Specificity and synergism of polypeptide growth factors in stimulating the synthesis of proteoglycans and a novel high molecular weight anionic glycoprotein by articular chondrocyte cultures

Journal of Rheumatology

Volumn 25, Issue 8, 1998, Pages 1578-1584

  Chopra, Ravi ^a,b   Anastassiades, Tassos ^a,b  

^a QUEEN S UNIVERSITY   (Canada)

^b Department of Medicine ^*

Author keywords

Articular cartilage; Cartilage repair; Glycoproteins; Polypeptide growth factors; Proteoglycans

Indexed keywords

ALCIAN BLUE; CHONDROITIN ABC LYASE; GLUCOSAMINE; GLYCOCONJUGATE; GLYCOPROTEIN; PLATELET DERIVED GROWTH FACTOR; PROTEOGLYCAN; SOMATOMEDIN; SULFATE; TOLONIUM CHLORIDE; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL CELL; ARTICLE; CARTILAGE CELL; CATTLE; CONTROLLED STUDY; MOLECULAR WEIGHT; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRECIPITATION; PRIORITY JOURNAL; PROTEOGLYCAN SYNTHESIS;

ANIMALS; CARTILAGE, ARTICULAR; CATTLE; CELL COUNT; CELLS, CULTURED; CHONDROCYTES; DRUG SYNERGISM; GLYCOPROTEINS; GROWTH SUBSTANCES; INSULIN-LIKE GROWTH FACTOR I; MOLECULAR WEIGHT; PEPTIDES; PLATELET-DERIVED GROWTH FACTOR; PROTEOGLYCANS; TRANSFORMING GROWTH FACTOR BETA;

EID: 0031928952     PISSN: 0315162X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Sporn MB, Roberts AB. What is TGF-β? In: Bock GR, Marsh J, editors. Clinical applications of TGF-β. Ciba Foundation Symposium, vol 157. New York: John Wiley & Sons; 1991:1-6.
2. Seyedin S, Thompson A, Bentz H, et al. Cartilage-inducing factor-A. Apparent identity to transforming growth factor-β. J Biol Chem 1986;261:5693-5.
3. Villiger PM, Lotz M. Differential expression of TGF beta isoforms by human articular chondrocytes in response to growth factors. J Cell Physiol 1992;151:318-25.
4. Wozney R, Rosen V, Celeste A, et al. Novel regulators of bone formation: molecular clones and activities. Science 1988;325:81-4.
5. Duncan H, Jundt J, Riddle JM, Pitchford W, Christopherson T: The tibial subchondral plate. A scanning electron microscopic study. J Bone Joint Surg 1987;69A:1212-20.
6. Clark JM. The structure of vascular channels in the subchondral plate. J Anat 1990;171:105-15.
7. Brown S, Irwin D, Anastassiades T. The effects of "Matrigenin" activity from bovine bone on the glycosaminoglycans of bovine articular cartilage in culture. A model for cartilage repair by bone derived factors. J Rheumatol 1989;16:209-16.
8. Howard S, Anastassiades T. Differential effects of bone-associated factors on newly synthesized anionic glycoconjugates by articular chondrocyte cultures from adult and immature bovines. J Rheumatol 1993;20:2083-94.
9. Fava R, Olsen N, Keski-Oja J, Moses H, Pincus T. Active and latent forms of transforming growth factor β activity in synovial effusions. J Exp Med 1989;169:291-6.
10. Luyten FP, Yu YM, Yanagashita M, Vukicevic S, Hammonds RG, Reddi AH. Natural bovine osteogenin and recombinant human bovine morphogenetic protein-2B are equipotent in the maintenance of proteoglycans in bovine articular cartilage explant cultures. J Biol Chem 1992;267:3691-5.
11. Morales TI, Joyce ME, Sobel ME, et al. Transforming growth factor-β in calf articular cartilage organ cultures: synthesis and distribution. Arch Biochem Biophys 1991;288:397-405.
12. Redini F, Daireaux M, Mauviel A, Galera P, Loyau G, Pujol J. Characterization of proteoglycans synthesized by rabbit articular chondrocytes in response to transforming growth factor-β. Biochim Biophys Acta 1991;1093:196-206.
13. Malemud CJ, Killeen W, Hering T, Purchio AF. Enhanced sulfated proteoglycan core protein synthesis by incubation of rabbit chondrocytes with recombinant transforming growth factor-β. J Cell Physiol 1991;149:152-9.
14. Guerne P-A, Sublet A, Lotz M. Growth factor responsiveness of human articular chondrocytes: distinct profiles in primary chondrocytes, subcultured chondrocytes and fibroblasts. J Cell Physiol 1994;158:476-84.
15. Crabb ID, Keefe O, Puzas JE, Rosier RN. Synergistic effect of transforming growth factor beta and fibroblast growth factor on DNA synthesis in chick growth plate chondrocytes. J Bone Miner Res 1990;5:1105-12.
16. Okazaki R, Sakai A, Nakamura T, Kunugita N, Norimura T, Suzuki K. Effects of transforming growth factor betas and basic fibroblast growth factor on articular chondrocytes obtained from immobilized rabbit knees. Ann Rheum Dis 1996;55:181-6.
17. Tauzaki T, Usa T, Matsumoto T, et al. Effect of transforming growth factor-beta on the insulin-like growth factor I autocrine/paracrine axis in cultured rat articular chondrocytes. Exp Cell Res 1994;215:9-16.
18. Chan KTC, Anastassiades TP. Isolation and partial characterization of a high molecular weight anionic glycoconjugate from transforming growth factor-β treated bovine articular chondrocyte cultures. Biochem Cell Biol 1996;74:233-40.
19. 2 concentrations. Analyt Biochem 1980;107:393-405.
20. Hronowski L, Anastassiades TP. The effect of cell density on net rates of glycosaminoglycan synthesis and secretion by cultured rat fibroblasts. J Biol Chem 1980;255:10091-9.
21. Lin HY, Moustakas A. TGF-β structure and function. Cell Mol Biol 1994;40:337-49.
22. Rechler M, Nissley P. The nature and regulation of the receptors for insulin-like growth factors. Annu Rev Physiol 1985;47:425-42.
23. Claesson-Welsh L. Signal transduction by the PDGF receptors. Prog Growth Factor Res 1994;5:37-54.
24. Nunes I, Gleizes PE, Metz CN, Rifkin DB. Latent transforming growth factor-beta binding protein domains involved in activation and transglutaminase-dependent cross-linking of latent transforming growth factor-beta. J Cell Biol 1997;136:1151-63.
25. Sah RL, Chen AC, Grodzinsky AJ, Trippel SB. Differential effects of bFGF and IGF-1 on matrix metabolism in calf and adult bovine cartilage explants. Arch Bioch Biophys 1994;308:137-47.
26. Malemud CJ. The role of growth factors in cartilage metabolism. Osteoarthritis 1993;19:569-81.
27. Hedbom E, Antonsson P, Hjerpe A, et al. Cartilage matrix proteins: An acidic oligomeric protein (COMP) detected only in cartilage. J Biol Chem 1992;267:6132-6.
28. Chan KT, Anastassiades TP. Anionic glyconjugates from differentiated and de-differentiated cultures of bovine articular chondrocytes: modulation by TGF-β. In Vitro Cell Develop Biol 1998; (in press).
29. Sokoloff L. Aging and degenerative diseases affecting cartilage. In: Hall BK, editor. Cartilage. Vol 3. New York: Academic Press; 1987.
30. Athanassiades A, Anastassiades T. A "coupled" subchondral bone-articular cartilage tissue culture system for the study of cartilage proteoglycan metabolism. In vitro Cell Develop Biol 1994;30A: 510-1.