Adult human exocrine pancreas differentiation to hepatocytes - Potential source of a human hepatocyte progenitor for use in toxicology research

Toxicology Research

Volumn 2, Issue 1, 2013, Pages 80-87

  Fairhall, Emma A ^a   Wallace, Karen ^a,b   White, Steven A ^a   Huang, Guo C ^c   Shaw, James A ^a   Wright, Sid C ^a   Charlton, Keith A ^b   Burt, Alastair D ^a   Wright, Matthew C ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF ABERDEEN   (United Kingdom)

^c KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DEXAMETHASONE; MESSENGER RNA; SERUM AND GLUCOCORTICOID REGULATED KINASE 1;

ACINAR CELL; ADULT; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CELL DIVISION; CONTROLLED STUDY; CORTICOSTEROID THERAPY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL; LONG TERM EXPOSURE; PANCREAS CELL; PRIORITY JOURNAL;

EID: 84877931055     PISSN: 2045452X     EISSN: 20454538     Source Type: Journal    
DOI: 10.1039/c2tx20061a     Document Type: Article

References (37)

1. C. N. Shen J. M. Slack D. Tosh Molecular basis of transdifferentiation of pancreas to liver Nat. Cell Biol. 2000 2 879 887
2. C. J. Marek G. A. Cameron L. J. Elrick G. M. Hawksworth M. C. Wright Generation of hepatocytes expressing functional cytochromes P450 from a pancreatic progenitor cell line in vitro Biochem. J. 2003 370 763 769 (Pubitemid 36399068)
3. K. Wallace C. J. Marek S. Hoppler M. C. Wright Glucocorticoid-dependent transdifferentiation of pancreatic progenitor cells into hepatocytes is dependent on transient suppression of WNT signalling J. Cell Sci. 2010 123 2103 2110
4. K. Wallace Q. Long E. A. Fairhall K. A. Charlton M. C. Wright Serine/threonine protein kinase SGK1 in glucocorticoid-dependent trans-differentiation of pancreatic acinar cells to hepatocytes J. Cell Sci. 2011 124 405 413
5. D. Eberhard K. O'Neill Z. D. Burke D. Tosh In vitro reprogramming of pancreatic cells to hepatocytes Methods Mol. Biol. 2010 636 285 292
6. K. Wallace E. A. Fairhall K. A. Charlton M. C. Wright AR42J-B-13 cell: an expandable progenitor to generate an unlimited supply of functional hepatocytes Toxicology 2010 278 277 287
7. K. Wallace C. J. Marek R. A. Currie M. C. Wright Exocrine pancreas trans-differentiation to hepatocytes - a physiological response to elevated glucocorticoid in vivo J. Steroid Biochem. Mol. Biol. 2009 116 76 85
8. K. Wallace P. A. Flecknell A. D. Burt M. C. Wright Disrupted pancreatic exocrine differentiation and malabsorption in response to chronic elevated systemic glucocorticoid Am. J. Pathol. 2010 177 1225 1232
9. P. A. Hall N. R. Lemoine Rapid acinar to ductal transdifferentiation in cultured human exocrine pancreas Am. J. Pathol. 1992 166 97 103
10. M. R. Vila J. Lloreta F. X. Real Normal human pancreas cultures display functional ductal characteristics Lab. Invest. 1994 71 423 431 (Pubitemid 24310024)
11. K. S. Zaret M. Grompe Generation and regeneration of cells of the liver and pancreas Science 2008 322 1490 1494
12. S. L. Lightman C. C. Wiles H. C. Atkinson D. E. Henley G. M. Russell J. A. Leendertz M. A. McKenna F. Spiga S. A. Wood B. L. Conway-Campbell The significance of glucocorticoid pulsatility Eur. J. Pharmacol. 2008 583 255 262
13. M. S. Rao R. S. Dwivedi V. Subbarao M. I. Usman D. G. Scarpelli M. R. Nemali A. Yeldandi S. Thangada S. Kumar J. K. Reddy Almost total conversion of pancreas to liver in the adult rat: a reliable model to study transdifferentiation Biochem. Biophys. Res. Commun. 1988 156 131 136
14. A. V. Yeldandi X. D. Tan R. S. Dwivedi V. Subbarao D. D. Smith Jr D. G. Scarpelli M. S. Rao J. K. Reddy Coexpression of glutamine synthetase and carbamoylphosphate synthase I genes in pancreatic hepatocytes of rat Proc. Natl. Acad. Sci. U. S. A. 1990 87 881 885
15. M. L. Krakowski M. R. Kritzik E. M. Jones T. Krahl J. Lee M. Arnush D. Gu N. Sarvetnick Pancreatic expression of keratinocyte growth factor leads to differentiation of islet hepatocytes and proliferation of duct cells Am. J. Pathol. 1999 154 683 691 (Pubitemid 29122587)
16. T. Yamaoka K. Yoshino T. Yamada M. Yano T. Matsui T. Yamaguchi M. Moritani J. Hata S. Noji M. Itakura Transgenic expression of FGF8 and FGF10 induces transdifferentiation of pancreatic islet cells into hepatocytes and exocrine cells Biochem. Biophys. Res. Commun. 2002 292 138 143 (Pubitemid 34687341)
17. S. Sumitran-Holgersson G. Nowak S. Thowfeequ S. Begum M. Joshi M. Jaksch A. Kjaeldgaard C. Jorns B. G. Ericzon D. Tosh Generation of hepatocyte-like cells from in vitro transdifferentiated human fetal pancreas Cell Transplant. 2009 18 183 193
18. J. R. Seckl M. C. Holmes Mechanisms of disease: glucocorticoids, their placental metabolism and fetal 'programming' of adult pathophysiology Nat. Clin. Pract. Endocrinol. Metab. 2007 3 479 488 (Pubitemid 46808745)
19. V. E. Murphy R. Smith W. B. Giles V. L. Clifton Endocrine regulation of human fetal growth: the role of the mother, placenta, and fetus Endocr. Rev. 2006 27 141 169
20. G. C. Liggins R. N. Howie A controlled trial of antepartum glucocorticoid treatment for prevention of the respiratory distress syndrome in premature infants Pediatrics 1972 50 515 525
21. P. L. Schmidt M. E. Sims H. T. Strassner R. H. Paul E. Mueller D. McCart Effect of antepartum glucocorticoid administration upon neonatal respiratory distress syndrome and perinatal infection Am. J. Obstet. Gynecol. 1984 148 178 186 (Pubitemid 14224254)
22. T. Hamazaki Y. Iiboshi M. Oka P. J. Papst A. M. Meacham L. I. Zon N. Terada Hepatic maturation in differentiating embryonic stem cells in vitro FEBS Lett. 2001 497 15 19 (Pubitemid 32480173)
23. Y. Yajima M. Sato M. Sumida S. Kawashima Mechanism of adult primitive mesenchymal ST-13 preadipocyte differentiation Endocrinology 2003 144 2559 2565 (Pubitemid 36629909)
24. A. S. Srivastava S. Kaushal R. Mishra T. A. Lane E. Carrier Dexamethasone facilitates erythropoiesis in murine embryonic stem cells differentiating into hematopoietic cells in vitro Biochem. Biophys. Res. Commun. 2006 346 508 516 (Pubitemid 43902713)
25. W. L. Randle J. M. Cha Y. S. Hwang K. L. Chan S. G. Kazarian J. M. Polak A. Mantalaris Integrated 3-dimensional expansion and osteogenic differentiation of murine embryonic stem cells Tissue Eng. 2007 13 2957 2970 (Pubitemid 350233080)
26. M. Ren L. Yan C. Z. Shang J. Cao F. P. Li J. Y. Li H. Cheng J. Min Sodium butyrate and dexamethasone promote exocrine pancreatic gene expression in mouse embryonic stem cells Acta Pharmacol. Sin. 2009 30 1289 1296
27. D. J. Elbaum E. M. Bender J. M. Brown P. L. Keyes Serum progesterone in pregnant rats with ectopic or in situ corpora lutea: correlation between amount of luteal tissue and progesterone concentration Biol. Reprod. 1975 13 541 545
28. E. A. Fairhall, K. Wallace, C. J. Schwab, C. J. Harrison, K. A. Charlton and M. C. Wright, The B-13 hepatic progenitor cell line specifically engrafts to the liver and pancreas, Manuscript submitted, 2012
29. D. E. Baker N. J. Harrison E. Maltby K. Smith H. D. Moore P. J. Shaw P. R. Heath H. Holden P. W. Andrews Adaptation to culture of human embryonic stem cells and oncogenesis in vivo Nat. Biotechnol. 2007 25 207 215 (Pubitemid 46227120)
30. E. L. Haughton S. J. Tucker C. J. Marek E. Durward V. Leel Z. Bascal T. Monaghan M. Koruth E. Collie-Duguid D. A. Mann J. E. Trim M. C. Wright Pregnane X receptor activators inhibit human hepatic stellate cell transdifferentiation in vitro Gastroenterology 2006 131 194 209 (Pubitemid 44015746)
31. G. C. Huang M. Zhao P. Jones S. Persaud R. Ramracheya K. Löbner M. R. Christie J. P. Banga M. Peakman P. Sirinivsan M. Rela N. Heaton S. Amiel The development of new density gradient media for purifying human islets and islet-quality assessments Transplantation 2004 77 143 145 (Pubitemid 38116889)
32. D. Alvaro G. Alpini P. Onori L. Perego G. Svegliata Baroni A. Franchitto L. Baiocchi S. S. Glaser G. LeSage F. Folli E. Gaudio Estrogens stimulate proliferation of intrahepatic biliary epithelium in rats Gastroenterology 2000 119 1681 1691 (Pubitemid 32198694)
33. R. M. Gow M. K. O'Bryan B. J. Canny G. T. Ooi M. P. Hedger Differential effects of dexamethasone treatment on lipopolysaccharide-induced testicular inflammation and reproductive hormone inhibition in adult rats J. Endocrinol. 2001 168 193 201 (Pubitemid 32099366)
34. M. Wagner E. Rudakova T. Volk Aldosterone-induced changes in the cardiac L-type Ca2+ current can be prevented by antioxidants in vitro and are absent in rats on low salt diet Pfluegers Arch. 2008 457 339 349
35. N. Binkley R. Novotny D. Krueger T. Kawahara Y. G. Daida G. Lensmeyer B. W. Hollis M. K. Drezner Low vitamin D status despite abundant sun exposure J. Clin. Endocrinol. Metab. 2007 92 2130 2135 (Pubitemid 46997111)
36. Y. Kato H. Suzuki S. Ikushiro S. Yamada M. Degawa Decrease in serum thyroxine level by phenobarbital in rats is not necessarily dependent on increase in hepatic UDP-glucuronosyltransferase Drug Metab. Dispos. 2005 33 1608 1612 (Pubitemid 41539957)
37. P. Simon M. Schneck T. Hochstetter E. Koutsouki M. Mittelbronn A. Merseburger C. Weigert A. Niess F. Lang Differential regulation of serum- and glucocorticoid-inducible kinase 1 (SGK1) splice variants based on alternative initiation of transcription Cell Physiol. Biochem. 2007 20 715 728 (Pubitemid 350059716)