Overexpression of cyclase-associated protein 2 in multistage hepatocarcinogenesis

Clinical Cancer Research

Volumn 12, Issue 18, 2006, Pages 5363-5368

  Shibata, Rie ^a   Mori, Taisuke ^a   Du, Wenlin ^a   Chuma, Makoto ^b   Gotoh, Masahiro ^b   Shimazu, Motohide ^a   Ueda, Masakazu ^a   Hirohashi, Setsuo ^b   Sakamoto, Michiie ^a  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE CYCLASE; CYCLASE ASSOCIATED PROTEIN 2; UNCLASSIFIED DRUG;

ARTICLE; CANCER STAGING; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; TUMOR GROWTH; UPREGULATION; WESTERN BLOTTING;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; BIOPSY; BLOTTING, WESTERN; CARCINOMA, HEPATOCELLULAR; GENE EXPRESSION PROFILING; HUMANS; IMMUNOHISTOCHEMISTRY; MEMBRANE PROTEINS; RNA, MESSENGER;

EID: 33749350144     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-05-2245     Document Type: Article

References (27)

1. Vogelstein B, Fearon ER, Hamilton SR, et al. Genetic alterations during colorectal-tumor development. N Engl J Med 1988;319:525-32.
2. Tsuda H, Hirohashi S, Shimosato Y, Terada M, Hasegawa H. Clonal origin of atypical adenomatous hyperplasia of the liver and clonal identity with hepatocellular carcinoma. Gastroenterology 1988;95:1664-6
3. Takayama T, Makuuchi M, Hirohashi S, et al. Malignant transformation of adenomatous hyperplasia to hepatocellular carcinoma. Lancet 1990;336:1150-3.
4. Sakamoto M, Hirohashi S, Shimosato Y. Early stages of multistep hepatocarcinogenesis: adenomatous hyperplasia and early hepatocellular carcinoma. Hum Pathol 1991;22:172-8.
5. Chuma M, Sakamoto M, Yamazaki K, et al. Expression profiling in multistage hepatocarcinogenesis: identification of HSP70 as a molecular marker of early hepatocellular carcinoma. Hepatology 2003;37:198-207.
6. Fedor-Chaiken M, Deschenes RJ, Broach JR. SRV2, a gene required for RAS activation of adenylate cyclase in yeast. Cell 1990;61:329-40.
7. Field J, Vojtek A, Ballester R, et al. Cloning and characterization of CAP, the S. cerevisiae gene encoding the 70 kD adenylyl cyclase-associated protein. Cell 1990;61:319-27.
8. Gerst JE, Ferguson K, Vojtek A, Wigler M, Field J. CAP is a bifunctional component of the Saccharomyces cerevisiae adenylyl cyclase complex. Mol Cell Biol 1991;11:1248-57.
9. Vojtek A, Haarer B, Field J, et al. Evidence for a functional link between profilin and CAP in the yeast S. cerevisiae. Cell 1991;66:497-505.
10. Noegel AA, Blau-Wasser R, Sultana H, et al. The cyclase-associated protein CAP as regulator of cell polarity and cAMP signaling in Dictyostelium. Mol Biol Cell 2004;15:934-45.
11. Baum B, Li W, Perrimon N. A cyclase-associated protein regulates actin and cell polarity during Drosophila oogenesis and in yeast. Curr Biol 2000;10:964-73.
12. Baum B, Perrimon N. Spatial control of the actin cytoskeleton in Drosophila epithelial cells. Nat Cell Biol 2001;3:883-90.
13. Hubberstey AV, Mottillo EP. Cyclase-associated proteins: CAPacity for linking signal transduction and actin polymerization. FASEB J 2002;16:487-99.
14. Kang CM, Jiang YW. Genome-wide survey of non-essential genes required for slowed DNA synthesis-induced filamentous growth in yeast. Yeast 2005;22:79-90.
15. Yusof AM, Hu NJ, Wlodawer A, Hofmann A. Structural evidence for variable oligomerization of the N-terminal domain of cyclase-associated protein (CAP). Proteins 2005;58:255-62.
16. Hubberstey A, Yu G, Loewith R, Lakusta C, Young D. Mammalian CAP interacts with CAP, CAP2, and actin. J Cell Biochem 1996;61:459-466.
17. Hirohashi S, Ishak KG, Kojiro M, et al. Hepatocellular carcinoma. In: Hamilton SR, Aaltonen LA, editors. Tumours of the digestive system. Lyon: IARC Press; 2000. p. 159-72.
18. Heid CA, Stevens J, Livak KJ, Williams PM. Real-time quantitative PCR. Genome Res 1996;6 986-94.
19. Kanai Y, Ushijima S, Nakanishi Y, Hirohashi S. Reduced mRNA expression of the DNA demethylase, MBD2, in human colorectal and stomach cancers. Biochem Biophys Res Commun 1999;264:962-6.
20. Genda T, Sakamoto M, Ichida T, et al. Cell motility mediated by rho and Rho-associated protein kinase plays a critical role in intrahepatic metastasis of human hepatocellular carcinoma. Hepatology 1999;30 1027-36.
21. Neo SY, Leow CK, Vega VB, et al. Identification of discriminators of hepatoma by gene expression profiling using a minimal data set approach. Hepatology 2004;39:944-53.
22. Yu G, Swiston J, Young D. Comparison of human CAP and CAP2, homologs of the yeast adenylyl cyclase-associated proteins. J Cell Sci 1994;107:1671-8.
23. Swiston J, Hubberstey A, Yu G, Young D. Differential expression of CAP and CAP2 in adult rat tissues. Gene 1995;165:273-7.
24. Cherkasova VA, McCully R, Wang Y, Hinnebusch A, Elion EA. A novel functional link between MAP kinase cascades and the Ras/cAMP pathway that regulates survival. Curr Biol 2003;13:1220-6.
25. Toda T, Cameron S, Sass P, Zoller M, Wigler M. Three different genes in S. cerevisiae encode the catalytic subunits of the cAMP-dependent protein kinase. Cell 1987;50:277-87.
26. Theveiein JM, de Winde JH. Novel sensing mechanisms and targets for the cAMP-protein kinase A pathway in the yeast Saccharomyces cerevisiae. Mol Microbiol 1999;33:904-18
27. Bertling E, Hotulainen P, Manila PK, Matilainen T, Salminen M, Lappalainen P. Cyclase-associated protein 1 (CAP1) promotes cofilin-induced actin dynamics in mammalian nonmuscle cells. Mol Biol Cell 2004;15:2324-34.