The unique disulfide bond-stabilized W1 β4-β1 loop in the α4 β-propeller domain regulates integrin α4β7 affinity and signaling

Journal of Biological Chemistry

Volumn 288, Issue 20, 2013, Pages 14228-14237

  Yue, Jiao ^a   Pan, YouDong ^a   Sun, LiFang ^a   Zhang, Kun ^a   Liu, Jie ^a   Lu, Ling ^a   Chen, JianFeng ^a  

^a INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CELL ADHESION MOLECULES; CONFORMATIONAL CHANGE; DISULFIDE BONDS; DYNAMIC INTERACTION; FOCAL ADHESION KINASE; INTEGRIN AFFINITY; MOLECULAR BASIS; REGULATORY ELEMENTS;

CELL ADHESION; GLYCOPROTEINS; INDUSTRY; PROPELLERS; SIGNALING;

COVALENT BONDS;

ALPHA4 INTEGRIN; FOCAL ADHESION KINASE; INTEGRIN ALPHA4BETA7; MAGNESIUM ION; MUCOSAL ADDRESSIN CELL ADHESION MOLECULE 1; PAXILLIN; PHORBOL 13 ACETATE 12 MYRISTATE; TALIN; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CELL ADHESION; CONTROLLED STUDY; DISULFIDE BOND; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME REGULATION; HUMAN; HUMAN CELL; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS;

AFFINITY REGULATION; CELL ADHESION; CELL SIGNALING; CELL SURFACE RECEPTOR; INTEGRIN; INTEGRIN Α4Β7; LIGAND BINDING PROTEIN; W1 Β4-Β1 LOOP;

AMINO ACID SEQUENCE; ANIMALS; CELL ADHESION; CHO CELLS; CRICETINAE; DISULFIDES; DNA, COMPLEMENTARY; HEK293 CELLS; HUMANS; INTEGRINS; LIGANDS; LYMPHOCYTES; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION;

EID: 84877913209     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.462630     Document Type: Article

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