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Volumn 65, Issue 4, 2013, Pages 590-599

Multitargeting and antimetastatic potentials of silibinin in human HepG-2 and PLC/PRF/5 hepatoma cells

Author keywords

[No Author keywords available]

Indexed keywords

ANGPT2 PROTEIN; ATP6L PROTEIN; CAP2 PROTEIN; CHEMOKINE RECEPTOR CCR6; CHEMOKINE RECEPTOR CCR7; CHEMOKINE RECEPTOR CXCR4; CLDN 10 PROTEIN; COMPLEMENTARY DNA; CORTACTIN; GELATINASE A; GELATINASE B; HK2 PROTEIN; KIAA0101 PROTEIN; MORTALIN; P21 ACTIVATED KINASE 1; PROTEIN P53; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SILIBININ; SPINK1 PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GLI2; UNCLASSIFIED DRUG;

EID: 84877943662     PISSN: 01635581     EISSN: 15327914     Source Type: Journal    
DOI: 10.1080/01635581.2013.770043     Document Type: Article
Times cited : (30)

References (69)
  • 1
    • 63049133092 scopus 로고    scopus 로고
    • Hepatocellular carcinoma incidence, mortality, and survival trends in the United States from 1975 to 2005
    • Altekruse, S F, Mcglynn, K A, and, Reichman, M E. 2009. Hepatocellular carcinoma incidence, mortality, and survival trends in the United States from 1975 to 2005. J Clin Oncol, 27: 1485-1491.
    • (2009) J Clin Oncol , vol.27 , pp. 1485-1491
    • Altekruse, S.F.1    McGlynn, K.A.2    Reichman, M.E.3
  • 2
    • 34250020201 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: Epidemiology and molecular carcinogenesis
    • El-Serag, H B, and, Rudolph, K L. 2007. Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology, 132: 2557-2576.
    • (2007) Gastroenterology , vol.132 , pp. 2557-2576
    • El-Serag, H.B.1    Rudolph, K.L.2
  • 3
    • 81155131890 scopus 로고    scopus 로고
    • Factors predicting occurrence and prognosis of hepatitis-B-virus-related hepatocellular carcinoma
    • Han, Y F, Zhao, J, Ma, L Y, Yin, J H, Chang, W J. 2011. Factors predicting occurrence and prognosis of hepatitis-B-virus-related hepatocellular carcinoma. World J Gastroenterol, 17: 4258-4270.
    • (2011) World J Gastroenterol , vol.17 , pp. 4258-4270
    • Han, Y.F.1    Zhao, J.2    Ma, L.Y.3    Yin, J.H.4    Chang, W.J.5
  • 4
    • 69149096126 scopus 로고    scopus 로고
    • The prevalence of hepatitis B surface antigen and anti-hepatitis B core antibody in Iran: A population-based study
    • Merat, S, Rezvan, H, Nouraie, M, Jamali, A, Assari, S. 2009. The prevalence of hepatitis B surface antigen and anti-hepatitis B core antibody in Iran: a population-based study. Arch Iran Med, 12: 225-231.
    • (2009) Arch Iran Med , vol.12 , pp. 225-231
    • Merat, S.1    Rezvan, H.2    Nouraie, M.3    Jamali, A.4    Assari, S.5
  • 5
    • 0036282936 scopus 로고    scopus 로고
    • P53 immunohistochemical scoring: An independent prognostic marker for patients after hepatocellular carcinoma resection
    • Qin, L X, Tang, Z Y, Ma, Z C, Wu, Z Q, Zhou, X D. 2002. P53 immunohistochemical scoring: an independent prognostic marker for patients after hepatocellular carcinoma resection. World J Gastroenterol, 8: 459-463.
    • (2002) World J Gastroenterol , vol.8 , pp. 459-463
    • Qin, L.X.1    Tang, Z.Y.2    Ma, Z.C.3    Wu, Z.Q.4    Zhou, X.D.5
  • 7
    • 0034893404 scopus 로고    scopus 로고
    • Hepatocellular carcinoma - Cause, treatment and metastasis
    • Tang, Z Y. 2001. Hepatocellular carcinoma-cause, treatment and metastasis. World J Gastroenterol, 7: 445-454.
    • (2001) World J Gastroenterol , vol.7 , pp. 445-454
    • Tang, Z.Y.1
  • 8
    • 79954417584 scopus 로고    scopus 로고
    • Molecular targeted therapy for hepatocellular carcinoma in the current and potential next strategies
    • Tanaka, S, and, Arii, S. 2011. Molecular targeted therapy for hepatocellular carcinoma in the current and potential next strategies. J Gastroenterol, 46: 289-296.
    • (2011) J Gastroenterol , vol.46 , pp. 289-296
    • Tanaka, S.1    Arii, S.2
  • 9
    • 35948981211 scopus 로고    scopus 로고
    • Identification and validation of a novel gene signature associated with the recurrence of human hepatocellular carcinoma
    • Wang, S M, Ooi, L L, and, Hui, K M. 2007. Identification and validation of a novel gene signature associated with the recurrence of human hepatocellular carcinoma. Clin Cancer Res, 13: 6275-6283.
    • (2007) Clin Cancer Res , vol.13 , pp. 6275-6283
    • Wang, S.M.1    Ooi, L.L.2    Hui, K.M.3
  • 10
    • 17444410030 scopus 로고    scopus 로고
    • Clinical analysis of the risk factors for recurrence of HCC and its relationship with HBV
    • Ou, D P, Yang, L Y, Huang, G W, Tao, Y M, Ding, X. 2005. Clinical analysis of the risk factors for recurrence of HCC and its relationship with HBV. World J Gastroenterol, 11: 2061-2066.
    • (2005) World J Gastroenterol , vol.11 , pp. 2061-2066
    • Ou, D.P.1    Yang, L.Y.2    Huang, G.W.3    Tao, Y.M.4    Ding, X.5
  • 11
    • 0035211762 scopus 로고    scopus 로고
    • The use of silymarin in the treatment of liver diseases
    • Saller, R, Meier, R, and, Brignoli, R. 2001. The use of silymarin in the treatment of liver diseases. Drugs, 61: 2035-2063.
    • (2001) Drugs , vol.61 , pp. 2035-2063
    • Saller, R.1    Meier, R.2    Brignoli, R.3
  • 12
    • 77956852506 scopus 로고    scopus 로고
    • Milk thistle in liver diseases: Past, present, future
    • Abenavoli, L, Capasso, R, Milic, N, and, Capasso, F. 2010. Milk thistle in liver diseases: past, present, future. Phytother Res, 24: 1423-1432.
    • (2010) Phytother Res , vol.24 , pp. 1423-1432
    • Abenavoli, L.1    Capasso, R.2    Milic, N.3    Capasso, F.4
  • 13
    • 51349164386 scopus 로고    scopus 로고
    • Multitargeted therapy of cancer by silymarin
    • Ramasamy, K, and, Agarwal, R. 2008. Multitargeted therapy of cancer by silymarin. Cancer Lett, 269: 352-362.
    • (2008) Cancer Lett , vol.269 , pp. 352-362
    • Ramasamy, K.1    Agarwal, R.2
  • 15
    • 77957598340 scopus 로고    scopus 로고
    • Antimetastatic efficacy of silibinin: Molecular mechanisms and therapeutic potential against cancer
    • Deep, G, and, Agarwal, R. 2010. Antimetastatic efficacy of silibinin: molecular mechanisms and therapeutic potential against cancer. Cancer Metastasis Rev, 29: 447-463.
    • (2010) Cancer Metastasis Rev , vol.29 , pp. 447-463
    • Deep, G.1    Agarwal, R.2
  • 16
    • 35248859158 scopus 로고    scopus 로고
    • Effects and mechanisms of silibinin on human hepatoma cell lines
    • Lah, J J, Cui, W, and, Hu, K Q. 2007. Effects and mechanisms of silibinin on human hepatoma cell lines. World J Gastroenterol, 13: 5299-5305.
    • (2007) World J Gastroenterol , vol.13 , pp. 5299-5305
    • Lah, J.J.1    Cui, W.2    Hu, K.Q.3
  • 17
    • 67651171486 scopus 로고    scopus 로고
    • Effects and mechanisms of silibinin on human hepatocellular carcinoma xenografts in nude mice
    • Cui, W, Gu, F, and, Hu, K Q. 2009. Effects and mechanisms of silibinin on human hepatocellular carcinoma xenografts in nude mice. World J Gastroenterol, 15: 1943-1950.
    • (2009) World J Gastroenterol , vol.15 , pp. 1943-1950
    • Cui, W.1    Gu, F.2    Hu, K.Q.3
  • 18
    • 48749115799 scopus 로고    scopus 로고
    • Effects of silibinin on cell growth and invasive properties of a human hepatocellular carcinoma cell line, HepG-2, through inhibition of extracellular signal-regulated kinase 1/2 phosphorylation
    • Momeny, M, Khorramizadeh, M R, Ghaffari, S H, Yousefi, M, Yekaninejad, M S. 2008. Effects of silibinin on cell growth and invasive properties of a human hepatocellular carcinoma cell line, HepG-2, through inhibition of extracellular signal-regulated kinase 1/2 phosphorylation. Eur J Pharmacol, 591: 13-20.
    • (2008) Eur J Pharmacol , vol.591 , pp. 13-20
    • Momeny, M.1    Khorramizadeh, M.R.2    Ghaffari, S.H.3    Yousefi, M.4    Yekaninejad, M.S.5
  • 19
    • 4644271628 scopus 로고    scopus 로고
    • Overexpression of cortactin is involved in motility and metastasis of hepatocellular carcinoma
    • Chuma, M, Sakamoto, M, Yasuda, J, Fujii, G, Nakanishi, K. 2004. Overexpression of cortactin is involved in motility and metastasis of hepatocellular carcinoma. J Hepatol, 41: 629-636.
    • (2004) J Hepatol , vol.41 , pp. 629-636
    • Chuma, M.1    Sakamoto, M.2    Yasuda, J.3    Fujii, G.4    Nakanishi, K.5
  • 20
    • 33845760019 scopus 로고    scopus 로고
    • Regulation of angiogenesis by Id-1 through hypoxia-inducible factor-1alpha-mediated vascular endothelial growth factor up-regulation in hepatocellular carcinoma
    • Lee, T K, Poon, R T, Yuen, A P, Ling, M T, Wang, X H. 2006. Regulation of angiogenesis by Id-1 through hypoxia-inducible factor-1alpha-mediated vascular endothelial growth factor up-regulation in hepatocellular carcinoma. Clin Cancer Res, 12: 6910-6919.
    • (2006) Clin Cancer Res , vol.12 , pp. 6910-6919
    • Lee, T.K.1    Poon, R.T.2    Yuen, A.P.3    Ling, M.T.4    Wang, X.H.5
  • 21
    • 77955483343 scopus 로고    scopus 로고
    • Overexpressed Id-1 is associated with patient prognosis and HBx expression in hepatitis B virus-related hepatocellular carcinoma
    • Ding, R, Han, S, Lu, Y, Guo, C, Xie, H. 2010. Overexpressed Id-1 is associated with patient prognosis and HBx expression in hepatitis B virus-related hepatocellular carcinoma. Cancer Biol Ther, 10: 299-307.
    • (2010) Cancer Biol Ther , vol.10 , pp. 299-307
    • Ding, R.1    Han, S.2    Lu, Y.3    Guo, C.4    Xie, H.5
  • 22
    • 39749200037 scopus 로고    scopus 로고
    • Association of mortalin (HSPA9) with liver cancer metastasis and prediction for early tumor recurrence
    • Yi, X, Luk, J M, Lee, N P, Peng, J, Leng, X. 2008. Association of mortalin (HSPA9) with liver cancer metastasis and prediction for early tumor recurrence. Mol Cell Proteomics, 7: 315-325.
    • (2008) Mol Cell Proteomics , vol.7 , pp. 315-325
    • Yi, X.1    Luk, J.M.2    Lee, N.P.3    Peng, J.4    Leng, X.5
  • 23
    • 34848837730 scopus 로고    scopus 로고
    • Overexpression of KIAA0101 predicts high stage, early tumor recurrence, and poor prognosis of hepatocellular carcinoma
    • Yuan, R H, Jeng, Y M, Pan, H W, Hu, F C, Lai, P L. 2007. Overexpression of KIAA0101 predicts high stage, early tumor recurrence, and poor prognosis of hepatocellular carcinoma. Clin Cancer Res, 13: 5368-5376.
    • (2007) Clin Cancer Res , vol.13 , pp. 5368-5376
    • Yuan, R.H.1    Jeng, Y.M.2    Pan, H.W.3    Hu, F.C.4    Lai, P.L.5
  • 24
    • 34248531653 scopus 로고    scopus 로고
    • P21-activated protein kinase is overexpressed in hepatocellular carcinoma and enhances cancer metastasis involving c-Jun NH2-terminal kinase activation and paxillin phosphorylation
    • Ching, Y P, Leong, V Y, Lee, M F, Xu, H T, Jin, D Y. 2007. P21-activated protein kinase is overexpressed in hepatocellular carcinoma and enhances cancer metastasis involving c-Jun NH2-terminal kinase activation and paxillin phosphorylation. Cancer Res, 67: 3601-3608.
    • (2007) Cancer Res , vol.67 , pp. 3601-3608
    • Ching, Y.P.1    Leong, V.Y.2    Lee, M.F.3    Xu, H.T.4    Jin, D.Y.5
  • 25
    • 33751170901 scopus 로고    scopus 로고
    • Overexpression of RhoA is associated with poor prognosis in hepatocellular carcinoma
    • Li, X R, Ji, F, Ouyang, J, Wu, W, Qian, L Y. 2006. Overexpression of RhoA is associated with poor prognosis in hepatocellular carcinoma. Eur J Surg Oncol, 32: 1130-1134.
    • (2006) Eur J Surg Oncol , vol.32 , pp. 1130-1134
    • Li, X.R.1    Ji, F.2    Ouyang, J.3    Wu, W.4    Qian, L.Y.5
  • 26
    • 33947704795 scopus 로고    scopus 로고
    • Overexpression of tumour-associated trypsin inhibitor (TATI) enhances tumour growth and is associated with portal vein invasion, early recurrence and a stage-independent prognostic factor of hepatocellular carcinoma
    • Lee, Y C, Pan, H W, Peng, S Y, Lai, P L, Kuo, W S. 2007. Overexpression of tumour-associated trypsin inhibitor (TATI) enhances tumour growth and is associated with portal vein invasion, early recurrence and a stage-independent prognostic factor of hepatocellular carcinoma. Eur J Cancer, 43: 736-744.
    • (2007) Eur J Cancer , vol.43 , pp. 736-744
    • Lee, Y.C.1    Pan, H.W.2    Peng, S.Y.3    Lai, P.L.4    Kuo, W.S.5
  • 27
    • 84859101650 scopus 로고    scopus 로고
    • Activation of STAT3 Signal pathway correlates with twist and e-cadherin expression in hepatocellular carcinoma and their clinical significance
    • Zhang, C H, Xu, G L, Jia, W D, Li, J S, Ma, J L. 2012. Activation of STAT3 Signal pathway correlates with twist and e-cadherin expression in hepatocellular carcinoma and their clinical significance. J Surg Res, 174: 120-129.
    • (2012) J Surg Res , vol.174 , pp. 120-129
    • Zhang, C.H.1    Xu, G.L.2    Jia, W.D.3    Li, J.S.4    Ma, J.L.5
  • 28
    • 33746884331 scopus 로고    scopus 로고
    • Stathmin overexpression cooperates with p53 mutation and osteopontin overexpression, and is associated with tumour progression, early recurrence, and poor prognosis in hepatocellular carcinoma
    • Yuan, R H, Jeng, Y M, Chen, H L, Lai, P L, Pan, H W. 2006. Stathmin overexpression cooperates with p53 mutation and osteopontin overexpression, and is associated with tumour progression, early recurrence, and poor prognosis in hepatocellular carcinoma. J Pathol, 209: 549-558.
    • (2006) J Pathol , vol.209 , pp. 549-558
    • Yuan, R.H.1    Jeng, Y.M.2    Chen, H.L.3    Lai, P.L.4    Pan, H.W.5
  • 29
    • 84866266607 scopus 로고    scopus 로고
    • Reduced survival of patients with hepatocellular carcinoma expressing hexokinase II
    • Gong, L, Cui, Z, Chen, P, Han, H, Peng, J. 2012. Reduced survival of patients with hepatocellular carcinoma expressing hexokinase II. Med Oncol, 29: 909-914.
    • (2012) Med Oncol , vol.29 , pp. 909-914
    • Gong, L.1    Cui, Z.2    Chen, P.3    Han, H.4    Peng, J.5
  • 30
    • 28144445732 scopus 로고    scopus 로고
    • Angiopoietin 2 displays a vascular endothelial growth factor dependent synergistic effect in hepatocellular carcinoma development in mice
    • Yoshiji, H, Kuriyama, S, Noguchi, R, Yoshii, J, Ikenaka, Y. 2005. Angiopoietin 2 displays a vascular endothelial growth factor dependent synergistic effect in hepatocellular carcinoma development in mice. Gut, 54: 1768-1775.
    • (2005) Gut , vol.54 , pp. 1768-1775
    • Yoshiji, H.1    Kuriyama, S.2    Noguchi, R.3    Yoshii, J.4    Ikenaka, Y.5
  • 31
    • 33749350144 scopus 로고    scopus 로고
    • Overexpression of cyclase-associated protein 2 in multistage hepatocarcinogenesis
    • Shibata, R, Mori, T, Du, W, Chuma, M, Gotoh, M. 2006. Overexpression of cyclase-associated protein 2 in multistage hepatocarcinogenesis. Clin Cancer Res, 12: 5363-5368.
    • (2006) Clin Cancer Res , vol.12 , pp. 5363-5368
    • Shibata, R.1    Mori, T.2    Du, W.3    Chuma, M.4    Gotoh, M.5
  • 32
    • 33645235093 scopus 로고    scopus 로고
    • Chemokine receptor CCR6 as a prognostic factor after hepatic resection for hepatocellular carcinoma
    • Uchida, H, Iwashita, Y, Sasaki, A, Shibata, K, Matsumoto, T. 2006. Chemokine receptor CCR6 as a prognostic factor after hepatic resection for hepatocellular carcinoma. J Gastroenterol Hepatol, 21: 161-168.
    • (2006) J Gastroenterol Hepatol , vol.21 , pp. 161-168
    • Uchida, H.1    Iwashita, Y.2    Sasaki, A.3    Shibata, K.4    Matsumoto, T.5
  • 33
    • 33745888428 scopus 로고    scopus 로고
    • Dissemination of hepatocellular carcinoma is mediated via chemokine receptor CXCR4
    • Schimanski, C C, Bahre, R, Gockel, I, Muller, A, Frerichs, K. 2006. Dissemination of hepatocellular carcinoma is mediated via chemokine receptor CXCR4. Br J Cancer, 95: 210-217.
    • (2006) Br J Cancer , vol.95 , pp. 210-217
    • Schimanski, C.C.1    Bahre, R.2    Gockel, I.3    Muller, A.4    Frerichs, K.5
  • 34
    • 67650246591 scopus 로고    scopus 로고
    • Chemokine receptor CXCR4 expression in hepatocellular carcinoma patients increases the risk of bone metastases and poor survival
    • 176
    • Xiang, Z L, Zeng, Z C, Tang, Z Y, Fan, J, Zhuang, P Y. 2009. Chemokine receptor CXCR4 expression in hepatocellular carcinoma patients increases the risk of bone metastases and poor survival. BMC Cancer, 9. 176
    • (2009) BMC Cancer , vol.9
    • Xiang, Z.L.1    Zeng, Z.C.2    Tang, Z.Y.3    Fan, J.4    Zhuang, P.Y.5
  • 35
    • 33750701429 scopus 로고    scopus 로고
    • Chemokine receptor CCR7 enhances intrahepatic and lymphatic dissemination of human hepatocellular cancer
    • Schimanski, C C, Bahre, R, Gockel, I, Junginger, T, Simiantonaki, N. 2006. Chemokine receptor CCR7 enhances intrahepatic and lymphatic dissemination of human hepatocellular cancer. Oncol Rep, 16: 109-113.
    • (2006) Oncol Rep , vol.16 , pp. 109-113
    • Schimanski, C.C.1    Bahre, R.2    Gockel, I.3    Junginger, T.4    Simiantonaki, N.5
  • 36
    • 4444354102 scopus 로고    scopus 로고
    • Chemokine CCL20 enhances the growth of HuH7 cells via phosphorylation of p44/42 MAPK in vitro
    • Fujii, H, Itoh, Y, Yamaguchi, K, Yamauchi, N, Harano, Y. 2004. Chemokine CCL20 enhances the growth of HuH7 cells via phosphorylation of p44/42 MAPK in vitro. Biochem Biophys Res Commun, 322: 1052-1058.
    • (2004) Biochem Biophys Res Commun , vol.322 , pp. 1052-1058
    • Fujii, H.1    Itoh, Y.2    Yamaguchi, K.3    Yamauchi, N.4    Harano, Y.5
  • 37
    • 33750733603 scopus 로고    scopus 로고
    • A homeobox protein, prox1, is involved in the differentiation, proliferation, and prognosis in hepatocellular carcinoma
    • Shimoda, M, Takahashi, M, Yoshimoto, T, Kono, T, Ikai, I. 2006. A homeobox protein, prox1, is involved in the differentiation, proliferation, and prognosis in hepatocellular carcinoma. Clin Cancer Res, 12: 6005-6011.
    • (2006) Clin Cancer Res , vol.12 , pp. 6005-6011
    • Shimoda, M.1    Takahashi, M.2    Yoshimoto, T.3    Kono, T.4    Ikai, I.5
  • 38
    • 17844395201 scopus 로고    scopus 로고
    • The liver-enriched transcription factor CREB-H is a growth suppressor protein underexpressed in hepatocellular carcinoma
    • Chin, K T, Zhou, H J, Wong, C M, Lee, J M, Chan, C P. 2005. The liver-enriched transcription factor CREB-H is a growth suppressor protein underexpressed in hepatocellular carcinoma. Nucleic Acids Res, 33: 1859-1873.
    • (2005) Nucleic Acids Res , vol.33 , pp. 1859-1873
    • Chin, K.T.1    Zhou, H.J.2    Wong, C.M.3    Lee, J.M.4    Chan, C.P.5
  • 39
    • 33645516795 scopus 로고    scopus 로고
    • DDX3, a DEAD box RNA helicase, is deregulated in hepatitis virus-associated hepatocellular carcinoma and is involved in cell growth control
    • Chang, P C, Chi, C W, Chau, G Y, Li, F Y, Tsai, Y H. 2006. DDX3, a DEAD box RNA helicase, is deregulated in hepatitis virus-associated hepatocellular carcinoma and is involved in cell growth control. Oncogene, 25: 1991-2003.
    • (2006) Oncogene , vol.25 , pp. 1991-2003
    • Chang, P.C.1    Chi, C.W.2    Chau, G.Y.3    Li, F.Y.4    Tsai, Y.H.5
  • 40
    • 0344827261 scopus 로고    scopus 로고
    • Silibinin upregulates the expression of cyclin-dependent kinase inhibitors and causes cell cycle arrest and apoptosis in human colon carcinoma HT-29 cells
    • Agarwal, C, Singh, R P, Dhanalakshmi, S, Tyagi, A K, Tecklenburg, M. 2003. Silibinin upregulates the expression of cyclin-dependent kinase inhibitors and causes cell cycle arrest and apoptosis in human colon carcinoma HT-29 cells. Oncogene, 22: 8271-8282.
    • (2003) Oncogene , vol.22 , pp. 8271-8282
    • Agarwal, C.1    Singh, R.P.2    Dhanalakshmi, S.3    Tyagi, A.K.4    Tecklenburg, M.5
  • 41
    • 33845899681 scopus 로고    scopus 로고
    • A phase i and pharmacokinetic study of silybin-phytosome in prostate cancer patients
    • Flaig, T W, Gustafson, D L, Su, L J, Zirrolli, J A, Crighton, F. 2007. A phase I and pharmacokinetic study of silybin-phytosome in prostate cancer patients. Invest New Drugs, 25: 139-146.
    • (2007) Invest New Drugs , vol.25 , pp. 139-146
    • Flaig, T.W.1    Gustafson, D.L.2    Su, L.J.3    Zirrolli, J.A.4    Crighton, F.5
  • 42
    • 76649085810 scopus 로고    scopus 로고
    • Silibinin inhibits invasive properties of human glioblastoma U87MG cells through suppression of cathepsin B and nuclear factor kappa B-mediated induction of matrix metalloproteinase 9
    • Momeny, M, Malehmir, M, Zakidizaji, M, Ghasemi, R, Ghadimi, H. 2010. Silibinin inhibits invasive properties of human glioblastoma U87MG cells through suppression of cathepsin B and nuclear factor kappa B-mediated induction of matrix metalloproteinase 9. Anticancer Drugs, 21: 252-260.
    • (2010) Anticancer Drugs , vol.21 , pp. 252-260
    • Momeny, M.1    Malehmir, M.2    Zakidizaji, M.3    Ghasemi, R.4    Ghadimi, H.5
  • 43
    • 79955477680 scopus 로고    scopus 로고
    • Radiation-induced intercellular signaling mediated by cytochrome-c via a p53-dependent pathway in hepatoma cells
    • He, M, Zhao, M, Shen, B, Prise, K M, and, Shao, C. 2011. Radiation-induced intercellular signaling mediated by cytochrome-c via a p53-dependent pathway in hepatoma cells. Oncogene, 30: 1947-1955.
    • (2011) Oncogene , vol.30 , pp. 1947-1955
    • He, M.1    Zhao, M.2    Shen, B.3    Prise, K.M.4    Shao, C.5
  • 44
    • 77955388300 scopus 로고    scopus 로고
    • Effects of the TP53 p.R249S mutant on proliferation and clonogenic properties in human hepatocellular carcinoma cell lines: Interaction with hepatitis B virus X protein
    • Gouas, D A, Shi, H, Hautefeuille, A H, Ortiz-Cuaran, S L, Legros, P C. 2010. Effects of the TP53 p.R249S mutant on proliferation and clonogenic properties in human hepatocellular carcinoma cell lines: interaction with hepatitis B virus X protein. Carcinogenesis, 31: 1475-1482.
    • (2010) Carcinogenesis , vol.31 , pp. 1475-1482
    • Gouas, D.A.1    Shi, H.2    Hautefeuille, A.H.3    Ortiz-Cuaran, S.L.4    Legros, P.C.5
  • 45
    • 0042968962 scopus 로고    scopus 로고
    • Molecular viral oncology of hepatocellular carcinoma
    • Block, T M, Mehta, A S, Fimmel, C J, and, Jordan, R. 2003. Molecular viral oncology of hepatocellular carcinoma. Oncogene, 22: 5093-5107.
    • (2003) Oncogene , vol.22 , pp. 5093-5107
    • Block, T.M.1    Mehta, A.S.2    Fimmel, C.J.3    Jordan, R.4
  • 46
    • 12244307464 scopus 로고    scopus 로고
    • Claudin-10 expression level is associated with recurrence of primary hepatocellular carcinoma
    • Cheung, S T, Leung, K L, Ip, Y C, Chen, X, Fong, D Y. 2005. Claudin-10 expression level is associated with recurrence of primary hepatocellular carcinoma. Clin Cancer Res, 11: 551-556.
    • (2005) Clin Cancer Res , vol.11 , pp. 551-556
    • Cheung, S.T.1    Leung, K.L.2    Ip, Y.C.3    Chen, X.4    Fong, D.Y.5
  • 47
    • 43849113286 scopus 로고    scopus 로고
    • Aberrant expression of the glycolytic enzymes aldolase B and type II hexokinase in hepatocellular carcinoma are predictive markers for advanced stage, early recurrence and poor prognosis
    • Peng, S Y, Lai, P L, Pan, H W, Hsiao, L P, and, Hsu, H C. 2008. Aberrant expression of the glycolytic enzymes aldolase B and type II hexokinase in hepatocellular carcinoma are predictive markers for advanced stage, early recurrence and poor prognosis. Oncol Rep, 19: 1045-1053.
    • (2008) Oncol Rep , vol.19 , pp. 1045-1053
    • Peng, S.Y.1    Lai, P.L.2    Pan, H.W.3    Hsiao, L.P.4    Hsu, H.C.5
  • 48
    • 39749200037 scopus 로고    scopus 로고
    • Association of mortalin (HSPA9) with liver cancer metastasis and prediction for early tumor recurrence
    • Yi, X LJ, Lee, N P, Peng, J, Leng, X, Guan, X Y. 2008. Association of mortalin (HSPA9) with liver cancer metastasis and prediction for early tumor recurrence. Mol Cell Proteomics, 7: 315-325.
    • (2008) Mol Cell Proteomics , vol.7 , pp. 315-325
    • Yi, X.L.1    Lee, N.P.2    Peng, J.3    Leng, X.4    Guan, X.Y.5
  • 49
    • 25844507808 scopus 로고    scopus 로고
    • Proteomic analysis of differentially expressed proteins in hepatocellular carcinoma developed in patients with chronic viral hepatitis C
    • Blanc, JFLC, Plomion, C, Schmitter, J M, Bathany, K, Gion, J M. 2005. Proteomic analysis of differentially expressed proteins in hepatocellular carcinoma developed in patients with chronic viral hepatitis C. Proteomics, 5: 3778-3789.
    • (2005) Proteomics , vol.5 , pp. 3778-3789
    • Blanc, J.1    Plomion, C.2    Schmitter, J.M.3    Bathany, K.4    Gion, J.M.5
  • 50
    • 37149041341 scopus 로고    scopus 로고
    • NS5ATP9, a gene up-regulated by HCV NS5A protein
    • Shi, L, Zhang, S L, Li, K, Hong, Y, Wang, Q. 2008. NS5ATP9, a gene up-regulated by HCV NS5A protein. Cancer Lett, 259: 192-197.
    • (2008) Cancer Lett , vol.259 , pp. 192-197
    • Shi, L.1    Zhang, S.L.2    Li, K.3    Hong, Y.4    Wang, Q.5
  • 51
    • 33846948601 scopus 로고    scopus 로고
    • The hepatitis B virus X protein promotes hepatocellular carcinoma metastasis by upregulation of matrix metalloproteinases
    • Ou, D P, Tao, Y M, Tang, F Q, and, Yang, L Y. 2007. The hepatitis B virus X protein promotes hepatocellular carcinoma metastasis by upregulation of matrix metalloproteinases. Int J Cancer, 120: 1208-1214.
    • (2007) Int J Cancer , vol.120 , pp. 1208-1214
    • Ou, D.P.1    Tao, Y.M.2    Tang, F.Q.3    Yang, L.Y.4
  • 52
    • 79959336054 scopus 로고    scopus 로고
    • Impact of antiviral therapy on the survival of patients after major hepatectomy for hepatitis B virus-related hepatocellular carcinoma
    • Chan, A C, Chok, K S, Yuen, W K, Chan, S C, Poon, R T. 2011. Impact of antiviral therapy on the survival of patients after major hepatectomy for hepatitis B virus-related hepatocellular carcinoma. Arch Surg, 146: 675-681.
    • (2011) Arch Surg , vol.146 , pp. 675-681
    • Chan, A.C.1    Chok, K.S.2    Yuen, W.K.3    Chan, S.C.4    Poon, R.T.5
  • 53
    • 45449095203 scopus 로고    scopus 로고
    • Association between hepatitis B and hepatocellular carcinoma recurrence in patients undergoing liver transplantation
    • Kiyici, M, Yilmaz, M, Akyildiz, M, Arikan, C, Aydin, U. 2008. Association between hepatitis B and hepatocellular carcinoma recurrence in patients undergoing liver transplantation. Transplant Proc, 40: 1511-1517.
    • (2008) Transplant Proc , vol.40 , pp. 1511-1517
    • Kiyici, M.1    Yilmaz, M.2    Akyildiz, M.3    Arikan, C.4    Aydin, U.5
  • 54
    • 80052036411 scopus 로고    scopus 로고
    • Induction of mutant p53-dependent apoptosis in human hepatocellular carcinoma by targeting stress protein mortalin
    • Lu, W J, Lee, N P, Kaul, S C, Lan, F, Poon, R T. 2011. Induction of mutant p53-dependent apoptosis in human hepatocellular carcinoma by targeting stress protein mortalin. Int J Cancer, 129: 1806-1814.
    • (2011) Int J Cancer , vol.129 , pp. 1806-1814
    • Lu, W.J.1    Lee, N.P.2    Kaul, S.C.3    Lan, F.4    Poon, R.T.5
  • 55
    • 79955827220 scopus 로고    scopus 로고
    • Mortalin-p53 interaction in cancer cells is stress dependent and constitutes a selective target for cancer therapy
    • Lu, W J, Lee, N P, Kaul, S C, Lan, F, Poon, R T. 2011. Mortalin-p53 interaction in cancer cells is stress dependent and constitutes a selective target for cancer therapy. Cell Death Differ, 18: 1046-1056.
    • (2011) Cell Death Differ , vol.18 , pp. 1046-1056
    • Lu, W.J.1    Lee, N.P.2    Kaul, S.C.3    Lan, F.4    Poon, R.T.5
  • 56
    • 33846705491 scopus 로고    scopus 로고
    • Evidence of a novel antiapoptotic factor: Role of inhibitor of differentiation or DNA binding (Id-1) in anticancer drug-induced apoptosis
    • Zhang, X, Ling, M T, Wong, Y C, and, Wang, X. 2007. Evidence of a novel antiapoptotic factor: role of inhibitor of differentiation or DNA binding (Id-1) in anticancer drug-induced apoptosis. Cancer Sci, 98: 308-314.
    • (2007) Cancer Sci , vol.98 , pp. 308-314
    • Zhang, X.1    Ling, M.T.2    Wong, Y.C.3    Wang, X.4
  • 57
    • 0242559090 scopus 로고    scopus 로고
    • Over-expression of Id-1 induces cell proliferation in hepatocellular carcinoma through inactivation of p16INK4a/RB pathway
    • Lee, T K, Man, K, Ling, M T, Wang, X H, Wong, Y C. 2003. Over-expression of Id-1 induces cell proliferation in hepatocellular carcinoma through inactivation of p16INK4a/RB pathway. Carcinogenesis, 24: 1729-1736.
    • (2003) Carcinogenesis , vol.24 , pp. 1729-1736
    • Lee, T.K.1    Man, K.2    Ling, M.T.3    Wang, X.H.4    Wong, Y.C.5
  • 58
    • 33845771270 scopus 로고    scopus 로고
    • Inhibition of growth and metastasis of human hepatocellular carcinoma by antisense oligonucleotide targeting signal transducer and activator of transcription 3
    • Li, W C, Ye, S L, Sun, R X, Liu, Y K, Tang, Z Y. 2006. Inhibition of growth and metastasis of human hepatocellular carcinoma by antisense oligonucleotide targeting signal transducer and activator of transcription 3. Clin Cancer Res, 12: 7140-7148.
    • (2006) Clin Cancer Res , vol.12 , pp. 7140-7148
    • Li, W.C.1    Ye, S.L.2    Sun, R.X.3    Liu, Y.K.4    Tang, Z.Y.5
  • 59
    • 77951490243 scopus 로고    scopus 로고
    • Chemokines and hepatocellular carcinoma
    • Huang, F, and, Geng, X P. 2010. Chemokines and hepatocellular carcinoma. World J Gastroenterol, 16: 1832-1836.
    • (2010) World J Gastroenterol , vol.16 , pp. 1832-1836
    • Huang, F.1    Geng, X.P.2
  • 60
    • 34248571816 scopus 로고    scopus 로고
    • Selective down-regulation of glioma-associated oncogene 2 inhibits the proliferation of hepatocellular carcinoma cells
    • Kim, Y, Yoon, J W, Xiao, X, Dean, N M, Monia, B P. 2007. Selective down-regulation of glioma-associated oncogene 2 inhibits the proliferation of hepatocellular carcinoma cells. Cancer Res, 67: 3583-3593.
    • (2007) Cancer Res , vol.67 , pp. 3583-3593
    • Kim, Y.1    Yoon, J.W.2    Xiao, X.3    Dean, N.M.4    Monia, B.P.5
  • 61
    • 80052498093 scopus 로고    scopus 로고
    • Proteomic identification of RhoA as a potential biomarker for proliferation and metastasis in hepatocellular carcinoma
    • Gou, L, Wang, W, Tong, A, Yao, Y, Zhou, Y. 2011. Proteomic identification of RhoA as a potential biomarker for proliferation and metastasis in hepatocellular carcinoma. J Mol Med, 89: 817-827.
    • (2011) J Mol Med , vol.89 , pp. 817-827
    • Gou, L.1    Wang, W.2    Tong, A.3    Yao, Y.4    Zhou, Y.5
  • 62
    • 77953049436 scopus 로고    scopus 로고
    • Stathmin1 overexpression associated with polyploidy, tumor-cell invasion, early recurrence, and poor prognosis in human hepatoma
    • Hsieh, S Y, Huang, S F, Yu, M C, Yeh, T S, Chen, T C. 2010. Stathmin1 overexpression associated with polyploidy, tumor-cell invasion, early recurrence, and poor prognosis in human hepatoma. Mol Carcinog, 49: 476-487.
    • (2010) Mol Carcinog , vol.49 , pp. 476-487
    • Hsieh, S.Y.1    Huang, S.F.2    Yu, M.C.3    Yeh, T.S.4    Chen, T.C.5
  • 63
    • 79952030682 scopus 로고    scopus 로고
    • Novel therapeutic potential in targeting microtubules by nanoparticle albumin-bound paclitaxel in hepatocellular carcinoma
    • Zhou, Q, Ching, A K, Leung, W K, Szeto, C Y, Ho, S M. 2011. Novel therapeutic potential in targeting microtubules by nanoparticle albumin-bound paclitaxel in hepatocellular carcinoma. Int J Oncol, 38: 721-731.
    • (2011) Int J Oncol , vol.38 , pp. 721-731
    • Zhou, Q.1    Ching, A.K.2    Leung, W.K.3    Szeto, C.Y.4    Ho, S.M.5
  • 64
    • 36749050385 scopus 로고    scopus 로고
    • Inhibition of hepatocellular carcinoma invasion by suppression of claudin-10 in HLE cells
    • Ip, Y C, Cheung, S T, Lee, Y T, Ho, J C, and, Fan, S T. 2007. Inhibition of hepatocellular carcinoma invasion by suppression of claudin-10 in HLE cells. Mol Cancer Ther, 6: 2858-2867.
    • (2007) Mol Cancer Ther , vol.6 , pp. 2858-2867
    • Ip, Y.C.1    Cheung, S.T.2    Lee, Y.T.3    Ho, J.C.4    Fan, S.T.5
  • 65
    • 34748922322 scopus 로고    scopus 로고
    • Apoptosis-inducing antitumor efficacy of hexokinase II inhibitor in hepatocellular carcinoma
    • Kim, W, Yoon, J H, Jeong, J M, Cheon, G J, Lee, T S. 2007. Apoptosis-inducing antitumor efficacy of hexokinase II inhibitor in hepatocellular carcinoma. Mol Cancer Ther, 6: 2554-2562.
    • (2007) Mol Cancer Ther , vol.6 , pp. 2554-2562
    • Kim, W.1    Yoon, J.H.2    Jeong, J.M.3    Cheon, G.J.4    Lee, T.S.5
  • 66
    • 33745642692 scopus 로고    scopus 로고
    • KIAA0101 (OEACT-1), an expressionally down-regulated and growth-inhibitory gene in human hepatocellular carcinoma
    • Guo, M, Li, J, Wan, D, and, Gu, J. 2006. KIAA0101 (OEACT-1), an expressionally down-regulated and growth-inhibitory gene in human hepatocellular carcinoma. BMC Cancer, 6 (109)
    • (2006) BMC Cancer , vol.6 , Issue.109
    • Guo, M.1    Li, J.2    Wan, D.3    Gu, J.4
  • 67
    • 23044467723 scopus 로고    scopus 로고
    • The growth and metastasis of human hepatocellular carcinoma xenografts are inhibited by small interfering RNA targeting to the subunit ATP6L of proton pump
    • Lu, X, Qin, W, Li, J, Tan, N, Pan, D. 2005. The growth and metastasis of human hepatocellular carcinoma xenografts are inhibited by small interfering RNA targeting to the subunit ATP6L of proton pump. Cancer Res, 65: 6843-6849.
    • (2005) Cancer Res , vol.65 , pp. 6843-6849
    • Lu, X.1    Qin, W.2    Li, J.3    Tan, N.4    Pan, D.5
  • 68
    • 77956110536 scopus 로고    scopus 로고
    • Molecular diagnosis of multistage hepatocarcinogenesis
    • Sakamoto, M, Effendi, K, and, Masugi, Y. 2010. Molecular diagnosis of multistage hepatocarcinogenesis. Jpn J Clin Oncol, 40: 891-896.
    • (2010) Jpn J Clin Oncol , vol.40 , pp. 891-896
    • Sakamoto, M.1    Effendi, K.2    Masugi, Y.3
  • 69
    • 0033932899 scopus 로고    scopus 로고
    • Hepatocyte migration during liver development requires Prox1
    • Sosa-Pineda, B, Wigle, J T, and, Oliver, G. 2000. Hepatocyte migration during liver development requires Prox1. Nat Genet, 25: 254-255.
    • (2000) Nat Genet , vol.25 , pp. 254-255
    • Sosa-Pineda, B.1    Wigle, J.T.2    Oliver, G.3


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