Ex vivo human skin experiments for the evaluation of safety of new cold atmospheric plasma devices

Clinical Plasma Medicine

Volumn 1, Issue 1, 2013, Pages 36-44

  Isbary, G ^a   Koritzer J ^b   Mitra, A ^b   Li, Y F ^b   Shimizu, T ^b   Schroeder, J ^d   Schlegel, J ^c   Morfill, G E ^b   Stolz, W ^a   Zimmermann, J L ^b  

^a Klinikum Schwabing   (Germany)

^b MAX PLANCK INSTITUT FÜR EXTRATERRESTRISCHE PHYSIK   (Germany)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^d UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

Chronic wounds; Clinical trial; Cold atmospheric plasma; H2AX; Plasma; Plasma medicine

Indexed keywords

NITRIC OXIDE; NITROUS OXIDE; OXYGEN;

ADULT; AGED; ARTICLE; CALCULATION; CAUCASIAN; CLINICAL ARTICLE; COLD ATMOSPHERIC PLASMA DEVICE; CONTROLLED STUDY; DEVICES; DNA DAMAGE; ELECTRON MICROSCOPY; EX VIVO STUDY; FEMALE; HISTOLOGY; HUMAN; MALE; PRIORITY JOURNAL; SAFETY; SKIN;

EID: 84876704082     PISSN: 22128166     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cpme.2012.10.001     Document Type: Article

References (39)

1. Klampfl T.G., Isbary G., Shimizu T., Li Y.F., Zimmermann J.L., Stolz W., et al. Cold atmospheric air plasma sterilization against spores and other microorganisms of clinical interest. Applied and Environmental Microbiology 2012, 78:5077-5082.
2. Maisch T., Shimizu T., Isbary G., Heinlin J., Karrer S., Klampfl T.G., et al. Contact-free inactivation of Candida albicans biofilm by cold-atmospheric air plasma. Applied and Environmental Microbiology 2012, 78:4242-4247.
3. Maisch T., Shimizu T., Li Y.-F., Heinlin J., Karrer S., Morfill G., et al. Decolonisation of MRSA, S. aureus and E. coli by cold-atmospheric plasma using a porcine skin model in vitro. PloS One 2012, 7:e34610.
4. Morfill G.E., Shimizu T., Steffes B., Schmidt H.U. Nosocomial infections-a new approach towards preventive medicine using plasmas. New Journal of Physics 2009, 11:1-10.
5. Niemira B.A. Cold plasma reduction of Salmonella and Escherichia coli O157:H7 on almonds using ambient pressure gases. Journal of Food Science 2012, 77:M171-M175.
6. Zimmermann J.L., Dumler K., Shimizu T., Morfill G.E., Wolf A., Boxhammer V., et al. Effects of cold atmospheric plasmas on adenoviruses in solution. Journal of Physics D: Applied Physics 2011, 44:1-9.
7. Ermolaeva S.A., Varfolomeev A.F., Chernukha M.Y., Yurov D.S., Vasiliev M.M., Kaminskaya A.A., et al. Bactericidal effects of non-thermal argon plasma in vitro, in biofilms and in the animal model of infected wounds. Journal of Medical Microbiology 2011, 60:75-83.
8. Ermolaeva S.A., Sysolyatina E.V., Kolkova N.I., Bortsov P., Tuhvatulin A.I., Vasiliev M.M., et al. Non-thermal argon plasma is bactericidal for the intracellular bacterial pathogen Chlamydia trachomatis. Journal of Medical Microbiology 2012, 61:793-799.
9. Lademann J., Richter H., Schanzer S., Patzelt A., Thiede G., Kramer A., et al. Comparison of the antiseptic efficacy of tissue-tolerable plasma and an octenidine hydrochloride-based wound antiseptic on human skin. Skin Pharmacology and Physiology 2012, 25:100-106.
10. Lademann O., Kramer A., Richter H., Patzelt A., Meinke M.C., Roewert-Huber J., et al. Antisepsis of the follicular reservoir by treatment with tissue-tolerable plasma (TTP). Laser Physics Letters 2011, 8:313-317.
11. Lademann O., Richter H., Meinke M.C., Patzelt A., Kramer A., Hinz P., et al. Drug delivery through the skin barrier enhanced by treatment with tissue-tolerable plasma. Experimental Dermatology 2011, 20:488-490.
12. Shimizu T., Zimmermann J.L., Morfill G.E. The bactericidal effect of surface micro-discharge plasma under different ambient conditions. New Journal of Physics 2011, 13:1-7.
13. Bender C., Partecke L.-I., Kindel E., Doering F., Lademann J., Heidecke C.-D., et al. The modified HET-CAM as a model for the assessment of the inflammatory response to tissue tolerable plasma. Toxicology in Vitro 2011, 25:530-537.
14. Kalghatgi S, Fridman G, Fridman A. Non-thermal dielectric barrier discharge plasma treatment of endothelial cells. In: Proceedings of the 30th IEEE engineering in medicine and biology society; 2008. p. 3578-81.
15. Kalghatgi S., Friedman G., Fridman A., Clyne A.M. Endothelial cell proliferation is enhanced by low dose non-thermal plasma through fibroblast growth Factor-2 release. Annals of Biomedical Engineering 2010, 38:748-757.
16. Nosenko T., Shimizu T., Morfill G.E. Designing plasmas for chronic wound disinfection. New Journal of Physics 2009, 11:1-19.
17. Pompl R., Jamitzky F., Shimizu T., Steffes B., Bunk W., Schmidt H.-U., et al. The effect of low-temperature plasma on bacteria as observed by repeated AFM imaging. New Journal of Physics 2009, 11:1-11.
18. Tipa R.S., Kroesen G.M.W. Plasma-stimulated wound healing. IEEE Transactions on Plasma Science 2011, 39:2978-2979.
19. Sensenig R., Kalghatgi S., Cerchar E., Fridman G., Shereshevsky A., Torabi B., et al. Non-thermal plasma induces apoptosis in melanoma cells via production of intracellular reactive oxygen species. Annals of Biomedical Engineering 2011, 39:674-687.
20. Heinlin J, Isbary G, Stolz W, Zeman F, Landthaler M, Morfill G, et al. A randomized two-sided placebo-controlled study on the efficacy and safety of atmospheric non-thermal argon plasma for pruritus. J Eur Acad Dermatol Venereol, in press. http://dx.doi.org/10.1111/j.1468-3083.2011.04395.x.
21. Isbary G., Heinlin J., Shimizu T., Zimmermann J.L., Morfill G., Schmidt H.U., et al. Successful and safe use of 2min cold atmospheric argon plasma in chronic wounds: results of a randomized controlled trial. British Journal of Dermatology 2012, 167:404-410.
22. Isbary G., Morfill G., Schmidt H.U., Georgi M., Ramrath K., Heinlin J., et al. A first prospective randomized controlled trial to decrease bacterial load using cold atmospheric argon plasma on chronic wounds in patients. British Journal of Dermatology 2010, 163:78-82.
23. Isbary G., Morfill G., Zimmermann J., Shimizu T., Stolz W. Cold atmospheric plasma: a successful treatment of lesions in Hailey-Hailey disease. Archives of Dermatology 2011, 147:388-390.
24. Heinlin J., Isbary G., Stolz W., Morfill G., Landthaler M., Shimizu T., et al. Plasma applications in medicine with a special focus on dermatology. Journal of the European Academy of Dermatology and Venereology 2011, 25:1-11.
25. Heinlin J., Morfill G., Landthaler M., Stolz W., Isbary G., Zimmermann J.L., et al. Plasma medicine: possible applications in dermatology. Journal der Deutschen Dermatologischen Gesellschaft 2010, 8:968-976.
26. Kong M.G., Kroesen G., Morfill G., Nosenko T., Shimizu T., van Dijk J., et al. Plasma medicine: an introductory review. New Journal of Physics 2009, 11:1-35.
27. Kogelschatz U. Dielectric-barrier discharges: their history, discharge physics, and industrial applications. Plasma Chemistry and Plasma Processing 2003, 23:1-46.
28. Guidlines on limits of exposure to ultraviolet radiation of wavelengths between 180nm and 400nm (incoherent optical radiation): ICNIRP (International Commission on Non-Ionizing Radiation Protection); 2004.
29. Center for Disease Control and Prevention (CDC) Ozone: NIOSH (National Institute for Occupational Safety and Health).
30. International Electrotechnical Commission IEC 60601 Medical equipment/medical electrical equipment-Part 1.
31. Yasuda H., Miura T., Kurita H., Takashima K., Mizuno A. Biological evaluation of DNA damage in bacteriophages inactivated by atmospheric pressure cold plasma. Plasma Processes and Polymers 2010, 7:301-308.
32. Vandamme M., Robert E., Lerondel S., Sarron V., Ries D., Dozias S., et al. ROS implication in a new antitumor strategy based on non-thermal plasma. International Journal of Cancer 2012, 130:2185-2194.
33. O'Connell D., Cox L.J., Hyland W.B., McMahon S.J., Reuter S., Graham W.G., et al. Cold atmospheric pressure plasma jet interactions with plasmid DNA. Applied Physics Letters 2011, 98:1-3.
34. Kalghatgi S., Kelly C.M., Cerchar E., Torabi B., Alekseev O., Fridman A., et al. Effects of non-thermal plasma on mammalian cells. PloS One 2011, 6:1-11.
35. Friedberg E.C. How nucleotide excision repair protects against cancer. Nature Reviews Cancer 2001, 1:22-33.
36. Leduc M., Guay D., Coulombe S., Leask R.L. Effects of non-thermal plasmas on DNA and mammalian cells. Plasma Processes and Polymers 2010, 7:899-909.
37. Durant S.T., Paffett K.S., Shrivastav M., Timmins G.S., Morgan W.F., Nickoloff J.A. UV radiation induces delayed hyperrecombination associated with hypermutation in human cells. Molecular and Cellular Biology 2006, 26:6047-6055.
38. DeFedericis H.C., Patrzyc H.B., Rajecki M.J., Budzinski E.E., Iijima H., Dawidzik J.B., et al. Singlet oxygen-induced DNA damage. Radiation Research 2006, 165:445-451.
39. Marnett L.J. Lipid peroxidation-DNA damage by malondialdehyde. Mutation Research: Fundamental and Molecular Mechanisms of Mutagenesis 1999, 424:83-95.