Insulin improves functional and metabolic recovery of reperfused working rat heart

Annals of Thoracic Surgery

Volumn 67, Issue 6, 1999, Pages 1682-1688

  Doenst, Torsten ^a   Richwine, R Todd ^a   Bray, Molly S ^a   Goodwin, Gary W ^a   Frazier, O H ^b   Taegtmeyer, Heinrich ^a  

^a Division of Cardiology   (United States)

^b UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; GLUCOSE; GLYCOGEN; INSULIN; POTASSIUM;

ANIMAL TISSUE; ARTICLE; GLUCOSE OXIDATION; GLUCOSE TRANSPORT; GLYCOGEN SYNTHESIS; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE REPERFUSION; INOTROPISM; ISOLATED HEART; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; CARDIOTONIC AGENTS; GLUCOSE; HEART; INSULIN; MALE; MYOCARDIAL CONTRACTION; MYOCARDIAL REPERFUSION INJURY; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0033001756     PISSN: 00034975     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0003-4975(99)00326-4     Document Type: Article

References (26)

1. Gradinak S., Coleman G.M., Taegtmeyer H., Sweeney M.S., Frazier O.H. Improved cardiac function with glucose-insulin-potassium after coronary bypass surgery. Ann Thorac Surg. 48:1989;484-489.
2. Sodi-Pallares D., Testelli M.R., Fishleder B.L., et al. Effects of intravenous infusion of a potassium-glucose-insulin solution on the electrocardiographic signs of myocardial infarction. Am J Cardiol. 9:1962;166-181.
3. Neely J.R., Grotyohann L.W. Role of glycolytic products in damage to myocardium dissociation of adenosine triphosphate levels and recovery of function of reperfused canine myocardium . Circ Res. 55:1984;816-824.
4. Apstein C.S., Gravino F.N., Haudenschild C.C. Determinants of a protective effect of glucose and insulin on the ischemic myocardium. Effects on contractile function, diastolic compliance, metabolism, and ultrastructure during ischemia and reperfusion. Circ Res. 52:1983;515-526.
5. Fath-Ordoubadi F., Beatt K.J. Glucose-insulin-potassium therapy for treatment of acute myocardial infarction. An overview of randomized placebo-controlled trials. Circulation. 96:1997;1152-1156.
6. Taegtmeyer H., Roberts A.F.C., Rayne A.E.G. Energy metabolism in reperfused rat heart return of function before normalization of ATP content . J Am Coll Cardiol. 6:1985;864-870.
7. Kudo N., Barr A.J., Barr R.L., Desai S., Lopaschuk G.D. High rates of fatty acid oxidation during reperfusion of ischemic hearts are associated with a decrease in malonyl-CoA levels due to an increase in 5′-AMP-activated protein kinase inhibition of acetyl-Coa carboxylase. J Biol Chem. 270:1995;17513-17520.
8. Goodwin G.W., Taegtmeyer H. Metabolic recovery of the isolated working rat heart after brief global ischemia. Am J Physiol. 267:1994;H462-H470.
9. Taegtmeyer H., Hems R., Krebs H.A. Utilization of energy providing substrates in the isolated working rat heart. Biochem J. 186:1980;701-711.
10. Goodwin G.W., Arteaga J.A., Taegtmeyer H. Glycogen turnover in the isolated working rat heart. J Biol Chem. 270:1995;9234-9240.
11. Doenst T., Guthrie P.H., Chemnitius J.-M., Zech R., Taegtmeyer H. Fasting, lactate, and insulin improve ischemia tolerance a comparison with ischemic preconditioning . Am J Physiol. 270:1996;H1607-H1615.
12. Zar J. Biostatistical analysis, 2nd ed. 1984;Prentice-Hall, Inglewood Cliffs.
13. Schneider C.A., Taegtmeyer H. Fasting in vivo delays myocardial cell damage after brief periods of ischemia in the isolated working rat heart. Circ Res. 68:1991;1045-1050.
14. Depre C., Hue L. Inhibition of glyocogenolysis by a glucose analogue in the working rat heart. J Mol Cell Cardiol. 29:1997;2253-2259.
15. Ferranini E., Santoro D., Bonadonnar R., Natali A., Parodi O., Camici P. Metabolic and hemodynamic effects of insulin on human hearts. Am J Physiol. 264:1993;E308-E315.
16. Baron A.D. Hemodynamic actions of insulin. Am J Physiol. 267:1994;E187-E222.
17. Barrett E., Schwartz R., Francis C., Zaret B. Regulation by insulin of myocardial glucose and fatty acid metabolism in the conscious dog. J Clin Invest. 74:1984;1073-1079.
18. Scherrer U., Sartori C. Insulin as a vascular and sympathoexcitatory hormone. Implications for blood pressure regulation, insulin sensitivity, and cardiovascular morbidity. Circulation. 96:1997;4104-4113.
19. Taegtmeyer H., Goodwin G.W., Doenst T., Frazier O.H. Substrate metabolism as a determinant for postischemic functional recovery of the heart. Am J Cardiol. 80:1997;3A-10A.
20. Hendrickson S.C., St. Louis J.D., Lowe J.E., Abdel-aleem S. Free fatty acid metabolism during myocardial ischemia and reperfusion. Mol Cell Biochem. 166:1997;85-94.
21. Gamble J., Lopaschuk G.D. Insulin inhibition of 5′ adenosine monophosphate-activated protein kinase in the heart results in activation of acetyl coenzyme A carboxylase and inhibition of fatty acid metabolism. Metabolism. 46:1997;1270-1274.
22. Mallet R.T., Hartman D.A., Bünger R. Glucose requirement for postischemic recovery of perfused working heart. Eur J Biochem. 188:1990;481-493.
23. Bolukoglu H., Goodwin G.W., Guthrie P.H., Carmical S.G., Chen T.M., Taegtmeyer H. Metabolic fate of glucose in reversible low-flow ischemia of the isolated working rat heart. Am J Physiol. 270:1996;H817-H826.
24. Lagerstrom C.F., Walker W.E., Taegtmeyer H. Failure of glycogen depletion to improve left ventricular function of the rabbit heart after hypothermic ischemic arrest. Circ Res. 63:1988;81-86.
25. McElroy D.D., Walker W.E., Taegtmeyer H. Glycogen loading improves left ventricular function of the rabbit heart after hypothermic ischemic arrest. J Appl Cardiol. 4:1989;455-465.
26. 2+ release and contractile protein function in intact mouse skeletal muscle. J Physiol. 498:1997;17-29. (Lond).