition of its biosynthesis results in protection of isolated guinea pig hearts against hypoxic damage
    • Dhar P.K., Grupp I.L., Schwartz A.et al. Reduction of carnitine content by inhibition of its biosynthesis results in protection of isolated guinea pig hearts against hypoxic damage. J Cardiovasc Pharmacol Ther. 1:1996;235-242.
    • (1996) J Cardiovasc Pharmacol Ther , vol.1 , pp. 235-242
    • Dhar, P.K.1    Grupp, I.L.2    Schwartz, A.3
  • 7
    • 85031375668 scopus 로고    scopus 로고
    • inventors: 1984, 1984-11-06. 3-(2,2,2-Trimethylhydrazinium) propionate and method for the preparation and use thereof. US patent 4481218
    • Eremeev A, Kalvinsh I, Semenikhina V, et al. inventors: 1984, 1984-11-06. 3-(2,2,2-Trimethylhydrazinium) propionate and method for the preparation and use thereof. US patent 4481218.
    • Eremeev, A.1    Kalvinsh, I.2    Semenikhina, V.3
  • 9
    • 0034214236 scopus 로고    scopus 로고
    • Carnitine transport into muscular cells. Inhibition of transport and cell growth by mildronate
    • Georges B., Le Borgne F., Galland S.et al. Carnitine transport into muscular cells. Inhibition of transport and cell growth by mildronate. Biochem Pharmacol. 59:2000;1357-1363.
    • (2000) Biochem Pharmacol , vol.59 , pp. 1357-1363
    • Georges, B.1    Le Borgne, F.2    Galland, S.3
  • 10
    • 0033919680 scopus 로고    scopus 로고
    • 2+ uptake activity in rats with congestive heart failure following myocardial infarction
    • 2+ uptake activity in rats with congestive heart failure following myocardial infarction. Mol Cell Biochem. 209:2000;39-46. a.
    • (2000) Mol Cell Biochem , vol.209 , pp. 39-46
    • Hayashi, Y.1    Ishida, H.2    Hoshiai, M.3
  • 11
    • 0034600294 scopus 로고    scopus 로고
    • Beneficial effects of MET-88, a gamma-butyrobetaine hydroxylase inhibitor in rats with heart failure following myocardial infarction
    • Hayashi Y., Kirimoto T., Asaka N.et al. Beneficial effects of MET-88, a gamma-butyrobetaine hydroxylase inhibitor in rats with heart failure following myocardial infarction. Eur J Pharmacol. 395:2000;217-224. b.
    • (2000) Eur J Pharmacol , vol.395 , pp. 217-224
    • Hayashi, Y.1    Kirimoto, T.2    Asaka, N.3
  • 12
    • 0033933263 scopus 로고    scopus 로고
    • Effects of MET-88, a gamma-butyrobetaine hydroxylase inhibitor, on tissue carnitine and lipid levels in rats
    • Hayashi Y., Muranaka Y., Kirimoto T.et al. Effects of MET-88, a gamma-butyrobetaine hydroxylase inhibitor, on tissue carnitine and lipid levels in rats. Biol Pharm Bull. 23:2000;770-773. c.
    • (2000) Biol Pharm Bull , vol.23 , pp. 770-773
    • Hayashi, Y.1    Muranaka, Y.2    Kirimoto, T.3
  • 14
    • 0034981428 scopus 로고    scopus 로고
    • Combination therapy in angina: A review of combined haemodynamic treatment and the role for combined haemodynamic and cardiac metabolic agents
    • Jackson G. Combination therapy in angina. a review of combined haemodynamic treatment and the role for combined haemodynamic and cardiac metabolic agents Int J Clin Pract. 55:2001;256-261.
    • (2001) Int J Clin Pract , vol.55 , pp. 256-261
    • Jackson, G.1
  • 15
    • 0011158679 scopus 로고    scopus 로고
    • Clinical efficacy and safety of mildronate in patients with ischemic heart disease and chronic heart failure
    • [in Russian]
    • Karpov R.S., Koshelskaja O.A., Vrublevskij A.V.et al. Clinical efficacy and safety of mildronate in patients with ischemic heart disease and chronic heart failure. Kardiologija. 6:2000;69-74. [in Russian].
    • (2000) Kardiologija , vol.6 , pp. 69-74
    • Karpov, R.S.1    Koshelskaja, O.A.2    Vrublevskij, A.V.3
  • 17
    • 0029836940 scopus 로고    scopus 로고
    • Beneficial effect of MET-88, a gamma-butyrobetaine hydroxylase inhibitor, on energy metabolism in ischemic dog hearts
    • Kirimoto T., Nobori K., Asaka N.et al. Beneficial effect of MET-88, a gamma-butyrobetaine hydroxylase inhibitor, on energy metabolism in ischemic dog hearts. Arch Int Pharmacodyn Ther. 331:1996;163-178.
    • (1996) Arch Int Pharmacodyn Ther , vol.331 , pp. 163-178
    • Kirimoto, T.1    Nobori, K.2    Asaka, N.3
  • 18
    • 0032940435 scopus 로고    scopus 로고
    • Pharmacokinetic analysis of the cardioprotective effect of 3-(2,2, 2-trimethylhydrazinium) propionate in mice: Inhibition of carnitine transport in kidney
    • Kuwajima M., Harashima H., Hayashi M.et al. Pharmacokinetic analysis of the cardioprotective effect of 3-(2,2, 2-trimethylhydrazinium) propionate in mice. inhibition of carnitine transport in kidney J Pharmacol Exp Ther. 289:1999;93-102.
    • (1999) J Pharmacol Exp Ther , vol.289 , pp. 93-102
    • Kuwajima, M.1    Harashima, H.2    Hayashi, M.3
  • 19
    • 0035021014 scopus 로고    scopus 로고
    • Influence of L-carnitine and its derivatives on myocardial metabolism and function in ischemic heart disease and during cardiopulmonary bypass
    • Lango R., Smolenski R.T., Narkiewicz M.et al. Influence of L-carnitine and its derivatives on myocardial metabolism and function in ischemic heart disease and during cardiopulmonary bypass. Cardiovasc Res. 51:2001;21-29.
    • (2001) Cardiovasc Res , vol.51 , pp. 21-29
    • Lango, R.1    Smolenski, R.T.2    Narkiewicz, M.3
  • 20
    • 0035080863 scopus 로고    scopus 로고
    • Optimizing cardiac energy metabolism: How can fatty acid and carbohydrate metabolism be manipulated?
    • Lopaschuk G.D. Optimizing cardiac energy metabolism. how can fatty acid and carbohydrate metabolism be manipulated? Coron Artery Dis. 12(Suppl 1):2001;S8-S11.
    • (2001) Coron Artery Dis , vol.12 , Issue.SUPPL. 1
    • Lopaschuk, G.D.1
  • 21
    • 0033807478 scopus 로고    scopus 로고
    • Mechanisms involved in the hemodynamic alterations in congestive heart failure as a basis for a rational pharmacological treatment
    • Marin J., Marin E., Gutierrez-Iniguez M.A.et al. Mechanisms involved in the hemodynamic alterations in congestive heart failure as a basis for a rational pharmacological treatment. Pharmacol Ther. 88:2000;15-31.
    • (2000) Pharmacol Ther , vol.88 , pp. 15-31
    • Marin, J.1    Marin, E.2    Gutierrez-Iniguez, M.A.3
  • 23
    • 0034451642 scopus 로고    scopus 로고
    • Pharmacological modulation, preclinical studies, and new clinical features of myocardial ischemic preconditioning
    • Napoli C., Pinto A., Cirino G. Pharmacological modulation, preclinical studies, and new clinical features of myocardial ischemic preconditioning. Pharmacol Ther. 88:2000;311-331.
    • (2000) Pharmacol Ther , vol.88 , pp. 311-331
    • Napoli, C.1    Pinto, A.2    Cirino, G.3
  • 24
    • 0032618293 scopus 로고    scopus 로고
    • Effect of mildronate on life quality of patients with chronic heart failure
    • [in Russian]
    • Nedoshivin A.O., Petrova N.N., Kutuzova A.E., Perepech N.B. Effect of mildronate on life quality of patients with chronic heart failure. Ter Arkh. 71:1999;10-12. [in Russian].
    • (1999) Ter Arkh , vol.71 , pp. 10-12
    • Nedoshivin, A.O.1    Petrova, N.N.2    Kutuzova, A.E.3    Perepech, N.B.4
  • 26
    • 0000932895 scopus 로고    scopus 로고
    • Role of metabolically active drugs in the management of ischemic heart disease
    • Schofield R.S., Hill J.A. Role of metabolically active drugs in the management of ischemic heart disease. Am J Cardiovasc Drugs. 1:2001;23-35.
    • (2001) Am J Cardiovasc Drugs , vol.1 , pp. 23-35
    • Schofield, R.S.1    Hill, J.A.2
  • 27
    • 0034772136 scopus 로고    scopus 로고
    • Signal transduction of ischemic preconditioning
    • Schulz R., Cohen M.V., Behrends M.et al. Signal transduction of ischemic preconditioning. Cardiovasc Res. 52:2001;181-198.
    • (2001) Cardiovasc Res , vol.52 , pp. 181-198
    • Schulz, R.1    Cohen, M.V.2    Behrends, M.3
  • 28
    • 0032012434 scopus 로고    scopus 로고
    • Use of antihypoxants in the acute period of myocardial infarction
    • [in Russian]
    • Semigolovskii N. Use of antihypoxants in the acute period of myocardial infarction. Anesteziol Reanimatol. 2:1998;56-59. [in Russian].
    • (1998) Anesteziol Reanimatol , vol.2 , pp. 56-59
    • Semigolovskii, N.1
  • 29
    • 0023853252 scopus 로고
    • 3-(2,2,2-trimethylhydrazinium) propionate (THP): A novel gamma-butyrobetaine hydroxylase inhibitor with cardioprotective properties
    • Simkhovich B.Z., Shutenko Z.V., Meirena D.V.et al. 3-(2,2,2-trimethylhydrazinium) propionate (THP). a novel gamma-butyrobetaine hydroxylase inhibitor with cardioprotective properties Biochem Pharmacol. 37:1988;195-202.
    • (1988) Biochem Pharmacol , vol.37 , pp. 195-202
    • Simkhovich, B.Z.1    Shutenko, Z.V.2    Meirena, D.V.3
  • 30
    • 0011160207 scopus 로고
    • Effect of mildronate on heart functioning, physical activity and life quality in patients of chronic heart failure
    • Skarda I., Klincare D., Vitols A.et al. Effect of mildronate on heart functioning, physical activity and life quality in patients of chronic heart failure. Latv Doc. 12:1995;17-24.
    • (1995) Latv Doc , vol.12 , pp. 17-24
    • Skarda, I.1    Klincare, D.2    Vitols, A.3
  • 31
    • 0034836831 scopus 로고    scopus 로고
    • Development and characterization of an animal model of carnitine deficiency
    • Spaniol M., Brooks H., Auer L.et al. Development and characterization of an animal model of carnitine deficiency. Eur J Biochem. 268:2001;1876-1887.
    • (2001) Eur J Biochem , vol.268 , pp. 1876-1887
    • Spaniol, M.1    Brooks, H.2    Auer, L.3
  • 32
    • 0033657264 scopus 로고    scopus 로고
    • Mechanisms of the optimization of oxygen metabolism under the effects of mafusol and mildronate during emergency implantation of hip prosthesis
    • [in Russian]
    • Stebleva T.F., Voitovich A.V., Mamaeva E.G.et al. Mechanisms of the optimization of oxygen metabolism under the effects of mafusol and mildronate during emergency implantation of hip prosthesis. Vestn Khir Im I I Grek. 159:2000;57-60. [in Russian].
    • (2000) Vestn Khir Im I I Grek , vol.159 , pp. 57-60
    • Stebleva, T.F.1    Voitovich, A.V.2    Mamaeva, E.G.3
  • 33
    • 0032480276 scopus 로고    scopus 로고
    • Energy substrate metabolism, myocardial ischemia, and targets for pharmacotherapy
    • Taegtmeyer H., King L.M., Jones B.E. Energy substrate metabolism, myocardial ischemia, and targets for pharmacotherapy. Am J Cardiol. 82:1998;54K-60K.
    • (1998) Am J Cardiol , vol.82
    • Taegtmeyer, H.1    King, L.M.2    Jones, B.E.3
  • 34
    • 0029001125 scopus 로고
    • Enhancement of activities relative to fatty acid oxidation in the liver of rats depleted of L-carnitine by D-carnitine and a gamma-butyrobetaine hydroxylase inhibitor
    • Tsoko M., Beauseigneur F., Gresti J.et al. Enhancement of activities relative to fatty acid oxidation in the liver of rats depleted of L-carnitine by D-carnitine and a gamma-butyrobetaine hydroxylase inhibitor. Biochem Pharmacol. 49:1995;1403-1410.
    • (1995) Biochem Pharmacol , vol.49 , pp. 1403-1410
    • Tsoko, M.1    Beauseigneur, F.2    Gresti, J.3
  • 35
    • 0033790085 scopus 로고    scopus 로고
    • 2+-ATPase and hexokinase type I in rat hearts with myocardial infarction
    • 2+-ATPase and hexokinase type I in rat hearts with myocardial infarction. Basic Res Cardiol. 95:2000;343-348.
    • (2000) Basic Res Cardiol , vol.95 , pp. 343-348
    • Yonekura, K.1    Eto, Y.2    Yokoyama, I.3
  • 36
    • 0034080255 scopus 로고    scopus 로고
    • Pharmacokinetics and biological fate of 3-(2,2, 2-trimethylhydrazinium) propionate dihydrate (MET-88), a novel cardioprotective agent, in rats
    • Yoshisue K., Yamamoto Y., Yoshida K.et al. Pharmacokinetics and biological fate of 3-(2,2, 2-trimethylhydrazinium) propionate dihydrate (MET-88), a novel cardioprotective agent, in rats. Drug Metab Dispos. 28:2000;687-694.
    • (2000) Drug Metab Dispos , vol.28 , pp. 687-694
    • Yoshisue, K.1    Yamamoto, Y.2    Yoshida, K.3


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