The O-Methyltransferase srsb catalyzes the decarboxylative methylation of alkylresorcylic acid during phenolic lipid biosynthesis by streptomyces griseus

Journal of Bacteriology

Volumn 194, Issue 6, 2012, Pages 1544-1551

  Nakano, Chiaki ^a   Funa, Nobutaka ^a   Ohnishi, Yasuo ^a   Horinouchi, Sueharu ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYL GROUP; HYDROXYL GROUP; MALONYL COENZYME A; METHYLMALONYL COENZYME A MUTASE; PROTEIN METHYLTRANSFERASE; RESORCINOL; S ADENOSYLMETHIONINE; SRSA PROTEIN; SRSB PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CROSS COUPLING REACTION; DECARBOXYLATION; IN VITRO STUDY; LIPOGENESIS; NONHUMAN; OPERON; PRIORITY JOURNAL; PROTEIN METHYLATION; PROTEIN STABILITY; STREPTOMYCES GRISEUS; STREPTOMYCES LIVIDANS;

HYDROXYBENZOIC ACIDS; LIPID METABOLISM; METHYLATION; METHYLTRANSFERASES; PHENOLS; RECOMBINANT PROTEINS; S-ADENOSYLMETHIONINE; STREPTOMYCES GRISEUS; STREPTOMYCES LIVIDANS; SUBSTRATE SPECIFICITY;

STREPTOMYCES GRISEUS; STREPTOMYCES LIVIDANS;

EID: 84857973395     PISSN: 00219193     EISSN: 10985530     Source Type: Journal    
DOI: 10.1128/JB.06406-11     Document Type: Article

References (15)

1. Austin MB, Noel JP. 2003. The chalcone synthase superfamily of type III polyketide synthases. Nat. Prod. Rep. 20:79 -110.
2. Awakawa T, Fujita N, Hayakawa M, Ohnishi Y, Horinouchi S. 2011. Characterization of the biosynthesis gene cluster for alkyl-Odihydrogeranyl-methoxyhydroquinones in Actinoplanes missouriensis. Chembiochem 12:439-448.
3. Blecher M. 1981. Synthesis of long-chain fatty acyl-CoA thioesters using N-hydroxysuccinimide esters. Methods Enzymol. 72:404-408.
4. Funa N, Awakawa T, Horinouchi S. 2007. Pentaketide resorcylic acid synthesis by type III polyketide synthase from Neurospora crassa. J. Biol. Chem. 282:14476 -14481.
5. Funa N, et al. 1999. A new pathway for polyketide synthesis in microorganisms. Nature 400:897- 899.
6. Funa N, Ozawa H, Hirata A, Horinouchi S. 2006. Phenolic lipid synthesis by type III polyketide synthases is essential for cyst formation in Azotobacter vinelandii. Proc. Natl. Acad. Sci. U. S. A. 103:6356-6361.
7. Funabashi M, Funa N, Horinouchi S. 2008. Phenolic lipids synthesized by type III polyketide synthase confer penicillin resistance on Streptomyces griseus. J. Biol. Chem. 283:13983-13991.
8. Hayashi T, Kitamura Y, Funa N, Ohnishi Y, Horinouchi S. 2011. Fatty acyl-AMP ligase involvement in the production of alkylresorcylic acid by a Myxococcus xanthus type III polyketide synthase. Chembiochem 12:2166- 2176.
9. Kagan RM, Clarke S. 1994. Widespread occurrence of three sequence motifs in diverse S-adenosylmethionine-dependent methyltransferases suggests a common structure for these enzymes. Arch. Biochem. Biophys. 310:417- 427.
10. Lau EY, Bruice TC. 1998. Importance of correlated motions in forming highly reactive near attack conformations in catechol O-methyltransferase. J. Am. Chem. Soc. 120:12387-12394.
11. Nakano C, Ozawa H, Akanuma G, Funa N, Horinouchi S. 2009. Biosynthesis of aliphatic polyketides by type III polyketide synthase and methyltransferase in Bacillus subtilis. J. Bacteriol. 191:4916-4923.
12. Ohnishi Y, et al. 2008. Genome sequence of the streptomycin-producing microorganism Streptomyces griseus IFO 13350. J. Bacteriol. 190:4050- 4060.
13. Takano E, White J, Thompson CJ, Bibb MJ. 1995. Construction of thiostrepton-inducible, high-copy-number expression vectors for use in Streptomyces spp. Gene 166:133-137.
14. Winter-Vann AM, Casey PJ. 2005. Post-prenylation-processing enzymes as new targets in oncogenesis. Nat. Rev. Cancer 5:405- 412.
15. Zubieta C, He X-Z, Dixon RA, Noel JP. 2001. Structures of two natural product methyltransferases reveal the basis for substrate specificity in plant O-methyltransferases. Nat. Struct. Biol. 8:271-279.