A preclinical study on the protective effect of melatonin against methotrexate-induced small intestinal damage: Effect mediated by attenuation of nitrosative stress, protein tyrosine nitration, and PARP activation

Cancer Chemotherapy and Pharmacology

Volumn 71, Issue 5, 2013, Pages 1209-1218

  Kolli, Viswa Kalyan ^a   Kanakasabapathy, Indirani ^a   Faith, Minnie ^a   Ramamoorthy, Hemalatha ^a   Isaac, Bina ^a   Natarajan, Kasthuri ^a   Abraham, Premila ^a  

^a CHRISTIAN MEDICAL COLLEGE   (India)

Author keywords

Anticancer drug; Melatonin; Methotrexate; Nitrosative stress; Small intestine

Indexed keywords

3 NITROTYROSINE; MELATONIN; METHOTREXATE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NITRATE;

ABSCESS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; DOSE RESPONSE; DRUG DOSE COMPARISON; INTESTINE CRYPT; INTESTINE VILLUS ATROPHY; MALE; MUCOSA INFLAMMATION; NITRATION; NITROSATIVE STRESS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SMALL INTESTINE MUCOSA;

ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; DOSE-RESPONSE RELATIONSHIP, DRUG; ENTEROCOLITIS; INTESTINAL MUCOSA; INTESTINE, SMALL; MALE; MELATONIN; METHOTREXATE; NITRATES; OXIDATIVE STRESS; POLY(ADP-RIBOSE) POLYMERASES; RATS; RATS, WISTAR; TYROSINE;

EID: 84877925091     PISSN: 03445704     EISSN: 14320843     Source Type: Journal    
DOI: 10.1007/s00280-013-2115-z     Document Type: Article

References (42)

1. Hardeland R, Coto-Montes A, Poeggeler B (2003) Circadian rhythms, oxidative stress and antioxidative defense mechanisms. Chronobiol Int 20:921-962
2. Burger D, Travis S (2011) Conventional medical management of inflammatory bowel disease. Gastroenterology 140:1827-1837
3. Saibeni S, Bollani S, Losco A, Michielan A, Sostegni R, Devani M, Lupinacci G, Pirola L, Cucino C, Meucci G, Basilisco G, D'Incà R, Bruno S (2012) The use of methotrexate for treatment of inflammatory bowel disease in clinical practice. Dig Liver Dis 44:123-127
4. Muscaritoli M, Grieco G, Capria S, Iori AP, Rossi Fanelli F (2002) Nutritional and metabolic support in patients undergoing bone marrow transplantation. Am J Clin Nutr 75:183-190
5. Keefe DM, Gibson RJ, Hauer-Jensen M (2004) Gastrointestinal mucositis. Semin Oncol Nurs 20:38-47
6. Nagakubo J, Tomimatsu T, Kitajima M, Takayama H, Aimi N, Horie T (2001) Characteristics of transport of fluoresceinated methotrexate in rat small intestine. Life Sci 69:739-747
7. Keefe DM, Cummins AG, Dale BM, Kotasek D, Robb TA, Sage RE (1997) Effect of high-dose chemotherapy on intestinal permeability in humans. Clin Sci (Lond) 92:385-389
8. Pico JL, Avila-Garavito A, Naccache P (1998) Mucositis: its occurrence, consequences, and treatment in the oncology setting. Oncologist 3:446-451
9. Ballabeni V, Ghizzardi P, Cattaruzza F, Bertoni S, Lagrasta CA, Impicciatore M (2006) The selective inhibition of inducible nitric oxide synthase prevents intestinal ischemia-reperfusion injury in mice. Nitric Oxide 14:212-218
10. Dong W, Mei Q, Yu J, Xu J-M, Xiang L, Xu Y (2003) Effect of melatonin on the expression of iNOS and COX-2 in rat models of colitis. World J Gastroenterol 9:1307-1311
11. Hosoi T, Goto H, Arisawa T (2001) Role of nitric oxide synthase inhibitor in experimental colitis induced by 2,4,6-trinitrobenzene sulphonic acid in rats. Clin Exp Pharmacol Physiol 28:9-12
12. Bian K, Harari Y, Zhong M, Lai M, Castro G, Weisbrodt N, Murad F (2001) Down-regulation of inducible nitric-oxide synthase (NOS-2) during parasite-induced gut inflammation: a path to identify a selective NOS-2 inhibitor. Mol Pharmacol 59:939-947
13. Kolli VK, Abraham P, Rabi S (2008) Methotrexate-induced nitrosative stress may play a critical role in small intestinal damage in the rat. Arch Toxicol 82:763-770
14. Leitão RF, Brito GA, Oriá RB, Braga-Neto MB, Bellaguarda EA, Silva JV, Gomes AS, Lima-Júnior RC, Siqueira FJ, Freire RS, Vale ML, Ribeiro RA (2011) Role of inducible nitric oxide synthase pathway on methotrexate-induced intestinal mucositis in rodents. BMC Gastroenterol 11:90-111
15. El-Boghdady NA (2011) Protective effect of ellagic acid and pumpkin seed oil against methotrexate-induced small intestine damage in rats. Indian J Biochem Biophys 48:380-387
16. Sewerynek E, Reiter RJ, Melchiorri D (1996) Oxidative damage in the liver induced by ischemia reperfusion: protection by melatonin. Hepatogastroenterology 43:898-905
17. Chang HM, Ling EA, Chen CF, Lue H, Wen CY, Shieh JY (2002) Melatonin attenuates the neuronal NADPH-d/NOS expression in the no dose ganglion of acute hypoxic rats. J Pineal Res 32:65-73
18. Ersoz N, Guven A, Cayci T, Uysal B, Turk E, Oztas E, Akgul EO, Korkmaz A, Cetiner S (2009) Comparison of the efficacy of melatonin and 1,400 W on renal ischemia/reperfusion injury: a role for inhibiting iNOS. Ren Fail 31:704-710
19. Kelly RW, Amato F, Seamark RF (1984) N-Acetyl-5-methoxy kynurenamine, a brain metabolite of melatonin, is a potent inhibitor of prostaglandin biosynthesis. Biochem Biophys Res Commun 121:372-379
20. Szabó C (2006) Poly (ADP-ribose) polymerase activation by reactive nitrogen species - relevance for the pathogenesis of inflammation. Nitric Oxide 14:169-179
21. Razzouk BI, Rose SR, Hongeng S, Wallace D, Smeltzer MP, Zacher M, Pui CH, Hudson MM (2007) Obesity in survivors of childhood acute lymphoblastic leukemia and lymphoma. J Clin Oncol 25:1183-1189
22. Kehoe JE, Harvey LP, Daly JM (1986) Alteration of chemotherapy toxicity using a chemically defined liquid diet in rats. Cancer Res 46:4047-4052
23. Warden RA, Noltorp RS, Lynn Francis J, Dunkley PR, O'Loughlin EV (1997) Vitamin A deficiency exacerbates methotrexate-induced jejunal injury in rats. J Nutr 127:770-776
24. Ucar M, Korkmaz A, Reiter RJ (2007) Melatonin alleviates lung damage induced by the chemical warfare agent nitrogen mustard. Toxicol Lett 173:124-131
25. Chiu CJ, McArdle AH, Brown R, Scott HJ, Gurd FN (1970) Intestinal mucosal lesion in low-flow states. I. A morphological, hemodynamic, and metabolic reappraisal. Arch Surg 101:478-483
26. Cuzzocrea S, Zingarelli B, Costantino G (1997) Beneficial effects of 3-aminobenzamide, an inhibitor of poly (ADP-ribose) synthetase in a rat model of splanchnic artery occlusion and reperfusion. Br J Pharmacol 121:1065-1074
27. Sastry KV, Moudgal RP, Mohan J, Tyagi JS, Rao GS (2002) Spectrophotometric determination of serum nitrite and nitrate by copper-cadmium alloy. Anal Biochem 306:79-82
28. Kupper JH, van Gool L, Muller M (1996) Detection of poly (ADP-ribose) polymerase and its reaction product by immunohistochemistry. Histochem J 28:391-395
29. Bubenik GA, Pang SF, Cockshut JR (2000) Circadian variation of portal, arterial and venous blood levels of melatonin in pigs and its relationship to food intake and sleep. J Pineal Res 28:9-15
30. Stefulj J, Hörtner M, Ghosh M (2001) Gene expression of the key enzymes of melatonin synthesis in extrapineal tissues of the rat. J Pineal Res 30:243-247
31. Bubenik GA, Brown GM (1997) Pinealectomy reduces melatonin levels in the serum but not in the gastrointestinal tract of rats. Biol Signals 6:40-44
32. Kvetnoy IM, Ingel IE, Kvetnaia TV, Malinovskaya NK, Rapoport SI, Raikhlin NT, Trofimov AV, Yuzhakov VV (2002) Gastrointestinal melatonin: cellular identification and biological role. Neuro Endocrinol Lett 23:121-132
33. Lee PPN, Pang SF (1993) Melatonin and its receptors in the gastrointestinal tract. Biol Signals 2:181-193
34. Pandi-Perumal SR, Srinivasan V, Maestroni GJM, Cardinali DP, Poeggeler B, Hardeland R (2006) Melatonin nature is most versatile biological signal? FEBS J 273:2813-2838
35. Seabra ML, Bignotto M, Pinto LR Jr, Tufik S (2000) Randomized, double-blind clinical trial, controlled with placebo, of the toxicology of chronic melatonin treatment. J Pineal Res 29:193-200
36. Weishaupt JH, Bartels C, Pölking E, Dietrich J, Rohde G, Poeggeler B, Mertens N, Sperling S, Bohn M, Hüther G, Schneider A, Bach A, Sirén AL, Hardeland R, Bähr M, Nave KA, Ehrenreich H (2006) Reduced oxidative damage in ALS by high-dose enteral melatonin treatment. J Pineal Res 41:313-323
37. Nordlund JJ, Lerner AB (1977) The effects of oral melatonin on skin color and on the release of pituitary hormones. J Clin Endocrinol Metab 45:768-774
38. Lusardi P, Piazza E, Fogari R (2000) Cardiovascular effects of melatonin in hypertensive patients well controlled by nifedipine: a 24-hour study. Br J Clin Pharmacol 49:423-427
39. Lewy AJ, Ahmed S, Sack RL (1996) Phase shifting the human circadian clock using melatonin. Behav Brain Res 73:131-134
40. Brzezinski A (1997) Melatonin in humans. N Engl J Med 336:186-195
41. Bejarano I, Espino J, Barriga C, Reiter RJ, Pariente JA, Rodríguez AB (2011) Pro-oxidant effect of melatonin in tumour leucocytes: relation with its cytotoxic and pro-apoptotic effects. Basic Clin Pharmacol Toxicol 108:14-20
42. Kadoma Y, Fujisawa S (2011) Radical-scavenging activity of melatonin, either alone or in combination with vitamin E, ascorbate or 2-mercaptoethanol as co-antioxidants, using the induction period method. In vivo 25:49-53