The biopsied donor liver: Incorporating macrosteatosis into high-risk donor assessment

Liver Transplantation

Volumn 16, Issue 7, 2010, Pages 874-884

  Spitzer, Austin L ^a   Lao, Oliver B ^b   Dick, André A S ^b   Bakthavatsalam, Ramasamy ^b   Halldorson, Jeffrey B ^b   Yeh, Matthew M ^c   Upton, Melissa P ^c   Reyes, Jorge D ^b   Perkins, James D ^b  

^a KAISER PERMANENTE   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADOLESCENT; ADULT; AGED; ANOXIA; ARTICLE; CHILD; COLD ISCHEMIA; FATTY LIVER; FEMALE; GRAFT SURVIVAL; HEAD INJURY; HEART DEATH; HUMAN; INFANT; LIVER BIOPSY; LIVER GRAFT REJECTION; LIVER TRANSPLANTATION; MACROSTEATOSIS; MAJOR CLINICAL STUDY; MALE; OBESITY; ORGAN DONOR; OUTCOME ASSESSMENT; PRESCHOOL CHILD; PRIORITY JOURNAL; RISK ASSESSMENT; RISK FACTOR; SCHOOL CHILD; STEATOSIS; STROKE; AGE; BIOPSY; DEATH; DONOR; GRAFT REJECTION; LIVER; MIDDLE AGED; NEWBORN; PATHOLOGY; PROPORTIONAL HAZARDS MODEL; REGISTER; RETROSPECTIVE STUDY; STANDARD; TRANSPLANTATION;

ADOLESCENT; ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; BIOPSY; CHILD; CHILD, PRESCHOOL; COLD ISCHEMIA; DEATH; FATTY LIVER; FEMALE; GRAFT REJECTION; HUMANS; INFANT; INFANT, NEWBORN; LIVER; LIVER TRANSPLANTATION; MALE; MIDDLE AGED; PROPORTIONAL HAZARDS MODELS; REGISTRIES; RETROSPECTIVE STUDIES; RISK ASSESSMENT; RISK FACTORS; TISSUE AND ORGAN PROCUREMENT; TISSUE DONORS; YOUNG ADULT;

EID: 77954169726     PISSN: 15276465     EISSN: 15276473     Source Type: Journal    
DOI: 10.1002/lt.22085     Document Type: Article

References (50)

1. Greig PD, Forster J, Superina RA, Strasberg SM, Mohamed M, Blendis LM, et al. Donor-specific factors predict graft function following liver transplantation. Transplant Proc 1990;22:2072-2073.
2. Ploeg RJ, D'Alessandro AM, Knechtle SJ, Stegall MD, Pirsch JD, Hoffmann RM, et al. Risk factors for primary dysfunction after liver transplantation-a multivariate analysis. Transplantation 1993;55:807-813.
3. Yersiz H, Shaked A, Olthoff K, Imagawa D, Shackleton C, Martin P, et al. Correlation between donor age and the pattern of liver graft recovery after transplantation. Transplantation 1995;60:790-794.
4. Eckhoff DE, Pirsch JD, D'Alessandro AM, Knechtle SJ, Young CJ, Geffner SR, et al. Pretransplant status and patient survival following liver transplantation. Transplantation 1995;60:920-925.
5. Grande L, Rull A, Rimola A, Garcia-Valdecasas JC, Manyalic M, Cabrer C, et al. Outcome of patients undergoing orthotopic liver transplantation with elderly donors (over 60 years). Transplant Proc 1997;29:3289-3290.
6. Ikegami T, Nishizaki T, Yanaga K, Shimada M, Kishikawa K, Nomoto K, et al. The impact of donor age on living donor liver transplantation. Transplantation 2000;70:1703-1707. (Pubitemid 32064823)
7. Kamath PS, Wiesner RH, Malinchoc M, Kremers W, Therneau TM, Kosberg CL, et al. A model to predict survival in patients with end-stage liver disease. Hepatology 2001;33:464-470.
8. Ghobrial RM, Gornbein J, Steadman R, Danino N, Markmann JF, Holt C, et al. Pretransplant model to predict posttransplant survival in liver transplant patients. Ann Surg 2002;236:315-323.
9. Rull R, Vidal O, Momblan D, González FX, López-Baodo MA, Fuster J, et al. Evaluation of potential liver donors: limits imposed by donor variables in liver transplantation. Liver Transpl 2003;9:389-393.
10. Thuluvath PI, Yoo HY, Thompson RE. A model to predict survival at one month, one year, and five years after liver transplantation based on pretransplant clinical characteristics. Liver Transpl 2003;9:527-532.
11. Bilbao I, Armadans L, Lazaro JL, Hidalgo E, Castells L, Margarit C. Predictive factors for early mortality following liver transplantation. Clin Transplant 2003;17:401-411.
12. Desai NM, Mange KC, Crawford MD, Abt PL, Frank AM, Markmann JW, et al. Predicting outcome after liver transplantation: utility of the model for end-stage liver disease and a newly derived discrimination function. Transplantation 2004;77:99-106.
13. Haydon GH, Hiltunen Y, Lucey MR, Collett D, Gunson B, Murphy N, et al. Self-organizing maps can determine outcome and match recipients and donors at orthotopic liver transplantation. Transplantation 2005;79:213-218.
14. Moore DE, Feurer ID, Speroff T, Gorden DL, Wright JK, Chari RS, et al. Impact of donor, technical, and recipient risk factors on survival and quality of life after liver transplantation. Arch Surg 2005;140:273-277.
15. Jacob M, Lewsey JD, Sharpin C, Gimson A, Rela M, van der Meulen JH. Systematic review and validation of prognostic models in liver transplantation. Liver Transpl 2005;11:814-825.
16. Burroughs AK, Sabin CA, Rolles K, Delvart V, Karam V, Buckels J, et al. 3-month and 12-month mortality after first liver transplant in adults in Europe: predictive models for outcome. Lancet 2006;367:225-232.
17. Cameron AM, Ghobrial RM, Yersiz H, Farmer DG, Lipshutz GS, Gordon SA, et al. Optimal utilization of donor grafts with extended criteria: a single-center experience in over 1000 liver transplants. Ann Surg 2006;243:748-755.
18. Mateo R, Cho Y, Singh G, Stapfer M, Donovan J, Kahn J, et al. Risk factors for graft survival after liver transplantation from donation after cardiac death donors: an analysis of OPTN/UNOS data. Am J Transplant 2006;6:791-796.
19. Lewsey JD, Dawwas M, Copley LP, Gimson A, van der Meulen JH. Developing a prognostic model for 90-day mortality after liver transplantation based on pretransplant recipient factors. Transplantation 2006;82:898-907.
20. Scuderi V, Ceriello A, Maida P, Aragiusto G, Arenga G, Carfora T, et al. The marginal donor: a single-center experience in orthotopic liver transplantation. Transplant Proc 2006;38:1069-1073. (Pubitemid 43815929)
21. Ioannou GN. Development and validation of a model predicting graft survival after liver transplantation. Liver Transpl 2006;12:1594-1606.
22. Perkins JD. Plethora of posttransplant survival prognostic models: how useful for clinical practice? Liver Transpl 2007;13:619-621.
23. Ferraz-Neto BH, Zurstrassen MP, Hidalgo R, Fonseca LE, Motta TD, Pandullo FL, et al. Donor liver dysfunction: application of a new scoring system to identify the marginal donor. Transplant Proc 2007;39:2516-2518.
24. Chan EY, Olson LC, Kisthard JA, Perkins JD, Bakthavatsalam R, Halldorson JB, et al. Ischemic cholangiopathy following liver transplantation from donation after cadiac death donors. Liver Transpl 2008;14:604-610. (Pubitemid 351696270)
25. Cescon M, Grazi GL, Cucchetti A, Ravaioli M, Ercolani G, Vivarelli M, et al. Improving the outcome of liver transplantation with very old donors with updated selection and management criteria. Liver Transpl 2008;14:672-679.
26. Halldorson JB, Bakthavatsalam R, Fix O, Reyes JD, Perkins JD. D-MELD, a simple predictor of post liver transplant mortality for optimization of donor/recipient matching. Am J Transplant 2009;9:318-326.
27. Gordon Burroughs S, Busuttil RW. Optimal utilization of extended hepatic grafts. Surg Today 2009;39:746-751.
28. Spitzer AL, Dick AA, Bakthavatsalam R, Halldorson JB, Salvalaggio PR, Reyes JD, et al. Intraoperative portal vein blood flow predicts allograft and patient survival following liver transplantation. HPB (Oxford) 2010;12:166-173.
29. Feng S, Goodrich NP, Bragg-Gresham JL, Dykstra DM, Punch JD, DebRoy MA, et al. Characteristics associated with liver graft failure: the concept of a donor risk index. Am J Transplant 2006;6:783-790.
30. Merion RM, Schaubel DE, Dykstra DM, Freeman RB, Port FK, Wolfe RA. The survival benefit of liver transplantation. Am J Transplant 2005;5:307-313.
31. Urena MA, Moreno Gonzalez E, Romero CJ, Ruiz-Delgado FC, Moreno Sanz C. An approach to the rational use of steatotic donor livers in liver transplantation. Hepatogastroenterology 1999;46:1164-1173.
32. Zamboni F, Franchello A, David E, Rocca G, Ricchiuti A, Lavezzo B, et al. Effect of macrovescicular steatosis and other donor and recipient characteristics on the outcome of liver transplantation. Clin Transplant 2001;15:53-57.
33. Verran D, Kusyk T, Painter D, Fisher J, Koorey D, Strasser S, et al. Clinical experience gained from the use of 120 steatotic donor livers for orthotopic liver transplantation. Liver Transpl 2003;9:500-505.
34. Soejima Y, Shimada M, Suehiro T, Kishikawa K, Yoshizumi T, Hashimoto K, et al. Use of steatotic graft in living-donor liver transplantation. Transplantation 2003;76:344-348.
35. Salizzoni M, Franchello A, Zamboni F, Ricchiuti A, Cocchis D, Fop F, et al. Marginal grafts: finding the correct treatment for fatty livers. Transpl Int 2003;16:486-493.
36. Fiorini RN, Kirtz J, Periyasamy B, Evans Z, Haines JK, Cheng G, et al. Development of an unbiased method for the estimation of liver steatosis. Clin Transplant 2004;18:700-706.
37. Franzén LE, Ekstedt M, Kechagias S, Bodin L. Semi-quantitative evaluation overestimates the degree of steatosis in liver biopsies: a comparison to stereological point counting. Mod Pathol 2005;18:912-916.
38. Briceño J, Padillo J, Rufián S, Solórzano G, Pera C. Assignment of steatotic livers by the Mayo model for end-stage liver disease. Transpl Int 2005;18:577-583.
39. Angelico M. Donor liver steatosis and graft selection for liver transplantation: a short review. Eur Rev Med Pharmacol Sci 2005;9:295-297. (Pubitemid 41387395)
40. Perez-Daga JA, Santoyo J, Suárez MA, Fernández-Aguilar JA, Ramírez C, Rodríguez-Cañete A, et al. Influence of degree of hepatic steatosis on graft function and postoperative complications of liver transplantation. Transplant Proc 2006;38:2468-2470.
41. Nikeghbalian S, Nejatollahi SM, Salahi H, Bahador A, Sabet B, Jalaeian H, et al. Does donor's fatty liver change impact on early mortality and outcome of liver transplantation. Transplant Proc 2007;39:1181-1183.
42. McCormack L, Petrowsky H, Jochum W, Mullhaupt B, Weber M, Clavien PA. Use of severely steatotic grafts in liver transplantation: a matched case-control study. Ann Surg 2007;246:940-948.
43. Angele MK, Rentsch M, Hartl WH, Wittmann B, Graeb C, Jauch KW, et al. Effect of graft steatosis on liver function and organ survival after liver transplantation. Am J Surg 2008;195:214-220.
44. Frongillo F, Avolio AW, Nure E, Mulè A, Pepe G, Magalini SC, et al. Quantification of degree of steatosis in extended criteria donor grafts with standardized histologic techniques: implications for graft survival. Transplant Proc 2009;41:1268-1272.
45. Kim WR, Asrani S, Pedersen RA, Heimbach J, Remers WK, Therneau TM. Donor race must be removed from the Donor Risk Index. Am J Transplant 2009;9(Suppl. 2):264.
46. Emre S, Schwartz ME, Altaca G, Sethi P, Fiel MI, Guy SR, et al. Safe use of hepatic allografts from donors older than 70 years. Transplantation 1996;62:62-65.
47. El-Badry AM, Breitenstein S, Jochum W, Washington K, Paradis V, Rubbia-Brandt L, et al. Assessment of hepatic steatosis by expert pathologists: the end of a gold standard. Ann Surg 2009;250:691-697.
48. Dick AA, Spitzer AL, Fix OK, Reyes JD, Perkins JD. High risk recipients in the different eras of liver transplantation. Presented at: 8th Annual State of the Art Winter Symposium: "The High Risk Recipient." American Society of Transplant Surgeons; January 25-27, 2009; Marco Island, FL.
49. Axelrod DA, Schnitzler M, Salvalaggio PR, Swindle J, Abecassis MM. The economic impact of the utilization of liver allografts with high donor risk index. Am J Transplant 2007;7:990-997.
50. Feng S. Steatotic livers for liver transplantation-life-saving but at a cost. Nat Clin Pract Gastroenterol Hepatol 2008;5:360-361.