The N- and L-type calcium channel blocker cilnidipine suppresses renal injury in Dahl rats fed a high-sucrose diet, an experimental model of metabolic syndrome

Nephron - Physiology

Volumn 101, Issue 1, 2005, Pages

  Konda, Tomoyuki ^a   Enomoto, Azusa ^a   Matsushita, Junko ^a   Takahara, Akira ^a   Moriyama, Toshiki ^b  

^a AJINOMOTO CO INC   (Japan)

^b OSAKA UNIVERSITY   (Japan)

Author keywords

Amlodipine; Chronic renal failure; Cilnidipine; Hypertension; Metabolic syndrome; N type calcium channel blocker

Indexed keywords

AMLODIPINE; ANGIOTENSIN; CALCIUM CHANNEL BLOCKING AGENT; CALCIUM CHANNEL L TYPE; CALCIUM CHANNEL N TYPE; CILNIDIPINE; INTERCELLULAR ADHESION MOLECULE 1; MESSENGER RNA; NORADRENALIN; RENIN; SUCROSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE; BLOOD SAMPLING; CELL INFILTRATION; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; FIBROSING ALVEOLITIS; HISTOPATHOLOGY; HYPERTROPHY; KIDNEY; KIDNEY INJURY; MALE; METABOLIC SYNDROME X; NONHUMAN; NORADRENALIN URINE LEVEL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEINURIA; RAT; URINALYSIS;

AMLODIPINE; ANIMALS; ANTIHYPERTENSIVE AGENTS; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, L-TYPE; CALCIUM CHANNELS, N-TYPE; DIETARY SUCROSE; DIHYDROPYRIDINES; DISEASE MODELS, ANIMAL; HYPERTENSION, RENAL; KIDNEY DISEASES; MALE; METABOLIC SYNDROME X; RATS; RATS, INBRED DAHL; TREATMENT OUTCOME;

EID: 23844487058     PISSN: 16602137     EISSN: None     Source Type: Journal    
DOI: 10.1159/000085713     Document Type: Article

References (50)

1. 2+ channels in evoked release of norepinephrine from sympathetic neurons. Science 1988;239:57-61.
2. Fogo AB: Glomerular hypertension, abnormal glomerular growth, and progression of renal diseases. Kidney Int 2000;75:S15-21.
3. DiBona GF, Kopp UC: Neural control of renal function. Physiol Rev 1997;77:75-197.
4. Thames MC: Renin release: Reflex control and adrenergic mechanisms. J Hypertens 1984;2(suppl 1):57-66.
5. Klein IH, Ligtenberg G, Neumann J, Oey PL, Koomans HA, Blankestijn PJ: Sympathetic nerve activity is inappropriately increased in chronic renal disease. J Am Soc Nephrol 2003;14:3239-3244.
6. Campese VM, Kogosov E, Koss M: Renal afferent denervation prevents the progression of renal disease in the renal ablation model of chronic renal failure in the rat. Am J Kidney Dis 1995;26:861-865.
7. Luippold G, Beilharz M, Muhlbauer B: Chronic renal denervation prevents glomerular hyperfiltration in diabetic rats. Nephrol Dial Transplant 2004;19:342-347.
8. 2+ channel in rat dorsal root ganglion neurons. J Pharmacol Exp Ther 1997;280:1184-1191.
9. 2+ current by cilnidipine (FRC-8653) in acutely dissociated rat sympathetic neurones. Br J Pharmacol 1997;122:37-42.
10. 2+ channel blocker, cilnidipine, on neurally mediated chronotropic response in anesthetized dogs. Eur J Pharmacol 2001;413:117-120.
11. Takahara A, Dohmoto H, Hisa H, Satoh S, Yoshimoto R: Cilnidipine attenuates renal nerve stimulation-induced renal vasoconstriction and antinatriuresis in anesthetized dogs. Jpn J Pharmacol 1997;75:27-32.
12. 2+ channels distributed in cardiovascular system. Int J Mol Med 1999;3:455-466.
13. Zhou X, Ono H, Ono Y, Frohlich ED: N- and L-type calcium channel antagonist improves glomerular dynamics, reverses severe nephrosclerosis, and inhibits apoptosis and proliferation in an L-NAME/SHR model. J Hypertens 2002;20:993-1000.
14. Ekstrand AV, Groop PH, Gronhagen-Riska C: Insulin resistance precedes microalbuminuria in patients with insulin-dependent diabetes mellitus. Nephrol Dial Transplant 1998;13:3079-3083.
15. Kubo M, Kiyohara Y, Kato I, Iwamoto H, Nakayama K, Hirakata H, Fujishima M: Effect of hyperinsulinemia on renal function in a general Japanese population: The Hisayama study. Kidney Int 1999;55:2450-2456.
16. Julius S, Jamerson K: Sympathetics, insulin resistance and coronary risk in hypertension: The 'chicken-and-egg' question. J Hypertens 1994;12:495-502.
17. 2+ channel blocker cilnidipine in comparison with that of amlodipine and nifedipine on insulin resistance in Dahl S rats. Jpn Pharmacol Ther 1999;27:53-60.
18. Takada M, Ura N, Higashiura K, Murakami H, Togashi N, Shimamoto K: Effects of cilnidipine on muscle fiber composition, capillary density and muscle blood flow in fructose-fed rats. Hypertens Res 2001;24:565-572.
19. Yagi S, Goto S, Yamamoto T, Kurihara S, Katayama S: Effect of cilnidipine on insulin sensitivity in patients with essential hypertension. Hypertens Res 2003;26:383-387.
20. Harada N, Ohnaka M, Sakamoto S, Niwa Y, Nakaya Y: Cilnidipine improves insulin sensitivity in the Otsuka Long-Evans Tokushima fatty rat, a model of spontaneous NIDDM. Cardiovasc Drugs Ther 1999;13:519-523.
21. Mori Y, Murakawa Y, Yokoyama J, Tajima N, Ikeda Y, Nobukata H, Ishikawa T, Shibutani Y: Effect of highly purified eicosapentaenoic acid ethyl ester on insulin resistance and hypertension in Dahl salt-sensitive rats. Metabolism 1999;48:1089-1095.
22. Zhang HY, Reddy S, Kotchen TA: A high sucrose, high linoleic acid diet potentiates hypertension in the Dahl salt sensitive rat. Am J Hypertens 1999;12:183-187.
23. Ono H, Ono Y, Takanohashi A, Matsuoka H, Frohlich ED: Apoptosis and glomerular injury after prolonged nitric oxide synthase inhibition in spontaneously hypertensive rats. Hypertension 2001;38:1300-1306.
24. Sugimoto H, Shikata K, Makino H, Ota K, Ota Z: Increased gene expression of insulin-like growth factor-I receptor in experimental diabetic rat glomeruli. Nephron 1996;72:648-653.
25. Moriyama T, Kawada N, Nagatoya K, Takeji M, Horio M, Ando A, Imai E, Hori M: Fluvastatin suppresses oxidative stress and fibrosis in the interstitium of mouse kidneys with unilateral ureteral obstruction. Kidney Int 2001;59:2095-2103.
26. Sugimoto H, Shikata K, Hirata K, Akiyama K, Matsuda M, Kushiro M, Shikata Y, Miyatake N, Miyasaka M, Makino H: Increased expression of intercellular adhesion molecule-1 (ICAM-1) in diabetic rat glomeruli: Glomerular hyperfiltration is a potential mechanism of ICAM-1 upregulation. Diabetes 1997;46:2075-2081.
27. Yoshida T, Kurella M, Beato F, Min H, Ingelfinger JR, Stears RL, Swinford RD, Gullans SR, Tang SS: Monitoring changes in gene expression in renal ischemia-reperfusion in the rat. Kidney Int 2002;61:1646-1654.
28. Yoshida K, Kohzuki M, Xu HL, Wu XM, Kamimoto M, Sato T: Effects of troglitazone and temocapril in spontaneously hypertensive rats with chronic renal failure. J Hypertens 2001;19:503-510.
29. Zhang S-L, Chen X, Hsieh TJ, Leclerc M, Henley N, Allidina A, Halle JP, Brunette MG, Filep JG, Tang SS, Ingelfinger JR, Chan JS: Hyperglycemia induces insulin resistance on angiotensinogen gene expression in diabetic rat kidney proximal tubular cells. J Endocrinol 2002;172:333-344.
30. Reaven GM, Ho H, Hoffmann BB: Somatostatin inhibition of fructose-induced hypertension. Hypertension 1989;14:117-120.
31. Cosenzi A, Sacerdote A, Seculin P, Odoni G, Plazzotta N, Bernobich E, Bellini G: Lacidipine prevents the hypertension and renal and cardiac changes induced by high-fructose diet in WKY rats. J Cardiovasc Pharmacol 1999;33:485-491.
32. O'Donnell MP, Kasiske BL, Katz SA, Schmitz PG, Keane WF: Lovastatin but not enalapril reduces glomerular injury in Dahl salt-sensitive rats. Hypertension 1992;20:651-658.
33. Uehara Y, Takada S, Hirawa N, Kawabata Y, Ohshima N, Numabe A, Ishimitsu T, Goto A, Yagi S, Omata M: Vasoconstrictors and renal protection induced by beta 1-selective adrenoceptor antagonist bisoprolol. J Cardiovasc Pharmacol 1994;23:897-906.
34. Hostetter TH, Olson JL, Rennke HG, Venkatachalam MA, Brenner BM: Hyperfiltration in remnant nephrons: A potentially adverse response to renal ablation. Am J Physiol 1981;241:F85-93.
35. Hostetter TH, Troy JL, Brenner BM: Glomerular hemodynamics in experimental diabetes mellitus. Kidney Int 1981;19:410-415.
36. Miyatake N, Shikata K, Sugimoto H, Kushiro M, Shikata Y, Ogawa S, Hayashi Y, Miyasaka M, Makino H: Intercellular adhesion molecule 1 mediates mononuclear cell infiltration into rat glomeruli after renal ablation. Nephron 1998;79:91-98.
37. Nguyen TT, Shou I, Funabiki K, Shirato I, Kubota K, Tomino Y: Correlations among expression of glomerular intercellular adhesion molecule 1 (ICAM-1), levels of serum soluble ICAM-1, and renal histopathology in patients with IgA nephropathy. Am J Nephrol 1999;19:495-459.
38. Nagel T, Resnick N, Atkinson WJ, Dewey CF Jr, Gimbrone MA Jr: Shear stress selectively upregulates intercellular adhesion molecule-1 expression in cultured human vascular endothelial cells. J Clin Invest 1994;94:885-891.
39. Morigi M, Zoja C, Figliuzzi M, Foppolo M, Micheletti G, Bontempelli M, Saronni M, Remuzzi G, Remuzzi A: Fluid shear stress modulates surface expression of adhesion molecules by endothelial cells. Blood 1995;85:1696-1703.
40. Mogensen CE: Early glomerular hyperfiltration in insulin-dependent diabetics and late nephropathy. Scand J Clin Lab Invest 1986;46:201-206.
41. Manitius J, Baines AD, Roszkiewicz A: The effect of high fructose intake on renal morphology and renal function in rats. J Physiol Pharmacol 1995;46:179-183.
42. Roy-Chaudhury P, Wu B, King G, Campbell M, Macleod AM, Haites NE, Simpson JG, Power DA: Adhesion molecule interactions in human glomerulonephritis: Importance of the tubulointerstitium. Kidney Int 1996;49:127-134.
43. Kliem V, Johnson RJ, Alpers CE, Yoshimura A, Couser WG, Koch KM, Floege J: Mechanisms involved in the pathogenesis of tubulointerstitial fibrosis in 5/6-nephrectomized rats. Kidney Int 1996;49:666-678.
44. Denton KM, Shweta A, Anderson WP: Preglomerular and postglomerular resistance responses to different levels of sympathetic activation by hypoxia. J Am Soc Nephrol 2002;13:27-34.
45. Schricker K, Hamann M, Macher A, Kramer BK, Kaissling B, Kurtz A: Effect of amlodipine on renin secretion and renin gene expression in rats. Br J Pharmacol 1996;119:744-750.
46. Mackie FE, Meyer TW, Campbell DJ: Effects of antihypertensive therapy on intrarenal angiotensin and bradykinin levels in experimental renal insufficiency. Kidney Int 2002;61:555-563.
47. Shihab FS, Bennett WM, Tanner AM, Andoh TF: Angiotensin II blockade decreases TGF-beta1 and matrix proteins in cyclosporine nephropathy. Kidney Int 1997;52:660-673.
48. Mezzano SA, Ruiz-Ortega M, Egido J: Angiotensin II and renal fibrosis. Hypertension 2001;38:635-638.
49. Mackenzie HS, Ziai F, Omer SA, Nadim MK, Taal MW: Angiotensin receptor blockers in chronic renal disease: The promise of a bright clinical future. J Am Soc Nephrol 1999;10:S283-286.
50. Kopp UC, DiBona GF: Neural regulation of renin secretion. Semin Nephrol 1993;13:543-551.