메뉴 건너뛰기




Volumn 19, Issue 4, 2008, Pages 1045-1053

Aberrant expression of the glycolytic enzymes aldolase B and type II hexokinase in hepatocellular carcinoma are predictive markers for advanced stage, early recurrence and poor prognosis

Author keywords

Aldolase B; Early tumor recurrence; Hepatocellular carcinoma; Portal vein invasion; Prognosis; Type II hexokinase

Indexed keywords

ALPHA FETOPROTEIN; ANTINEOPLASTIC AGENT; FRUCTOSE BISPHOSPHATE ALDOLASE; HEXOKINASE; MESSENGER RNA; MUTANT PROTEIN; PROTEIN P53;

EID: 43849113286     PISSN: 1021335X     EISSN: None     Source Type: Journal    
DOI: 10.3892/or.19.4.1045     Document Type: Article
Times cited : (78)

References (50)
  • 1
    • 0029051439 scopus 로고
    • Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
    • Wang GL, Jiang BH, Rue EA and Semenza GL: Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci USA 92: 5510-5514, 1995.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 5510-5514
    • Wang, G.L.1    Jiang, B.H.2    Rue, E.A.3    Semenza, G.L.4
  • 2
    • 0030963616 scopus 로고    scopus 로고
    • The hypoxic response: Huffing and HIFing
    • Guillemin K and Krasnow MA: The hypoxic response: huffing and HIFing. Cell 89: 9-12, 1997.
    • (1997) Cell , vol.89 , pp. 9-12
    • Guillemin, K.1    Krasnow, M.A.2
  • 3
    • 11444255268 scopus 로고
    • On respiratory impairment in cancer cells
    • Warburg O: On respiratory impairment in cancer cells. Science 124: 269-270, 1956.
    • (1956) Science , vol.124 , pp. 269-270
    • Warburg, O.1
  • 4
    • 34249792922 scopus 로고    scopus 로고
    • Glutamine metabolism and signaling in the liver
    • Haussinger D and Schliess F: Glutamine metabolism and signaling in the liver. Front Biosci 12: 371-391, 2007.
    • (2007) Front Biosci , vol.12 , pp. 371-391
    • Haussinger, D.1    Schliess, F.2
  • 6
    • 0027960973 scopus 로고
    • Glucose is essential for proliferation and the glycolytic enzyme induction that provokes a transition to glycolytic energy production
    • Greiner EF, Guppy M and Brand K: Glucose is essential for proliferation and the glycolytic enzyme induction that provokes a transition to glycolytic energy production. J Biol Chem 269: 31484-31490, 1994.
    • (1994) J Biol Chem , vol.269 , pp. 31484-31490
    • Greiner, E.F.1    Guppy, M.2    Brand, K.3
  • 7
    • 0033079597 scopus 로고    scopus 로고
    • Oncogenic alterations of metabolism
    • Dang CV and Semenza GL: Oncogenic alterations of metabolism. Trends Biochem Sci 24: 68-72, 1999.
    • (1999) Trends Biochem Sci , vol.24 , pp. 68-72
    • Dang, C.V.1    Semenza, G.L.2
  • 8
    • 19944433653 scopus 로고    scopus 로고
    • Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase
    • Selak MA, Armour SM, MacKenzie ED, et al: Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase. Cancer Cell 7: 77-85, 2005.
    • (2005) Cancer Cell , vol.7 , pp. 77-85
    • Selak, M.A.1    Armour, S.M.2    MacKenzie, E.D.3
  • 9
    • 28544446058 scopus 로고    scopus 로고
    • Mitochondrial tumour suppressors: A genetic and biochemical update
    • Gottlieb E and Tomlinson LP: Mitochondrial tumour suppressors: a genetic and biochemical update. Nat Rev 5: 857-866, 2005.
    • (2005) Nat Rev , vol.5 , pp. 857-866
    • Gottlieb, E.1    Tomlinson, L.P.2
  • 10
    • 33745713432 scopus 로고    scopus 로고
    • p53 and metabolism: Inside the TIGAR
    • Green DR and Chipuk JE: p53 and metabolism: Inside the TIGAR. Cell 126: 30-32, 2006.
    • (2006) Cell , vol.126 , pp. 30-32
    • Green, D.R.1    Chipuk, J.E.2
  • 11
    • 0030991485 scopus 로고    scopus 로고
    • Detachment of glycolytic enzymes from cytoskeleton of melanoma cells induced by calmodulin antagonists
    • Glass-Marmor L and Beitner R: Detachment of glycolytic enzymes from cytoskeleton of melanoma cells induced by calmodulin antagonists. Eur J Pharmacol 328: 241-248, 1997.
    • (1997) Eur J Pharmacol , vol.328 , pp. 241-248
    • Glass-Marmor, L.1    Beitner, R.2
  • 12
    • 0034110966 scopus 로고    scopus 로고
    • Detachment of the glycolytic enzymes, phosphofructokinase and aldolase, from cytoskeleton of melanoma cells, induced by local anesthetics
    • Schwartz D and Beitner R: Detachment of the glycolytic enzymes, phosphofructokinase and aldolase, from cytoskeleton of melanoma cells, induced by local anesthetics. Mol Genet Metab 69: 159-164, 2000.
    • (2000) Mol Genet Metab , vol.69 , pp. 159-164
    • Schwartz, D.1    Beitner, R.2
  • 13
    • 3042605000 scopus 로고    scopus 로고
    • Glucose-based total parenteral nutrition does not stimulate glucose uptake by human tumours
    • Bozzetti F, Gavazzi C, Mariani L and Crippa F: Glucose-based total parenteral nutrition does not stimulate glucose uptake by human tumours. Clin Nutr 23: 417-421, 2004.
    • (2004) Clin Nutr , vol.23 , pp. 417-421
    • Bozzetti, F.1    Gavazzi, C.2    Mariani, L.3    Crippa, F.4
  • 14
    • 0141988691 scopus 로고    scopus 로고
    • Initial experience in small animal tumor imaging with a clinical positron emission tomography/computed tomography scanner using 2-[F-18] fluoro-2-deoxy-D-glucose
    • Tatsumi M, Nakamoto Y, Traughber B, Marshall LT, Geschwind JF and Wahl RL: Initial experience in small animal tumor imaging with a clinical positron emission tomography/computed tomography scanner using 2-[F-18] fluoro-2-deoxy-D-glucose. Cancer Res 63: 6252-6257, 2003.
    • (2003) Cancer Res , vol.63 , pp. 6252-6257
    • Tatsumi, M.1    Nakamoto, Y.2    Traughber, B.3    Marshall, L.T.4    Geschwind, J.F.5    Wahl, R.L.6
  • 15
    • 2542529171 scopus 로고    scopus 로고
    • Relationships between oxygen and glucose metabolism in human liver tumours: Positron emission tomography using (15)O and (18)F-deoxyglucose
    • Fukuda K, Taniguchi H, Koh T, Kunishima S and Yamagishi H: Relationships between oxygen and glucose metabolism in human liver tumours: positron emission tomography using (15)O and (18)F-deoxyglucose. Nucl Med Commun 25: 577-583, 2004.
    • (2004) Nucl Med Commun , vol.25 , pp. 577-583
    • Fukuda, K.1    Taniguchi, H.2    Koh, T.3    Kunishima, S.4    Yamagishi, H.5
  • 16
    • 0036515402 scopus 로고    scopus 로고
    • Chen CJ, You SL, Lin LH, Hsu WL and Yang YW: Cancer epidemiology and control in Taiwan: A brief review. Jpn J Clin Oncol 32: 566-S81, 2002.
    • Chen CJ, You SL, Lin LH, Hsu WL and Yang YW: Cancer epidemiology and control in Taiwan: A brief review. Jpn J Clin Oncol 32: 566-S81, 2002.
  • 17
    • 0040480322 scopus 로고    scopus 로고
    • Glucose regulates the promoter activity of aldolase A and pyruvate kinase M2 via dephosphorylation of Sp1
    • Schafer D, Hamm-Kunzelmann B and Brand K: Glucose regulates the promoter activity of aldolase A and pyruvate kinase M2 via dephosphorylation of Sp1. FEBS Lett 417: 325-328, 1997.
    • (1997) FEBS Lett , vol.417 , pp. 325-328
    • Schafer, D.1    Hamm-Kunzelmann, B.2    Brand, K.3
  • 18
    • 0037026608 scopus 로고    scopus 로고
    • Critical roles of AMP-activated protein kinase in constitutive tolerance of cancer cells to nutrient deprivation and tumor formation
    • Kato K, Ogura T, Kishimoto A, Minegishi Y, Nakajima N, Miyazaki M and Esumi H: Critical roles of AMP-activated protein kinase in constitutive tolerance of cancer cells to nutrient deprivation and tumor formation. Oncogene 21: 6082-6090, 2002.
    • (2002) Oncogene , vol.21 , pp. 6082-6090
    • Kato, K.1    Ogura, T.2    Kishimoto, A.3    Minegishi, Y.4    Nakajima, N.5    Miyazaki, M.6    Esumi, H.7
  • 19
    • 0034327361 scopus 로고    scopus 로고
    • Remarkable tolerance of tumor cells to nutrient deprivation: Possible new biochemical target for cancer therapy
    • Izuishi K, Kato K, Ogura T, Kinoshita T and Esumi H: Remarkable tolerance of tumor cells to nutrient deprivation: possible new biochemical target for cancer therapy. Cancer Res 60: 6201-6207, 2000.
    • (2000) Cancer Res , vol.60 , pp. 6201-6207
    • Izuishi, K.1    Kato, K.2    Ogura, T.3    Kinoshita, T.4    Esumi, H.5
  • 20
    • 0035900767 scopus 로고    scopus 로고
    • Glucose catabolism in cancer cells: Identification and characterization of a marked activation response of the type II hexokinase gene to hypoxic conditions
    • Mathupala SP, Rempel A and Pedersen PL: Glucose catabolism in cancer cells: identification and characterization of a marked activation response of the type II hexokinase gene to hypoxic conditions. J Biol Chem 276: 43407-43412, 2001.
    • (2001) J Biol Chem , vol.276 , pp. 43407-43412
    • Mathupala, S.P.1    Rempel, A.2    Pedersen, P.L.3
  • 21
    • 0029063507 scopus 로고
    • Glucose catabolism in cancer cells. Isolation, sequence, and activity of the promoter for type II hexokinase
    • Mathupala SP, Rempel A and Pedersen PL: Glucose catabolism in cancer cells. Isolation, sequence, and activity of the promoter for type II hexokinase. J Biol Chem 270: 16918-16925, 1995.
    • (1995) J Biol Chem , vol.270 , pp. 16918-16925
    • Mathupala, S.P.1    Rempel, A.2    Pedersen, P.L.3
  • 22
    • 0038012340 scopus 로고    scopus 로고
    • Glucose metabolism in cancer. Evidence that demethylation events play a role in activating type II hexokinase gene expression
    • Goel A, Mathupala SP and Pedersen PL: Glucose metabolism in cancer. Evidence that demethylation events play a role in activating type II hexokinase gene expression. J Biol Chem 278: 15333-15340, 2003.
    • (2003) J Biol Chem , vol.278 , pp. 15333-15340
    • Goel, A.1    Mathupala, S.P.2    Pedersen, P.L.3
  • 23
    • 0028149343 scopus 로고
    • Differences in expression and intracellular distribution of hexokinase isoenzymes in rat liver cells of different transformation stages
    • Rempel A, Bannasch P and Mayer D: Differences in expression and intracellular distribution of hexokinase isoenzymes in rat liver cells of different transformation stages. Biochim Biophys Acta 1219: 660-668, 1994.
    • (1994) Biochim Biophys Acta , vol.1219 , pp. 660-668
    • Rempel, A.1    Bannasch, P.2    Mayer, D.3
  • 24
    • 0025820814 scopus 로고
    • Remarkably enhanced expression of the type II hexokinase in rat hepatoma cell line AH130
    • Shinohara Y, Ichihara J and Terada H: Remarkably enhanced expression of the type II hexokinase in rat hepatoma cell line AH130. FEBS Lett 291: 55-57, 1991.
    • (1991) FEBS Lett , vol.291 , pp. 55-57
    • Shinohara, Y.1    Ichihara, J.2    Terada, H.3
  • 25
    • 0020079964 scopus 로고
    • Stability of hexokinase II in vitro and in ascites tumor cells
    • Rose IA and Warms JV: Stability of hexokinase II in vitro and in ascites tumor cells. Arch Biochem Biophys 213: 625-634, 1982.
    • (1982) Arch Biochem Biophys , vol.213 , pp. 625-634
    • Rose, I.A.1    Warms, J.V.2
  • 26
    • 0346689991 scopus 로고    scopus 로고
    • Hexokinase II and VEGF expression in liver tumors: Correlation with hypoxia-inducible factor 1 alpha and its significance
    • Yasuda S, Arii S, Mon A, et al: Hexokinase II and VEGF expression in liver tumors: correlation with hypoxia-inducible factor 1 alpha and its significance. J Hepatol 40: 117-123, 2004.
    • (2004) J Hepatol , vol.40 , pp. 117-123
    • Yasuda, S.1    Arii, S.2    Mon, A.3
  • 27
    • 0029891049 scopus 로고    scopus 로고
    • Glucose catabolism in cancer cells: Amplification of the gene encoding type II hexokinase
    • Rempel A, Mathupala SP, Griffin CA, Hawkins AL and Pedersen PL: Glucose catabolism in cancer cells: amplification of the gene encoding type II hexokinase. Cancer Res 56: 2468-2471, 1996.
    • (1996) Cancer Res , vol.56 , pp. 2468-2471
    • Rempel, A.1    Mathupala, S.P.2    Griffin, C.A.3    Hawkins, A.L.4    Pedersen, P.L.5
  • 28
    • 0030882879 scopus 로고    scopus 로고
    • Glucose catabolism in cancer cells. The type II hexokinase promoter contains functionally active response elements for the tumor suppressor p53
    • Mathupala SF, Heese C and Pedersen PL: Glucose catabolism in cancer cells. The type II hexokinase promoter contains functionally active response elements for the tumor suppressor p53. J Biol Chem 272: 22776-22780, 1997.
    • (1997) J Biol Chem , vol.272 , pp. 22776-22780
    • Mathupala, S.F.1    Heese, C.2    Pedersen, P.L.3
  • 29
    • 33646951330 scopus 로고
    • Novel Aspects of the Human Aldolase Gene Family and its Expression in Tumor Cells
    • Cimino F, Birkmayer GD, Klavins JV, Pimentel E and Salvatore F eds, Walter de Gruyter, Berlin, pp
    • Izzo P, Costanzo P, Lupo A and Salvatore F: Novel Aspects of the Human Aldolase Gene Family and its Expression in Tumor Cells. In: Human tumor markers. Cimino F, Birkmayer GD, Klavins JV, Pimentel E and Salvatore F (eds). Walter de Gruyter, Berlin, pp889-898, 1987.
    • (1987) Human tumor markers , pp. 889-898
    • Izzo, P.1    Costanzo, P.2    Lupo, A.3    Salvatore, F.4
  • 30
    • 0028327047 scopus 로고
    • Alteration of aldolase isozymes in serum and tissues of patients with cancer and other diseases
    • Asaka M, Kimura T, Meguro T, Kato M, Kudo M, Miyazaki T and Alpert E: Alteration of aldolase isozymes in serum and tissues of patients with cancer and other diseases. J Clin Lab Anal 8: 144-148, 1994.
    • (1994) J Clin Lab Anal , vol.8 , pp. 144-148
    • Asaka, M.1    Kimura, T.2    Meguro, T.3    Kato, M.4    Kudo, M.5    Miyazaki, T.6    Alpert, E.7
  • 32
    • 0019815655 scopus 로고
    • Energy metabolism of tumor cells. Requirement for a form of hexokinase with a propensity for mitochondrial binding
    • Bustamante E, Morris HP and Pedersen PL: Energy metabolism of tumor cells. Requirement for a form of hexokinase with a propensity for mitochondrial binding. J Biol Chem 256: 8699-8704, 1981.
    • (1981) J Biol Chem , vol.256 , pp. 8699-8704
    • Bustamante, E.1    Morris, H.P.2    Pedersen, P.L.3
  • 33
    • 0036321444 scopus 로고    scopus 로고
    • Underexpression of mRNA in human hepatocellular carcinoma focusing on eight loci
    • Kinoshita M and Miyata M: Underexpression of mRNA in human hepatocellular carcinoma focusing on eight loci. Hepatology 36: 433-438, 2002.
    • (2002) Hepatology , vol.36 , pp. 433-438
    • Kinoshita, M.1    Miyata, M.2
  • 34
    • 0025887693 scopus 로고
    • Clona]ity and clonal evolution of hepatocellular carcinoma with multiple nodules
    • Hsu HC, Chiou TJ, Chen JY, Lee CS, Lee PH and Peng SY: Clona]ity and clonal evolution of hepatocellular carcinoma with multiple nodules. Hepatology 13: 923-928, 1991.
    • (1991) Hepatology , vol.13 , pp. 923-928
    • Hsu, H.C.1    Chiou, T.J.2    Chen, J.Y.3    Lee, C.S.4    Lee, P.H.5    Peng, S.Y.6
  • 35
    • 0038340658 scopus 로고    scopus 로고
    • Overexpression of osteopontin is associated with intrahepatic metastasis, early recurrence, and poorer prognosis of surgically resected hepatocellular carcinoma
    • Pan HW, Ou YH, Peng SY, et al: Overexpression of osteopontin is associated with intrahepatic metastasis, early recurrence, and poorer prognosis of surgically resected hepatocellular carcinoma. Cancer 98: 119-127, 2003.
    • (2003) Cancer , vol.98 , pp. 119-127
    • Pan, H.W.1    Ou, Y.H.2    Peng, S.Y.3
  • 36
    • 4544301860 scopus 로고    scopus 로고
    • High alpha-fetoprotein level correlates with high stage, early recurrence and poor prognosis of hepatocellular carcinoma: Significance of hepatitis virus infection, age, p53 and beta-catenin mutations
    • Peng SY, Chen WJ, Lai PL, Jeng YM, Sheu JC and Hsu HC: High alpha-fetoprotein level correlates with high stage, early recurrence and poor prognosis of hepatocellular carcinoma: significance of hepatitis virus infection, age, p53 and beta-catenin mutations. Int J Cancer 112: 44-50, 2004.
    • (2004) Int J Cancer , vol.112 , pp. 44-50
    • Peng, S.Y.1    Chen, W.J.2    Lai, P.L.3    Jeng, Y.M.4    Sheu, J.C.5    Hsu, H.C.6
  • 37
    • 33751232623 scopus 로고    scopus 로고
    • Role of L2DTL, cell cycle-regulated nuclear and centrosome protein, in aggressive hepatocellular carcinoma
    • Pan HW, Chou HY, Liu SH, Peng SY, Liu CL and Hsu HC: Role of L2DTL, cell cycle-regulated nuclear and centrosome protein, in aggressive hepatocellular carcinoma. Cell Cycle 5: 2676-2687, 2006.
    • (2006) Cell Cycle , vol.5 , pp. 2676-2687
    • Pan, H.W.1    Chou, H.Y.2    Liu, S.H.3    Peng, S.Y.4    Liu, C.L.5    Hsu, H.C.6
  • 38
    • 33746884331 scopus 로고    scopus 로고
    • Stathmin overexpression cooperates with p53 mutation and osteopontin overexpression, and is associated with tumour progression, early recurrence, and poor prognosis in hepatocellular carcinoma
    • Yuan RH, Jeng YM, Chen HL, et al: Stathmin overexpression cooperates with p53 mutation and osteopontin overexpression, and is associated with tumour progression, early recurrence, and poor prognosis in hepatocellular carcinoma. J Pathol 209: 549-558, 2006.
    • (2006) J Pathol , vol.209 , pp. 549-558
    • Yuan, R.H.1    Jeng, Y.M.2    Chen, H.L.3
  • 39
    • 0027483964 scopus 로고
    • Expression of p53 gene in 184 unifocal hepatocellular carcinomas: Association with tumor growth and invasiveness
    • Hsu HC, Tseng HJ, Lai PL, Lee PH and Peng SY: Expression of p53 gene in 184 unifocal hepatocellular carcinomas: association with tumor growth and invasiveness. Cancer Res 53: 4691-4694, 1993.
    • (1993) Cancer Res , vol.53 , pp. 4691-4694
    • Hsu, H.C.1    Tseng, H.J.2    Lai, P.L.3    Lee, P.H.4    Peng, S.Y.5
  • 40
    • 0028286440 scopus 로고
    • Mutations of p53 gene in hepatocellular carcinoma (HCC) correlate with tumor progression and patient prognosis
    • Hsu HC, Peng SY, Lai PL, Chu JS and Lee PH: Mutations of p53 gene in hepatocellular carcinoma (HCC) correlate with tumor progression and patient prognosis. Int J Oncol 4: 1341-1347, 1994.
    • (1994) Int J Oncol , vol.4 , pp. 1341-1347
    • Hsu, H.C.1    Peng, S.Y.2    Lai, P.L.3    Chu, J.S.4    Lee, P.H.5
  • 41
    • 0029815613 scopus 로고    scopus 로고
    • Surgical resection for recurrent hepatocellular carcinoma: Prognosis and analysis of risk factors
    • Hu RH, Lee PH, Yu SC, et al: Surgical resection for recurrent hepatocellular carcinoma: prognosis and analysis of risk factors. Surgery 120: 23-29, 1996.
    • (1996) Surgery , vol.120 , pp. 23-29
    • Hu, R.H.1    Lee, P.H.2    Yu, S.C.3
  • 42
    • 0034255520 scopus 로고    scopus 로고
    • Different risk factors and prognosis for early and late intrahepatic recurrence after resection of hepatocellular carcinoma
    • Poon RT, Fan ST, Ng IO, Lo CM, Liu CL and Wong J: Different risk factors and prognosis for early and late intrahepatic recurrence after resection of hepatocellular carcinoma. Cancer 89: 500-507, 2000.
    • (2000) Cancer , vol.89 , pp. 500-507
    • Poon, R.T.1    Fan, S.T.2    Ng, I.O.3    Lo, C.M.4    Liu, C.L.5    Wong, J.6
  • 43
    • 13844250595 scopus 로고    scopus 로고
    • Hypoxia stimulates proliferation of human hepatoma cells through the induction of hexokinase II expression
    • Gwak GY, Yoon JH, Kim KM, Lee HS, Chung JW and Gores GJ: Hypoxia stimulates proliferation of human hepatoma cells through the induction of hexokinase II expression. J Hepatol 42: 358-364, 2005.
    • (2005) J Hepatol , vol.42 , pp. 358-364
    • Gwak, G.Y.1    Yoon, J.H.2    Kim, K.M.3    Lee, H.S.4    Chung, J.W.5    Gores, G.J.6
  • 45
    • 0025876591 scopus 로고
    • The p53 tumour suppressor gene
    • Levine AJ, Momand J and Finlay CA: The p53 tumour suppressor gene. Nature 351: 453-456, 1991.
    • (1991) Nature , vol.351 , pp. 453-456
    • Levine, A.J.1    Momand, J.2    Finlay, C.A.3
  • 46
    • 0026669469 scopus 로고
    • p53 function and dysfunction
    • Vogelstein B, Kinzler KW: p53 function and dysfunction. Cell 70: 523-526, 1992.
    • (1992) Cell , vol.70 , pp. 523-526
    • Vogelstein, B.1    Kinzler, K.W.2
  • 47
    • 0027435469 scopus 로고
    • Inactive p53 mutants may enhance the transcriptional activity of wild-type p53
    • Zhang W, Shay JW and Deisseroth A: Inactive p53 mutants may enhance the transcriptional activity of wild-type p53. Cancer Res 53: 4772-4775, 1993.
    • (1993) Cancer Res , vol.53 , pp. 4772-4775
    • Zhang, W.1    Shay, J.W.2    Deisseroth, A.3
  • 49
    • 25144475032 scopus 로고    scopus 로고
    • p53 gain-of-function: Tumor biology and bioinformatics come together
    • Koonin EV, Rogozin IB and Glazko GV: p53 gain-of-function: tumor biology and bioinformatics come together. Cell Cycle 4: 686-688, 2005.
    • (2005) Cell Cycle , vol.4 , pp. 686-688
    • Koonin, E.V.1    Rogozin, I.B.2    Glazko, G.V.3
  • 50
    • 33748211158 scopus 로고    scopus 로고
    • Gain of function of mutant p53: The mutant p53/NF-Y protein complex reveals an aberrant transcriptional mechanism of cell cycle regulation
    • Di Agostino S, Strano S, Emiliozzi V, et al: Gain of function of mutant p53: the mutant p53/NF-Y protein complex reveals an aberrant transcriptional mechanism of cell cycle regulation. Cancer Cell 10: 191-202, 2006.
    • (2006) Cancer Cell , vol.10 , pp. 191-202
    • Di Agostino, S.1    Strano, S.2    Emiliozzi, V.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.