Involvement of N-type Ca2+ channels in the fibrotic process of the kidney in rats

American Journal of Physiology - Renal Physiology

Volumn 304, Issue 6, 2013, Pages

  Mishima, Keiichiro ^a   Maeshima, Akito ^a   Miya, Masaaki ^a   Sakurai, Noriyuki ^a   Ikeuchi, Hidekazu ^a   Hiromura, Keiju ^a   Nojima, Yoshihisa ^a  

^a GUNMA UNIVERSITY   (Japan)

Author keywords

Epithelial mesenchymal transition; N type calcium channel; Renal fibrosis; Unilateral ureteral obstruction

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; AMLODIPINE; CALCIUM CHANNEL L TYPE; CALCIUM CHANNEL N TYPE; CILNIDIPINE; COLLAGEN TYPE 1; COLLAGEN TYPE 3; COLLAGEN TYPE 4; LAMININ; MESSENGER RNA; VIMENTIN; ACTIN; CADHERIN; CALCIUM CHANNEL BLOCKING AGENT; DIHYDROPYRIDINE DERIVATIVE; SMOOTH MUSCLE ACTIN, RAT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; EPITHELIAL MESENCHYMAL TRANSITION; EXTRACELLULAR MATRIX; IMMUNOHISTOCHEMISTRY; KIDNEY FIBROSIS; MACROPHAGE; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAT; REAL TIME POLYMERASE CHAIN REACTION; URETER OBSTRUCTION; WESTERN BLOTTING; ANIMAL; CELL PROLIFERATION; COMPARATIVE STUDY; DISEASE MODEL; DRUG EFFECT; KIDNEY; METABOLISM; WISTAR RAT;

ACTINS; AMLODIPINE; ANIMALS; CADHERINS; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, L-TYPE; CALCIUM CHANNELS, N-TYPE; CELL PROLIFERATION; DIHYDROPYRIDINES; DISEASE MODELS, ANIMAL; EPITHELIAL-MESENCHYMAL TRANSITION; KIDNEY; MACROPHAGES; MALE; RATS; RATS, WISTAR; URETERAL OBSTRUCTION;

MLCS; MLOWN;

EID: 84877928589     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00561.2012     Document Type: Article

References (34)

1. Boor P, Ostendorf T, Floege J. Renal fibrosis: novel insights into mechanisms and therapeutic targets. Nat Rev Nephrol 6: 643-656, 2010.
2. Bowersox SS, Singh T, Luther RR. Selective blockade of N-type voltage-sensitive calcium channels protects against brain injury after transient focal cerebral ischemia in rats. Brain Res 747: 343-347, 1997.
3. Chung YH, Shin CM, Kim MJ, Shin DH, Yoo YB, Cha CI. Spatial and temporal distribution of N-type Ca(2+) channels in gerbil global cerebral ischemia. Brain Res 902: 294-300, 2001.
4. DiBona GF. Nervous kidney. Interaction between renal sympathetic nerves and the renin-angiotensin system in the control of renal function. Hypertension 36: 1083-1088, 2000.
5. DiBona GF, Kopp UC. Neural control of renal function. Physiol Rev 77: 75-197, 1997.
6. Fan YY, Kohno M, Nakano D, Ohsaki H, Kobori H, Suwarni D, Ohashi N, Hitomi H, Asanuma K, Noma T, Tomino Y, Fujita T, Nishiyama A. Cilnidipine suppresses podocyte injury and proteinuria in metabolic syndrome rats: possible involvement of N-type calcium channel in podocyte. J Hypertens 28: 1034-1043, 2010.
7. 2+ channel in rat dorsal root ganglion neurons. J Pharmacol Exp Ther 280: 1184-1191, 1997.
8. 2+ channels in evoked release of norepinephrine from sympathetic neurons. Science 239: 57-61, 1988.
9. Kalluri R. EMT: when epithelial cells decide to become mesenchymal-like cells. J Clin Invest 119: 1417-1419, 2009.
10. Klein IH, Ligtenberg G, Neumann J, Oey PL, Koomans HA, Blank-estijn PJ. Sympathetic nerve activity is inappropriately increased in chronic renal disease. J Am Soc Nephrol 14: 3239-3244, 2003.
11. Kobayashi N, Mori Y, Mita S, Nakano S, Kobayashi T, Tsubokou Y, Matsuoka H. Effects of cilnidipine on nitric oxide and endothelin-1 expression and extracellular signal-regulated kinase in hypertensive rats. Eur J Pharmacol 422: 149-157, 2001.
12. Konda T, Enomoto A, Aritomi S, Niinuma K, Koganei H, Ogawa T, Nitta K. Different effects of L/N-type and L-type calcium channel blockers on the renin-angiotensin-aldosterone system in SHR/Izm. Am J Nephrol 30: 155-161, 2009.
13. Konda T, Enomoto A, Matsushita J, Takahara A, Moriyama T. The N- and L-type calcium channel blocker cilnidipine suppresses renal injury in dahl rats fed a high-sucrose diet, an experimental model of metabolic syndrome. Nephron Physiol 101: p1-13, 2005.
14. Konoshita T, Makino Y, Kimura T, Fujii M, Wakahara S, Arakawa K, Inoki I, Nakamura H, Miyamori I. A new-generation N/L-type calcium channel blocker leads to less activation of the renin-angiotensin system compared with conventional L type calcium channel blocker. J Hypertens 28: 2156-2160, 2010.
15. Liu J, Yang F, Yang XP, Jankowski M, Pagano PJ. NAD(P)H oxidase mediates angiotensin II-induced vascular macrophage infiltration and medial hypertrophy. Arterioscler Thromb Vasc Biol 23: 776-782, 2003.
16. Liu Y. New insights into epithelial-mesenchymal transition in kidney fibrosis. J Am Soc Nephrol 21: 212-222, 2010.
17. Maeshima A. Label-retaining cells in the kidney: origin of regenerating cells after renal ischemia. Clin Exp Nephrol 11: 269-274, 2007.
18. Maeshima A, Maeshima K, Nojima Y, Kojima I. Involvement of Pax-2 in the action of activin A on tubular cell regeneration. J Am Soc Nephrol 13: 2850-2859, 2002.
19. Maeshima A, Sakurai H, Nigam SK. Adult kidney tubular cell population showing phenotypic plasticity, tubulogenic capacity, and integration capability into developing kidney. J Am Soc Nephrol 17: 188-198, 2006.
20. Maeshima A, Yamashita S, Nojima Y. Identification of renal progenitorlike tubular cells that participate in the regeneration processes of the kidney. J Am Soc Nephrol 14: 3138-3146, 2003.
21. Maeshima A, Zhang YQ, Nojima Y, Naruse T, Kojima I. Involvement of the activin-follistatin system in tubular regeneration after renal ischemia in rats. J Am Soc Nephrol 12: 1685-1695, 2001.
22. Morimoto S, Yano Y, Maki K, Iwasaka T. Renal and vascular protective effects of cilnidipine in patients with essential hypertension. J Hypertens 25: 2178-2183, 2007.
23. Ricardo SD, van Goor H, Eddy AA. Macrophage diversity in renal injury and repair. J Clin Invest 118: 3522-3530, 2008.
24. Schwab A. Function and spatial distribution of ion channels and transporters in cell migration. Am J Physiol Renal Physiol 280: F739-F747, 2001.
25. Shimizu H, Nakagami H, Yasumasa N, Mariana OK, Kyutoku M, Koriyama H, Nakagami F, Shimamura M, Rakugi H, Morishita R. Cilnidipine, but not amlodipine, ameliorates osteoporosis in ovariecto-mized hypertensive rats through inhibition of the N-type calcium channel. Hypertens Res 35: 77-81, 2012.
26. Takatsu M, Hattori T, Murase T, Ohtake M, Kato M, Nashima K, Nakashima C, Takahashi K, Ito H, Niinuma K, Aritomi S, Murohara T, Nagata K. Comparison of the effects of cilnidipine and amlodipine on cardiac remodeling and diastolic dysfunction in Dahl salt-sensitive rats. J Hypertens 30: 1845-1855, 2012.
27. Tominaga M, Ohya Y, Tsukashima A, Kobayashi K, Takata Y, Koga T, Yamashita Y, Fujishima Y, Abe I, Fujishima M. Ambulatory blood pressure monitoring in patients with essential hypertension treated with a new calcium antagonist, cilnidipine. Cardiovasc Drugs Ther 11: 43-48, 1997.
28. 2+ current by cilnidipine (FRC-8653) in acutely dissociated rat sympathetic neurones. Br J Pharmacol 122: 37-42, 1997.
29. Uneyama H, Uchida H, Konda T, Yoshimoto R, Akaike N. Selectivity of dihydropyridines for cardiac L-type and sympathetic N-type Ca2+ channels. Eur J Pharmacol 373: 93-100, 1999.
30. Valentino K, Newcomb R, Gadbois T, Singh T, Bowersox S, Bitner S, Justice A, Yamashiro D, Hoffman BB, Ciaranello R, Miljanich G, Ramachandran J. A selective N-type calcium channel antagonist protects against neuronal loss after global cerebral ischemia. Proc Natl Acad Sci USA 90: 7894-7897, 1993.
31. Yamashita S, Maeshima A, Kojima I, Nojima Y. Activin A is a potent activator of renal interstitial fibroblasts. J Am Soc Nephrol 15: 91-101, 2004.
32. Yamashita S, Maeshima A, Nojima Y. Involvement of renal progenitor tubular cells in epithelial-to-mesenchymal transition in fibrotic rat kidneys. J Am Soc Nephrol 16: 2044-2051, 2005.
33. Zhao PL, Wang XT, Zhang XM, Cebotaru V, Cebotaru L, Guo G, Morales M, Guggino SE. Tubular and cellular localization of the cardiac L-type calcium channel in rat kidney. Kidney Int 61: 1393-1406, 2002.
34. Zhou X, Ono H, Ono Y, Frohlich ED. N- and L-type calcium channel antagonist improves glomerular dynamics, reverses severe nephrosclerosis, and inhibits apoptosis and proliferation in an l-NAME/SHR model. J Hypertens 20: 993-1000, 2002.