-
1
-
-
34748825490
-
Fingolimod: A novel immunosuppressant for multiple sclerosis
-
Brown BA, Kantesaria PP, McDevitt LM. Fingolimod: a novel immunosuppressant for multiple sclerosis. Ann Pharmacother 2007; 41: 1660-1668.
-
(2007)
Ann Pharmacother
, vol.41
, pp. 1660-1668
-
-
Brown, B.A.1
Kantesaria, P.P.2
McDevitt, L.M.3
-
2
-
-
0032908474
-
A double-blind, placebo-controlled, randomized trial of cladribine in relapsing-remitting multiple sclerosis
-
Romine JS, Sipe JC, Koziol JA, et al. A double-blind, placebo-controlled, randomized trial of cladribine in relapsing-remitting multiple sclerosis. Proc Assoc Am Physicians 1999;111: 35-44.
-
(1999)
Proc Assoc Am Physicians
, vol.111
, pp. 35-44
-
-
Romine, J.S.1
Sipe, J.C.2
Koziol, J.A.3
-
3
-
-
34247375995
-
Dimethylfumarate inhibits nuclear binding of nuclear factor kappaB but not of nuclear factor of activated T cells and CCAAT/enhancer binding protein beta in activated human T cells
-
Gerdes S, Shakery K, Mrowietz U. Dimethylfumarate inhibits nuclear binding of nuclear factor kappaB but not of nuclear factor of activated T cells and CCAAT/enhancer binding protein beta in activated human T cells. Br J Dermatol 2007;156: 838-842.
-
(2007)
Br J Dermatol
, vol.156
, pp. 838-842
-
-
Gerdes, S.1
Shakery, K.2
Mrowietz, U.3
-
4
-
-
0029846154
-
Selective stimulation of T helper 2 cytokine responses by the anti-psoriasis agent monomethylfumarate
-
de Jong R, Bezemer AC, Zomerdijk TP, et al. Selective stimulation of T helper 2 cytokine responses by the anti-psoriasis agent monomethylfumarate. Eur J Immunol 1996;26: 2067-2074.
-
(1996)
Eur J Immunol
, vol.26
, pp. 2067-2074
-
-
de Jong, R.1
Bezemer, A.C.2
Zomerdijk, T.P.3
-
5
-
-
0030913951
-
Dimethylfumarate is an inhibitor of cytokine-induced E-selectin, VCAM-1, and ICAM-1 expression in human endothelial cells
-
Vandermeeren M, Janssens S, Borgers M, Geysen J. Dimethylfumarate is an inhibitor of cytokine-induced E-selectin, VCAM-1, and ICAM-1 expression in human endothelial cells. Biochem Biophys Res Commun 1997; 234: 19-23.
-
(1997)
Biochem Biophys Res Commun
, vol.234
, pp. 19-23
-
-
Vandermeeren, M.1
Janssens, S.2
Borgers, M.3
Geysen, J.4
-
6
-
-
11844304978
-
Dimethylfumarate for psoriasis: More than a dietary curiosity
-
Mrowietz U, Asadullah K. Dimethylfumarate for psoriasis: more than a dietary curiosity. Trends Mol Med 2005;11: 43-48.
-
(2005)
Trends Mol Med
, vol.11
, pp. 43-48
-
-
Mrowietz, U.1
Asadullah, K.2
-
7
-
-
15244353263
-
Treatment with laquinimod reduces development of active MRI lesions in relapsing MS
-
Polman C, Barkhof F, Sandberg-Wollheim M, et al. Treatment with laquinimod reduces development of active MRI lesions in relapsing MS. Neurology 2005;64: 987-991.
-
(2005)
Neurology
, vol.64
, pp. 987-991
-
-
Polman, C.1
Barkhof, F.2
Sandberg-Wollheim, M.3
-
8
-
-
11144357311
-
Synthesis and biological evaluation of new 1,2-dihydro-4-hydroxy-2-oxo-3-quinolinecarboxamides for treatment of autoimmune disorders: Structure-activity relationship
-
Jonsson S, Andersson G, Fex T, et al. Synthesis and biological evaluation of new 1,2-dihydro-4-hydroxy-2-oxo-3-quinolinecarboxamides for treatment of autoimmune disorders: structure-activity relationship. J Med Chem 2004;47: 2075-2088.
-
(2004)
J Med Chem
, vol.47
, pp. 2075-2088
-
-
Jonsson, S.1
Andersson, G.2
Fex, T.3
-
9
-
-
4744340401
-
Laquinimod (ABR-215062) suppresses the development of experimental autoimmune encephalomyelitis, modulates the Th1/Th2 balance and induces the Th3 cytokine TGF-beta in Lewis rats
-
Yang JS, Xu LY, Xiao BG, et al. Laquinimod (ABR-215062) suppresses the development of experimental autoimmune encephalomyelitis, modulates the Th1/Th2 balance and induces the Th3 cytokine TGF-beta in Lewis rats. J Neuroimmunol 2004;156: 3-9.
-
(2004)
J Neuroimmunol
, vol.156
, pp. 3-9
-
-
Yang, J.S.1
Xu, L.Y.2
Xiao, B.G.3
-
10
-
-
26844454904
-
Application of population pharmacokinetics to cladribine
-
Lindemalm S, Savic RM, Karlsson MO, et al. Application of population pharmacokinetics to cladribine. BMC Pharmacol 2005; 5: 4.
-
(2005)
BMC Pharmacol
, vol.5
, pp. 4
-
-
Lindemalm, S.1
Savic, R.M.2
Karlsson, M.O.3
-
11
-
-
0034122123
-
Leflunomide: An immunomodulatory drug for the treatment of rheumatoid arthritis and other autoimmune diseases
-
Herrmann ML, Schleyerbach R, Kirschbaum BJ. Leflunomide: an immunomodulatory drug for the treatment of rheumatoid arthritis and other autoimmune diseases. Immunopharmacology 2000;47: 273-289.
-
(2000)
Immunopharmacology
, vol.47
, pp. 273-289
-
-
Herrmann, M.L.1
Schleyerbach, R.2
Kirschbaum, B.J.3
-
12
-
-
0031179645
-
The immunosuppressive metabolite of leflunomide, A77 1726, affects murine T cells through two biochemical mechanisms
-
Elder RT, Xu X, Williams JW, et al. The immunosuppressive metabolite of leflunomide, A77 1726, affects murine T cells through two biochemical mechanisms. J Immunol 1997;159: 22-27.
-
(1997)
J Immunol
, vol.159
, pp. 22-27
-
-
Elder, R.T.1
Xu, X.2
Williams, J.W.3
-
13
-
-
0027501428
-
Inhibition of the epidermal growth factor receptor tyrosine kinase activity by leflunomide
-
Mattar T, Kochhar K, Bartlett R, et al. Inhibition of the epidermal growth factor receptor tyrosine kinase activity by leflunomide. FEBS Lett 1993;334: 161-164.
-
(1993)
FEBS Lett
, vol.334
, pp. 161-164
-
-
Mattar, T.1
Kochhar, K.2
Bartlett, R.3
-
14
-
-
4344639961
-
Suppressive effect of leflunomide metabolite (A77 1726) on metalloproteinase production in IL-1 beta stimulated rheumatoid synovial fibroblasts
-
Migita K, Miyashita T, Ishibashi H, et al. Suppressive effect of leflunomide metabolite (A77 1726) on metalloproteinase production in IL-1 beta stimulated rheumatoid synovial fibroblasts. Clin Exp Immunol 2004;137: 612-616.
-
(2004)
Clin Exp Immunol
, vol.137
, pp. 612-616
-
-
Migita, K.1
Miyashita, T.2
Ishibashi, H.3
-
15
-
-
0032519992
-
Inhibition of JAK3 and STAT6 tyrosine phosphorylation by the immunosuppressive drug leflunomide leads to a block in IgG1 production
-
Siemasko K, Chong AS, Jack HM, et al. Inhibition of JAK3 and STAT6 tyrosine phosphorylation by the immunosuppressive drug leflunomide leads to a block in IgG1 production. J Immunol 1998;160: 1581-1588.
-
(1998)
J Immunol
, vol.160
, pp. 1581-1588
-
-
Siemasko, K.1
Chong, A.S.2
Jack, H.M.3
-
16
-
-
0029052321
-
Inhibition of protein tyrosine phosphorylation in T cells by a novel immunosuppressive agent, leflunomide
-
Xu X, Williams JW, Bremer EG, et al. Inhibition of protein tyrosine phosphorylation in T cells by a novel immunosuppressive agent, leflunomide. J Biol Chem 1995;270: 12398-12403.
-
(1995)
J Biol Chem
, vol.270
, pp. 12398-12403
-
-
Xu, X.1
Williams, J.W.2
Bremer, E.G.3
-
17
-
-
0030014489
-
Two activities of the immunosuppressive metabolite of leflunomide, A77 1726. Inhibition of pyrimidine nucleotide synthesis and protein tyrosine phosphorylation
-
Xu X, Williams JW, Gong H, et al. Two activities of the immunosuppressive metabolite of leflunomide, A77 1726. Inhibition of pyrimidine nucleotide synthesis and protein tyrosine phosphorylation. Biochem Pharmacol 1996;52: 527-534.
-
(1996)
Biochem Pharmacol
, vol.52
, pp. 527-534
-
-
Xu, X.1
Williams, J.W.2
Gong, H.3
-
18
-
-
0031721092
-
Dose-dependent enhancing and inhibitory effects of A77 1726 (leflunomide) on cytotoxic T lymphocyte induction
-
Hoskin DW, Taylor RM, Makrigiannis AP, et al. Dose-dependent enhancing and inhibitory effects of A77 1726 (leflunomide) on cytotoxic T lymphocyte induction. Int J Immunopharmacol 1998;20: 505-513.
-
(1998)
Int J Immunopharmacol
, vol.20
, pp. 505-513
-
-
Hoskin, D.W.1
Taylor, R.M.2
Makrigiannis, A.P.3
-
19
-
-
0033557695
-
Immunosuppressive leflunomide metabolite (A77 1726) blocks TNF-dependent nuclear factor-kappa B activation and gene expression
-
Manna SK, Aggarwal BB. Immunosuppressive leflunomide metabolite (A77 1726) blocks TNF-dependent nuclear factor-kappa B activation and gene expression. J Immunol 1999;162: 2095-2102.
-
(1999)
J Immunol
, vol.162
, pp. 2095-2102
-
-
Manna, S.K.1
Aggarwal, B.B.2
-
20
-
-
25444448197
-
Disruption of the interaction of T cells with antigen-presenting cells by the active leflunomide metabolite teriflunomide: Involvement of impaired integrin activation and immunologic synapse formation
-
Zeyda M, Poglitsch M, Geyeregger R, et al. Disruption of the interaction of T cells with antigen-presenting cells by the active leflunomide metabolite teriflunomide: involvement of impaired integrin activation and immunologic synapse formation. Arthritis Rheum 2005;52: 2730-2739.
-
(2005)
Arthritis Rheum
, vol.52
, pp. 2730-2739
-
-
Zeyda, M.1
Poglitsch, M.2
Geyeregger, R.3
-
21
-
-
0032773737
-
A771726, the active metabolite of leflunomide, directly inhibits the activity of cyclo-oxygenase-2 in vitro and in vivo in a substrate-sensitive manner
-
Hamilton LC, Volnovic I, Warner TD. A771726, the active metabolite of leflunomide, directly inhibits the activity of cyclo-oxygenase-2 in vitro and in vivo in a substrate-sensitive manner. Br J Pharmacol 1999; 127: 1589-1596.
-
(1999)
Br J Pharmacol
, vol.127
, pp. 1589-1596
-
-
Hamilton, L.C.1
Volnovic, I.2
Warner, T.D.3
-
22
-
-
0034143656
-
Cell-specific inhibition of inducible nitric oxide synthase activation by leflunomide
-
Jankovic V, Samardzic T, Stosic-Grujicic S, et al. Cell-specific inhibition of inducible nitric oxide synthase activation by leflunomide. Cell Immunol 2000;199: 73-80.
-
(2000)
Cell Immunol
, vol.199
, pp. 73-80
-
-
Jankovic, V.1
Samardzic, T.2
Stosic-Grujicic, S.3
-
23
-
-
0035910348
-
Leflunomide inhibits activation of inducible nitric oxide synthase in rat astrocytes
-
Miljkovic D, Samardzic T, Mostarica Stojkovic M, et al. Leflunomide inhibits activation of inducible nitric oxide synthase in rat astrocytes, Brain Res 2001;889: 331-338.
-
(2001)
Brain Res
, vol.889
, pp. 331-338
-
-
Miljkovic, D.1
Samardzic, T.2
Mostarica Stojkovic, M.3
-
24
-
-
0345491507
-
Exposure of T lymphocytes to leflunomide but not to dexamethasone favors the production by monocytic cells of interleukin-1 receptor antagonist and the tissue-inhibitor of metalloproteinases-1 over that of interleukin-1 beta and metalloproteinases
-
Deage V, Burger D, Dayer JM. Exposure of T lymphocytes to leflunomide but not to dexamethasone favors the production by monocytic cells of interleukin-1 receptor antagonist and the tissue-inhibitor of metalloproteinases-1 over that of interleukin-1 beta and metalloproteinases. Eur Cytokine Netw 1998;9: 663-668.
-
(1998)
Eur Cytokine Netw
, vol.9
, pp. 663-668
-
-
Deage, V.1
Burger, D.2
Dayer, J.M.3
-
25
-
-
0037105395
-
Restriction of de novo pyrimidine biosynthesis inhibits Th1 cell activation and promotes Th2 cell differentiation
-
Dimitrova P, Skapenko A, Herrmann ML, et al. Restriction of de novo pyrimidine biosynthesis inhibits Th1 cell activation and promotes Th2 cell differentiation. J Immunol 2002;169: 3392-3399.
-
(2002)
J Immunol
, vol.169
, pp. 3392-3399
-
-
Dimitrova, P.1
Skapenko, A.2
Herrmann, M.L.3
-
26
-
-
7644223637
-
Modulation of effector cell functions in experimental autoimmune encephalomyelitis by leflunomide - mechanisms independent of pyrimidine depletion
-
Korn T, Magnus T, Toyka K, Jung S. Modulation of effector cell functions in experimental autoimmune encephalomyelitis by leflunomide - mechanisms independent of pyrimidine depletion. J Leukoc Biol 2004;76: 950-960.
-
(2004)
J Leukoc Biol
, vol.76
, pp. 950-960
-
-
Korn, T.1
Magnus, T.2
Toyka, K.3
Jung, S.4
-
28
-
-
33645799680
-
A Phase II study of the safety and efficacy of teriflunomide in multiple sclerosis with relapses
-
O'Connor PW, Li D, Freedman MS. et al. A Phase II study of the safety and efficacy of teriflunomide in multiple sclerosis with relapses. Neurology 2006;66: 894-900.
-
(2006)
Neurology
, vol.66
, pp. 894-900
-
-
O'Connor, P.W.1
Li, D.2
Freedman, M.S.3
-
29
-
-
6744262231
-
A comparison of the efficacy and safety of leflunomide and methotrexate for the treatment of rheumatoid arthritis
-
Emery P, Breedveld FC, Lemmel EM, et al. A comparison of the efficacy and safety of leflunomide and methotrexate for the treatment of rheumatoid arthritis. Rheumatology (Oxford) 2000;39: 655-665.
-
(2000)
Rheumatology (Oxford)
, vol.39
, pp. 655-665
-
-
Emery, P.1
Breedveld, F.C.2
Lemmel, E.M.3
-
30
-
-
0033053835
-
Efficacy and safety of leflunomide compared with placebo and sulphasalazine in active rheumatoid arthritis: A double-blind, randomised, multicentre trial. European Leflunomide Study Group
-
Smolen JS, Kalden JR, Scott DL, et al. Efficacy and safety of leflunomide compared with placebo and sulphasalazine in active rheumatoid arthritis: a double-blind, randomised, multicentre trial. European Leflunomide Study Group. Lancet 1999;353: 259-266.
-
(1999)
Lancet
, vol.353
, pp. 259-266
-
-
Smolen, J.S.1
Kalden, J.R.2
Scott, D.L.3
-
31
-
-
51649107200
-
-
Kappos L, Miller DH, MacManus DG, et al. BG00012, a novel oral fumarate is effective in patients with relapsing-remitting multiple sclerosis. In: ECTRIMS. Madrid: Multiple Sclerosis, SAGE publications 2006.
-
Kappos L, Miller DH, MacManus DG, et al. BG00012, a novel oral fumarate is effective in patients with relapsing-remitting multiple sclerosis. In: ECTRIMS. Madrid: Multiple Sclerosis, SAGE publications 2006.
-
-
-
-
32
-
-
77955799815
-
Oral fingolimod (FTY720) for relapsing multiple sclerosis
-
Kappos L, Antel J, Comi G, et al. Oral fingolimod (FTY720) for relapsing multiple sclerosis. N Engl Med 2006;355: 1124-1140.
-
(2006)
N Engl Med
, vol.355
, pp. 1124-1140
-
-
Kappos, L.1
Antel, J.2
Comi, G.3
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