Cold atmospheric plasma devices for medical issues

Expert Review of Medical Devices

Volumn 10, Issue 3, 2013, Pages 367-377

  Isbary, Georg ^a   Shimizu, Tetsuji ^b   Li, Yang Fang ^b   Stolz, Wilhelm ^a   Thomas, Hubertus M ^b   Morfill, Gregor E ^b   Zimmermann, Julia L ^b  

^a Klinikum Schwabing   (Germany)

^b MAX PLANCK INSTITUT FÜR EXTRATERRESTRISCHE PHYSIK   (Germany)

Author keywords

cancer therapy; cold atmospheric plasma; disinfection; nonthermal plasma; plasma medicine; sterilization; tissue tolerable plasma; wound healing

Indexed keywords

CANCER THERAPY; COLD ATMOSPHERIC PLASMAS; NONTHERMAL PLASMA; PLASMA MEDICINES; WOUND HEALING;

CELL CULTURE; DISINFECTION; ELECTRIC FIELDS; IONIZATION OF GASES; STERILIZATION (CLEANING); TISSUE; ULTRAVIOLET RADIATION;

PLASMAS;

ION; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE; STAINLESS STEEL; TOXIC GAS;

ANTIBIOTIC RESISTANCE; ANTIMICROBIAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ATMOSPHERIC PRESSURE; BACTERICIDAL ACTIVITY; BIOSAFETY; CANCER THERAPY; CELL FUNCTION; CELL METABOLISM; CELLS; CLASSIFICATION; CLINICAL TRIAL (TOPIC); COLD ATMOSPHERIC PLASMA DEVICE; DENTAL PROCEDURE; ELECTRIC CURRENT; ELECTRIC FIELD; ELECTRIC RESISTANCE; ELECTRODE; ELECTRON; EXHAUST GAS; FUNGAL STRAIN; GAS; HAILEY HAILEY DISEASE; HUMAN; IONIZATION; IONTOPHORESIS; MEDICAL CARE; MEDICAL DEVICE; MOLECULE; PATHOGENESIS; PHASE 1 CLINICAL TRIAL (TOPIC); PHASE 2 CLINICAL TRIAL (TOPIC); PLASMA; REVIEW; RISK ASSESSMENT; TISSUES; TOOTH ROOT CANAL; ULTRAVIOLET RADIATION;

ATMOSPHERE; EQUIPMENT AND SUPPLIES; HUMANS; PLASMA GASES; RISK ASSESSMENT;

EID: 84877894148     PISSN: 17434440     EISSN: 17452422     Source Type: Journal    
DOI: 10.1586/erd.13.4     Document Type: Review

References (77)

1. Ayliffe G; Minimal Access Therapy Decontamination Working Group. Decontamination of minimally invasive surgical endoscopes and accessories. J. Hosp. Infect. 45(4), 263-277 (2000).
2. Kilmer S, Semchyshyn N, Shah G, Fitzpatrick R. A pilot study on the use of a Plasma Skin Regeneration device (PSR) in full facial rejuvenation procedures. J. Am. Aca. Dermatol. 52(3), P44 (2005).
3. Kilmer S, Semchyshyn N, Shah G, Fitzpatrick R. A pilot study on the use of a plasma skin regeneration device (Portrait PSR3) in full facial rejuvenation procedures. Lasers Med. Sci. 22(2), 101-109 (2007).
4. Klämpfl TG, Isbary G, Shimizu T et al. Cold atmospheric air plasma sterilization against spores and other microorganisms of clinical interest. Appl. Environ. Microbiol. 78(15), 5077-5082 (2012).
5. Venkatesh KS, Ramanujam P. Endoscopic therapy for radiation proctitis-induced hemorrhage in patients with prostatic carcinoma using argon plasma coagulator application. Surg. Endosc. 16(4), 707-710 (2002).
6. Weltmann K-D, Kindel E, Von Woedtke T, Haehnel M, Stieber M, Brandenburg R. Atmospheric-pressure plasma sources: prospective tools for plasma medicine. Pure Appl. Chem. 82(6), 1223-1237 (2010).
7. Weltmann K-D, Von Woedtke T. Campus PlasmaMed - from basic research to clinical proof. IEEE T. Plasma Sci. 39(4), 1015-1025 (2011).
8. Weltmann K-D, Von Woedtke T. Basic requirements for plasma sources in medicine. Eur. Phy. J. Appl. Phys. 55(1), 13807 (2011).
9. Nagaraj G, Balasubramanian M, Kalghatgi S et al. Mechanism of blood coagulation by non-thermal atmospheric pressure dielectric barrier discharge plasma. Blood 110(11), 929A (2007).
10. Maisch T, Shimizu T, Isbary G et al. Contact-free inactivation of Candida albicans biofilms by cold atmospheric air plasma. Appl. Environ. Microbiol. 78(12), 4242-4247 (2012).
11. Maisch T, Shimizu T, Li YF et al. Decolonisation of MRSA, S. aureus and E. coli by cold-atmospheric plasma using a porcine skin model in vitro. PLoS One 7(4), e34610 (2012).
12. Maisch T, Shimizu T, Mitra A et al. Contact-free cold atmospheric plasma treatment of Deinococcus radiodurans. J. Ind. Microbiol. Biotechnol. 39(9), 1367-1375 (2012).
13. Zimmermann JL, Dumler K, Shimizu T et al. Effects of cold atmospheric plasmas on adenoviruses in solution. J. Phys. D. Appl. Phys. 44(50), 505201 (2011).
14. Kumarasamy KK, Toleman MA, Walsh TR et al. Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study. Lancet Infect. Dis. 10(9), 597-602 (2010).
15. Piddock LJV. The crisis of no new antibiotics: what is the way forward? Lancet Infect. Dis. 12, 249-253 (2012).
16. Sacks R, Greene L. New management of gonorrhoea. Impact of antibiotic resistance. BMJ 342, d3523 (2011).
17. Zimmermann JL, Shimizu T, Schmidt HU, Li Y-F, Morfill G, Isbary G. Test for bacterial resistance build-up against plasma treatment. New J. Phys. 14, 1-14 (2012).
18. Kong MG, Kroesen G, Morfill G et al. Plasma medicine: an introductory review. New J. Phys. 11, 1-36 (2009).
19. Fridman G, Peddinghaus M, Ayan H et al. Blood coagulation and living tissue sterilization by floating-electrode dielectric barrier discharge in air. Plasma Chem. Plasma P. 26(4), 425-442 (2006).
20. Kalia YN, Naik A, Garrison J, Guy RH. Iontophoretic drug delivery. Adv. Drug Deliv. Rev. 56(5), 619-658 (2004).
21. Stoffels E, Flikweert AJ, Stoffels WW, Kroesen GMW. Plasma needle: a nondestructive atmospheric plasma source for fine surface treatment of (bio)materials. Plasma Sources Sci. Technol. 11(4), 383-388 (2002).
22. Laroussi M, Akan T. Arc-free atmospheric pressure cold plasma jets: a review. Plasma Process Polymers 4(9), 777-788 (2007).
23. Cao Z, Walsh JL, Kong MG. Atmospheric plasma jet array in parallel electric and gas flow fields for three-dimensional surface treatment. Appl. Phys. Lett. 94(2), 021501 (2009).
24. Kogelschatz U. Dielectric-barrier discharges: their history, discharge physics, and industrial applications. Plasma Chem. Plasma P. 23(1), 1-46 (2003).
25. Wang D, Matsumoto T, Namihira T, Akiyama H. Development of higher yield ozonizer based on nano-seconds pulsed discharge. J. Adv. Oxid. Technol. 13(1), 71-78 (2010).
26. Ehlbeck J, Schnabel U, Polak M et al. Low temperature atmospheric pressure plasma sources for microbial decontamination. J. Phys. D. Appl. Phys. 44(1), 1-18 (2011).
27. Fridman G, Friedman G, Gutsol A, Shekhter AB, Vasilets VN, Fridman A. Applied plasma medicine. Plasma Process. Polym. 5(6), 503-533 (2008).
28. Dobrynin D, Friedman G, Fridman A, Starikovskiy A. Inactivation of bacteria using DC corona discharge: role of ions and humidity. New J. Phys. 13, 103033 (2011).
29. Fridman G, Brooks AD, Balasubramanian M et al. Comparison of direct and indirect effects of non-thermal atmosphericpressure plasma on bacteria. Plasma Process. Polym. 4(4), 370-375 (2007).
30. Kalghatgi S, Kelly CM, Cerchar E et al. Effects of non-thermal plasma on mammalian cells. PLoS One 6(1), e16270 (2011).
31. Sensenig R, Kalghatgi S, Cerchar E et al. Non-thermal plasma induces apoptosis in melanoma cells via production of intracellular reactive oxygen species. Ann. Biomed. Eng. 39(2), 674-687 (2011).
32. Daeschlein G, Scholz S, Ahmed R et al. Cold plasma is well-tolerated and does not disturb skin barrier or reduce skin moisture. J. Dtsch. Dermatol. Ges. 10(7), 509-515 (2012).
33. Daeschlein G, Scholz S, Ahmed R et al. Skin decontamination by low-temperature atmospheric pressure plasma jet and dielectric barrier discharge plasma. J. Hosp. Infect. 81(3), 177-183 (2012).
34. Kuchenbecker M, Bibinov N, Kaemlimg A, Wandke D, Awakowicz P, Viol W. Characterization of DBD plasma source for biomedical applications. J. Phys. D. Appl. Phys. 42(4), 045212 (2009).
35. Nosenko T, Shimizu T, Morfill GE. Designing plasmas for chronic wound disinfection. New J. Phys. 11, 1-20 (2009).
36. Ermolaeva SA, Varfolomeev AF, Chernukha MY et al. Bactericidal effects of non-thermal argon plasma in vitro, in biofilms and in the animal model of infected wounds. J. Med. Microbiol. 60(Pt 1), 75-83 (2011).
37. Shimizu T, Steffes B, Pompl R et al. Characterization of microwave plasma torch for decontamination. Plasma Process. Polym. 5(6), 577-582 (2008).
38. Ermolaeva SA, Sysolyatina EV, Kolkova NI et al. Non-thermal argon plasma is bactericidal for the intracellular bacterial pathogen Chlamydia trachomatis. J. Med. Microbiol. 61(Pt 6), 793-799 (2012).
39. Isbary G, Heinlin J, Shimizu T et al. Successful and safe use of 2 min cold atmospheric argon plasma in chronic wounds: results of a randomized controlled trial. Br. J. Dermatol. 167(2), 404-410 (2012).
40. Isbary G, Morfill G, Schmidt HU et al. A first prospective randomized controlled trial to decrease bacterial load using cold atmospheric argon plasma on chronic wounds in patients. Br. J. Dermatol. 163(1), 78-82 (2010).
41. Shimizu T, Nosenko T, Morfill GE, Sato T, Schmidt H-U, Urayama T. Characterization of low-temperature microwave plasma treatment with and without UV light for disinfection. Plasma Process. Polym. 7(3-4), 288-293 (2010).
42. Heinlin J, Isbary G, Stolz W et al. A randomized two-sided placebo-controlled study on the efficacy and safety of atmospheric non-thermal argon plasma for pruritus. J. Eur. Acad. Dermatol. Venereol. 27(3), 324-331 (2013).
43. Isbary G, Morfill G, Zimmermann J, Shimizu T, Stolz W. Cold atmospheric plasma: a successful treatment of lesions in Hailey-Hailey disease. Arch. Dermatol. 147(4), 388-390 (2011).
44. Laroussi M, Hynes W, Akan T, Lu X, Tendero C. The plasma pencil: a source of hypersonic cold plasma bullets for biomedical applications. IEEE T. Plasma Sci. 36(4), 1298-1299 (2008).
45. Laroussi M, Mendis DA, Rosenberg M. Plasma interaction with microbes. New J. Phys. 5, 1-11 (2003).
46. Laroussi M, Tendero C, Lu X, Alla S, Hynes WL. Inactivation of bacteria by the plasma pencil. Plasma Process. Polym. 3(6-7), 470-473 (2006).
47. Weltmann KD, Brandenburg R, Von Woedtke T et al. Antimicrobial treatment of heat sensitive products by miniaturized atmospheric pressure plasma jets (APPJs). J. Phys. D. Appl. Phys. 41(19), 194008 (2008).
48. Lademann J, Richter H, Alborova A et al. Risk assessment of the application of a plasma jet in dermatology. J. Biomed. Opt. 14(5), 054025 (2009).
49. Lademann O, Richter H, Patzelt A et al. Application of a plasma-jet for skin antisepsis: analysis of the thermal action of the plasma by laser scanning microscopy. Laser Phys. Lett. 7(6), 458-462 (2010).
50. Douat C, Bauville G, Fleury M, Laroussi M, Puech V. Dynamics of colliding microplasma jets. Plasma Sources Sci. Tech. 21(3), 034010 (2012).
51. Douat C, Fleury M, Laroussi M, Puech V. Interactions between two counterpropagating plasma bullets. Ieee T. Plasma Sci. 39(11), 2298-2299 (2011).
52. Daeschlein G, Von Woedtke T, Kindel E, Brandenburg R, Weltmann K-D, Juenger M. Antibacterial activity of an atmospheric pressure plasma jet against relevant wound pathogens in vitro on a simulated wound environment. Plasma Process. Polym. 7(3-4), 224-230 (2010).
53. Kim SJ, Chung TH, Bae SH, Leem SH. Characterization of atmospheric pressure microplasma jet source and its application to bacterial inactivation. Plasma Process. Polym. 6(10), 676-685 (2009).
54. Kim SJ, Chung TH, Bae SH, Leem SH. Bacterial inactivation using atmospheric pressure single pin electrode microplasma jet with a ground ring. Appl. Phys. Lett. 94(14), 023702 (2009).
55. Lee HW, Kim GJ, Kim JM, Park JK, Lee JK, Kim GC. Tooth bleaching with nonthermal atmospheric pressure plasma. J. Endod. 35(4), 587-591 (2009).
56. Lee HW, Nam SH, Mohamed A-H, Kim GC, Lee JK. Atmospheric pressure plasma jet composed of three electrodes: application to tooth bleaching. Plasma Process. Polym. 7(3-4), 274-280 (2010).
57. Weltmann KD, Kindel E, Brandenburg R et al.: Atmospheric pressure plasma jet for medical therapy: plasma parameters and risk estimation. Contrib. Plasma Phys. 49(9), 631-640 (2009).
58. Kim SJ, Chung TH, Bae SH, Leem SH. Induction of apoptosis in human breast cancer cells by a pulsed atmospheric pressure plasma jet. Appl. Phys. Lett. 97(2), 023702 (2010).
59. Vandamme M, Robert E, Lerondel S, Pouvesle JM, Le Pape A. Non thermal plasmas, a new strategy in oncology? Med. Sci. (Paris) 28(2), 154-156 (2012).
60. Vandamme M, Robert E, Lerondel S et al. ROS implication in a new antitumor strategy based on non-thermal plasma. Int. J. Cancer 130(9), 2185-2194 (2012).
61. Vandamme M, Robert E, Pesnel S et al. Antitumor effect of plasma treatment on U87 Glioma xenografts: preliminary results. Plasma Process. Polym. 7(3-4), 264-273 (2010).
62. Lee HJ, Shon CH, Kim YS, Kim S, Kim GC, Kong MG. Degradation of adhesion molecules of G361 melanoma cells by a non-thermal atmospheric pressure microplasma. New J. Phys. 11, 1-13 (2009).
63. Yan X, Xiong Z, Zou F et al. Plasmainduced death of HepG2 cancer cells: intracellular effects of reactive species. Plasma Process. Polym. 9(1), 59-66 (2012).
64. Volotskova O, Hawley TS, Stepp MA, Keidar M. Targeting the cancer cell cycle by cold atmospheric plasma. Sci. Rep. 2
65. Lee JK, Kim MS, Byun JH, Kim KT, Kim GC, Park GY. Biomedical applications of low temperature atmospheric pressure plasmas to cancerous cell treatment and tooth bleaching. Jap. J. Appl. Phys. 50(8), 08JF01 (2011).
66. Kim JY, Ballato J, Foy P et al. Apoptosis of lung carcinoma cells induced by a flexible optical fiber-based cold microplasma. Biosens. Bioelectron. 28(1), 333-338 (2011).
67. Keidar M, Walk R, Shashurin A et al. Cold plasma selectivity and the possibility of a paradigm shift in cancer therapy. Br. J. Cancer 105(9), 1295-1301 (2011).
68. Isbary G, Koeritzer J, Mitra A et al. Ex vivo human skin experiments for the evaluation of safety of new cold atmospheric plasma devices. Clin. Plasma Med. J. doi:10.1016/j. cpme.2012.10.001 (2012) (Epub ahead of print).
69. Welz C, Becker S, Li Y-F et al. Effects of cold atmospheric plasma on mucosal tissue culture. J. Phys. D. Appl. Phys. 46, 045401 (2013).
70. Boxhammer V, Li Y-F, Koeritzer J et al. Investigation of the mutagenic potential of cold atmospheric plasma. Mutat. Res. doi:10.1016/j.mrgentox.2012. 12.015 (2013) (Epub ahead of print).
71. Li Y-F, Shimizu T, Zimmermann JL, Morfill GE. Cold atmospheric plasma for surface disinfection. Plasma Process. Polym. 9(6), 585-589 (2012).
72. Ahn HJ, Kim KI, Kim G, Moon E, Yang SS, Lee JS. Atmospheric-pressure plasma jet induces apoptosis involving mitochondria via generation of free radicals. PLoS One 6(11), e28154 (2011).
73. Brun P, Brun P, Vono M et al. Disinfection of ocular cells and tissues by atmosphericpressure cold plasma. PLoS One 7(3), e33245 (2012).
74. Sakiyama Y, Graves DB, Chang H-W, Shimizu T, Morfill GE. Plasma chemistry model of surface microdischarge in humid air and dynamics of reactive neutral species. J. Phys. D. Appl. Phys. 45(42), 425201 (2012).
75. Shimizu T, Sakiyama Y, Graves DB, Zimmermann JL, Morfill GE. The dynamics of ozone generation and mode transition in air surface micro-discharge plasma at atmospheric pressure. New J. Phys. 14, 1-11 (2012).
76. Guidelines on limits of exposure to ultraviolet radiation of wavelengths between 180 nm and 400nm (incoherent optical radiation). ICNIRP (International Commission on Non-Ionizing Radiation Protection) (2004). www.icnirp.de/ documents/UV2004.pdf
77. Biological effects of ultraviolet radiation relevant to health with particular reference to sunbeds for cosmetic purposes. European Commission Report of SCCP (Scientific committee on consumer products) (2006). http://ec.europa.eu/health/ph-risk/ committees/04-sccp/docs/sccp-o-031b. pdf