메뉴 건너뛰기




Volumn 124, Issue 3, 2011, Pages 405-413

Serine/threonine protein kinase SGK1 in glucocorticoid-dependent transdifferentiation of pancreatic acinar cells to hepatocytes

Author keywords

Dexamethasone; Liver; LY294002; Pancreas; Reprogramming; Stem cell

Indexed keywords

ADENOSINE TRIPHOSPHATE; BETA CATENIN; DEXAMETHASONE; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; ISOENZYME; MESSENGER RNA; MINERALOCORTICOID RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; RECOMBINANT ENZYME; SERUM AND GLUCOCORTICOID REGULATED KINASE 1; SERUM AND GLUCOCORTICOID REGULATED KINASE 1C; SERUM AND GLUCOCORTICOID REGULATED KINASE 1F; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR LEF; UNCLASSIFIED DRUG; WNT PROTEIN;

EID: 79551542894     PISSN: 00219533     EISSN: 14779137     Source Type: Journal    
DOI: 10.1242/jcs.077503     Document Type: Article
Times cited : (15)

References (42)
  • 2
    • 85047681190 scopus 로고    scopus 로고
    • Discovery of PDK1, one of the missing links in insulin signal transduction. Colworth Medal Lecture
    • Alessi, D. R. (2001). Discovery of PDK1, one of the missing links in insulin signal transduction. Colworth Medal Lecture. Biochem. Soc. Trans. 29, 1-14.
    • (2001) Biochem. Soc. Trans. , vol.29 , pp. 1-14
    • Alessi, D.R.1
  • 3
    • 0023221667 scopus 로고
    • Cloning of human mineralocorticoid receptor complementary DNA: Structural and functional kinship with the glucocorticoid receptor
    • Arriza, J. L., Weinberger, C. and Cerelli, G. (1987). Cloning of human mineralocorticoid receptor complementary DNA: structural and functional kinship with the glucocorticoid receptor. Science 237, 268-275.
    • (1987) Science , vol.237 , pp. 268-275
    • Arriza, J.L.1    Weinberger, C.2    Cerelli, G.3
  • 4
    • 0035882103 scopus 로고    scopus 로고
    • The PIF-binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB
    • Biondi, R. M., Kieloch, A., Currie, R. A., Deak, M. and Alessi, D. R. (2001). The PIF-binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB. EMBO J. 20, 4380-4390.
    • (2001) EMBO J. , vol.20 , pp. 4380-4390
    • Biondi, R.M.1    Kieloch, A.2    Currie, R.A.3    Deak, M.4    Alessi, D.R.5
  • 5
    • 14044279923 scopus 로고    scopus 로고
    • Gene regulation of ENaC subunits by serumand glucocorticoid-inducible kinase-1
    • Boyd, C. and Naray-Fejes-Toth, A. (2005). Gene regulation of ENaC subunits by serumand glucocorticoid-inducible kinase-1. Am. J. Physiol. Renal. Physiol. 288, F505-F512.
    • (2005) Am. J. Physiol. Renal. Physiol. , vol.288
    • Boyd, C.1    Naray-Fejes-Toth, A.2
  • 6
    • 17144376759 scopus 로고    scopus 로고
    • Therapeutic potential of transdifferentiated cells
    • Burke, Z. D. and Tosh, D. (2005). Therapeutic potential of transdifferentiated cells. Clin. Sci. 108, 309-321.
    • (2005) Clin. Sci. , vol.108 , pp. 309-321
    • Burke, Z.D.1    Tosh, D.2
  • 9
    • 0037234487 scopus 로고    scopus 로고
    • Stimulus-dependent regulation of serum and glucocorticoid inducible protein kinase (SGK) transcription, subcellular localization and enzymatic activity
    • Firestone, G. L., Giampaolo, J. R. and O'Keeffe, B. A. (2003). Stimulus-dependent regulation of serum and glucocorticoid inducible protein kinase (SGK) transcription, subcellular localization and enzymatic activity. Cell. Physiol. Biochem. 13, 1-12.
    • (2003) Cell. Physiol. Biochem. , vol.13 , pp. 1-12
    • Firestone, G.L.1    Giampaolo, J.R.2    O'Keeffe, B.A.3
  • 10
    • 58649092475 scopus 로고    scopus 로고
    • mTOR complex-2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum and glucocorticoid induced protein kinase-1 (SGK1)
    • Garcia-Martinez, J. M. and Alessi, D. R. (2008). mTOR complex-2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum and glucocorticoid induced protein kinase-1 (SGK1). Biochem. J. 416, 375-385.
    • (2008) Biochem. J. , vol.416 , pp. 375-385
    • Garcia-Martinez, J.M.1    Alessi, D.R.2
  • 13
    • 33847367723 scopus 로고    scopus 로고
    • Wnt signalling: Variety at the core
    • Hoppler, S. and Kavanagh, C. L. (2007). Wnt signalling: variety at the core. J. Cell Sci. 120, 385-393.
    • (2007) J. Cell Sci. , vol.120 , pp. 385-393
    • Hoppler, S.1    Kavanagh, C.L.2
  • 14
    • 0033571416 scopus 로고    scopus 로고
    • Characterization of the structure and regulation of two novel isoforms of serum- And glucocorticoid-induced protein kinase
    • Kobayashi, T., Deak, M., Morrice, N. and Cohen, P. (1999). Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase. Biochem. J. 344, 189-197.
    • (1999) Biochem. J. , vol.344 , pp. 189-197
    • Kobayashi, T.1    Deak, M.2    Morrice, N.3    Cohen, P.4
  • 15
    • 33749500123 scopus 로고    scopus 로고
    • (Patho)physiological significance of the serum- and glucocorticoid- inducible kinase isoforms
    • Lang, F., Böhmer, C., Palmada, M., Seebohm, G., Strutz-Seebohm, N. and Vallon, V. (2006). (Patho)physiological significance of the serum- and glucocorticoid-inducible kinase isoforms. Physiol. Rev. 86, 1151-1178.
    • (2006) Physiol. Rev. , vol.86 , pp. 1151-1178
    • Lang, F.1    Böhmer, C.2    Palmada, M.3    Seebohm, G.4    Strutz-Seebohm, N.5    Vallon, V.6
  • 16
    • 2542575642 scopus 로고    scopus 로고
    • Plasticity in the adult rat pancreas: Transdifferentiation of exocrine to hepatocyte-like cells in primary culture
    • Lardon, J., De Breuck, S., Rooman, I., Van Lommel, L., Kruhøffer, M., Orntoft, T., Schuit, F. and Bouwens, L. (2004). Plasticity in the adult rat pancreas: transdifferentiation of exocrine to hepatocyte-like cells in primary culture. Hepatology 39, 1499-1507.
    • (2004) Hepatology , vol.39 , pp. 1499-1507
    • Lardon, J.1    De Breuck, S.2    Rooman, I.3    Van Lommel, L.4    Kruhøffer, M.5    Orntoft, T.6    Schuit, F.7    Bouwens, L.8
  • 17
    • 68249093818 scopus 로고    scopus 로고
    • Targeting the phosphoinositide 3-kinase pathway in cancer
    • Liu, P., Cheng, H., Roberts, T. M. and Zhao, J. J. (2009) Targeting the phosphoinositide 3-kinase pathway in cancer. Nat. Rev. Drug Discov. 8, 627-644.
    • (2009) Nat. Rev. Drug Discov. , vol.8 , pp. 627-644
    • Liu, P.1    Cheng, H.2    Roberts, T.M.3    Zhao, J.J.4
  • 18
    • 0242500447 scopus 로고    scopus 로고
    • Generation of hepatocytes expressing functional cytochromes P450 from a pancreatic progenitor cell line in vitro
    • Marek, C. J., Cameron, G. A., Elrick, L. J., Hawksworth, G. M. and Wright, M. C. (2003). Generation of hepatocytes expressing functional cytochromes P450 from a pancreatic progenitor cell line in vitro. Biochem. J. 370, 763-769.
    • (2003) Biochem. J. , vol.370 , pp. 763-769
    • Marek, C.J.1    Cameron, G.A.2    Elrick, L.J.3    Hawksworth, G.M.4    Wright, M.C.5
  • 19
    • 18844432520 scopus 로고    scopus 로고
    • Pregnenolone-16alpha-carbonitrile inhibits rodent liver fibrogenesis via PXR (pregnane X receptor)-dependent and PXR-independent mechanisms
    • Marek, C. J., Tucker, S. J., Konstantinou, D. K., Elrick, L. J., Haefner, D., Sigalas, C., Murray, G. I., Goodwin, B. and Wright, M. C. (2005). Pregnenolone-16alpha-carbonitrile inhibits rodent liver fibrogenesis via PXR (pregnane X receptor)-dependent and PXR-independent mechanisms. Biochem. J. 387, 601-608.
    • (2005) Biochem. J. , vol.387 , pp. 601-608
    • Marek, C.J.1    Tucker, S.J.2    Konstantinou, D.K.3    Elrick, L.J.4    Haefner, D.5    Sigalas, C.6    Murray, G.I.7    Goodwin, B.8    Wright, M.C.9
  • 21
    • 0035060702 scopus 로고    scopus 로고
    • The ERK MAP kinase pathway mediates induction of SGK (serum- And glucocorticoid-inducible kinase) by growth factors
    • Mizuno, H. and Nishida, E. (2001). The ERK MAP kinase pathway mediates induction of SGK (serum- and glucocorticoid-inducible kinase) by growth factors. Genes Cells 6, 261-268.
    • (2001) Genes Cells , vol.6 , pp. 261-268
    • Mizuno, H.1    Nishida, E.2
  • 23
    • 28844439793 scopus 로고    scopus 로고
    • Interaction of nuclear receptors with the Wnt/beta-catenin/Tcf signaling axis: Wnt you like to know?
    • Mulholland, D. J., Dedhar, S., Coetzee, G. A. and Nelson, C. C. (2005). Interaction of nuclear receptors with the Wnt/beta-catenin/Tcf signaling axis: Wnt you like to know? Endocr. Rev. 26, 898-915.
    • (2005) Endocr. Rev. , vol.26 , pp. 898-915
    • Mulholland, D.J.1    Dedhar, S.2    Coetzee, G.A.3    Nelson, C.C.4
  • 25
    • 0033151832 scopus 로고    scopus 로고
    • Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathway
    • Park, J., Leong, M. L., Buse, P., Maiyar, A. C., Firestone, G. L. and Hemmings, B. A. (1999). Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathway. EMBO J. 18, 3024-3033.
    • (1999) EMBO J. , vol.18 , pp. 3024-3033
    • Park, J.1    Leong, M.L.2    Buse, P.3    Maiyar, A.C.4    Firestone, G.L.5    Hemmings, B.A.6
  • 27
    • 85047683614 scopus 로고    scopus 로고
    • Minireview: 11beta-hydroxysteroid dehydrogenase type 1- A tissue-specific amplifier of glucocorticoid action
    • Seckl, J. R. and Walker, B. R. (2001). Minireview: 11beta-hydroxysteroid dehydrogenase type 1- a tissue-specific amplifier of glucocorticoid action. Endocrinology 142, 1371-1376.
    • (2001) Endocrinology , vol.142 , pp. 1371-1376
    • Seckl, J.R.1    Walker, B.R.2
  • 28
    • 0033672199 scopus 로고    scopus 로고
    • Molecular basis of transdifferentiation of pancreas to liver
    • Shen, C. N., Slack, J. M. and Tosh, D. (2000). Molecular basis of transdifferentiation of pancreas to liver. Nat. Cell Biol. 2, 879-887.
    • (2000) Nat. Cell Biol. , vol.2 , pp. 879-887
    • Shen, C.N.1    Slack, J.M.2    Tosh, D.3
  • 29
    • 35848960829 scopus 로고    scopus 로고
    • Differential regulation of serum- and glucocorticoid-inducible kinase 1 (SGK1) splice variants based on alternative initiation of transcription
    • Simon, P., Schneck, M., Hochstetter, T., Koutsouki, E., Mittelbronn, M., Merseburger, A., Weigert, C., Niess, A. and Lang, F. (2007). Differential regulation of serum- and glucocorticoid-inducible kinase 1 (SGK1) splice variants based on alternative initiation of transcription. Cell Physiol. Biochem. 20, 715-728.
    • (2007) Cell Physiol. Biochem. , vol.20 , pp. 715-728
    • Simon, P.1    Schneck, M.2    Hochstetter, T.3    Koutsouki, E.4    Mittelbronn, M.5    Merseburger, A.6    Weigert, C.7    Niess, A.8    Lang, F.9
  • 30
    • 0037124070 scopus 로고    scopus 로고
    • Glucocorticoids inhibit cell cycle progression in differentiating osteoblasts via glycogen synthase kinase-3beta
    • Smith, E., Coetzee, G. A. and Frenkel, B. (2002). Glucocorticoids inhibit cell cycle progression in differentiating osteoblasts via glycogen synthase kinase-3beta. J. Biol. Chem. 277, 18191-18197.
    • (2002) J. Biol. Chem. , vol.277 , pp. 18191-18197
    • Smith, E.1    Coetzee, G.A.2    Frenkel, B.3
  • 31
    • 0031973119 scopus 로고    scopus 로고
    • Co-regulation of pituitary tumor cell adhesion and prolactin gene expression by glucocorticoid
    • Spangler, P. R. and Delidow, B. C. (1998). Co-regulation of pituitary tumor cell adhesion and prolactin gene expression by glucocorticoid. J. Cell Physiol. 174, 115-124.
    • (1998) J. Cell Physiol. , vol.174 , pp. 115-124
    • Spangler, P.R.1    Delidow, B.C.2
  • 32
    • 0026659272 scopus 로고
    • Development of Cushing's syndrome in corticotropin-releasing factor transgenic mice
    • Stenzel-Poore, M. P., Cameron, V. A., Vaughan, J., Sawchenko, P. E. and Vale, W. (1992). Development of Cushing's syndrome in corticotropin-releasing factor transgenic mice. Endocrinology 130, 3378-3386.
    • (1992) Endocrinology , vol.130 , pp. 3378-3386
    • Stenzel-Poore, M.P.1    Cameron, V.A.2    Vaughan, J.3    Sawchenko, P.E.4    Vale, W.5
  • 34
    • 0030999989 scopus 로고    scopus 로고
    • Cloning and characterization of a putative human serine/threonine protein kinase transcriptionally modified during anisotonic and isotonic alterations of cell volume
    • Waldegger, S., Barth, P., Raber, G. and Lang F. (1997). Cloning and characterization of a putative human serine/threonine protein kinase transcriptionally modified during anisotonic and isotonic alterations of cell volume. Proc. Natl. Acad. Sci. USA 94, 4440-4445.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 4440-4445
    • Waldegger, S.1    Barth, P.2    Raber, G.3    Lang, F.4
  • 35
    • 0032908120 scopus 로고    scopus 로고
    • h-Sgk serine-threonine protein kinase gene as transcriptional target of transforming growth factor beta in human intestine
    • Waldegger, S., Klingel, K., Barth, P., Sauter, M., Rfer, M. L., Kandolf, R. and Lang, F. (1999). h-Sgk serine-threonine protein kinase gene as transcriptional target of transforming growth factor beta in human intestine. Gastroenterol. 116, 1081-1088.
    • (1999) Gastroenterol. , vol.116 , pp. 1081-1088
    • Waldegger, S.1    Klingel, K.2    Barth, P.3    Sauter, M.4    Rfer, M.L.5    Kandolf, R.6    Lang, F.7
  • 36
    • 67449096674 scopus 로고    scopus 로고
    • Exocrine pancreas trans-differentiation to hepatocytes-a physiological response to elevated glucocorticoid in vivo
    • Wallace, K., Marek, C. J., Currie, R. A. and Wright, M. C. (2009). Exocrine pancreas trans-differentiation to hepatocytes-a physiological response to elevated glucocorticoid in vivo. J. Steroid Biochem. Mol. Biol. 116, 76-85.
    • (2009) J. Steroid Biochem. Mol. Biol. , vol.116 , pp. 76-85
    • Wallace, K.1    Marek, C.J.2    Currie, R.A.3    Wright, M.C.4
  • 37
    • 78649760585 scopus 로고    scopus 로고
    • AR42J-B-13 cell: An expandable progenitor to generate an unlimited supply of functional hepatocytes
    • Wallace, K., Fairhall, E. A., Charlton, K. A. and Wright, M. C. (2010a). AR42J-B-13 cell: an expandable progenitor to generate an unlimited supply of functional hepatocytes. Toxicology 278, 277-287.
    • (2010) Toxicology , vol.278 , pp. 277-287
    • Wallace, K.1    Fairhall, E.A.2    Charlton, K.A.3    Wright, M.C.4
  • 38
    • 77953608751 scopus 로고    scopus 로고
    • Disrupted pancreatic exocrine differentiation and malabsorption in response to chronic elevated systemic glucocorticoid
    • Wallace, K., Flecknell, P. A., Burt, A. D. and Wright, M. C. (2010b). Disrupted pancreatic exocrine differentiation and malabsorption in response to chronic elevated systemic glucocorticoid. Am. J. Pathol. 177, 1225-1232.
    • (2010) Am. J. Pathol. , vol.177 , pp. 1225-1232
    • Wallace, K.1    Flecknell, P.A.2    Burt, A.D.3    Wright, M.C.4
  • 39
    • 77953575574 scopus 로고    scopus 로고
    • Glucocorticoid-dependent trans-differentiation of pancreatic progenitor cells into hepatocytes is dependent on transient suppression of WNT signalling
    • Wallace, K., Marek, C. J., Hoppler, S. and Wright, M. C. (2010c). Glucocorticoid-dependent trans-differentiation of pancreatic progenitor cells into hepatocytes is dependent on transient suppression of WNT signalling. J. Cell Sci. 123, 2103-2110.
    • (2010) J. Cell Sci. , vol.123 , pp. 2103-2110
    • Wallace, K.1    Marek, C.J.2    Hoppler, S.3    Wright, M.C.4
  • 40
    • 67651040754 scopus 로고    scopus 로고
    • Identification and action of N-myc downstream regulated gene 4 A2 in rat pancreas
    • Wang, J. F. and Hill, D. J. (2009). Identification and action of N-myc downstream regulated gene 4 A2 in rat pancreas. J. Endocrinol. 201, 15-25.
    • (2009) J. Endocrinol. , vol.201 , pp. 15-25
    • Wang, J.F.1    Hill, D.J.2
  • 41
    • 0034830886 scopus 로고    scopus 로고
    • Gliotoxin stimulates the apoptosis of human and rat hepatic stellate cells and enhances the resolution of liver fibrosis in rats
    • Wright, M. C., Issa, R., Smart, D. E., Trim, N., Murray, G. I., Primrose, J. N., Arthur, M. J., Iredale, J. P. and Mann, D. A. (2001). Gliotoxin stimulates the apoptosis of human and rat hepatic stellate cells and enhances the resolution of liver fibrosis in rats. Gastroenterology 121, 685-698.
    • (2001) Gastroenterology , vol.121 , pp. 685-698
    • Wright, M.C.1    Issa, R.2    Smart, D.E.3    Trim, N.4    Murray, G.I.5    Primrose, J.N.6    Arthur, M.J.7    Iredale, J.P.8    Mann, D.A.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.