Different effects of L/N-type and L-type calcium channel blockers on the renin-angiotensin-aldosterone system in SHR/Izm

American Journal of Nephrology

Volumn 30, Issue 2, 2009, Pages 155-161

  Konda, Tomoyuki ^a   Enomoto, Azusa ^a   Aritomi, Shizuka ^a   Niinuma, Kazumi ^a   Koganei, Hajime ^a   Ogawa, Tetsuya ^b   Nitta, Kosaku ^b  

^a AJINOMOTO CO INC   (Japan)

^b TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

Author keywords

Aldosterone; Calcium channel blocker, N type; Cilnidipine; Hypertension

Indexed keywords

AMLODIPINE; ANGIOTENSIN II; CALCIUM CHANNEL BLOCKING AGENT; CALCIUM CHANNEL L TYPE; CALCIUM CHANNEL N TYPE; CILNIDIPINE; NORADRENALIN;

ADRENERGIC ACTIVITY; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG MEGADOSE; KIDNEY CORTEX; LOW DRUG DOSE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; SCANNING ELECTRON MICROSCOPY; SPONTANEOUSLY HYPERTENSIVE RAT; SYMPATHETIC TONE; SYSTOLIC BLOOD PRESSURE;

ALDOSTERONE; AMLODIPINE; ANGIOTENSIN II; ANIMALS; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, L-TYPE; CALCIUM CHANNELS, N-TYPE; CONOTOXINS; DIHYDROPYRIDINES; HUMANS; MALE; NOREPINEPHRINE; RATS; RATS, INBRED SHR; RENIN; RENIN-ANGIOTENSIN SYSTEM; TIME FACTORS;

EID: 62949140625     PISSN: 02508095     EISSN: None     Source Type: Journal    
DOI: 10.1159/000210396     Document Type: Article

References (23)

1. 2+ channels in evoked release of norepinephrine from sympathetic neurons. Science 1988; 239: 57-61.
2. DiBona GF, Kopp UC: Neural control of renal function. Physiol Rev 1997; 77: 75-197.
3. Fogo AB: Glomerular hypertension, abnormal glomerular growth, and progression of renal diseases. Kidney Int 2000; 75:S15-S21.
4. Thames MC: Renin release: reflex control and adrenergic mechanisms. J Hypertens 1984; 2(suppl 1):57-66. (Pubitemid 15215261)
5. Klein IH, Ligtenberg G, Neumann J, Oey PL, Koomans HA, Blankestijn PJ: Sympathetic nerve activity is inappropriately increased in chronic renal disease. J Am Soc Nephrol 2003; 14: 3239-3244. (Pubitemid 37509299)
6. 2+ channel in rat dorsal root ganglion neurons. J Pharmacol Exp Ther 1997; 280: 1184-1191.
7. 2+ current by cilnidipine (FRC-8653) in acutely dissociated rat sympathetic neurones. Br J Pharmacol 1997; 122: 37-42.
8. Hosono M, Himura T, Watanabe K, Hayashi Y, Ohnishi H, Takata Y, Kato H: Inhibitory effect of cilnidipine on pressor response to acute cold stress in spontaneously hypertensive rats. Jpn J Pharmacol 1995; 69: 119-125.
9. Takahara A, Dohmoto H, Hisa H, Satoh S, Yoshimoto R: Cilnidipine attenuates renal nerve stimulation-induced renal vasoconstriction and antinatriuresis in anesthetized dogs. Jpn J Pharmacol 1997; 75: 27-32. (Pubitemid 27462572)
10. 2+ channel blocker cilnidipine on neurally mediated chronotropic response in anesthetized dogs. Eur J Pharmacol 2001; 413: 117-120.
11. Konda T, Enomoto A, Matsushita J, Takahara A, Moriyama T: The N- and L-type calcium channel blocker, cilnidipine suppresses renal injury in Dahl rats fed a high-sucrose diet, an experimental model of metabolic syndrome. Nephron Physiol 2005; 101: 1-13. (Pubitemid 41159949)
12. Konda T, Enomoto A, Takahara A, Yamamoto H: Effects of L/N-type calcium channel antagonist, cilnidipine on progressive renal injuries in Dahl salt-sensitive rats. Biol Pharm Bull 2006; 29: 933-937.
13. Sato A, Saruta T: Aldosterone-induced organ damage: plasma aldosterone level and inappropriate salt status. Hypertens Res 2004; 27: 303-310. (Pubitemid 38832669)
14. Greenberg B, Zannad F, Pitt B: Role of aldosterone blockade for treatment of heart failure and post-acute myocardial infarction. Am J Cardiol 2006; 97: 34F-40F. (Pubitemid 43673931)
15. Yoneda M, Sanada H, Yatabe J, Midorikawa S, Hashimoto S, Sasaki M, Katoh T, Watanabe T, Andrews PM, Jose PA, Felder RA: Differential effects of angiotensin II type-1 receptor antisense oligonucleotides on renal function in spontaneously hypertensive rats. Hypertension 2005; 46: 58-65. (Pubitemid 40946491)
16. Kopp UC, DiBona GF: Neural regulation of renin secretion. Semin Nephrol 1993; 13: 543-551.
17. Holmer SR, Kaissling B, Putnik K, Pfeifer M, Kramer BK, Riegger GA, Kurtz A: Beta-adrenergic stimulation of renin expression in vivo. J Hypertens 1997; 15: 1471-1479. (Pubitemid 28039576)
18. Schricker K, Hamann M, Macher A, Kramer BK, Kaissling B, Kurtz A: Effect of amlodipine on renin secretion and renin gene expression in rats. Br J Pharmacol 1996; 119: 744-750. (Pubitemid 26356588)
19. Mackie FE, Meyer TW, Campbell DJ: Effects of antihypertensive therapy on intrarenal angiotensin and bradykinin levels in experimental renal insufficiency. Kidney Int 2002; 61: 555-563.
20. Uebele VN, Nuss CE, Renger JJ, Connolly TM: Role of voltage-gated calcium channels in potassium-stimulated aldosterone secretion from rat adrenal zona glomerulosa cells. J Steroid Biochem Mol Biol 2004; 92: 209-218.
21. Imagawa K, Okayama S, Takaoka M, Kawata H, Naya N, Nakajima T, Horii M, Uemura S, Saito Y: Inhibitory effect of efonidipine on aldosterone synthesis and secretion in human adrenocarcinoma (H295R) cells. J Cardiovasc Pharmacol 2006; 47: 133-138. (Pubitemid 44378236)
22. Lesouhaitier O, Chiappe A, Rossier MF: Aldosterone increases T-type calcium currents in human adrenocarcinoma (H295R) cells by inducing channel expression. Endocrinology 2001; 142: 4320-4330. (Pubitemid 32907060)
23. Pitt B: Effect of aldosterone blockade in patients with systolic left ventricular dysfunction: implications of the RALES and EPHESUS studies. Mol Cell Endocrinol 2004; 217: 53-58.