4-Hydroxy-3-methyl-6-(1-methyl-2-oxoalkyl)pyran-2-one Synthesis by a Type III Polyketide Synthase from Rhodospirillum centenum

ChemBioChem

Volumn 14, Issue 8, 2013, Pages 1006-1013

  Awakawa, Takayoshi ^a   Sugai, Yoshinori ^a   Otsutomo, Kanae ^a   Ren, Shukun ^b   Masuda, Shinji ^b   Katsuyama, Yohei ^a   Horinouchi, Sueharu ^a   Ohnishi, Yasuo ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

Biosynthesis; Methylmalonyl CoA; Polyketide synthases; Polyketides; Rhodospirillum

Indexed keywords

4 HYDROXY 3 METHYL 6 (1 METHYL 2 OXOALKYL)PYRAN 2 ONE; POLYKETIDE SYNTHASE; PUTATIVE TYPE III POLYKETIDE SYNTHASE; PYRAN; UNCLASSIFIED DRUG;

ALDOL REACTION; ARTICLE; CATALYSIS; CONTROLLED STUDY; IN VITRO STUDY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; RHODOSPIRILLUM CENTENUM; SYNTHESIS;

ACYL COENZYME A; ACYLTRANSFERASES; GENETIC LOCI; MALONYL COENZYME A; PYRANS; RHODOSPIRILLUM CENTENUM; SUBSTRATE SPECIFICITY;

BACTERIA (MICROORGANISMS); PHOTOBACTERIA; RHODOSPIRILLUM; RHODOSPIRILLUM CENTENUM;

EID: 84878012494     PISSN: 14394227     EISSN: 14397633     Source Type: Journal    
DOI: 10.1002/cbic.201300066     Document Type: Article

References (18)

1. M. B. Austin, J. P. Noel, Nat. Prod. Rep. 2003, 20, 79-110.
2. N. Funa, H. Ozawa, A. Hirata, S. Horinouchi, Proc. Natl. Acad. Sci. USA 2006, 103, 6356-6361.
3. A. Miyanaga, N. Funa, T. Awakawa, S. Horinouchi, Proc. Natl. Acad. Sci. USA 2008, 105, 871-876.
4. M. Funabashi, N. Funa, S. Horinouchi, J. Biol. Chem. 2008, 283, 13983-13991.
5. C. Nakano, N. Funa, Y. Ohnishi, S. Horinouchi, J. Bacteriol. 2012, 194, 1544-1551.
6. T. Hayashi, Y. Kitamura, N. Funa, Y. Ohnishi, S. Horinouchi, ChemBioChem 2011, 12, 2166-2176.
7. C. Nakano, H. Ozawa, G. Akanuma, N. Funa, S. Horinouchi, J. Bacteriol. 2009, 191, 4916-4923.
8. T. Awakawa, N. Fujita, M. Hayakawa, Y. Ohnishi, S. Horinouchi, ChemBioChem 2011, 12, 439-448.
9. J. Favinger, R. Stadtwald, H. Gest, Antonie van Leeuwenhoek 1989, 55, 291-296.
10. J. E. Berleman, C. E. Bauer, Microbiology 2004, 150, 383-390.
11. J. E. Berleman, B. M. Hasselbring, C. E. Bauer, J. Bacteriol. 2004, 186, 5834-5841.
12. A. C. Giddens, L. Nielsen, H. I. Boshoff, D. Tasdemir, R. Perozzo, M. Kaiser, F. Wang, J. C. Sacchettini, B. R. Copp, Tetrahedron 2008, 64, 1242-1249.
13. J. L. Burdett, M. T. Rogers, J. Am. Chem. Soc. 1964, 86, 2105-2109.
14. M. Bassetti, G. Cerichelli, B. Floris, Tetrahedron 1988, 44, 2997-3004.
15. P. Saxena, G. Yadav, D. Mohanty, R. S. Gokhale, J. Biol. Chem. 2003, 278, 44780-44790.
16. N. Funa, Y. Ohnishi, Y. Ebizuka, S. Horinouchi, J. Biol. Chem. 2002, 277, 4628-4635.
17. M. B. Austin, M. Izumikawa, M. E. Bowman, D. W. Udwary, J. Ferrer, B. S. Moore, J. P. Noel, J. Biol. Chem. 2004, 279, 45162-45174.
18. N. Funa, T. Awakawa, S. Horinouchi, J. Biol. Chem. 2007, 282, 14476-14481.